Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
Permanent URI for this communityhttps://hdl.handle.net/20.500.14719/1741
Browse
566 results
Search Results
Publication Metadata only Screening of anxiety and quality of life in people with epilepsy(W B SAUNDERS CO LTD, 2017) Gur-Ozmen, Selen; Leibetseder, Annette; Cock, Hannah R.; Agrawal, Niruj; von Oertzen, Tim J.; City St Georges, University of London; Bahcesehir University; City St Georges, University of LondonPurpose: Up to 60% of people with epilepsy (PwE) have psychiatric comorbidity including anxiety. Anxiety remains under recognized in PwE. This study investigates if screening tools validated for depression could be used to detect anxiety disorders in PWE. Additionally it analyses the effect of anxiety on QoL. Method: 261 participants with a confirmed diagnosis of epilepsy were included. Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Emotional Thermometers (ET), both validated to screen for depression were used. Hospital Anxiety and Depression Scale-Anxiety (HADS-A) with a cut off for moderate and severe anxiety was used as the reference standard. QoL was measured with EQ5-D. Sensitivity, specificity, positive and negative predictive value and ROC analysis as well as multivariate regression analysis were performed. Results: Patients with depression (n=46) were excluded as multivariate regression analysis showed that depression was the only significant determinant of having anxiety in the group. Against HADS-A, NDDI-E and ET-7 showed highest level of accuracy in recognizing anxiety with ET7 being the most effective tool. QoL was significantly reduced in PwE and anxiety. Conclusion: Our study showed that reliable screening for moderate to severe anxiety in PwE without co-morbid depression is feasible with screening tools for depression. The cut off values for anxiety are different from those for depression in ET7 but very similar in NDDI-E. ET7 can be applied to screen simultaneously for depression and pure anxiety. Anxiety reduces significantly QoL. We recommend screening as an initial first step to rule out patients who are unlikely to have anxiety. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.Publication Metadata only The 2010 Eurobarometer on the life sciences(2011) Gaskell, George D.; Allansdottir, Agnes; Allum, Nick; Castro, Paula; Esmer, Yilmaz; Fischler, Claude; Jackson, Jonathan; Kronberger, Nicole; Hampel, Jürgen; Mejlgaard, Niels; Gaskell, George D., London School of Economics and Political Science, London, United Kingdom; Allansdottir, Agnes, Università degli Studi di Siena, Siena, Italy; Allum, Nick, University of Essex, Colchester, United Kingdom; Castro, Paula, Iscte – Instituto Universitário de Lisboa, Lisbon, Portugal; Esmer, Yilmaz, Bahçeşehir Üniversitesi, Istanbul, Turkey; Fischler, Claude, École des Hautes Études en Sciences Sociales, Paris, France; Jackson, Jonathan, London School of Economics and Political Science, London, United Kingdom; Kronberger, Nicole, Johannes Kepler University Linz, Linz, Austria; Hampel, Jürgen, Universität Stuttgart, Stuttgart, Germany; Mejlgaard, Niels, Aarhus Universitet, Aarhus, Denmark[No abstract available]Publication Open Access Recessive LAMC3 mutations cause malformations of occipital cortical development(2011) Barak, Tanyeri; Kwan, Kenneth Y.; Louvi, Angeliki; Demirbilek, Veysi; Sütçü Saygı, Serap; Tüysüz, Beyhan; Choi, Murim; Boyacı, Hüseyin; Doerschner, Katja; Zhu, Ying; Barak, Tanyeri, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Kwan, Kenneth Y., Department of Neurobiology, Yale School of Medicine, New Haven, United States, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, United States; Louvi, Angeliki, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States; Demirbilek, Veysi, Department of Neurology, Istanbul University-Cerrahpasa, Istanbul, Turkey; Saygı, Serap Sütçü, Department of Neurology, Hacettepe Üniversitesi, Ankara, Turkey; Tüysüz, Beyhan, Department of Pediatrics, Istanbul University-Cerrahpasa, Istanbul, Turkey; Choi, Murim, Department of Genetics, Yale School of Medicine, New Haven, United States; Boyaci, Huseyin, Department of Psychology, Bilkent Üniversitesi, Ankara, Turkey, National Magnetic Resonance Research Center, Bilkent Üniversitesi, Ankara, Turkey; Doerschner, Katja, Department of Psychology, Bilkent Üniversitesi, Ankara, Turkey, National Magnetic Resonance Research Center, Bilkent Üniversitesi, Ankara, Turkey; Zhu, Ying, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, United StatesThe biological basis for regional and inter-species differences in cerebral cortical morphology is poorly understood. We focused on consanguineous Turkish families with a single affected member with complex bilateral occipital cortical gyration abnormalities. By using whole-exome sequencing, we initially identified a homozygous 2-bp deletion in LAMC3, the laminin 33 gene, leading to an immediate premature termination codon. In two other affected individuals with nearly identical phenotypes, we identified a homozygous nonsense mutation and a compound heterozygous mutation. In human but not mouse fetal brain, LAMC3 is enriched in postmitotic cortical plate neurons, localizing primarily to the somatodendritic compartment. LAMC3 expression peaks between late gestation and late infancy, paralleling the expression of molecules that are important in dendritogenesis and synapse formation. The discovery of the molecular basis of this unusual occipital malformation furthers our understanding of the complex biology underlying the formation of cortical gyrations. © 2011 Nature America, Inc. All rights reserved. © 2011 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Response to Commentary: 'Methodological concerns in usability evaluation of software prototypes' by Khajouei et al.(2011) Karahoca, Adem; Karahoca, Dilek Yiğit; Bayraktar, Erkan; Tatoglu, Ekrem; Karahoca, Adem, Department of Software Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karahoca, Dilek Yiğit, Department of Software Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bayraktar, Erkan, Department of Industrial Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Tatoglu, Ekrem, Faculty of Economics and Administrative Sciences, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Metadata only The impact of conservative discourses in family policies, population politics, and gender rights in Poland and Turkey(2011) Korkut, Umut; Eslen-Ziya, Hande; Korkut, Umut, Glasgow Business School, Glasgow Caledonian University, Glasgow, United Kingdom; Eslen-Ziya, Hande, Bahçeşehir Üniversitesi, Istanbul, TurkeyThis article uses childcare as a case study to test the impact of ideas that embody a traditional understanding of gender relations in relation to childcare. Conservative ideas regard increasing female labor market participation as a cause of decreasing fertility on the functioning of a set of general policies to increase fertility rates. It looks into the Polish and Turkish contexts for empirical evidence. The Polish context shows a highly institutionalized system of family policies in contrast to almost unessential institutions in Turkey. Formally, the labor market participation of women is much lower in Turkey than in Poland. Yet, given the size of the informal market in Turkey, womens labor participation is obviously higher than what appears in the statistics. Bearing in mind this divergence, the article suggests Poland and Turkey as two typologies for studying population politics in contexts where socially conservative ideas regarding gender remain paramount. We qualify ideas as conservative if they enforce a traditional understanding of gender relations in care-giving and underline womens role in the labor market as an element of declining fertility. In order to delineate ideational impact, this article looks into how ideas (a) supplant and (b) substitute formal institutions. Therefore, we argue that there are two mechanisms pertaining to the dominance of conservative conventions: conservative ideas may either supplant the institutional impact on family policies, or substitute them thanks to a superior reasoning which societies assign to them. Furthermore, conservative conventions prevail alongside womens customary unpaid work as care-givers regardless of the level of their formal workforce participation. We propose as our major findings for the literature of population politics that ideas, as ubiquitous belief systems, are more powerful than institutions since they provide what is perceived as legitimate, acceptable, and good for the societies under study. In the end, irrespective of the presence of institutions, socially conservative ideas prevail. © The Author 2011. Published by Oxford University Press. All rights reserved. © 2012 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only A new methodology to associate snps with human diseases according to their pathway related context(2011) Bakir-Güngör, Burcu; Sezerman, Osman Uğur; Bakir-Güngör, Burcu, Biological Sciences and Bioengineering Program, Sabancı Üniversitesi, Tuzla, Turkey, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sezerman, Osman Uğur, Biological Sciences and Bioengineering Program, Sabancı Üniversitesi, Tuzla, TurkeyGenome-wide association studies (GWAS) with hundreds of żthousands of single nucleotide polymorphisms (SNPs) are popular strategies to reveal the genetic basis of human complex diseases. Despite many successes of GWAS, it is well recognized that new analytical approaches have to be integrated to achieve their full potential. Starting with a list of SNPs, found to be associated with disease in GWAS, here we propose a novel methodology to devise functionally important KEGG pathways through the identification of genes within these pathways, where these genes are obtained from SNP analysis. Our methodology is based on functionalization of important SNPs to identify effected genes and disease related pathways. We have tested our methodology on WTCCC Rheumatoid Arthritis (RA) dataset and identified: i) previously known RA related KEGG pathways (e.g., Toll-like receptor signaling, Jak-STAT signaling, Antigen processing, Leukocyte transendothelial migration and MAPK signaling pathways), ii) additional KEGG pathways (e.g., Pathways in cancer, Neurotrophin signaling, Chemokine signaling pathways) as associated with RA. Furthermore, these newly found pathways included genes which are targets of RA-specific drugs. Even though GWAS analysis identifies 14 out of 83 of those drug target genes, newly found functionally important KEGG pathways led to the discovery of 25 out of 83 genes, known to be used as drug targets for the treatment of RA. Among the previously known pathways, we identified additional genes associated with RA (e.g. Antigen processing and presentation, Tight junction). Importantly, within these pathways, the associations between some of these additionally found genes, such as HLA-C, HLA-G, PRKCQ, PRKCZ, TAP1, TAP2 and RA were verified by either OMIM database or by literature retrieved from the NCBI PubMed module. With the whole-genome sequencing on the horizon, we show that the full potential of GWAS can be achieved by integrating pathway and network-oriented analysis and prior knowledge from functional properties of a SNP. © 2011 Bakir-Gungor, Sezerman. © 2012 Elsevier B.V., All rights reserved.Publication Metadata only Feature extraction using time-frequency/scale analysis and ensemble of feature sets for crackle detection(2011) Serbes, Görkem; Sakar, C. Okan; Kahya, Yasemin Palanduz; Aydın, Nizamettin; Serbes, Görkem, Department of Mechanical Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sakar, C. Okan, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kahya, Yasemin Palanduz, Department of Electrical Engineering, Boğaziçi Üniversitesi, Bebek, Turkey; Aydın, Nizamettin, Department of Computer Engineering, Yıldız Teknik Üniversitesi, Istanbul, TurkeyPulmonary crackles are used as indicators for the diagnosis of different pulmonary disorders. Crackles are very common adventitious sounds which have transient characteristic. From the characteristics of crackles such as timing and number of occurrences, the type and the severity of the pulmonary diseases can be obtained. In this study, a novel method is proposed for crackle detection. In this method, various feature sets are extracted using time-frequency and time-scale analysis. The extracted feature sets are fed into support vector machines both individually and as an ensemble of networks. Besides, as a preprocessing stage in order to improve the success of the model, frequency bands containing no-information are removed using dual tree complex wavelet transform, which is a shift invariant transform with limited redundancy and an improved version of discrete wavelet transform. The comparative results of individual feature sets and ensemble of sets with pre-processed and non pre-processed data are proposed. © 2011 IEEE. © 2012 Elsevier B.V., All rights reserved.Publication Metadata only Icon and user interface design for emergency medical information systems: A case study(2012) Salman, Yücel Batu; Cheng, Hongin; Patterson, Patrick E.; Salman, Yücel Batu, Department of Software Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Cheng, Hongin, Department of Industrial and Management Engineering, Kyungsung University, Busan, South Korea; Patterson, Patrick E., Edward E. Whitacre Jr. College of Engineering, Lubbock, United StatesA usable medical information system should allow for reliable and accurate interaction between users and the system in emergencies. A participatory design approach was used to develop a medical information system in two Turkish hospitals. The process consisted of task and user analysis, an icon design survey, initial icon design, final icon design and evaluation, and installation of the iconic medical information system with the icons. We observed work sites to note working processes and tasks related to the information system and interviewed medical personnel. Emergency personnel then participated in the design process to develop a usable graphical user interface, by drawing icon sketches for 23 selected tasks. Similar sketches were requested for specific tasks such as family medical history, contact information, translation, addiction, required inspections, requests and applications, and nurse observations. The sketches were analyzed and redesigned into computer icons by professional designers and the research team. A second group of physicians and nurses then tested the understandability of the icons. The user interface layout was examined and evaluated by system users, followed by the system's installation. Medical personnel reported the participatory design process was interesting and believed the resulting designs would be more familiar and friendlier. © 2011 Elsevier Ireland Ltd. © 2013 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Open Access A reference finding rarely seen in primary hyperparathyroidism: Brown tumor(Hindawi Limited, 2012) Mantar, Ferhan; Gündüz, Şeyda Gülenay; Gündüz, Umut Rıza; Mantar, Ferhan, Department of Endocrinology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Gündüz, Şeyda Gulenay, Department of Medical Oncology, Akdeniz Üniversitesi, Antalya, Turkey; Gündüz, Umut Riza, Department of Surgery, Antalya Education and Research Hospital, Antakya, TurkeyPrimary hyperparathyroidism is an endocrinopathy which is characterized with the hypersecretion of parathormone. During the progress of the disease bone loss takes place due to resorption on the subperiosteal and endosteal surfaces. Brown tumor is a localized form of osteitis fibrosa cystica, being part of the hyperparathyroid bone disease. It is rarely the first symptom of hyperparathyroidism. Nowadays, the diagnosis is made at an asymptomatic or minimally symptomatic stage. We present a male patient presented with a massive painless swelling in the left maxilla as the first manifestation of primary hyperparathyroidism due to a parathyroid adenoma. Parathyroidectomy was performed, and there was a regression of the bone lesion, without the need of performing other local surgical procedures. © 2012 F. Mantar et al. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only DICLENS: Divisive clustering ensemble with automatic cluster number(2012) Mimaroglu, Selim N.; Aksehirli, Emin; Mimaroglu, Selim N., Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Aksehirli, Emin, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, TurkeyClustering has a long and rich history in a variety of scientific fields. Finding natural groupings of a data set is a hard task as attested by hundreds of clustering algorithms in the literature. Each clustering technique makes some assumptions about the underlying data set. If the assumptions hold, good clusterings can be expected. It is hard, in some cases impossible, to satisfy all the assumptions. Therefore, it is beneficial to apply different clustering methods on the same data set, or the same method with varying input parameters or both. We propose a novel method, DICLENS, which combines a set of clusterings into a final clustering having better overall quality. Our method produces the final clustering automatically and does not take any input parameters, a feature missing in many existing algorithms. Extensive experimental studies on real, artificial, and gene expression data sets demonstrate that DICLENS produces very good quality clusterings in a short amount of time. DICLENS implementation runs on standard personal computers by being scalable, and by consuming very little memory and CPU. © 2006 IEEE. © 2012 Elsevier B.V., All rights reserved.