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Publication Open Access Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations(2010) Bilgüvar, Kaya; Öztürk, Ali Kemal; Louvi, Angeliki; Kwan, Kenneth Y.; Choi, Murim; Tatlí, Burak; Yalnizoǧlu, Dilek; Tüysüz, Beyhan; Caglayan, Ahmet Okay; Gökben, Sarenur; Bilgüvar, Kaya, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Öztürk, Ali Kemal, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Louvi, Angeliki, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Kwan, Kenneth Y., Department of Neurobiology, Yale School of Medicine, New Haven, United States, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, United States; Choi, Murim, Department of Genetics, Yale School of Medicine, New Haven, United States; Tatlí, Burak, Department of Pediatrics, İstanbul Tıp Fakültesi, Istanbul, Turkey; Yalnizoǧlu, Dilek, Department of Pediatrics, Hacettepe Üniversitesi, Ankara, Turkey; Tüysüz, Beyhan, Department of Pediatrics, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Caglayan, Ahmet Okay,; Gökben, Sarenur, Department of Pediatrics, Ege University Medical School, Izmir, TurkeyThe development of the human cerebral cortex is an orchestrated process involving the generation of neural progenitors in the periventricular germinal zones, cell proliferation characterized by symmetric and asymmetric mitoses, followed by migration of post-mitotic neurons to their final destinations in six highly ordered, functionally specialized layers1,2. An understanding of the molecular mechanisms guiding these intricate processes is in its infancy, substantially driven by the discovery of rare mutations that cause malformations of cortical development3-6. Mapping of disease loci in putative Mendelian forms of malformations of cortical development has been hindered by marked locus heterogeneity, small kindred sizes and diagnostic classifications that may not reflect molecular pathogenesis. Here we demonstrate the use of whole-exome sequencing to overcome these obstacles by identifying recessive mutations in WD repeat domain 62 (WDR62) as the cause of a wide spectrum of severe cerebral cortical malformations including microcephaly, pachygyria with cortical thickening as well as hypoplasia of the corpus callosum. Some patients with mutations in WDR62 had evidence of additional abnormalities including lissencephaly, schizencephaly, polymicrogyria and, in one instance, cerebellar hypoplasia, all traits traditionally regarded as distinct entities. In mice and humans, WDR62 transcripts and protein are enriched in neural progenitors within the ventricular and subventricular zones. Expression of WDR62 in the neocortex is transient, spanning the period of embryonic neurogenesis. Unlike other known microcephaly genes, WDR62 does not apparently associate with centrosomes and is predominantly nuclear in localization. These findings unify previously disparate aspects of cerebral cortical development and highlight the use of whole-exome sequencing to identify disease loci in settings in which traditional methods have proved challenging. © 2010 Macmillan Publishers Limited. All rights reserved. © 2012 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Open Access Two-directional intercoronary communication: Visualization of a very rare coronary anomaly and cause of ischemia(2013) Yıldız, Abdülmelik; Tekiner, Fatih; Karabay, Kanber Öcal; Bitigen, Atila; Yildiz, Abdülmelik, Department of Cardiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Tekiner, Fatih, Department of Cardiology, Medical Park Hospital, Bursa, Turkey; Karabay, Kanber Öcal, Department of Cardiology, Demiroglu Bilim University, Istanbul, Turkey; Bitigen, Atila, Altinbas Universitesi, Istanbul, Turkey[No abstract available]Publication Open Access Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography(2013) Kirişli, Hortense A.; Schaap, Michiel; Metz, Coert T.; Dharampal, Anoeshka S.; Meijboom, Willem Bob; Papadopoulou, Stella Lida; Dedic, Admir; Nieman, Koen; de Graaf, Michiel A.; Meijs, Matthijs F.L.; Kirişli, Hortense A., Erasmus MC, Rotterdam, Netherlands, Department of Radiology, Leids Universitair Medisch Centrum, Leiden, Netherlands; Schaap, Michiel, Erasmus MC, Rotterdam, Netherlands; Metz, Coert T., Erasmus MC, Rotterdam, Netherlands; Dharampal, Anoeshka S., Department of Radiology, Erasmus MC, Rotterdam, Netherlands, Department of Cardiology, Erasmus MC, Rotterdam, Netherlands; Meijboom, Willem Bob, Department of Cardiology, Erasmus MC, Rotterdam, Netherlands; Papadopoulou, Stella Lida, Department of Radiology, Erasmus MC, Rotterdam, Netherlands; Dedic, Admir, Department of Cardiology, Erasmus MC, Rotterdam, Netherlands; Nieman, Koen, Department of Radiology, Erasmus MC, Rotterdam, Netherlands, Department of Cardiology, Erasmus MC, Rotterdam, Netherlands; de Graaf, Michiel A., Department of Cardiology, Leids Universitair Medisch Centrum, Leiden, Netherlands, Royal Netherlands Academy of Arts and Sciences - KNAW, Amsterdam, Netherlands; Meijs, Matthijs F.L., Department of Cardiology, University Medical Center Utrecht, Utrecht, NetherlandsThough conventional coronary angiography (CCA) has been the standard of reference for diagnosing coronary artery disease in the past decades, computed tomography angiography (CTA) has rapidly emerged, and is nowadays widely used in clinical practice. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms devised to detect and quantify the coronary artery stenoses, and to segment the coronary artery lumen in CTA data. The objective of this evaluation framework is to demonstrate the feasibility of dedicated algorithms to: (1) (semi-)automatically detect and quantify stenosis on CTA, in comparison with quantitative coronary angiography (QCA) and CTA consensus reading, and (2) (semi-)automatically segment the coronary lumen on CTA, in comparison with expert's manual annotation. A database consisting of 48 multicenter multivendor cardiac CTA datasets with corresponding reference standards are described and made available. The algorithms from 11 research groups were quantitatively evaluated and compared. The results show that (1) some of the current stenosis detection/quantification algorithms may be used for triage or as a second-reader in clinical practice, and that (2) automatic lumen segmentation is possible with a precision similar to that obtained by experts. The framework is open for new submissions through the website, at http://coronary.bigr.nl/stenoses/. © 2013 Elsevier B.V. © 2014 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Open Access Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia(2013) Kaser, Muzaffer; Soltész, Fruzsina; Lawrence, Philip; Miller, Sam R.; Dodds, Chris Martin; Croft, Rodney J.; Dudas, Robert B.; Zaman, Rashid; Fernández-Egea, Emilio; Müller, Ulrich; Kaser, Muzaffer, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, Bahçeşehir Üniversitesi, Istanbul, Turkey, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom; Soltész, Fruzsina, Medicines Discovery and Development, GlaxoSmithKline plc., Brentford, United Kingdom; Lawrence, Philip, Medicines Discovery and Development, GlaxoSmithKline plc., Brentford, United Kingdom; Miller, Sam R., Medicines Discovery and Development, GlaxoSmithKline plc., Brentford, United Kingdom; Dodds, Chris Martin, Medicines Discovery and Development, GlaxoSmithKline plc., Brentford, United Kingdom; Croft, Rodney J., Department of Psychology, University of Wollongong, Wollongong, Australia; Dudas, Robert B., Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom; Zaman, Rashid, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, Essex Partnership University NHS Foundation Trust, Wickford, United Kingdom; Fernández-Egea, Emilio, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom; Müller, Ulrich, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United KingdomBackground: Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia. Method: 21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning. Results: Mean MMN amplitude was significantly lower in patients with schizophrenia (95% CI 0.18 - 0.77). Patients showed significantly lower EEG power (95% CI -1.02 - -0.014) in the ∼4-7 Hz frequency range (theta band) between 170 and 210 ms. Patients with schizophrenia showed cognitive impairment in multiple domains of CANTAB. However, MMN impairments in amplitude and power were not correlated with clinical measures, medication dose, social functioning or neurocognitive performance. Conclusion: The findings from this study suggested that while MMN may be a useful marker to probe NMDA receptor mediated mechanisms and associated impairments in gain control and perceptual changes, it may not be a useful marker in association with clinical or cognitive changes. Trial-by-trial EEG power analysis can be used as a measure of brain dynamics underlying MMN deficits which also can have implications for the use of MMN as a biomarker for drug discovery. © 2013 Kaser et al. © 2014 Elsevier B.V., All rights reserved.Publication Open Access Neoadjuvant treatment with preoperative radiotherapy for extremity soft tissue sarcomas: Long-term results from a single institution in Turkey(Asian Pacific Organization for Cancer Prevention kyyoo@plaza.snu.ac.kr,, 2014) Öner Dinçbaş, Fazilet H.; Çolpan Öksüz, Didem; Yetmen, Özlem; Hız, M.; Dervişoğlu, Sergülen; Turna, Hande Zeynep; Kantarcı, Fatih; Mandel, Nil Molinas; Koca, Sedat S.; Oner Dincbas, Fazilet H., Department of Radiation Oncology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Çolpan Öksüz, Didem, Department of Radiation Oncology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Yetmen, Özlem, Department of Radiation Oncology, Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey; Hiz, M., Department of Orthopaedic Surgery, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Dervişoģlu, Sergülen, Department of Pathology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Turna, Hande Zeynep, Department of Medical Oncology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Kantarci, Fatih, Department of Radiology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Mandel, Nil Molinas, Department of Medical Oncology, VKV Amerikan Hastanesi, Istanbul, Turkey; Koca, Sedat S., Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, TurkeyBackground: To assess the long term clinical outcome of preoperative radiotherapy with or without chemotherapy followed by limb sparing surgery in patients with non-metastatic soft tissue sarcomas (STS) of the extremities. Materials and Methods: Sixty patients with locally advanced STS were retrospectively analyzed. The median tumor diameter was 12 cm. All patients were treated with preoperative radiotherapy delivered with two different fractionation schedules (35Gy/10fr or 46-50Gy/23-25fr). Neoadjuvant chemotherapy was added to 44 patients with large and/or high grade tumors. Surgery was performed 2-6 weeks after radiotherapy. Chemotherapy was completed up to 6 courses after surgery in patients who had good responses. Results: Median follow-up time was 67 months (8-268 months). All of the patients had limb sparing surgery. The 5-year local control (LC), disease free (DFS) and overall survival (OSS) rates for all of the patients were 81%, 48.1% and 68.3% respectively. 5-year LC, DFS and cause specific survival (CSS) were 81.7%, 47%, 69.8%, and 80%, 60%, 60% in the chemoradiotherapy and radiotherapy groups, respectively. On univariate analysis, patients who were treated with hypofractionation experienced significantly superior LC, DFS and CSS rates with similar rates of late toxicity when compared with patients who were treated with conventional fractionation and statistical significance was retained on multivariate analysis. Conclusions: Treatment results are consistent with the literature. As neoadjuvant chemoradiotherapy provides effective LC and CSS with acceptable morbidity, it should be preferred for patients with large and borderline resectable STS. © 2017 Elsevier B.V., All rights reserved.Publication Open Access Early ambulatory discharge is safe and feasible after transradial coronary interventions(Elsevier Ireland Ltd P.O. Box 211 Amsterdam 1000 AE, 2014) Aydın, Alper; Gürol, Tayfun; Soylu, Özer; Dağdeviren, Bahadır; Aydin, Alper, Department of Cardiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Gürol, Tayfun, Department of Cardiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Soylu, Özer, Department of Cardiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Daǧdeviren, Bahadïr, Department of Cardiology, Bahçeşehir Üniversitesi, Istanbul, TurkeyBackground: At present, there are no definite criteria for selecting patients eligible for same-day discharge after percutaneous coronary interventions (PCI). With rapid ambulation and reduced vascular complication rates, transradial PCI have many features that favorably reduce costs and hospital stay. This study aimed to demonstrate the possibility of early ambulatory discharge following transradial percutaneous coronary interventions. Methods: 254 consecutive patients undergoing transradial PCI (elective, urgent, and emergent) at our center was observed during hospital stay. Patient demographics, angiographic characteristics, post-procedural complications, and timing of these post-procedural events were recorded. Results: A total of 336 lesions were treated among 299 vessels with 277 stents. One hundred fifty-two (45.2%) lesions were Type C. There were 26 chronic total occlusions (CTO). One hundred fifty-five (61%) patients were discharged on the same day after the procedure. 24 complications (12.6%) occurred and were divided into three groups according to occurrence time. 13 (54.2%) occurred within the first 2. h and 11 (45.8%) occurred after the 24-hour period. No complications were observed between the 2nd and 24th hours. Conclusions: Same-day discharge with a 2-hour observation period is safe and feasible after successful transradial PCI in appropriate patients. Although a minor number of complications occurred, these did not occur between the 2nd and 24th hours. Same-day discharge after successful transradial PCI could be an alternative for better utilization of resources. © 2014 . © 2014 Elsevier B.V., All rights reserved.Publication Open Access Chemical composition, larvicidal, and biting deterrent activity of essential oils of two subspecies of tanacetum argenteum (Asterales: Asteraceae) and Individual Constituents Against Aedes aegypti (Diptera: Culicidae)(Entomological Society of America 10001 Derekwood Lane, Suite 100 Lanham MD 20706-4876, 2014) Ali, Abbas; Tabanca, Nurhayat; Kürkçüoğlu, Mine K.; Duran, Ahmet; Blythe, Eugene K.; Khan, Ikhlas A.; Başer, K. Hüsnü Can; Ali, Abbas, National Center for Natural Products Research, University of Mississippi School of Pharmacy, University, United States; Tabanca, Nurhayat, National Center for Natural Products Research, University of Mississippi School of Pharmacy, University, United States; Kürkçüoĝlu, Mine K., Department of Pharmacognosy, Anadolu Üniversitesi, Eskisehir, Turkey; Duran, Ahmet, Department of Biology, Selçuk Üniversitesi, Selçuklu, Turkey; Blythe, Eugene K., South Mississippi Branch Experiment Station, Coastal Research and Extension Center, Biloxi, United States; Khan, Ikhlas A., National Center for Natural Products Research, University of Mississippi School of Pharmacy, University, United States, Department of Pharmacognosy, University of Mississippi, University, United States, Department of Pharmacognosy, College of Pharmacy, Riyadh, Saudi Arabia; Başer, K. Hüsnü Can, Department of Botany and Microbiology, College of Sciences, Riyadh, Saudi Arabia, Technology Transfer Office, Bahçeşehir Üniversitesi, Istanbul, TurkeyWater-distilled essential oils from dried aerial parts of Tanacetum argenteum (Lam.) Willd. subsp. argenteum (Lam.) and T. argenteum (Lam.) Willd. subsp. canum (C. Koch) Grierson were analyzed by gas chromatography and gas chromatography-mass spectrometry. In total, 27 and 32 components were identified representing 97.2 and 98.7% of essential oils of subsp. argenteum and canum, respectively. Main compounds of T. argenteum subsp. argenteum were βpinene (67.9%) and β-pinene (4.8%), whereasβ-pinene (53.6%), 1, 8-cineole (14.8%), and camphor (4.7%) were the major constituents of subsp. canum. Essential oil of T. argenteum subsp. canum at 10 μg/cm2 with Biting Deterrent Index (BDI) value of 0.73 showed activity similar to N,N-Diethyl-meta-toluamide (DEET) at 25 mol/cm2, whereas the activity of essential oil of subsp. argenteum was lower (BDI β 0.47) than subsp. canum and DEET. Based on 95% CIs, activity of β-caryophyllene (BDI value β 0.54) and caryophyllene oxide (BDI β 0.66) were signi+cantly lower than DEET. In larval bioassays, essential oil of T. argenteum subsp. argenteum showed LC50 value of 93.34 ppm, whereas T. argenteum subsp. canum killed only 40% of the larvae at the highest dose of 125 ppm. Among the pure compounds, -caryophyllene (LC50 β 26 ppm) was the most potent compound followed by caryophyllene oxide (LC50 β 29 ppm), which was also similar to (-)-β-pinene (LC50 β 35.9 ppm) against 1-d-old Ae. aegypti larvae at 24-h post treatment. Compounds (-)-β-pinene and (-)-α-pinene showed similar larvicidal activity. Activity of (+)-β-pinene with LC50 value of was similar to the essential oil of T. argenteum subsp. argenteum. © 2014 Entomological Society of America. © 2014 Elsevier B.V., All rights reserved.Publication Open Access Bubble over the head: Adeloye-Odeku disease in a Turkish child-case report(Turkish Neurosurgical Society, 2014) Yılmaz, Baran; Urgun, Kamran; Ekşi̇, Murat Şakir; Tanrıkulu, Bahattin; Bayri, Yaşar; Yilmaz, Baran, Department of Neurosurgery, Cizre Devlet Hastanesi, Sirnak, Turkey; Urgun, Kamran, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Ekşi̇, Murat Şakir, Department of Neurosurgery, Marmara Üniversitesi, Istanbul, Turkey; Tanrikulu, Bahattin, Department of Neurosurgery, Marmara Üniversitesi, Istanbul, Turkey; Bayri, Yasar, Department of Neurosurgery, Marmara Üniversitesi, Istanbul, TurkeyAdeloye-Odeku disease is composed of dermoid cyst over anterior fontanelle, first described in 1971. We present an 11-year-old girl with a soft, fluctuant swelling over bregma. The lesion content was isointense to cerebrospinal fluid on both T2W and FLAIRW images. There was a lytic area under the lesion, seen on CT. The lesion was totally excised. Histopathology confirmed the diagnosis. The case was unique, because a fibrous band was observed extending to superior sagittal sinus and it has never been reported before. Although lesions are sub-aponeurotic, because of this kind of fibrous band, a thorough examination with neuroimaging tools is very important for planning of surgery. © 2017 Elsevier B.V., All rights reserved.Publication Open Access Core curriculum (CC) of spinal surgery: A step forward in defining our profession(Turkish Association of Orthopaedics and Traumatology totbid@todbid.org.tr, 2014) Acaroğlu, Emre R.; Kahraman, Serdar; Şenköylü, Alpaslan; Berk, Haluk; Caner, Hakan H.; Özkan, Seçil; Alanay, Ahmet; Demirkıran, Gökhan Halil; Derinçek, Alihan; Erkan, Serkan; Acaroglu, Emre R., Ankara Spine Center, Ankara, Turkey; Kahraman, Serdar, Department of Neurosurgery, Yeni Yüzyidotlessl University, Istanbul, Turkey; Şenköylü, Alpaslan, Department of Orthopaedics and Traumatology, Gazi Üniversitesi, Ankara, Turkey; Berk, Haluk, Department of Orthopaedics and Traumatology, Dokuz Eylül Üniversitesi, Izmir, Turkey; Caner, Hakan H., Department of Neurosurgery, Başkent Üniversitesi, Ankara, Turkey; Özkan, Sečil, Department of Public Health, Gazi Üniversitesi, Ankara, Turkey; Alanay, Ahmet, Acibadem Maslak Hospital, Istanbul, Turkey; Demirkiran, Gökhan Halil, Hacettepe Üniversitesi, Ankara, Turkey; Derinçek, Alihan, Başkent Üniversitesi, Ankara, Turkey; Erkan, Serkan, Manisa Celâl Bayar Üniversitesi, Manisa, TurkeyObjective: The aim our study was to establish a core curriculum (CC) for spine surgery incorporating knowledge, skills and attitudes to help define spine surgery as a medical specialty and serve as a guide for specific spine surgery training. Methods: A committee was established to prepare the CC. Five modules were established, Basic Sciences, Spinal Trauma, Degenerative Spine Diseases, Destructive Spine Pathologies and Spinal Deformity. Prepared CC modules were evaluated in a consensus meeting, translated and reevaluated in a second consensus meeting before being accepted as final. Results: In the five modules, 54 subject headings (19 for Basic Sciences, 10 for Spinal Trauma, 4 for Degenerative Spine Diseases, 4 for Destructive Spine Pathologies and 17 for Spinal Deformity) and 165 specific subjects (59 for Basic Sciences, 32 for Spinal Trauma, 10 for Degenerative Spine Diseases, 23 for Destructive Spine Pathologies and 41 for Spinal Deformity) were defined. Learning outcomes and entry and exit criteria were defined for all subjects. Conclusion: This CC may form the basis of spinal surgery training, defining spinal surgery as a medical specialty and help us spine surgeons to develop better defined identities. © 2019 Elsevier B.V., All rights reserved.Publication Open Access Risk for malignant and borderline ovarian neoplasms following basic preoperative evaluation by ultrasonography, Ca125 level and age(Asian Pacific Organization for Cancer Prevention kyyoo@plaza.snu.ac.kr,, 2014) Karadağ, Burak; Koçak, Müberra; Kayıkçıoğlu, Fulya; Ercan, Fedi; Dilbaz, Berna Ö.; Köse, M. F.; Haberal, Ali; Karadaǧ, Burak, Department of Obstetrics and Gynecology, Ankara Teaching and Research Hospital, Ankara, Turkey; Koçak, Müberra, Edremit State Hospital, Balikesir, Turkey; Kayikçioǧlu, Fulya, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey; Ercan, Fedi, Department of Obstetrics and Gynecology, Necmettin Erbakan Üniversitesi, Meram, Turkey; Dilbaz, Berna Ö., Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Ankara, Turkey; Kose, M. F., Department of Obstetrics and Gynecology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Haberal, Ali, Department of Obstetrics and Gynecology, Başkent Üniversitesi, Ankara, TurkeyObjective: To verify the basic preoperative evaluation in the discrimination between benign and malignant adnexal masses in our clinical practice. Materials and Methods: Data were collected on the records of 636 women with adnexal masses who had undergone surgery either by open or endoscopic approaches. Those with obvious signs of malignancy, any history of cancer, emergency surgeries without basic evaluation were excluded. The preoperative features by age, ultrasound and serum Ca125 level were compared with final histopathological diagnosis at the four departments of the institution. These are the general gynecology (Group 1: exploratory laparotomy), the gynecologic endoscopy (Group 2: laparoscopy and adnexectomy), the gynecological oncology (Group 3: staging laparotomy) and the gynecologic endocrinology and infertility (Group 4: laparoscopy and cystectomy). Results: There were simple and complex cyst rates of 22.3% and 77.2%, respectively. There were 86.3% benign, 4.1% (n:20) borderline ovarian tumor (BOT) and 6.4% (n:48) malignant lesions. There were 3 BOT and 9 ovarian cancers in Group 1 and one BOT and two ovarian cancer in the Group 2. During the surgery, 15 BOT (75%) and 37 ovarian cancer (77%) were detected in the Group 3, only one BOT was encountered in the Group 4. The risk of rate of unsuspected borderline or focally invasive ovarian cancer significantly increased by age, size, complex morphology and Ca125 (95% CI, OR=2.72, OR=6.60, OR=6.66 and OR=4.69, respectively). Conclusions: Basic preoperative evaluation by comprehensive ultrasound imaging combined with age and Ca125 level has proved highly accurate for prediction of unexpected malignancies. Neither novel markers nor new imaging techniques provide better information that allow clinicians to assess the feasibility of the planned surgery, consequently, the risk of inadvertent cyst rupture during laparoscopy may be significantly decreased in selected cases. © 2016 Elsevier B.V., All rights reserved.