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Publication Metadata only A Review of Methods for the Preservation of Laryngeal Nerves During Thyroidectomy(KARE PUBL, 2018) Uludag, Mehmet; Tanal, Mert; Isgor, Adnan; University of Health Sciences Turkey; Bahcesehir University; Memorial Healthcare GroupPublication Metadata only Standards and Definitions in Neck Dissections of Differentiated Thyroid Cancer(YERKURE TANITIM YAYINCILIK HIZMETLERI AS, 2018) Uludag, Mehmet; Tanal, Mert; Isgor, Adnan; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Bahcesehir University; Memorial Healthcare GroupPublication Metadata only THE TURKISH STRAITS SYSTEM AS A PHYLOGEOGRAPHIC BOUNDARY - A LITERATURE REVIEW(TURKISH MARINE RESEARCH FOUNDATION-TUDAV, 2016) Kalkan, Evrim; Karhan, Selahattin Unsal; Bilgin, Rasit; Hemond, Elizabeth M.; Ozsoy, E; Cagatay, MN; Balkis, N; Balkis, N; Ozturk, B; Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Istanbul University; Bogazici University; Bahcesehir UniversityPublication Metadata only Lupus Miliaris Disseminatus Faciei: A Case Report and Brief Literature Review(YERKURE TANITIM YAYINCILIK HIZMETLERI AS, 2018) Cerman, Asli Aksu; Karabay, Ezgi Aktas; Yalcin, Ozben; Altunay, Ilknur Kivanc; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Bahcesehir UniversityPublication Metadata only Primary Patency With Stenting Versus Balloon Angioplasty for Arteriovenous Graft Failure: A Systematic Review and Meta-Analysis(H M P COMMUNICATIONS, 2019) Marmagkiolis, Konstantinos; Iliescu, Cezar; Edupuganti, Mohan Mallikarjuna Rao; Saad, Marwan; Boudoulas, Konstantinos Dean; Gupta, Akash; Lontos, Nikolaos; Cilingiroglu, Mehmet; Adventist Health Services; AdventHealth; (AdventHealth) West Florida Division; West Florida Hospital; AdventHealth Tampa; University of Texas System; UTMD Anderson Cancer Center; University of Texas Health Science Center Houston; University of Arkansas System; University of Arkansas Medical Sciences; Egyptian Knowledge Bank (EKB); Ain Shams University; University System of Ohio; Ohio State University; Baylor College of Medicine; Bahcesehir UniversityObjectives. To evaluate the efficacy of advanced stent technology in the management of failing arteriovenous grafts (AVGs). Background. End-stage renal disease rates and the need for hemodialysis are increasing worldwide. AVG remains a common dialysis access site. Several techniques have been previously suggested to restore and preserve AVG patency. A quantitative evaluation and synthesis of this information are essential in elucidating the role of newer stent platforms for the management of failing AVG. Methods. We performed a literature search using PubMed, Web of Science, and Embase from January 2006 to December 2017. Studies comparing the primary patency rates with stent placement vs balloon angioplasty alone in patients with failed AVGs were included. Results. Seven studies with a total of 1109 patients met the inclusion criteria. The mean graft age was 2.89 years in the stent group and 3.29 years in the balloon angioplasty group. Stent placement was associated with improved primary patency rates compared with balloon angioplasty alone at short-term (3-month) follow-up (73.2% vs 42.6%, respectively, risk ratio [RR], 0.55, 95% confidence interval [CI], 0.35-0.88, P=.01) and mid-term (6-month) follow-up (50.8% vs 18.4%, respectively, RR, 0.65, 95% CI, 0.51-0.82, P<.001). The primary patency rates remained favorable with stent placement at 12-month (40.3% vs 13.0%, respectively, RR, 0.69, 95% CI, 0.63-0.77, P<.001) and 24-month follow-up (20.5% vs 6.8%, RR, 0.86, 95% CI, 0.80-0.92, P<.001) compared with balloon angioplasty alone. Conclusions. Stent placement is associated with improved patency rates compared with balloon angioplasty alone.Publication Metadata only The Onco-cardiologist Dilemma: to Implant, to Defer, or to Avoid Transcatheter Aortic Valve Replacement in Cancer Patients with Aortic Stenosis?(SPRINGER, 2019) Balanescu, Serban Mihai; Balanescu, Dinu Valentin; Donisan, Teodora; Yang, Eric H.; Palaskas, Nicolas; Lopez-Mattei, Juan; Hassan, Saamir; Kim, Peter; Cilingiroglu, Mehmet; Marmagkiolis, Konstantinos; Kar, Biswajit; Iliescu, Cezar; Carol Davila University of Medicine & Pharmacy; University of Texas System; UTMD Anderson Cancer Center; University of California System; University of California Los Angeles; Bahcesehir University; Adventist Health Services; AdventHealth; (AdventHealth) West Florida Division; West Florida Hospital; AdventHealth Pepin Heart Institute; University of Texas System; University of Texas Health Science Center HoustonPurpose of ReviewAging is associated with an increased prevalence of both cancer and heart disease. The progression of aortic valve calcification to aortic stenosis may be accelerated by both cardiovascular risk factors and cancer treatments, such as radiotherapy with mediastinal involvement. Symptomatic aortic stenosis is occasionally diagnosed in cancer patients undergoing cardiovascular evaluation, likewise, cancer is often recognized during assessment preceding aortic valve interventions. In these complex cases, physicians face difficult treatment decisions. Due to a myriad of clinical presentations of cancer and valve disease, specific guidelines for this patient population are not currently in place. Management is currently based on clinical judgment, on an individual basis.Recent FindingsPatients with cancer in remission or with a favorable prognosis should be treated according to current cardiovascular guidelines. In these patients, aortic valve replacement can be performed either by surgery or transcatheter. Significant challenges arise in patients with active cancer, especially those receiving anti-cancer treatment. Recent data suggests that these patients can be offered aortic valve replacement, with a trend of favoring the transcatheter route in order to minimize perioperative risk and complications associated with major surgery. Patients with advanced cancer and severe aortic stenosis should be offered palliative care and can benefit from aortic balloon valvuloplasty if indicated. Modern cancer treatments associated with improved long-term prognosis may allow the appropriate cure of aortic stenosis.SummaryWe discuss the protocol, outcomes, and evolving recommendations of aortic valve replacement in cancer patients with aortic stenosis.Publication Metadata only Biological Approaches to Treating Intervertebral Disk Degeneration: Devising Stem Cell Therapies(SAGE PUBLICATIONS INC, 2015) Han, Inbo; Ropper, Alexander E.; Konya, Deniz; Kabatas, Serdar; Toktas, Zafer; Aljuboori, Zaid; Zeng, Xiang; Chi, John H.; Zafonte, Ross; Teng, Yang D.; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Pochon Cha University; Barrow Neurological Institute; Bahcesehir University; Reyap Hospital; University of Louisville; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Spaulding Rehabilitation Hospital; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare SystemIntervertebral disk (IVD) degeneration is a common, chronic, and complex degeneration process that frequently leads to back pain and disability, resulting in a major public health issue. In this review we describe biological therapies under preclinical or clinical development with an emphasis on stem cell-based multimodal approaches that target prevention and treatment of IVD degeneration. Systematical review of the basic science and clinical literature was performed to summarize the current status of devising biological approaches to treating IVD degeneration. Since the exact mechanisms underlying IVD degeneration have not yet been fully elucidated and conservative managements appear to be mostly ineffective, current surgical treatment focuses on removal of the pathological disk tissues combined with spinal fusion. The treatment options, however, often produce insufficient efficacy and even serious complications. Therefore, there have been growing demands and endeavors for developing novel regenerative biology-guided strategies for repairing the IVD via delivery of exogenous growth factors, introduction of therapeutic genes, and transplantation of stem cells, or combinatorial therapies. Overall, the data suggest that when applied under a recovery neurobiology principle, multimodal regimens comprising ex vivo engineered stem cell-based disks hold a high potential promise for efficacious clinical translations.Publication Metadata only Posterior Rigid Instrumentation of C7: Surgical Considerations and Biomechanics at the Cervicothoracic Junction. A Review of the Literature(ELSEVIER SCIENCE INC, 2018) Bayoumi, Ahmed B.; Efe, Ibrahim E.; Berk, Selim; Kasper, Ekkehard M.; Toktas, Zafer Orkun; Konya, Deniz; Bahcesehir University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical SchoolBACKGROUND: The cervicothoracic junction is a challenging anatomic transition in spine surgery. It is commonly affected by different types of diseases that may significantly impair stability in this region. The seventh cervical vertebra (C7) is an atypical cervical vertebra with unique anatomic features compared to subaxial cervical spine (C3 to C6). C7 has relatively broader laminae, larger pedicles, smaller lateral masses, and a long nonbifid spinous process. These features allow a variety of surgical methods for performing posterior rigid instrumentation in the form of different types of screws, such as lateral mass screws, pedicle screws, transfacet screws, and intralaminar screws. Many biomechanical studies on cadavers have evaluated and compared different types of implants at C7. METHODS: We reviewed PubMed/ Medlineby using specific combinations of keywords to summarize previously published articles that examined C7 posterior rigid instrumentation thoroughly in an experimental fashion on patients or cadavers with additional descriptive radiologic parameters for evaluation of the optimum surgical technique for each type. RESULTS: A total of 44 articles were reported, including 22 articles that discussed anatomic considerations (entry points, sagittal and axial trajectories, and features of screws) and another 22 articles that discussed the relevant biomechanical testing at this transitional region if C7 was directly involved in terms of receiving posterior rigid implants. CONCLUSIONS: C7 can accommodate different types of screws, which can provide additional benefits and risks based on availability of bony purchase, awareness of surgical technique, biomechanics, and anatomic considerations.Publication Metadata only Surgery for Benign Gynecological Disorders Improve Endometrium Receptivity: A Systematic Review of the Literature(SAGE PUBLICATIONS INC, 2017) Celik, Onder; Acet, Mustafa; Kucuk, Tansu; Haberal, Esra Tustas; Acet, Tuba; Bozkurt, Murat; Sahin, Levent; Verit, Fatma Ferda; Caliskan, Eray; Istanbul Medipol University; Acibadem University; Istanbul Umraniye Training & Research Hospital; Sakarya University; Kafkas University; Bahcesehir UniversityRegardless of the anatomical locations, some benign gynecological disorders (BGDs) such as peritoneal endometriosis, ovarian endometrioma, adenomyosis, uterine leiomyomas, endometrial polyps, uterine septum, and hydrosalpinges may lead to implantation failure. Despite progress in medical therapies, surgery remains a mainstay of BGDs treatment. Although our knowledge of endometrial receptivity after BGDs surgery is limited, it has allowed for significant improvement in the treatment of female subfertility. Many researchers studied on pregnancy outcome following BGDs surgery, but they did not investigate the possible impact of surgery on endometrial receptivity. They, therefore, concluded that pregnancy rates improved after BGDs surgery based on clinical observations. Many of these clinicians believe that surgical resection of BGDs leads to removal of local mechanical effect over the endometrium. Moreover, they accept that BGDs surgery may inhibit the detrimental signaling and secretion of some molecules from the BGDSs into the endometrium that may lead to favorable effect on the endometrium. However, so far, data from randomized controlled trials or systematic review or meta-analyses to answer the question whether surgical treatment of BGDs can improve endometrial receptivity are lacking. The purpose of this systematic review was to evaluate the results of available publications dealing with the impact of reproductive surgery for BGDs on endometrial receptivity.Publication Metadata only MitraClip Implantation in Younger Patients and Pediatric Populations: 19 Year-Old Patient with Multiple Comorbidities and a Prior Mitral Valve Annuloplasty(ELSEVIER INC, 2019) Ates, Ismail; Kaya, Zeynettin; Karaaslan, Doruk C.; Mutlu, Deniz; Cilingiroglu, Mehmet; Bahcesehir University; Medical Park Hospitals Group; Koc University; Istanbul University; Istanbul University - CerrahpasaMitraClip is an effective treatment method for severe mitral regurgitation in high-risk populations in terms of reducing morbidity and frequency of hospitalizations. Efficacy and safety of MitraClip device in elderly population have been established, yet there are only 2 case reports of MitraClip implantation in the younger patients, who generally tend to have less surgical risk (Gorenflo et al., Joffe et al., 2016). Wedescribe a 19-year-old patient with severe mitral regurgitation with prior mitral valve annuloplasty and received MitraClip implantation due to high-surgical risk. (C) 2018 Published by Elsevier Inc.