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Publication Metadata only Modafinil augmentation therapy in unipolar and bipolar depression: A systematic review and meta-analysis of randomized controlled trials(Physicians Postgraduate Press Inc., 2013) Goss, Alexander J.; Kaser, Muzaffer; Costafreda, Sergi G.; Sahakian, Barbara Jacquelyn; Fu, Cynthia H.Y.; Goss, Alexander J., School of Medicine, Leeds, United Kingdom; Kaser, Muzaffer, Bahçeşehir Üniversitesi, Istanbul, Turkey, Department of Psychiatry and MRC, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom; Costafreda, Sergi G., Department of Old Age Psychiatry, King's College London, London, United Kingdom; Sahakian, Barbara Jacquelyn, Department of Psychiatry and MRC, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom; Fu, Cynthia H.Y., School of Psychology, University of East London, London, United KingdomObjective: Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and neurovegetative symptoms such as fatigue. The objective of this study was to examine the efficacy and tolerability of augmentation of first-line therapies with the novel stimulantlike agent modafinil in MDD and bipolar depression. Data Sources: MEDLINE/PubMed, PsycINFO, 1980-April 2013 were searched using the following terms: (modafinil or armodafinil) and (depressi* or depressed or major depressive disorder or major depression or unipolar or bipolar or dysthymi*). Inclusion criteria were as follows: randomized controlled trial (RCT) design, sample comprising adult patients (18-65 years) with unipolar or bipolar depression, diagnosis according to DSM-IV, ICD-10, or other well-recognized criteria, modafinil or armodafinil given as augmentation therapy in at least 1 arm of the trial, and publication in English in a peer-reviewed journal. Study Selection: Double-blind, randomized, placebocontrolled clinical trials of adjunctive treatment with modafinil or armodafinil of standard treatment for depressive episodes in MDD and bipolar depression were selected. Data Extraction: Two independent appraisers assessed the eligibility of the trials. A random-effects meta-analysis with DerSimonian-Laird method was used. Moderator effects were evaluated by meta-regression. Results: Data from 6 RCTs, with a total of 910 patients with MDD or bipolar depression, consisting of 4 MDD RCTs (n = 568) and 2 bipolar depression RCTs (n = 342) were analyzed. The meta-analysis revealed significant effects of modafinil on improvements in overall depression scores (point estimate = ?0.35, 95% CI, ?0.61 to ?0.10) and remission rates (odds ratio = 1.61, 95% CI, 1.04 to 2.49). The treatment effects were evident in both MDD and bipolar depression, with no difference between disorders. Modafinil showed a significant positive effect on fatigue symptoms (95% CI, ?0.42 to ?0.05). The adverse events were no different from placebo. Conclusions: Modafinil is an effective augmentation strategy for acute depressive episodes, including for symptoms of fatigue, in both unipolar and bipolar disorders. © Copyright 2013 Physicians Postgraduate Press, Inc. © 2015 Elsevier B.V., All rights reserved.Publication Metadata only AT1 antagonists: A patent review (2008 - 2012)(2013) Mavromoustakos, Thomas M.; Agelis, George; Durdagi, Serdar; Mavromoustakos, Thomas M., Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece; Agelis, George, Department of Chemistry, University of Patras, Rio, Greece, Eldrug S.A., Patra, Greece; Durdagi, Serdar, Department of Biophysics, Bahçeşehir Üniversitesi, Istanbul, TurkeyIntroduction: For two decades a class of pharmaceutical molecules with proved beneficial therapeutic properties, especially in hypertension, has been introduced in the market aiming to specifically prevent the detrimental effects of the peptide hormone Angiotensin II at the AT1 receptor. The prototype of this class was losartan and based on its structure, several drugs were launched and also called 'Sartans'. New structural features on these molecules can provide multi-target properties in the RAS or other systems. New methodologies were developed for the treatment of hypertension utilizing either AT1 antagonists alone or as cocktails. Areas covered: In this review article, authors aim to cover information provided by patents of the years 2008-2012. The rationale of writing this review article is to cover the most important patents which can forward the field with new important discoveries. Expert opinion: From the patent investigation it is clear that new areas on the subject are still offered for new discoveries. New structural features can be still considered in the synthetic compounds that can advance the knowledge and beneficial effects on diseases related to Angiotensin II and AT1 receptor. There is era also for new formulations (i.e., cyclodextrins, polymers and liposomes). The multitarget approach can be further strengthened and more combinations can be sought in the rational drug design for seeking cocktails. Furthermore, the revealing of the complexity of the RAS offers new avenues for novel targets and this must not be overlooked. © 2013 Informa UK, Ltd. © 2013 Elsevier B.V., All rights reserved.Publication Metadata only Ultrasound-guided thrombin injection for the treatment of iatrogenic femoral artery pseudoaneurysms(Turkiye Klinikleri Turkocagi Caddesi No. 30 Balgat 06520, 2014) Aksoy, Şevki Murat; Sarici, Inanç Şamil; Uçar, Adem; Yanar, Fatih; Agcaoglu, O.; Kurtoǧlu, Mehmet Hamdi; Aksoy, Şevki Murat, Department of General Surgery, İstanbul Tıp Fakültesi, Istanbul, Turkey; Sarici, Inanç Şamil, Department of General Surgery, İstanbul Tıp Fakültesi, Istanbul, Turkey; Uçar, Adem, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yanar, Fatih, Department of General Surgery, İstanbul Tıp Fakültesi, Istanbul, Turkey; Agcaoglu, O., Department of General Surgery, İstanbul Tıp Fakültesi, Istanbul, Turkey; Kurtoǧlu, Mehmet Hamdi, Department of General Surgery, İstanbul Tıp Fakültesi, Istanbul, TurkeyObjective: The aim of this study is to review our experience with percutaneous ultrasonography (USG) guided thrombin injection to treat iatrogenic femoral artery pseudoaneurysms and to assess the safety of the procedure. Material and Methods: From January 2007 to January 2011, 41 patients with iatrogenic femoral pseudoaneurysms, were included in the study. The medical records concerned the demographics, the pseudoaneurysm size and site, thrombin dose that was injected, efficacy and safety of the procedure and postintervenional follow-up for one year. Results: There were 39 (95.1%) patients, who were eligible to be included in the study. Twenty-four (61.5%) patients were male and 15 (38.5%) patients were female. The mean age was 72±11 years (49-88). All of the pseudoaneurysms were originated from the common femoral arteries. The mean maximum transverse diameter of the pseudoaneurysms was 3.7±1.1 cm (2 - 6.5 cm). The mean neck diameter was 5±1.1 mm (3-7.5 mm). After the first thrombin injection, complete thrombosis of the pseudoaneurysm occured in 34 (87.1%) of the patients. A secondary thrombin injection was required in 5 (12.8%) patients. USG-guided thrombin injection failed in 2 (5.3%) patients. There was not any complications during the follow-up. Conclusion: USG-guided thrombin injection is an effective technique for the treatment of post-catheterisation pseudoaneurysms, which is easy to perform, safe, well tolerated and highly successful in good selected patients. Copyright © 2014 by Türkiye Klinikleri. © 2014 Elsevier B.V., All rights reserved.Publication Metadata only Incidence and severity of retinopathy of prematurity in Turkey(BMJ Publishing Group [email protected], 2015) Bas, Ahmet Yagmur; Koç, Esin Merve; Dílmen, Uǧur; Oĝuz, Şerife Suna; Ovalı, Hüsnü Fahri; Demirel, Nihal; Zenciroǧlu, Ayşeg̈ul; Tekin, Neslihan; Caner, Ibrahim; Arslanoǧlu, Sertaç; Bas, Ahmet Yagmur, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Kecioren, Turkey; Koç, Esin Merve, Department of Neonatology, Gazi Üniversitesi, Ankara, Turkey; Dílmen, Uǧur, Department of Neonatology, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey; Oĝuz, Şerife Suna, Department of Neonatology, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey; Ovalı, Hüsnü Fahri, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey; Demirel, Nihal, Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, Kecioren, Turkey; Zenciroǧlu, Ayşeg̈ul, Dr. Sami Ulus Maternity and Children's Hospital, Ankara, Turkey; Tekin, Neslihan, Eskişehir Osmangazi Üniversitesi, Eskisehir, Turkey; Caner, Ibrahim, Ataturk University, Faculty of Medicine, Erzurum, Turkey; Arslanoǧlu, Sertaç, Dr. Behcet Uz Children's Hospital, Izmir, TurkeyBackground: The purpose of this study was to estimate the current incidence of retinopathy of prematurity (ROP) and the need for treatment in preterm infants in Turkey. Methods: The study included preterm infants who had been screened for ROP between 2011 and 2013 in 49 neonatal intensive care units. Infants with birth weight (BW) ≤1500 g or ≤32 weeks' gestational age and those with BW >1500 g or >32 weeks' GA with an unstable clinical course were included. The incidence of any ROP or severe ROP and treatment modalities were determined. Results: The study population included 15 745 preterm infants: 11 803 (75%) with GA ≤32 weeks, and 3942 (25%) with GA >32 weeks. Overall, 30% were found to have any stage of ROP, and 5% had severe ROP. Severe ROP was diagnosed in 8.2% of infants with BW ≤1500 g and 0.6% of infants with BW >1500 g. Of all infants diagnosed with ROP, 16.5% needed laser photocoagulation, and 20 patients born at >32 weeks' GA required this treatment modality. Vitroretinal surgery was performed in 28 infants with severe ROP: 23 with GA ≤28 weeks and 5 with GA 29-32 weeks. Conclusions: The findings of our study have the important implication that more mature babies are at risk of severe ROP requiring treatment. An effective programme for detecting and treating ROP should be established in Turkey. © 2019 Elsevier B.V., All rights reserved.Publication Metadata only A systematic review of Ibn Sina's (Avicenna) studies: Reflections on anatomy(Sociedad Anatomica Espanola [email protected], 2016) Keskinbora, Kadircan H.; Keskinbora, Kader; Keskinbora, Kadircan H., Department of Ophthalmology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Keskinbora, Kader, Department of Anesthesiology, Bahçeşehir Üniversitesi, Istanbul, TurkeyIbn Sina made significant and long-lasting contributions to almost all fields of science, with an influence spanning over many centuries. Ibn Sina's medical masterpiece, Al-Qanun (Canon) may be considered as a compilation of his medical knowledge. Although the Canon was influenced by other prominent figures of ancient medical traditions, who were appraised throughout the text, it also included a considerable deal of original writings. Following the footsteps of previous traditions, the Canon also presented genuine observations and descriptions of diseases that had not been published before, showing Ibn Sina's ability for synthetizing existing knowledge with his own view in such a way as to influence the practice of medicine for centuries. The Canon is divided into five sections, each of which focuses on separate topics of medicine. The first book may be regarded as the most comprehensive one, discussing the four basic humors, i.e. the blood, phlegm, yellow bile, and black bile. The book also includes detailed anatomical descriptions. Similarly, in other sections of the Canon, anatomical changes that may occur in relation to pathological or disease states have also been described. Through this book, the reader can witness the significant and fundamental contribution to the science of anatomy as well as to the other fields of medicine. In this article, representative examples of his contribution will be presented. The Canon has been a fundamental textbook in schools of medicine in Europe and in other places in the Eastern World since the 12th Century up to the end of the 17th century. Not surprisingly, in Bologna, Padua and other locations throughout Europe, Sina's Canon has been a great inspiration for many scientists including Andreas Vesalius and William Harvey, among others. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only A comparison of off- and on-pump beating-heart coronary artery bypass surgery on long-term cardiovascular events(Clinics Cardive Publishing (PTY)Ltd PO Box 1013, Durbanville, 7551, 2017) Gürbüz, Orçun; Kumtepe, Gencehan; Yolgösteren, Atif; Özkan, Hakan; Karal, Ilker Hasan; Ercan, Abdulkadir; Ener, Serdar; Gürbüz, Orçun, Department of Cardiovascular Surgery, Balikesir Üniversitesi, Balikesir, Turkey; Kumtepe, Gencehan, Department of Cardiovascular Surgery, Balikesir Üniversitesi, Balikesir, Turkey; Yolgösteren, Atif, Department of Cardiovascular Surgery, Bursa Uludağ Üniversitesi, Bursa, Turkey; Özkan, Hakan, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karal, Ilker Hasan, Department of Cardiovascular Surgery, Samsun Education and Research Hospital, Samsun, Turkey; Ercan, Abdulkadir, Department of Cardiovascular Surgery, Balikesir Üniversitesi, Balikesir, Turkey; Ener, Serdar, Department of Cardiovascular Surgery, Doruk Hospital, Bursa, TurkeyObjective: Our aim was to compare short-term outcomes and long-term major adverse cardiovascular event (MACE)-free survival and independent predictors of long-term MACE after off-pump (OPCAB) versus on-pump beating-heart (ONBHCAB) coronary artery bypass grafting (CABG). Methods: We retrospectively reviewed data of all consecutive patients who underwent elective CABG, performed by the same surgeon, from January 2003 to October 2009. A propensity score analysis was carried out to adjust for baseline characteristics and a total of 398 patients were included: ONBHCAB (n = 181), OPCAB (n = 217). Results: OPCAB was associated with significantly shorter ventilation times (p ≤ 0.001), intensive care unit stay (p ≤ 0.001) and hospital stay (p ≤ 0.001). The total blood loss was significantly more in the ONBHCAB group (p ≤ 0.001), and accordingly, the number of transfused blood units was significantly lower in the OPCAB group (p ≤ 0.001). Incidence of peri-operative renal complications were significantly higher in the ONBHCAB group (p = 0.004). The OPCAB group showed significantly lower long-term MACE-free survival (p = 0.029). The mean number of transfused blood units was the only independent predictor of MACE (HR: 1.218, 95% CI: 1.0891.361, p = 0.001). Conclusion: OPCAB provided better long-term MACE-free survival compared with ONBHCAB. Fewer units of blood transfused following OPCAB surgery may have been the main reason for this result. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Surgery for Benign Gynecological Disorders Improve Endometrium Receptivity: A Systematic Review of the Literature(SAGE Publications Inc. [email protected], 2017) Çelik, Önder; Acet, Mustafa; Küçük, Tansu; Haberal, Esra Tuştaş; Acet, Tuba; Bozkurt, Murat; Şahin, Levent; Verit, Fatma Ferda; Çalişkan, Eray; Çelik, Önder, Department of Obstetrics and Gynecology, Private Clinic, Usak, Turkey; Acet, Mustafa, Department of Obstetrics and Gynecology, İstanbul Medipol Üniversitesi, Istanbul, Turkey; Küçük, Tansu, Department of Obstetrics and Gynecology, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Haberal, Esra Tuştaş, Department of Obstetrics and Gynecology, Umraniye Education and Research Hospital, Istanbul, Turkey; Acet, Tuba, Department of Obstetrics and Gynecology, Medicine Hospital, Istanbul, Turkey; Bozkurt, Murat, Department of Obstetrics and Gynecology, Sakarya Üniversitesi, Serdivan, Turkey; Şahin, Levent, Department of Obstetrics and Gynecology, Kafkas Üniversitesi, Kars, Turkey; Verit, Fatma Ferda, Department of Obstetrics and Gynecology, Suleymaniye Maternity Education and Research Hospital, Istanbul, Turkey; Çalişkan, Eray, Department of Obstetrics and Gynecology, Bahçeşehir Üniversitesi, Istanbul, TurkeyRegardless of the anatomical locations, some benign gynecological disorders (BGDs) such as peritoneal endometriosis, ovarian endometrioma, adenomyosis, uterine leiomyomas, endometrial polyps, uterine septum, and hydrosalpinges may lead to implantation failure. Despite progress in medical therapies, surgery remains a mainstay of BGDs treatment. Although our knowledge of endometrial receptivity after BGDs surgery is limited, it has allowed for significant improvement in the treatment of female subfertility. Many researchers studied on pregnancy outcome following BGDs surgery, but they did not investigate the possible impact of surgery on endometrial receptivity. They, therefore, concluded that pregnancy rates improved after BGDs surgery based on clinical observations. Many of these clinicians believe that surgical resection of BGDs leads to removal of local mechanical effect over the endometrium. Moreover, they accept that BGDs surgery may inhibit the detrimental signaling and secretion of some molecules from the BGDSs into the endometrium that may lead to favorable effect on the endometrium. However, so far, data from randomized controlled trials or systematic review or meta-analyses to answer the question whether surgical treatment of BGDs can improve endometrial receptivity are lacking. The purpose of this systematic review was to evaluate the results of available publications dealing with the impact of reproductive surgery for BGDs on endometrial receptivity. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Posterior Rigid Instrumentation of C7: Surgical Considerations and Biomechanics at the Cervicothoracic Junction. A Review of the Literature(Elsevier Inc. [email protected], 2018) Bayoumi, Ahmed B.; Efe, Ibrahim Efecan; Berk, Selim; Kasper, Ekkehard Matthias; Toktaş, Zafer Orkun; Konya, Deniz; Bayoumi, Ahmed B., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Efe, Ibrahim Efecan, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey, Department of Neurosurgery, Charité – Universitätsmedizin Berlin, Berlin, Germany; Berk, Selim, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kasper, Ekkehard Matthias, Division of Neurosurgery, Harvard Medical School, Boston, United States; Toktaş, Zafer Orkun, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Konya, Deniz, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyBackground: The cervicothoracic junction is a challenging anatomic transition in spine surgery. It is commonly affected by different types of diseases that may significantly impair stability in this region. The seventh cervical vertebra (C7) is an atypical cervical vertebra with unique anatomic features compared to subaxial cervical spine (C3 to C6). C7 has relatively broader laminae, larger pedicles, smaller lateral masses, and a long nonbifid spinous process. These features allow a variety of surgical methods for performing posterior rigid instrumentation in the form of different types of screws, such as lateral mass screws, pedicle screws, transfacet screws, and intralaminar screws. Many biomechanical studies on cadavers have evaluated and compared different types of implants at C7. Methods: We reviewed PubMed/Medline by using specific combinations of keywords to summarize previously published articles that examined C7 posterior rigid instrumentation thoroughly in an experimental fashion on patients or cadavers with additional descriptive radiologic parameters for evaluation of the optimum surgical technique for each type. Results: A total of 44 articles were reported, including 22 articles that discussed anatomic considerations (entry points, sagittal and axial trajectories, and features of screws) and another 22 articles that discussed the relevant biomechanical testing at this transitional region if C7 was directly involved in terms of receiving posterior rigid implants. Conclusions: C7 can accommodate different types of screws, which can provide additional benefits and risks based on availability of bony purchase, awareness of surgical technique, biomechanics, and anatomic considerations. © 2018 Elsevier B.V., All rights reserved.Publication Metadata only Ethical considerations on novel neuronal interfaces(Springer-Verlag Italia s.r.l. [email protected], 2018) Keskinbora, Kadircan H.; Keskinbora, Kader; Keskinbora, Kadircan H., Department of Medical Ethics and History of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Keskinbora, Kader, School of Medicine, İstinye Üniversitesi, Istanbul, TurkeyWireless powered implants, each smaller than a grain of rice, have the potential to scan and stimulate brain cells. Further research may lead to next-generation brain-machine interfaces for controlling prosthetics, exoskeletons, and robots, as well as electroceuticals to treat disorders of the brain and body. In conditions that can be particularly alleviated with brain stimulation, the use of such mini devices may pose certain challenges. Health professionals are becoming increasingly more accountable in decision-making processes that have impacts on the life quality of individuals. It is possible to transmit such stimulation using remote control principles. Perhaps, the most important concern regarding the use of these devices termed as neural dust is represented by the possibility of controlling affection and other mental functions via waves reaching the brain using more advanced versions of such devices. This will not only violate the respect for authority principle of ethics, but also medical ethics, and may potentially lead to certain incidents of varying vehemence that may be considered illegal. Therefore, a sound knowledge and implementation of ethical principles is becoming a more important issue on the part of healthcare professionals. In both the ethical decision-making process and in ethical conflicts, it may be useful to re-appraise the principles of medical ethics. In this article, the ethical considerations of these devices are discussed. © 2018 Elsevier B.V., All rights reserved.Publication Metadata only Effectiveness of platinum-based treatment for triple negative metastatic breast cancer: A meta-analysis(Asian Pacific Organization for Cancer Prevention [email protected],, 2018) Kaya, Vildan; Yildirim, Mustafa; Yazici, Gözde; Gündüz, Şeyda Gulenay; Bozcuk, Hakan Şat; Paydaş, Semra; Kaya, Vildan, Department of Radiation Oncology, Medstar Antalya Hospital, Antakya, Turkey; Yildirim, Mustafa, Department of Internal Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yazici, Gözde, Department of Radiation Oncology, Hacettepe Üniversitesi, Ankara, Turkey; Gündüz, Şeyda Gulenay,; Bozcuk, Hakan Şat,; Paydaş, Semra,Background: Triple-negative breast cancer (TNBC) is a sub-group of breast cancers with a particularly poor prognosis. The results of studies investigating the role of platinum-based chemotherapy (PBC) in metastatic TNBC (mTNBC) have been conflicting. In this meta-analysis, our aim was to assess the effectiveness of PBCs for mTNBCs. Methods: The PubMed, Cochrane Controlled Trials Register Databases, and EBSCOhost databases were accessed. The English language was used as the search language and only human studies were included. The Newcastle-Ottawa Quality Assessment Scale and the Jadad scoring system were used to evaluate the quality of the included randomized controlled studies. Results: Seven studies and 1,571 patients were included in this meta-analysis. The pooled hazard ratio (HR) for overall survival (OS), evaluated on the basis of six studies, showed the use of PBC regimes to be related to OS in mTNBCs (HR 0.620, 95% CI 0.513-0.749, p: < 0.001). Four studies containing HR and abstract statistics used for HR calculation were included in the meta-analysis for progression-free survival (PFS). The pooled HR again indicated a significant relation (HR, 0.628, 95% CI, 0.501-0.786, p: < 0.001). Conclusions: In this meta-analysis, we confirmed that PBC regimes provide OS and PFS advantages compared to non-PBC regimes. The use of PBC regimes could be a good choice in mTNBC patients for better quality of life and survival. © 2018 Elsevier B.V., All rights reserved.