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Publication Metadata only Subclinical hypothyroidism: Is it important in intracytoplasmic sperm injection cycles?(GALENOS YAYINCILIK, 2017) Caliskan, Eray; Ergin, Rahime Nida; Oztekin, Deniz Can; Kars, Bulent; Cakir, Seda; Sofuoglu, Kenan; Bahcesehir University; Izmir Tepecik Training & Research Hospital; University of Health Sciences Turkey; Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital; University of Health Sciences Turkey; Istanbul Zeynep Kamil Maternity & Children's Diseases Training & Research HospitalObjective: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women. Materials and Methods: A retrospective case-control study was conducted. Out of 2529 ICSI cycles evaluated, 41 women with hypothyroidism, 28 women with hyperthyroidism, and 128 women with subclinical hyperthyroidism were excluded, and 2336 cycles were analyzed. Women were identified as having subclinical hypothyroidism (case group, n=105) in the presence of a thyroid-stimulating hormone level >4.5 mU/L and normal free T4 and compared with euthyroid controls (n=2231). Results: The mean age, body mass index, day 3 follicle-stimulating hormone level, and antral follicle count of the study patients were similar to the control group (p>0.5). The cycle cancellation rate of the study group was similar to the control group (13.3% vs. 7.6%, p=0.1). The clinical pregnancy rate was 21.2% in the study group, which was significantly lower than the 35.8% in the control group (p=0.04). The take-home baby rate was also significantly lower in the study group compared with the control groups (13.5% vs. 31.4% respectively, p=0.01). Conclusion: Both the clinical pregnancy rate and the take-home baby rate is lower in women with subclinical hypothyroidism at the time of ICSI cycle.Publication Metadata only The evaluation of analytical thinking skills and reaction tests on performance in female football players: their impact on in-game decision-making processes(SPRINGERNATURE, 2025) Yalcin, Gamze; Genc, Hazal; Bahcesehir University; Bahcesehir UniversityBackground Quick and accurate decision-making is crucial for individual and team success in football. Cognitive skills such as analytical thinking and reaction time enhance in-game performance. This study aimed to evaluate the effects of analytical thinking skills and reaction time on the performance of female football players and to explore their influence on decision-making processes during gameplay. Materials and methods A total of 40 female football players participated in the study. Decision-making simulations and selective reaction tests were used to assess cognitive performance, while reaction times to visual stimuli were measured using Blazepod devices. Physical performance was evaluated through the Y Balance Test to assess lower extremity dynamic balance and postural control. Additionally, the Tampa Scale for Kinesiophobia was administered to assess fear of injury and its potential impact on performance. Results A significant positive correlation was found between analytical thinking skills and in-game decision-making processes (r = 0.68, p < 0.01). A moderate-to-strong negative correlation was found between reaction time and decision-making time (r = - 0.52, p < 0.05). Multiple linear regression analysis indicated that the decision-making score significantly positively affected kinesiophobia (B = 1.101, p = 0.030), with the model explaining 24.7% of the variance in kinesiophobia scores (R-2 = 0.247). Conclusion These findings suggest that cognitive and physical parameters are associated with in-game performance in female football players. Monitoring and enhancing these components may contribute to developing more effective training and performance strategies.Publication Metadata only Prediction of cyclosporine A blood levels: An application of the adaptive-network-based fuzzy inference system (ANFIS) in assisting drug therapy(2008) Gören, Sezer; Karahoca, Adem; Onat, Filiz Yilmaz; Gören, Mehmet Zafer; Gören, Sezer, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karahoca, Adem, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Onat, Filiz Yilmaz, Department of Pharmacology and Clinical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey; Gören, Mehmet Zafer, Department of Pharmacology and Clinical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, TurkeyObjective: Therapeutic drug monitoring (TDM) is a procedure in which the levels of drugs are assayed in various body fluids with the aim of individualizing the dose of critical drugs, such as cyclosporine A. Cyclosporine A assays are performed in blood. Methods: We proposed the use of the Takagi and Sugeno-type adaptive-network-based fuzzy inference system (ANFIS) to predict the concentration of cyclosporine A in blood samples taken from renal transplantation patients. We implemented the ANFIS model using TDM data collected from 138 patients and 20 input parameters. Input parameters for the model consisted of concurrent use of drugs, blood levels, sampling time, age, gender, and dosing intervals. Results: Fuzzy modeling produced eight rules. The developed ANFIS model exhibited a root mean square error (RMSE) of 0.045 with respect to the training data and an error of 0.057 with respect to the checking data in the MATLAB environment. Conclusion: ANFIS can effectively assist physicians in choosing best therapeutic drug dose in the clinical setting. © 2008 Springer-Verlag. © 2009 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Caregiving style, problem solving strategies, anger style and health status in women caregivers of alzheimer patients and healthy elderly, Alzhei̇mer hastalarina ve saǧlikli yaşlilara bakimveren kadin yakinlarda bakim verme tarzi, problem çözme strateji̇leri̇,öfke tarzlari ve saǧlik durumunun i̇ncelenmeṡi(2009) Korkut, Yeflim; Sertel-Berk, Hanife Özlem; Korkut, Yeflim, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sertel-Berk, Hanife Özlem, Psikoloji Anabilim Dali, Istanbul Üniversitesi, Istanbul, TurkeyIntroduction: The principle aim of this study is to investigate the caregiving style of the participants and the kind of support they receive, to compare anger levels, problem solving approaches and health problems of Alzheimer Disease (AD) patient female caregivers with a control group. This study further examines the effect of group, age, health status, anger style and problem solving style on depression. Materials and Method: 42 female caregivers (22 AD and 20 control) participated in the study. They were given a demographic questionnaire, Beck Depression Inventory-BDI, State-Trait Anger Scale-STAS and Problem Solving Inventory-PSI. Results: Results indicated that both AD and control group caregivers were similar in terms of caregiving style. Though AD and control group caregivers did not differ in terms PSI and BDI, there were significant differences between those who reported illness and those who did not in terms of impatient and thoughtful approach sub-tests of PSI. The regression analysis showed that age and repressed anger significantly explained the variation in BDI. Conclusion: Altogether results showed that in a relatively low at risk women caregivers group, regardless of being AD caregiver or not, age and repressed anger are important factors on depression levels. Health status of caregiver seems to be a determining factor on PSI. © 2009 Elsevier B.V., All rights reserved.Publication Metadata only Coupled nonparametric shape and moment-based intershape pose priors for multiple basal ganglia structure segmentation(2010) Uzunbaş, Mustafa Gökhan; Soldea, Octavian; Ünay, Devrim; Çetin, Müjdat; Unal, Gozde Bozkurt; Erçil, Aytül; Ekin, Ahmet; Uzunbaş, Mustafa Gökhan, Faculty of Engineering and Natural Sciences, Sabancı Üniversitesi, Tuzla, Turkey, Department of Computer Science, Piscataway, United States; Soldea, Octavian, Faculty of Engineering and Natural Sciences, Sabancı Üniversitesi, Tuzla, Turkey; Ünay, Devrim, Department of Electrical and Electronic Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Çetin, Müjdat, Faculty of Engineering and Natural Sciences, Sabancı Üniversitesi, Tuzla, Turkey; Unal, Gozde Bozkurt, Faculty of Engineering and Natural Sciences, Sabancı Üniversitesi, Tuzla, Turkey; Erçil, Aytül, Faculty of Engineering and Natural Sciences, Sabancı Üniversitesi, Tuzla, Turkey; Ekin, Ahmet, Video Processing and Analysis Group, Philips Research, Eindhoven, NetherlandsThis paper presents a new active contour-based, statistical method for simultaneous volumetric segmentation of multiple subcortical structures in the brain. In biological tissues, such as the human brain, neighboring structures exhibit co-dependencies which can aid in segmentation, if properly analyzed and modeled. Motivated by this observation, we formulate the segmentation problem as a maximum a posteriori estimation problem, in which we incorporate statistical prior models on the shapes and intershape (relative) poses of the structures of interest. This provides a principled mechanism to bring high level information about the shapes and the relationships of anatomical structures into the segmentation problem. For learning the prior densities we use a nonparametric multivariate kernel density estimation framework. We combine these priors with data in a variational framework and develop an active contour-based iterative segmentation algorithm. We test our method on the problem of volumetric segmentation of basal ganglia structures in magnetic resonance images. We present a set of 2-D and 3-D experiments as well as a quantitative performance analysis. In addition, we perform a comparison to several existent segmentation methods and demonstrate the improvements provided by our approach in terms of segmentation accuracy. © 2010 IEEE. © 2010 Elsevier B.V., All rights reserved.Publication Metadata only The impact of conservative discourses in family policies, population politics, and gender rights in Poland and Turkey(2011) Korkut, Umut; Eslen-Ziya, Hande; Korkut, Umut, Glasgow Business School, Glasgow Caledonian University, Glasgow, United Kingdom; Eslen-Ziya, Hande, Bahçeşehir Üniversitesi, Istanbul, TurkeyThis article uses childcare as a case study to test the impact of ideas that embody a traditional understanding of gender relations in relation to childcare. Conservative ideas regard increasing female labor market participation as a cause of decreasing fertility on the functioning of a set of general policies to increase fertility rates. It looks into the Polish and Turkish contexts for empirical evidence. The Polish context shows a highly institutionalized system of family policies in contrast to almost unessential institutions in Turkey. Formally, the labor market participation of women is much lower in Turkey than in Poland. Yet, given the size of the informal market in Turkey, womens labor participation is obviously higher than what appears in the statistics. Bearing in mind this divergence, the article suggests Poland and Turkey as two typologies for studying population politics in contexts where socially conservative ideas regarding gender remain paramount. We qualify ideas as conservative if they enforce a traditional understanding of gender relations in care-giving and underline womens role in the labor market as an element of declining fertility. In order to delineate ideational impact, this article looks into how ideas (a) supplant and (b) substitute formal institutions. Therefore, we argue that there are two mechanisms pertaining to the dominance of conservative conventions: conservative ideas may either supplant the institutional impact on family policies, or substitute them thanks to a superior reasoning which societies assign to them. Furthermore, conservative conventions prevail alongside womens customary unpaid work as care-givers regardless of the level of their formal workforce participation. We propose as our major findings for the literature of population politics that ideas, as ubiquitous belief systems, are more powerful than institutions since they provide what is perceived as legitimate, acceptable, and good for the societies under study. In the end, irrespective of the presence of institutions, socially conservative ideas prevail. © The Author 2011. Published by Oxford University Press. All rights reserved. © 2012 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Icon and user interface design for emergency medical information systems: A case study(2012) Salman, Yücel Batu; Cheng, Hongin; Patterson, Patrick E.; Salman, Yücel Batu, Department of Software Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Cheng, Hongin, Department of Industrial and Management Engineering, Kyungsung University, Busan, South Korea; Patterson, Patrick E., Edward E. Whitacre Jr. College of Engineering, Lubbock, United StatesA usable medical information system should allow for reliable and accurate interaction between users and the system in emergencies. A participatory design approach was used to develop a medical information system in two Turkish hospitals. The process consisted of task and user analysis, an icon design survey, initial icon design, final icon design and evaluation, and installation of the iconic medical information system with the icons. We observed work sites to note working processes and tasks related to the information system and interviewed medical personnel. Emergency personnel then participated in the design process to develop a usable graphical user interface, by drawing icon sketches for 23 selected tasks. Similar sketches were requested for specific tasks such as family medical history, contact information, translation, addiction, required inspections, requests and applications, and nurse observations. The sketches were analyzed and redesigned into computer icons by professional designers and the research team. A second group of physicians and nurses then tested the understandability of the icons. The user interface layout was examined and evaluated by system users, followed by the system's installation. Medical personnel reported the participatory design process was interesting and believed the resulting designs would be more familiar and friendlier. © 2011 Elsevier Ireland Ltd. © 2013 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Standardization of Turkish form of metacognition questionnaire for children and adolescents: The relationships with anxiety and obsessive-compulsive symptoms(2012) Irak, Metehan; Irak, Metehan, Department of Psychology, Bahçeşehir Üniversitesi, Istanbul, TurkeyObjective: There were two aims of the present study. The first aim was to evaluate the psychometric properties of the Metacognition Questionnaire for Children and Adolescents (MCQ-C) among Turkish children and adolescents. The second aim was to analyze relationships between metacognitive processes, anxiety, and obsessive-compulsive symptoms among Turkish children and adolescents. Method: Four hundred and seventy primary and high school students (205 female, 265 male) from 71 different public schools in Istanbul participated in the study. Three questionnaires were used. In addition to MCQ-C, State-Trait Anxiety Scale for Children and Maudsley Obsessive- Compulsive Inventory were administrated in the study. Results: The Turkish form of MCQ-C showed acceptable to good test-retest reliability and good internal consistency and convergent validity. Construct validity was evaluated by confirmatory factor analysis using AMOS. The fit indices of confirmatory factor analysis suggested an acceptable fit to a four-factor model consistent with the original MCQ-C. Significant positive correlations between subscales of MCQ-C and measures of anxiety and obsessive-compulsive symptoms provided further support for the convergent validity of the Turkish form of MCQ-C. Group comparisons showed that the effect of age was significant on the MCQ-C positive meta-worry subscale only, on the other hand, effect of gender was significant on MCQ-C negative meta-worry subscale and total score. Conclusion: The psychometric properties of Turkish form of MCQ-C showed that the instrument is a valuable addition to the assessment of metacognition for Turkish children and adolescents. © 2012 Elsevier B.V., All rights reserved.Publication Metadata only Collection and analysis of a Parkinson speech dataset with multiple types of sound recordings(Institute of Electrical and Electronics Engineers Inc., 2013) Erdogdu Sakar, Betul; Isenkul, M. Erdem; Sakar, C. Okan; Sertbaş, Ahmet; Gürgen, Fïkret S.; Delil, Sakir; Apaydin, H.; Kursun, Olcay; Erdogdu Sakar, Betul, Department of Computer Programming, Bahçeşehir Üniversitesi, Istanbul, Turkey; Isenkul, M. Erdem, Department of Computer Engineering, Istanbul Üniversitesi, Istanbul, Turkey; Sakar, C. Okan, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sertbaş, Ahmet, Department of Computer Engineering, Istanbul Üniversitesi, Istanbul, Turkey; Gürgen, Fïkret S., Department of Computer Engineering, Boğaziçi Üniversitesi, Bebek, Turkey; Delil, Sakir, Department of Neurology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Apaydin, H., Department of Neurology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Kursun, Olcay, Department of Computer Engineering, Istanbul Üniversitesi, Istanbul, TurkeyThere has been an increased interest in speech pattern analysis applications of Parkinsonism for building predictive telediagnosis and telemonitoring models. For this purpose, we have collected a wide variety of voice samples, including sustained vowels, words, and sentences compiled from a set of speaking exercises for people with Parkinson's disease. There are two main issues in learning from such a dataset that consists of multiple speech recordings per subject: 1) How predictive these various types, e.g., sustained vowels versus words, of voice samples are in Parkinson's disease (PD) diagnosis? 2) How well the central tendency and dispersion metrics serve as representatives of all sample recordings of a subject? In this paper, investigating our Parkinson dataset using well-known machine learning tools, as reported in the literature, sustained vowels are found to carry more PD-discriminative information. We have also found that rather than using each voice recording of each subject as an independent data sample, representing the samples of a subject with central tendency and dispersion metrics improves generalization of the predictive model. © 2013 IEEE. © 2022 Elsevier B.V., All rights reserved.Publication Metadata only Thyroid dyshormonogenesis is mainly caused by TPO mutations in consanguineous community(2013) Cangül, Hakan; Aycan, Zehra; Olivera-Nappa, Alvaro; Saǧlam, Halil; Schoenmakers, Nadia A.; Boelaert, Kristien; Çetinkaya, Semra Çaǧlar; Tarim, Ömer Faruk; Böber, Ece; Darendeli̇Ler, Feyza F.; Cangül, Hakan, Department of Medical Genetics, Bahçeşehir Üniversitesi, Istanbul, Turkey, Centre for Rare Diseases and Personalised Medicine, University of Birmingham, Birmingham, United Kingdom; Aycan, Zehra, Division of Paediatric Endocrinology, Children's Hospital, Ankara, Turkey; Olivera-Nappa, Alvaro, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Saǧlam, Halil, Department of Paediatric Endocrinology, Bursa Uludağ Üniversitesi, Bursa, Turkey; Schoenmakers, Nadia A., University of Cambridge, Cambridge, United Kingdom; Boelaert, Kristien, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, United Kingdom; Çetinkaya, Semra Çaǧlar, Division of Paediatric Endocrinology, Children's Hospital, Ankara, Turkey; Tarim, Ömer Faruk, Department of Paediatric Endocrinology, Bursa Uludağ Üniversitesi, Bursa, Turkey; Böber, Ece, Department of Pediatrics, Dokuz Eylül Üniversitesi, Izmir, Turkey; Darendeli̇Ler, Feyza F., Pediatric Endocrinology Unit, İstanbul Tıp Fakültesi, Istanbul, TurkeyObjective In this study, we aimed to investigate the genetic background of thyroid dyshormonogenesis (TDH). Context Thyroid dyshormonogenesis comprises 10-15% of all cases of congenital hypothyroidism (CH), which is the most common neonatal endocrine disorder, and might result from disruptions at any stage of thyroid hormone biosynthesis. Currently seven genes (NIS, TPO, PDS, TG, IYD, DUOX2 and DUOXA2) have been implicated in the aetiology of the disease. Design As TDH is mostly inherited in an autosomal recessive manner, we planned to conduct the study in consanguineous/multi-case families. Patients One hundred and four patients with congenital TDH all coming from consanguineous and/or multi-case families. Measurements Initially, we performed potential linkage analysis of cases to all seven causative-TDH loci as well as direct sequencing of the TPO gene in cases we could not exclude linkage to this locus. In addition, in silico analyses of novel missense mutations were carried out. Results TPO had the highest potential for linkage and we identified 21 TPO mutations in 28 TDH cases showing potential linkage to this locus. Four of 10 distinct TPO mutations detected in this study were novel (A5T, Y55X, E596X, D633N). Conclusions This study underlines the importance of molecular genetic studies in diagnosis, classification and prognosis of CH and proposes a comprehensive mutation screening by new sequencing technology in all newly diagnosed primary CH cases. © 2012 John Wiley & Sons Ltd. © 2014 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.