Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
Permanent URI for this communityhttps://hdl.handle.net/20.500.14719/1741
Browse
13 results
Search Results
Publication Metadata only Standards and Definitions in Neck Dissections of Differentiated Thyroid Cancer(YERKURE TANITIM YAYINCILIK HIZMETLERI AS, 2018) Uludag, Mehmet; Tanal, Mert; Isgor, Adnan; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Bahcesehir University; Memorial Healthcare GroupPublication Metadata only Hormone receptor status and survival of medullary breast cancer patients(SAUDI MED J, 2017) Aksoy, Asude; Odabas, Hatice; Kaya, Serap; Bozkurt, Oktay; Degirmenci, Mustafa; Topcu, Turkan O.; Aytekin, Aydin; Arpaci, Erkan; Avci, Nilufer; Pilanci, Kezban N.; Cinkir, Havva Y.; Bozkaya, Yakup; Cirak, Yalcin; Gumus, Mahmut; Firat University; Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital; Marmara University; Bahcesehir University; Bezmialem Vakif University; Istanbul Haseki Training & Research Hospital; Ankara Numune Training & Research Hospital; Erciyes University; Karadeniz Technical University; Gazi University; Dr. Abdurrahman Yurtaslan Oncology Hospital; Zonguldak Bulent Ecevit University; Ali Osman Sonmez Oncology HospitalObjectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uniand multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05). Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.Publication Metadata only Surgical approaches for papillary microcarcinomas: Turkey's perspective(AVES, 2018) Makay, Ozer; Ozdemir, Murat; Senyurek, Yasemin Giles; Tunca, Fatih; Duren, Mete; Uludag, Mehmet; Haciyanli, Mehmet; Icoz, Gokhan; Isgor, Adnan; Ozbas, Serdar; Ozcan, Zehra; Tezelman, Serdar; Ege University; Ege University; Istanbul University; Istanbul University - Cerrahpasa; Istanbul University; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Izmir Katip Celebi University; Bahcesehir University; Guven Hastanesi; Koc UniversityObjectives: The incidence of papillary microcarcinomas, which are defined as thyroid cancers of <10mm in size, has been increasing in the last decade. Herein, we present internet-based questionnaire results performed by the Turkish Association of Endocrine Surgery with the aim to evaluate the perspective of the management of papillary microcarcinomas in Turkey. Material and Methods: The user-friendly questionnaire consisted of 13 questions in total. These questions mainly addressed the surgical management of nodules and cancer of <1 cm in size. Patient management before, during, and after surgical intervention was also included, additionally, the active surveillance approach was questioned. Results: There were 420 responders in total who were of multidisciplinary origin (endocrinologists, surgeons, nuclear medicine specialists, pathologists, and oncologists). Total thyroidectomy was the predominant treatment approach (65%) for the classical type of microcarcinoma limited in one lobe, whereas in cases of microcarcinomas incidentally diagnosed during hemithyroidectomy, complementary surgery approach was advised by 40% of the responders. The responders found capsule invasion (86%) and patient based management (94%) of high importance. The percentage of the responders who recommended radioactive iodine ablation in incidental cancers having no aggressive criteria was 51%. The survey participants that were against routine central dissection in these cases accounted for 73% of the responders. The recommendation of active surveillance (follow-up without any interventional therapy) was limited with 9% responders. Conclusion: The results of the questionnaire demonstrated that there have been various choices in Turkey for the surgical treatment of the papillary microcarcinomas.Publication Metadata only Can Active Surveillance be an Alternative to Surgery in Papillary Thyroid Microcarcinoma?: The Current Situation Worldwide(KARE PUBL, 2018) Aygun, Nurcihan; Isgor, Adnan; Uludag, Mehmet; University of Health Sciences Turkey; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Bahcesehir University; Memorial Healthcare GroupPapillary thyroid carcinoma is the most common endocrine malignancy. Papillary thyroid microcarcinomas (PTMCs) are tumors with a size of <= 1 cm. The biological behavior of these tumors differs due to the presence of their aggressive features. The prognosis of PTMCs with high-risk features, such as clinical node metastasis, distant metastasis, and significant extrathyroidal extension to the tracheal or recurrent laryngeal nerve invasion, is poor, even if a sufficient immediate surgery is performed at diagnosis. However, PTMCs without these aggressive features are low-risk tumors because of their indolent and slow growth behaviors. The increase in thyroid cancer incidence is mostly a result of overdiagnosis of small low-risk PTMCs with indolent clinical course. Despite the sudden increase in thyroid cancer incidence worldwide, cancer mortality did not increase. Although the traditional treatment strategy for PTMC is immediate surgery at diagnosis, because of the rather low disease-specific mortality rate, low recurrence rate, and potential risk for postoperative complications, active surveillance has been proposed recently as an alternative option for PTMCs without invasion, metastasis, or cytological or molecular characteristics. The recent data support that active surveillance of low-risk PTMC should be the initial treatment modality, because only a small percentage of low-risk PTMCs show signs of progression, and delayed surgery has not caused significant recurrence. However, recent management guidelines are shifting toward more conservative treatments, such as active surveillance. Although there is an increase in the number of studies related to active surveillance, prospective studies have been mostly from academic referral centers in Japan. The world still needs class 1 evidence extended prospective studies originating from different geographic regions. Active surveillance may be a good alternative to immediate surgery for appropriately selected patients with PTMC.Publication Metadata only Analysis of Patients With Stage IIIC Endometrial Cancer(BMJ PUBLISHING GROUP, 2014) Turan, Taner; Ureyen, Isin; Duzguner, Ipek; Ozkaya, Enis; Tasci, Tolga; Karalok, Alper; Boran, Nurettin; Kose, M. Faruk; Tulunay, Gokhan; Etlik Zubeyde Hanim Gynecology Education & Research Hospital; Dr. Sami Ulus Education & Research Hospital; Bahcesehir UniversityObjective We aimed to define the factors that are related to recurrence and survival in patients with stage IIIC endometrial carcinoma in this study. Materials and Methods A total of 147 patients who underwent staging surgery and had a diagnosis of stage IIIC1 to IIIC2 endometrial cancer according to the International Federation of Gynecology and Obstetrics 2009 were included. Patients whose data could not be obtained and patients with a diagnosis of uterine sarcoma and with synchronous tumors were excluded. Results Mean age of the patients was 58.6 years. Among these patients, 63 had stage IIIC1 and 84 had stage IIIC2 disease. Extrauterine spread was detected in 22% of the patients. Median number of paraaortic (PA) and pelvic lymph nodes removed were 16.5 and 38, respectively. Paraaortic and pelvic nodal involvements were detected in 84 patients and 125 patients, respectively. Radiotherapy was applied more commonly as an adjuvant therapy. Three-year progression-free survival (PFS) and 3-year disease-specific survival (DSS) were 65% and 84%, respectively. Seventy percent of the recurrences were outside the pelvis. Site of metastatic lymph nodes and the number of metastatic PA lymph nodes were associated with 3-year PFS and lymphovascular space invasion, site of metastatic lymph nodes and the presence of recurrence were associated with 3-year DSS in the univariate analysis. Although any surgicopathological factor was not related to 3-year PFS, only the presence of recurrence was an independent prognostic factor for a 3-year DSS in the multivariate analysis (hazard ratio, 0.017, 95% confidence interval, 0.002-0.183). Conclusions The number of debulked metastatic lymph nodes and PA involvement were associated with recurrence in the univariate analysis. The presence of recurrence was the only independent prognostic factor detecting survival. Therefore, systematic lymphadenectomy involving PA lymph nodes instead of sampling should be performed in patients with high risk for nodal involvement in endometrial cancer.Publication Metadata only Lung Adenocarcinoma Metastasis Mimicking Peripheral Nerve Sheath Tumor: Case Report and Review of Literature(ELSEVIER SCIENCE INC, 2018) Oktay, Kadir; Guzel, Ebru; Bitiren, Muharrem; Simsek, Serkan; Yildirim, Mustafa; Guzel, Aslan; Lokman Hekim Hospital; Bahcesehir University; Bahcesehir UniversityRoot metastases of solid organ carcinomas are rare entities. Because of their rare occurrence, they can be confused with nerve sheath tumors, such as schwannomas or neurofibromas, when detected by magnetic resonance imaging. In this paper, we reported a case of a 72-year-old woman with S1 root metastasis originating from lung adenocarcinoma. In addition, we reviewed the literature and presented the diagnosis and treatment stages of this pathology. Surgical resection should be the main treatment for symptomatic metastases. Gross total resection of tumors is usually not possible with preservation of neurologic functions. Nerve root decompression, subtotal resection, and adjuvant treatments seem to represent the best treatment option for these patients.Publication Metadata only Comparison of advanced stage mucinous epithelial ovarian cancer and serous epithelial ovarian cancer with regard to chemosensitivity and survival outcome: a matched case-control study(KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY, 2013) Karabuk, Emine; Kose, M. Faruk; Hizli, Deniz; Taskin, Salih; Karadag, Burak; Turan, Taner; Boran, Nurettin; Ozfuttu, Ahmet; Ortac, U. Firat; Etlik Zubeyde Hanim Gynecology Education & Research Hospital; Bahcesehir University; Fatih University; Ankara University; Etlik Zubeyde Hanim Gynecology Education & Research HospitalObjective: The aim of this study was to compare clinicopathologic characteristics, surgery outcomes and survival outcomes of patients with stage III and IV mucinous epithelial ovarian cancer (mEOC) and serous epithelial ovarian carcinoma (sEOC). Methods: Patients who had surgery for advanced stage (III or IV) mEOC were evaluated retrospectively and defined as the study group. Women with sEOC who were matched for age and stage of disease were randomly chosen from the database and defined as the control group. The baseline disease characteristics of patients and platinum-based chemotherapy efficacy (response rate, progression-free survival and overall survival [OS]) were compared. Results: A total of 138 women were included in the study: 50 women in the mEOC group and 88 in the sEOC group. Patients in the mEOC group had significantly less grade 3 tumors and CA-125 levels and higher rate of para-aortic and pelvic lymph node metastasis. Patients in the mEOC group had significantly less platinum sensitive disease (57.9% vs. 70.8%, p=0.03) and had significantly poorer OS outcome when compared to the sEOC group (p=0.001). The risk of death for mEOC patients was significantly higher than for sEOC patients (hazard ratio, 2.14, 95% confidence interval, 1.34 to 3.42). Conclusion: Advanced stage mEOC patients have more platinum resistance disease and poorer survival outcome when compared to advanced stage sEOC. Therefore, novel chemotherapy strategies are warranted to improve survival outcome in patients with mEOC.Publication Metadata only A novel predictive marker for the recurrence of nasal polyposis following endoscopic sinus surgery(SPRINGER, 2016) Boztepe, Osman Fatih; Gun, Taylan; Demir, Meltem; Gur, Ozer Erdem; Ozel, Deniz; Dogru, Harun; Medical Park Hospitals Group; Bahcesehir University; Medical Park Hospitals Group; Antalya Training & Research Hospital; Akdeniz UniversityWe aimed to determine the value of neutrophil-to-lymphocyte (NLR) ratio for prediction of recurrence in patients subjected to endoscopic sinus surgery. Higher neutrophil counts mean more chronic inflammation so the NLR value could show the inflammatory level resulting with higher incidence of recurrence. From January 2011 to March 2013, we performed a retrospective review of the complete blood count samples from 192 patients with chronic sinusitis who underwent endoscopic sinus surgery. The patients were divided into two groups based on the presence of nasal polyps. NLR and platelet-to-lymphocyte (PLR) ratios were analyzed. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value for significant differences in variables between the recurrence and non-recurrence groups. The ROC analysis results revealed an NLR cut-off of 3.13 and a PLR cut-off of 208.75. Our analysis revealed that NLR is an independent risk factor for recurrence of chronic sinusitis in patients subjected to endoscopic sinus surgery (p = 0.006), whereas the PLR was not a predictive factor for recurrence (p = 0.167). Our study revealed that the NLR could be used to predict disease recurrence before endoscopic sinus surgery. However, additional studies are needed to confirm these results.Publication Metadata only Analysis of Patients with 1988 FIGO Stage-II Endometrial Cancer(AKAD DOKTORLAR YAYINEVI, 2014) Ureyen, Isin; Turan, Taner; Kimyon, Gunsu; Karalok, Alper; Tasci, Tolga; Boran, Nurettin; Tulunay, Gokhan; Kose, M. Faruk; Etlik Zubeyde Hanim Gynecology Education & Research Hospital; Etlik Zubeyde Hanim Gynecology Education & Research Hospital; Bahcesehir UniversityManagement of stage II endometrial cancer still has many controversies. We evaluated patients with stage II (FIGO 1988) endometrial cancer operated in our clinic in terms of treatment modalities, surgico-pathological factors, recurrence rates and patterns. Fifty-three patients with 1988 FIGO stage II endometrial cancer who underwent staging surgery between January 1993 and December 2012 were included in this study. The mean age of the patients was 57 years. Cervical invasion couldn't be detected in the preoperative pelvic examination in 47 patients (88.7%). Thirty-eight patients received simple hysterectomy (SH) and 15 patients had radical hysterectomy (RH). All patients received pelvic and paraaortic lymphadenectomy. Forty-two patients took adjuvant radiotherapy. The median follow-up time of the patient population was 39 months (range 1-139 months). Recurrence was observed in four patients. There was no statistically significant difference between the RH and SH groups in terms of recurrence (p= 0.53). Advanced age, deep myometrial invasion and the lower number of harvested lymph nodes were associated with recurrence. Systemic adjuvant therapy may be involved in the first-line treatment plan in order to prevent distant failures, since they continue to be responsible for the most of the recurrences and mortality despite radical surgeries and different protocols of adjuvant radiotherapy.Publication Metadata only MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer(ELSEVIER, 2016) Kara, Murat; Kaplan, Mehmet; Bozgeyik, Ibrahim; Ozcan, Onder; Celik, Ozgur Ilhan; Bozgeyik, Esra; Yumrutas, Onder; Mugla Sitki Kocman University; Bahcesehir University; Adiyaman University; Mugla Sitki Kocman University; Mugla Sitki Kocman University; Gaziantep UniversityBreast cancer is major public health problem predominantly effects female population. Current therapeutic approaches to deal with breast cancer are still lack of effectiveness. Thus, identifying/developing novel strategies to fight against breast cancer is very important. The frequent deletions at 8p21.3-22 chromosomal location nearby D8S254 marker enabled the discovery of a novel tumor suppressor gene, MTUS1. Subsequently, MTUS1 was demonstrated to be less expressed in a variety cancer types including breast cancer. Also, it is obvious that gene expression is widely regulated by miRNAs. Here, we aimed to report differential expression of MTUS1 and its regulatory miRNAs in breast cancer and fibroadenoma tissues. Dynamic analysis of MTUS1 expression levels and its miRNAs regulators were attained by Fluidigm 96 x 96 Dynamic Array Expression chips and reactions were performed in Fluidigm BioMark (TM) HD System qPCR. Consequently, MTUS1 mRNA levels were significantly diminished in breast cancer tissues and elevated in fibroadenoma tissues. Also, among MTUS1 targeting miRNAs, miR-183-5p was identified to be overexpressed in breast cancer and down-regulated in fibroadenoma tissues. Also, expression levels of MTUS1 and miR-183-5p were well correlated with clinical parameters. In particular, MTUS1 expression was found to be diminished and miR-183-5p expression was elevated with the advancing stage. In conclusion, as a potential therapeutic target, miR-183-5p can be a chief regulator of MTUS1 and MTUS1-miR-183-5p axis may have significant influence in the pathology of breast cancer. (c) 2016 Elsevier B.V. All rights reserved.