Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Metadata only The breast lesion excision system procedure: An optimal solution for the management of indeterminate BI-RADS category 3 breast lesions in women with severe anxiety(SAUDI MED J, 2018) Hot, Semih; Coskun, Zafer U.; Akcakaya, Adem; Bender, Omer; Turkmen, Ulku A.; Nayir, Pinar O.; Sari, Ayhan; Hot, Ayse B.; University of Health Sciences Turkey; Istanbul Okmeydani Training & Research Hospital; Istanbul Okmeydani Training & Research Hospital; University of Health Sciences Turkey; Bezmialem Vakif University; Istanbul Yeni Yuzyil University; Bahcesehir University; Giresun University; Giresun University; Diyarbakir Training & Research Hospital; Ministry of Health - Turkey; Dr. Joseph Azizoglu Silvan State HospitalObjectives: To evaluate the efficacy of the Breast lesion excision system (BLES) procedure as a primary excisional biopsy for the management of breast imaging-reporting and data system (BI-RADS) category 3, small, and solid breast lesions in women having severe breast cancer anxiety. Methods: A retospective study was conducted on 68 patients who underwent a BLES procedure. The study protocol was approved by the local ethical committee of Yeni Yuzyil University in Istanbul, Turkey. The study was carried out according to the principles of the Helsinki Declaration. Small breast lesions removed using a (12, 15 or 20 mm) wand from September 2011 to November 2014. These were category 3 lesions as determined by ultrasound (US) imaging according to BI-RADS. The radiological and pathological sizes of these lesions, the complete excision rates, the procedure durations, the pathological diagnosis, the complications, and the imaging findings before and after the procedure were all recorded. Results: All the patients had a benign pathology. The mean duration of procedure was 12 (range=8-22) minutes. There was no major complication during the procedure and in the following period. Only some small hematomas were determined in 3 (4.2%) patients, and no additional surgical intervention was performed. Conclusion: The BLES procedure is an optimal solution for the management of indeterminate BI-RADS category 3 breast lesions in women with severe anxiety.Publication Metadata only Prognostic value of soluble factors of angiogenesis and adhesion processes in head and neck squamous cell carcinomas(DERMAN MEDICAL PUBL, 2018) Gun, Taylan; Ikinciogullari, Aykut; Boztepe, Osman Fatih; Ensari, Serdar; Dere, Huseyin; Bahcesehir University; Ankara Numune Training & Research Hospital; Karabuk University; Ankara Yildirim Beyazit UniversityAim: In this study, we aimed to define the prognostic value of two factors related to angiogenesis and adhesion processes of head and neck squamous cell carcinomas. The prominent angiogenesis molecule is vascular endothelial growth factor (VEGF). The vascular cell adhesion molecule (VCAM) first attracted attention more than two decades ago as endothelial adhesion receptor with key function for leukocyte recruitment in term of cellular immune response. Material and Method: 35 patients with head and neck squamous cell carcinomas were enrolled in this study. The control group consisted of 20 people who had no sign of regional or systemic diseases. 33 patients were male and 2 patients were female. Mean age was 59.7 years (28-76). Results: We showed that VEGF levels in the patient group were significantly higher than in the control group (p=0.001). However, when comparing the VEGF levels of different stages, there was no statistical significant difference between the stages. Discussion: Serum VEGF levels can provide sufficient information for the early diagnosis of the disease but prognosis may not be evaluated according to the results of our study. VCAM levels were not specific and sensitive to use as a tumor marker but VCAM may be a valuable factor to determine the prognosis and tumor aggression in cancer patients.Publication Metadata only THE ALBUMIN-GLOBULIN RATIO PREDICTING MORTALITY IN GASTRIC CARCINOMA(CARBONE EDITORE, 2016) Aksoy, Asude; Durak, Serdar; Ozturk, Turkan; Avci, Nilufer; Cirak, Yalcin; Deger, Ayse Nur; Bilgic, Yilmaz; Koca, Suleyman Serdar; Ozcan, Mete; Goktas, Sevil; Bozdag, Ahmet; Firat University; Firat University; Karadeniz Technical University; Ali Osman Sonmez Oncology Hospital; Bahcesehir University; Dumlupinar University; Inonu University; Firat University; Denizli State Hospital; Elazig Training & Research HospitalIntroduction: The potential effects of serum albumin and albumin-globulin rate on survival were investigated in patients with gastric carcinoma. Materials and methods: The biochemical values of 204 patients under chemotherapy evaluation were obtained retrospectively from archive data. Albumin-globulin ratio values were calculated using albumin/total protein-albumin formula. The values of albumin-globulin ratio and albumin were categorized as 3 groups using receiver operating characteristic analysis and a descending order. Results: The calculated cut-off value for albumin-globulin ratio was 1.14: 34.4-79.7 by receiver operating characteristic. The median survival was 20.7 months (15.9-25.5), 20.1 months (15.1-25.1), 16 months (11.8-20.1), respectively in 1st, 2nd, 3rd groups for albumin-globulin ratio (p=0.46). The median overall survival was 18.3 months (123-24.2), 21.6 months (16.8-26.3), 18.01 months (13.5-22.4) in 1st, 2nd, 3rd groups for albumin, respectively (p=0.52). There were no statistical significant differences by Kaplan-Meier method for albumin-globulin ratio, albumin p>0.05. The effects of clinicopathological and biochemical characteristics on mortality were assessed by Cox-proportional hazard regression analysis. The independent predictors of mortality were observed high grade, the presence of perineural invasion of the tumor, high nodal involvement (p:0.01, p:0.001, p:0.01), respectively. Conclusion: Albumin-globulin ratio and albumin values alone may not be useful parameters to predict mortality and survival in patients with gastric carcinoma.Publication Metadata only Can Active Surveillance be an Alternative to Surgery in Papillary Thyroid Microcarcinoma?: The Current Situation Worldwide(KARE PUBL, 2018) Aygun, Nurcihan; Isgor, Adnan; Uludag, Mehmet; University of Health Sciences Turkey; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Bahcesehir University; Memorial Healthcare GroupPapillary thyroid carcinoma is the most common endocrine malignancy. Papillary thyroid microcarcinomas (PTMCs) are tumors with a size of <= 1 cm. The biological behavior of these tumors differs due to the presence of their aggressive features. The prognosis of PTMCs with high-risk features, such as clinical node metastasis, distant metastasis, and significant extrathyroidal extension to the tracheal or recurrent laryngeal nerve invasion, is poor, even if a sufficient immediate surgery is performed at diagnosis. However, PTMCs without these aggressive features are low-risk tumors because of their indolent and slow growth behaviors. The increase in thyroid cancer incidence is mostly a result of overdiagnosis of small low-risk PTMCs with indolent clinical course. Despite the sudden increase in thyroid cancer incidence worldwide, cancer mortality did not increase. Although the traditional treatment strategy for PTMC is immediate surgery at diagnosis, because of the rather low disease-specific mortality rate, low recurrence rate, and potential risk for postoperative complications, active surveillance has been proposed recently as an alternative option for PTMCs without invasion, metastasis, or cytological or molecular characteristics. The recent data support that active surveillance of low-risk PTMC should be the initial treatment modality, because only a small percentage of low-risk PTMCs show signs of progression, and delayed surgery has not caused significant recurrence. However, recent management guidelines are shifting toward more conservative treatments, such as active surveillance. Although there is an increase in the number of studies related to active surveillance, prospective studies have been mostly from academic referral centers in Japan. The world still needs class 1 evidence extended prospective studies originating from different geographic regions. Active surveillance may be a good alternative to immediate surgery for appropriately selected patients with PTMC.Publication Metadata only What has changed about the eight edition of the differentiated thyroid carcinomas TNM classification system? How will it effect the clinical practice?(KARE PUBL, 2017) Uludag, Mehmet; Isgor, Adnan; University of Health Sciences Turkey; Bahcesehir UniversityThe eighth edition of the TNM classification system was announced. Thyroid cancers were included in the fourth edition of the TNM classification system which was published in 1987. Each version of the TNM system which is updated based on evidence in the literature, includes some important differences from the previous version for the differentiated thyroid carcinomas (DTCs), like other cancers. Seventeen different classification systems for thyroid cancer have been developed until today. Some of these systems are quite complex and are difficult to use in practice. It has been shown that the TNM system with the new regaulations is the most consistent and applicable staging system for DTC in different patient groups, and the TNM system is now the most commonly used classification system in thyroid cancer, as in other cancer types. The most important update of the eighth version is that the age as prognostic factor is regulated as younger and older than 55 years, which has been divided as younger/older than 45 years of age in prior editions. Furthermore, the change in the definition of T3 in the T stage is remarkable. In the seventh edition, the definition of minimally invasive extrathyroidal extension and the definition of perithyroidal soft tissue included in its example have been abolished. Macroscopic extension into any of the strap muscles was moved to the T3 category in the eighth edition. In N staging in the 7th edition, the upper mediastinal lymph node involvement which took place in N1b was moved to the N1a category. In the eighth edition, it is observed that generally in patients over 55 years old have a stage downgrade in all stages compared to the seventh edition. In the eighth edition, the appropriate tumor stage can easily be determined. In patients under the age of 55 years, patients with distant metastases were defined as stage II, and without as stage I. Patients with distant metastasis over the age of 55 years are defined as stage IVB. The stages of patients without distant metastases over the age of 55 years can be defined by other clinical features (intrathyroidal tumor, macroscopic extrathyroidal extension, lymph node metastasis and distant metastasis). If there is no lymph node metastasis in patients with intrathyroidal tumors smaller than 4 cm (T1, T2), it is called stage 1, and stage II, if lymph node metastasis is present. Patients with intrathyroidal tumors greater than 4 cm (T3) are placed in stage II, regardless of lymph node status (N0 or N1). In tumors with macroscopic extrathyroidal extension, irrespective of the lymph node metastasis, the tumor is in stage II if only invasive into the strap muscles, and stage III if extended to subcutaneous tissue, larynx, trachea, recurrent laryngeal nerve and esophagus, and stage IVA if extended to the prevertebral fascia, mediastinal vessels or if surrounded carotid artery. TNM classification is a staging system that reliably predicts disease-specific survival in the DTC. The eighth edition of TNM compared to the previous editions classifies a large proportion of patients with DTC in low-risk groups in terms of mortality, and initial evaluations show that it may be more suitable in predicting disease-specific survival.