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Publication Open Access A preliminary study of tracking B-cell kinetics in patients with lung transplantation by monitoring kappa-deleting recombination excision circles(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2022) Akbulut, Zeynep; Akdeniz, Tuba; Vayvada, Mustafa; Kalamanoğlu, Merih; Yeğinsu, Ali; Yanıkkaya Demirel, Gülderen; Kutlu, Cemal Asım; Maltepe University; Yeditepe University; Bahcesehir University; Istanbul Yeni Yuzyil University; Yeditepe University; Bahcesehir UniversityBackground: This study aims to evaluate humoral immune system response by measuring copy numbers of kappa-deleting recombination excision circles (KREC) gene segment from B lymphocytes in patients with lung transplantation. Methods: Between September 2015 and November 2016, a total of 11 patients (8 males, 3 females, mean age: 45.4 +/- 12.0 years, range, 23 to 59 years) who underwent lung transplantation with different primary indications were included. The copy numbers of KREC gene segment were quantified using real-time polymerase chain reaction method in peripheral blood samples collected pre- and post-transplantation. The samples of the patients were compared with the KREC levels in deoxyribonucleic acid extracted from blood samples of healthy children. Results: There was no significant change in KREC levels between pre- and post-operation (p=0.594 and p=0.657), although the median values indicated that the highest increase in the KREC levels (7x10(5)-12x10(5) , 85-170) was on Day 7 of transplantation. There was a positive correlation between the KREC levels (mL in blood) and lymphocytes at 24 h after transplantation (p=0.043) and between KREC copies per 10(6) of blood and age on Day 7. Conclusion: Our preliminary results suggest that KREC levels as an indicator of B lymphocyte production are elevated after lung transplantation. A prognostic algorithm by tracking B cell kinetics after post-transplantation for long-term follow-up can be developed following the confirmation of these preliminary results with more patient samples.Publication Open Access Trace Elements in the Soil-Plant Systems of Copper Mine Areas-A Case Study From Murgul Copper Mine From the Black Sea Region of Turkey(TECH SCIENCE PRESS, 2019) Ozturk, Munir; Altay, Volkan; Kucuk, Mahir; Yalcin, Ibrahim Ertugrul; Ege University; Ege University; Hatay Mustafa Kemal University; Bahcesehir UniversityThis study presents a case study on the heavy metal analysis of soil and plant samples around the Murgul copper mine, one of the first and most important mining areas in Turkey. An attempt has been made to investigate the status of trace elements like Al3+, Fe2+, Cu2+, Zn2+, Pb2+, Ni2+, Co2+ and Cd2+ in soils and plants. The sampling localities were taken from 500 m, 600 m, and 1000 m altitudes around the factory and at 1400 m in the forest zone. The aboveground parts and foliage ash of Silene compacta, Tussilago farfara, Smilax excelsa, Rhododendron ponticum, R. luteum, and herbal mix were analysed. The results of analysis have revealed the minimum and maximum concentrations measured in the plants as follows, aluminium (20-8985 mg kg(-1)), cadmium (0.0-0.5 mg kg(-1)), cobalt (0.0-5.5 mg kg(-1)), copper (0.0-347.5 mg kg(-1)), iron (25-9320 mg kg(-1)), lead (2-51 mg kg(-1)), nickel (1.5-16.5 mg kg(-1)), and zinc (13.0-221.0 mg kg(-1)). In the soil the concentrations of aluminium, cadmium, cobalt, copper, iron, lead, nickel, and zinc vary between 33-457, 0.0-0.0, 0.0-0.4, 0.1-88.7, 14-50, 0.3-4.1, 0.2-0.8, and 4.0-20.3 mg kg(-1) respectively. These findings enlighten the fact that copper is generally toxic in the soils as well as plants. Silene compacta has been recorded as a high copper accumulator, behaving as a healthy plant on the polluted sites of the area alongside the Murgul creek (especially at 600 m). This study stresses the fact that it is imperative to assess and monitor the levels of heavy metals in the environment due to anthropogenic activities, including mining, for evaluation of human exposure and for sustainable environment.Publication Metadata only Cognitive Backgrounds of Problem Solving: A Comparison of Open-ended vs. Closed Mathematics Problems(MODESTUM LTD, 2015) Bahar, Abdulkadir; Maker, C. June; Bahcesehir University; University of ArizonaProblem solving has been a core theme in education for several decades. Educators and policy makers agree on the importance of the role of problem solving skills for school and real life success. A primary purpose of this study was to investigate the influence of cognitive abilities on mathematical problem solving performance of elementary students. The author investigated this relationship by separating performance in open-ended and closed situations. Findings of the study indicated that the cognitive abilities explained 32.3% (open-ended) and 48.2% (closed) of the variance in mathematical problem solving performance as a whole. Mathematical knowledge and general intelligence were found to be the only variables that contributed significant variance to closed problem solving performance. General creativity and verbal ability were found to be the only variables that contributed significant variance to open-ended problem solving performance.Publication Open Access A mentorship model for teacher education: Young STEM researchers and practitioners program(MEHMET TEKEREK, 2022) Yabas, Defne; Bozoğlu, Hayriye Sinem; Bahçeşehir ÜniversitesiThe current research is about the impact of the young STEM researchers and practitioners program implemented within the STEM: Integrated teaching project. The aim of the program is to incorporate STEM integrated teaching knowledge in the teacher preparation period. In this phenomenological study, we explored five pre-school teachers' program experiences and their STEM conceptions. Data were collected with semi-structured interviews, including questions about the impact and elements of the program and participants' STEM conceptions. Content analysis showed that awareness for STEM education, development of integrated teaching knowledge, and program elements were the emergent themes about the program experience. Teacher candidates responded to the models that include real-world problems and engineering as contexts as most desirable when shown STEM education models to understand their STEM conceptions. The young STEM researchers and practitioners program can be evaluated as a developing model to be incorporated into teacher education programs. Further research can explore how pre-service teachers form their STEM conceptions and develop their integrated teaching knowledge.Publication Open Access Fizyoterapi ve Rehabilitasyon Öğrencilerinin Öğrenme Stili Tercihlerine Göre Akademik Başarı, Akademik Öz Güven ve Eğitim Ortamı Algısının Karşılaştırılması(2025) Açar, Görkem; Delibay, Aylin Aydoğdu; Kiloatar, Hümeyra; Turan, Onur; Bahçeşehir Üniversitesi; Kütahya Sağlık Bilimleri Üniversitesi; İstanbul Atlas ÜniversitesiBu çalışmanın amacı lisans düzeyindeki fizyoterapi ve rehabilitasyon öğrencilerinin farklı öğrenme stili tercihlerine göre akademik başarılarını, akademik özgüvenlerini ve öğrenme çevrelerini incelemekti. Çalışmaya lisans düzeyindeki 180 fizyoterapi ve rehabilitasyon öğrencisi dahil edilmiştir. Bireylerin öğrenme stili tercihleri Kolb Öğrenme Stili Envanteri-3 ile, öğrenme çevreleri Dundee Mevcut Eğitim Ortamı Değerlendirme Ölçeği (DREEM) ile, özgüvenleri ise Akademik Özgüven Ölçeği (AÖÖ) ile değerlendirilmiştir. Bireylerin akademik başarıları Genel Akademik Not Ortalamaları aracılığıyla değerlendirilmiştir. Farklı öğrenme stillerini tercih eden bireylerin Akademik Özgüven Ölçeği ile ölçülen akademik özgüvenleri benzerdi (p>0,05). Farklı öğrenme stillerini tercih eden bireylerin DREEM anketiyle ölçülen öğrenme çevresi algıları istatistiksel olarak farklıydı (p<0,05). Özümseyen öğrenme stilini tercih eden öğrencilerinin DREEM puanı ayrıştıran ve yerleştiren öğrenme stilini tercih eden bireylere göre daha düşük bulundu (p<0,05). Farklı öğrenme stillerini tercih eden bireylerin akademik başarıları istatistiksel olarak farklı bulundu (p<0,05). Değiştiren ve ayrıştıran öğrenme stillerine sahip öğrenciler arasında (χ² = 16.36, p = 0.0025), ayrıca yerleştiren ve ayrıştıran öğrenme stillerine sahip öğrenciler arasında (χ² = 16.37, p = 0.0025) istatistiksel olarak anlamlı farklılıklar bulunmuştur. Bu çalışma, fizyoterapi ve rehabilitasyon öğrencilerinde öğrenme stili tercihlerinin akademik başarı ve öğrenme ortamı algısı üzerinde anlamlı bir etkisi olduğunu ortaya koymuştur. Özümseyen öğrenme stiline sahip öğrencilerin eğitim ortamına yönelik memnuniyet düzeylerinin daha düşük olduğu, ayrıştırıcı öğrenme stiline sahip öğrencilerin ise akademik başarılarının daha düşük olduğu bulunmuştur. Buna karşılık, akademik özgüven düzeyleri öğrenme stilleri arasında anlamlı bir farklılık göstermemiştir. Bu bulgular, farklı öğrenme stillerine uygun eğitim stratejilerinin geliştirilmesinin, fizyoterapi ve rehabilitasyon eğitiminde öğrenci memnuniyetini ve akademik başarıyı artırabileceğini göstermektedir.Publication Open Access Popular Culture: From Being an Enemy of the Feminist Movement to a Tool for Women's Liberation?(John Wiley and Sons Inc, 1999) Kirca, Süheyla; Kirca, Süheyla, Public Relations Department, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Open Access House mice with metacentric chromosomes in the Middle East(Mendelian Society of Lund, 2000) Gündüz, Islam; Tez, Cosslkun; Searle, Jeremy B.; Gündüz, Islam, Department of Biology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Tez, Cosslkun, Department of Biology, Erciyes Üniversitesi, Kayseri, Turkey; Searle, Jeremy B., Department of Biology, University of York, York, United Kingdom[No abstract available]Publication Open Access The synthesis of novel crown ethers, part VII [1]. Coumarin derivatives of benzocrowns and cation binding from fluorescence spectra(Springer Netherlands, 2000) Erk, Çakil L.; Bulut, Mustafa; Göçen, Ayten; Erk, Çakil L., Department of Chemistry, İstanbul Teknik Üniversitesi, Istanbul, Turkey; Bulut, Mustafa, Department of Chemistry, Marmara Üniversitesi, Istanbul, Turkey; Göçen, Ayten, Department of Chemistry, Bahçeşehir Üniversitesi, Istanbul, Turkey4-[3-(1-benzopyran-2-one)] derivatives of benzo[12]crown-4, benzo[15]crown-5 and benzo-[18]crown-6 were synthesized from 4-[3-(1-benzopyran-2-one)]-1,2-dihydroxy-benzene reacting with bis-ethyleneglycol dihalides or pentaethylene glycol ditosylate in alkali carbonate/DMF/water. The original products were identified by high resolution EI-mass spectra as well us IR, 1H-NMR and 13C-NMR spectroscopy. The 1 : 1 binding constants of Mg2+, Li+, Na+ and K+ with the coumarin-benzocrowns were estimated using fluorescence emission spectroscopy in acetonitrile. The complexing enhanced quenching fluorescence spectra (CEQFS) and complexing enhanced fluorescence spectra (CEFS) exhibited the ion binding powers due to cationic recognition rules of the macrocycles. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Fluorine determination in human and animal bones by particle-induced gamma-ray emission(Springer Verlag, 2001) Sastri, Chaturvedula S.; Lyengar, Venkatesh; Blondiaux, Gilbert B.; Tessier, Yves; Petri, Hermann; Hoffmann, Peter S.; Aras, Namık K.; Zaichick, Vladimir Ye; Ortner, Hugo Manfred; Sastri, Chaturvedula S., Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, Germany; Lyengar, Venkatesh, International Atomic Energy Agency, Vienna, Vienna, Austria; Blondiaux, Gilbert B., Centre de Recherches Internationales Sciences Po, Paris, France; Tessier, Yves, Centre de Recherches Internationales Sciences Po, Paris, France; Petri, Hermann, Forschungszentrum Jülich GmbH, Julich, Germany; Hoffmann, Peter S., Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, Germany; Aras, Namik K., Department of Chemistry, Middle East Technical University (METU), Ankara, Turkey, Bahçeşehir Üniversitesi, Istanbul, Turkey; Zaichick, Vladimir Ye, A. Tsyb Medical Radiological Research Center, Obninsk, Russian Federation; Ortner, Hugo Manfred, Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, GermanyFluorine was determined in the iliac crest bones of patients and in ribs collected from post-mortem investigations by particle-induced gamma-ray emission based on the 19F(p,p′y)19F reaction, using 2.0/2.5 MeV protons. The results indicate that for 68% of the human samples the F concentration is in the range 500-1999 μg g-1. For comparison purposes fluorine was also determined in some animal bones, in some animal tissues lateral profiles of fluorine were measured. © Springer-Verlag 2001. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Substrate specificity, heat inactivation and inhibition of polyphenol oxidase from different aubergine cultivars(2002) Doǧan, Mehmet; Arslan, Oktay; Doǧan, Serap D.; Doǧan, Mehmet, Department of Chemistry, Bahçeşehir Üniversitesi, Istanbul, Turkey; Arslan, Oktay, Department of Chemistry, Bahçeşehir Üniversitesi, Istanbul, Turkey; Doǧan, Serap D., Department of Biology, Bahçeşehir Üniversitesi, Istanbul, TurkeyThe effects of substrate specificity, heat inactivation, temperature, pH and inhibitors on polyphenol oxidase (PPO) activity obtained from three different aubergine cultivars were investigated to identify the most appropriate aubergine cultivar for dried preparations. PPO obtained from different aubergine cultivars (cultivars I, II and III) was partially purified by (NH4)2SO4 precipitation followed by dialysis. PPO showed activity with catechol and 4-methylcatechol but not with L-tyrosine. The best substrate for cultivar I (Vmax: 3333.3 EU min-1 mL-1, Km: 8.7 mM and Vmax/Km: 384.9 min-1) and cultivar III (Vmax: 1000 EU min-1 mL-1, Km: 9.3 mM and Vmax/Km: 107.5 min-1) was catechol, but 4-methylcatechol was the best substrate for cultivar II (Kmax: 5000 EU min-1 mL-1, Km: 35.5 mM and Vmax/Km: 140.8 min-1). The optimum pH for aubergine PPO was 7.0 with catechol as a substrate and 6.0 with 4-methylcatechol. Heat inactivation studies showed a decrease in enzyme activity at temperatures above 40 °C. For catechol and 4-methylcatechol substrates, the optimum temperature for maximum PPO activity was 30 °C for all aubergine cultivars except cultivar I using catechol which was 20 °C. The effects of compounds such as tropolone, D,L-dithiothreitrol and glutathione as inhibitors of the reactions catalysed by PPO were tested. Generally, tropolone was the most effective inhibitor. © 2011 Elsevier B.V., All rights reserved.