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Publication Metadata only Sleep bruxism is related to decreased inhibitory control of trigeminal motoneurons, but not with reticulobulbar system(Springer-Verlag Italia s.r.l. [email protected], 2017) Inan, Rahşan Adviye; Şenel, Gülçin Benbir; Yavlal, Figen; Karadeniz, Derya Kulac; Gündüz, Ayşegül Ş.; Kiziltan, Meral Erdemir; Inan, Rahşan Adviye, Department of Neurology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey; Şenel, Gülçin Benbir, Department of Neurology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Yavlal, Figen, Department of Neurology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karadeniz, Derya Kulac, Department of Neurology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Gündüz, Ayşegül Ş., Department of Neurology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Kiziltan, Meral Erdemir, Department of Neurology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, TurkeySleep bruxism (SB) is a stereotyped movement disorder characterized by grinding or clenching of the teeth during sleep. We aimed to understand the abnormal networks related to the excitability of masticatory pathways in patients with SB. Eleven patients with SB and age- and gender-matched 20 healthy subjects were prospectively enrolled in our study. The masseter inhibitory reflex (MIR) after electrical stimulation and auditory startle reaction (ASR) were examined. For MIR responses, durations of early and late silent period (SP) were shorter and the degree of suppression of SPs was significantly lower in SB group in comparison to those obtained in healthy subjects. The ASR responses even of the masseter muscle, however, were similar between patients with SB and healthy individuals. Abnormal MIR provides support for the decreased inhibitory control of the central masticatory circuits in SB whereas normal ASR suggests the integrity and normal functioning of brainstem pathways mediating startle reaction. Although the sample size is small, our results are in line with previous findings and suggest an abnormally decreased inhibition in trigeminal motoneurons to masseter muscle rather than reticulobulbar pathways in patients with SB. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Clinical outcomes of acute kidney injury developing outside the hospital in elderly(Springer Netherlands, 2017) Turgutalp, Kenan; Bardak, Simge; Horoz, Mehmet; Helvacı, İlter; Demir, Serap Baspinar; Kıykım, Ahmet Alper; Turgutalp, Kenan, Department of Internal Medicine, Mersin Üniversitesi, Mersin, Turkey; Bardak, Simge, Department of Internal Medicine, Mersin Üniversitesi, Mersin, Turkey; Horoz, Mehmet, Department of Internal Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Helvacı, İlter, Department of Business Information Management, Mersin Üniversitesi, Mersin, Turkey; Demir, Serap Baspinar, Department of Internal Medicine, Mersin Üniversitesi, Mersin, Turkey; Kıykım, Ahmet Alper, Department of Internal Medicine, Mersin Üniversitesi, Mersin, TurkeyPurpose: Although various studies have improved our knowledge about the clinical features and outcomes of acute kidney injury developing in the hospital (AKI-DI) in elderly subjects, data about acute kidney injury developing outside the hospital (AKI-DO) in elderly patients (age ≥ 65 years) are still extremely limited. This study was performed to investigate prevalence, clinical outcomes, hospital cost and related factors of AKI-DO in elderly and very elderly patients. Methods: We conducted a prospective, observational study in patients (aged ≥ 65 years) who were admitted to our center between May 01, 2012, and May 01, 2013. Subjects with AKI-DO were divided into two groups as elderly (group 1, 65–75 years old) and very elderly (group 2, >75 years old). Control group (group 3) consisted of the hospitalized patients aged 65 years and older with normal serum creatinine level. In-hospital outcomes and 6-month outcomes were recorded. Rehospitalization rate within 6 months of discharge was noted. Hospital costs and mortality rates of each group were investigated. Risk factors for AKI-DO were determined. Results: The incidence of AKI-DO that required hospitalization in elderly and very elderly patients was 5.8 % (136/2324) and 11 % (100/905), respectively (p < 0.001), with an overall incidence of 7.3 % (236/3229). Chronic kidney disease (CKD) was developed in 43.4 % of group 1 and 67 % of group 2 within the 6 months of discharge (p < 0.001). Progression to CKD was significantly lower in the control group than in groups 1 and 2 (p < 0.001). Mortality rates for groups 1, 2 and 3 were 23.5 % (n = 32), 31 % (n = 31) and 4.2 % (n = 8), respectively (p < 0.05). Rehospitalization rate within the 6 months of discharge for the groups with AKI-DO was higher than for the control group (p < 0.001). Hospital cost of groups 1 and 2 was significantly higher than that of the control group (p < 0.001). Nonsteroidal anti-inflammatory drugs (NSAIDs) (OR: 6.839, 95 % CI = 4.392–10.648), angiotensin-converting enzyme inhibitors (ACEI) (OR: 7.846, 95 % CI = 5.161–11.928), angiotensin receptor blockers (ARB) (OR: 6.466, 95 % CI = 4.813–8.917), radiocontrast agents (OR: 8.850, 95 % CI = 5.857–13.372), hypertension (OR: 4.244, 95 % CI = 2.729–6.600), diabetes mellitus (OR: 2.303, 95 % CI = 1.411–3.761), heart failure (OR: 3.647, 95 % CI = 2.276–5.844) and presence of infection (OR: 3.149, 95 % CI = 1.696–5.845) were found as the risk factors for AKI-DO in elderly patients (p < 0.001 for all). Patients with AKI-DO had higher 6-month mortality rate (HR 1.721, 95 % CI: 1.451–2.043, p < 0.001). Mortality risk increased 0.519 times at 20th day. Conclusions: The incidence of AKI-DO requiring hospitalization is higher in very elderly patients than elderly ones, especially in male gender. Use of ACEI, ARB, NSAID and radiocontrast agents is the main risk factors for the development of AKI-DO in the elderly. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Publication rates of presentations at annual scientific meetings of the Turkish neurosurgical society(Turkish Neurosurgical Society [email protected], 2017) Ekşi̇, Murat Şakir; Kaplan, Sümeyye Çoruh; Yilmaz, Baran; Akakin, Akin In; Toktaş, Zafer Orkun; Konya, Deniz; Kilic, Turker D.; Ekşi̇, Murat Şakir, Department of Orthopedic Surgery-Spine Center, University of California, San Francisco, San Francisco, United States; Kaplan, Sümeyye Çoruh, Neurosurgery Clinic, Bismil Devlet Hastanesi, Diyarbakir, Turkey; Yilmaz, Baran, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Akakin, Akin In, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Toktaş, Zafer Orkun, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Konya, Deniz, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kilic, Turker D., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyAim: National and international society meetings are suitable mediums at which diverse research topics from basic, clinical and translational sciences can be presented to an audience of peers. In this study, our purpose was to evaluate publication rates of presentations in the last recent four years' annual scientific meetings of Turkish Neurosurgical Society (TNS). Material and Methods: Abstracts of both podium and poster presentations were retrieved from the congress booklets of TNS. Study timeline included TNS annual scientific meetings of 2011, 2012, 2013, and 2014. Abstract titles and author names of the abstracts were searched in Pubmed/MEDLINE and Google Scholar databases. Results: In total, 3105 presentations to an audience took place in the annual scientific meetings of TNS organized between 2011 and 2014. Acceptance rate of these studies by peer-reviewed scientific journals was 326 (10.5%). In sub-analysis, there were 2408 electronic posters (148 accepted, 6.1%), 195 poster presentations with discussion (44 accepted, 22.6%), and 502 podium presentations (134 accepted, 26.7%). ConclusIon: Acceptance rate of podium presentations in annual scientific meeting of TNS is at comparable levels with similar organizations on the world. However, the rate is lower for poster presentations. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives(Elsevier Ltd, 2017) Zengin Kurt, Belma; Gazioğlu, Işil; Daǧ, Aydan; Salmas, Ramin Ekhteiari; Kayık, Gülru; Durdagi, Serdar; Sönmez, Fatih; Zengin Kurt, Belma, Department of Pharmaceutical Chemistry, Bezmiâlem Vakıf Üniversitesi, Istanbul, Turkey; Gazioğlu, Işil, Department of Analytical Chemistry, Bezmiâlem Vakıf Üniversitesi, Istanbul, Turkey; Daǧ, Aydan, Department of Pharmaceutical Chemistry, Bezmiâlem Vakıf Üniversitesi, Istanbul, Turkey; Salmas, Ramin Ekhteiari, Department of Biophysics, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kayık, Gülru, Department of Chemistry, İstanbul Teknik Üniversitesi, Istanbul, Turkey; Durdagi, Serdar, Department of Biophysics, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sönmez, Fatih, Pamukova Vocational High School, Sakarya Üniversitesi, Serdivan, TurkeyNew thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was found to be the most potent AChE inhibitor with IC50values of 2.22 μM, and 5-isopropyl-2-methylphenyl (4-fluorophenyl)carbamate (30) exhibited the strongest inhibition against BuChE with IC50value of 0.02 μM. Additionally, the result of H4IIE hepatoma cell toxicity assay for compounds 18, 20, 29, 30 and 35 showed negligible cell death at 0.07–10 μM. Moreover in order to better understand the inhibitory profiles of these molecules, molecular modeling studies were applied. Binding poses of studied compounds at the binding pockets of AChE and BuChE targets were determined. Predicted binding energies of these compounds as well as structural and dynamical profiles of molecules at the target sites were estimated using induced fit docking (IFD) algorithms and post-processing molecular dynamics (MD) simulations methods (i.e., Molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) approaches). © 2017 Elsevier B.V., All rights reserved.Publication Metadata only SUBRETINAL CANNULATION AS A COMPLICATION of SUTURE TRABECULOTOMY SURGERY in A PEDIATRIC PATIENT(Lippincott Williams and Wilkins [email protected], 2017) Wise, Justin; Toygar, Okan; Correa, Zelia M.; Miller, Daniel M.; Sisk, Robert Andrew; Wise, Justin, University of Cincinnati College of Medicine, Cincinnati, United States; Toygar, Okan, Cincinnati Eye Institute, Cincinnati, United States, Department of Ophthalmology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Correa, Zelia M., Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, United States; Miller, Daniel M., Cincinnati Eye Institute, Cincinnati, United States, Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, United States; Sisk, Robert Andrew, Cincinnati Eye Institute, Cincinnati, United States, Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, United StatesPurpose: To report a case of inadvertent subretinal cannulation of ab externo suture trabeculotomy surgery associated with serous macular detachment. Methods: Retrospective case report. Ophthalmic examination and portable spectral domain optical coherence tomography (Envisu C2300, Bioptogen, Morrisville, NC) were performed under general anesthesia. Results: A 5-year-old girl with uveitis secondary to oligoarticular juvenile idiopathic arthritis underwent trabeculotomy surgery of the left eye for steroid-induced glaucoma refractory to medical management. The surgery was complicated by inadvertent subretinal cannulation with the prolene suture. Multiple, arcuate, hypopigmented subretinal tracks, originating from the ora serrata, were observed. Spectral domain optical coherence tomography images through the macula revealed subretinal fluid overlying funduscopically visible tracks, defects in photoreceptor outer segments overlying the tracks, and normal choroidal anatomy. The serous macular detachment resolved spontaneously after 4 months and visual acuity returned to baseline 20/25 in the left eye, consistent with reversible localized damage to the outer retina and retinal pigment epithelium. Conclusion: We report a case of inadvertent subretinal cannulation during suture trabeculotomy surgery that resulted in serous macular detachment which resolved spontaneously. The inadvertent complication demonstrated a pathway for administration of therapeutics to the subretinal space. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development(Taylor and Francis Ltd [email protected], 2017) Kayık, Gülru; Tüzün, Nurcan Şenyurt; Durdagi, Serdar; Kayık, Gülru, Department of Chemistry, İstanbul Teknik Üniversitesi, Istanbul, Turkey, Department of Pharmacy, Università di Pisa, Pisa, Italy; Tüzün, Nurcan Şenyurt, Department of Chemistry, İstanbul Teknik Üniversitesi, Istanbul, Turkey; Durdagi, Serdar, Department of Biophysics, Bahçeşehir Üniversitesi, Istanbul, TurkeyThe essential biological function of phosphodiesterase (PDE) type enzymes is to regulate the cytoplasmic levels of intracellular second messengers, 3′,5′-cyclic guanosine monophosphate (cGMP) and/or 3′,5′-cyclic adenosine monophosphate (cAMP). PDE targets have 11 isoenzymes. Of these enzymes, PDE5 has attracted a special attention over the years after its recognition as being the target enzyme in treating erectile dysfunction. Due to the amino acid sequence and the secondary structural similarity of PDE6 and PDE11 with the catalytic domain of PDE5, first-generation PDE5 inhibitors (i.e. sildenafil and vardenafil) are also competitive inhibitors of PDE6 and PDE11. Since the major challenge of designing novel PDE5 inhibitors is to decrease their cross-reactivity with PDE6 and PDE11, in this study, we attempt to identify potent tadalafil-like PDE5 inhibitors that have PDE5/PDE6 and PDE5/PDE11 selectivity. For this aim, the similarity-based virtual screening protocol is applied for the clean drug-like subset of ZINC database that contains more than 20 million small compounds. Moreover, molecular dynamics (MD) simulations of selected hits complexed with PDE5 and off-targets were performed in order to get insights for structural and dynamical behaviors of the selected molecules as selective PDE5 inhibitors. Since tadalafil blocks hERG1 K channels in concentration dependent manner, the cardiotoxicity prediction of the hit molecules was also tested. Results of this study can be useful for designing of novel, safe and selective PDE5 inhibitors. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only A comparison of off- and on-pump beating-heart coronary artery bypass surgery on long-term cardiovascular events(Clinics Cardive Publishing (PTY)Ltd PO Box 1013, Durbanville, 7551, 2017) Gürbüz, Orçun; Kumtepe, Gencehan; Yolgösteren, Atif; Özkan, Hakan; Karal, Ilker Hasan; Ercan, Abdulkadir; Ener, Serdar; Gürbüz, Orçun, Department of Cardiovascular Surgery, Balikesir Üniversitesi, Balikesir, Turkey; Kumtepe, Gencehan, Department of Cardiovascular Surgery, Balikesir Üniversitesi, Balikesir, Turkey; Yolgösteren, Atif, Department of Cardiovascular Surgery, Bursa Uludağ Üniversitesi, Bursa, Turkey; Özkan, Hakan, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karal, Ilker Hasan, Department of Cardiovascular Surgery, Samsun Education and Research Hospital, Samsun, Turkey; Ercan, Abdulkadir, Department of Cardiovascular Surgery, Balikesir Üniversitesi, Balikesir, Turkey; Ener, Serdar, Department of Cardiovascular Surgery, Doruk Hospital, Bursa, TurkeyObjective: Our aim was to compare short-term outcomes and long-term major adverse cardiovascular event (MACE)-free survival and independent predictors of long-term MACE after off-pump (OPCAB) versus on-pump beating-heart (ONBHCAB) coronary artery bypass grafting (CABG). Methods: We retrospectively reviewed data of all consecutive patients who underwent elective CABG, performed by the same surgeon, from January 2003 to October 2009. A propensity score analysis was carried out to adjust for baseline characteristics and a total of 398 patients were included: ONBHCAB (n = 181), OPCAB (n = 217). Results: OPCAB was associated with significantly shorter ventilation times (p ≤ 0.001), intensive care unit stay (p ≤ 0.001) and hospital stay (p ≤ 0.001). The total blood loss was significantly more in the ONBHCAB group (p ≤ 0.001), and accordingly, the number of transfused blood units was significantly lower in the OPCAB group (p ≤ 0.001). Incidence of peri-operative renal complications were significantly higher in the ONBHCAB group (p = 0.004). The OPCAB group showed significantly lower long-term MACE-free survival (p = 0.029). The mean number of transfused blood units was the only independent predictor of MACE (HR: 1.218, 95% CI: 1.0891.361, p = 0.001). Conclusion: OPCAB provided better long-term MACE-free survival compared with ONBHCAB. Fewer units of blood transfused following OPCAB surgery may have been the main reason for this result. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Galactorrhea after selective serotonin reuptake inhibitor use in an adolescent girl: A case report(Lippincott Williams and Wilkins [email protected], 2017) Kaba, Duygu; Öner, Özgür; Kaba, Duygu, Department of Child and Adolescent Psychiatry, Ankara Üniversitesi, Ankara, Turkey; Öner, Özgür, Department of Child and Adolescent Psychiatry, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Metadata only The effect of long-pulsed nd:Yag laser for the treatment of onychomycosis(American Podiatric Medical Association [email protected], 2017) Okan, Gökhan; Tarikçi, Nagehan; Gökdemir, Gonca; Okan, Gökhan, Kemerburgaz Tip Fakültesi Mahmutbey Dilmenler Caddesi, Altinbas Universitesi, Istanbul, Turkey; Tarikçi, Nagehan, Department of Dermatology, Simav City Hospital, Kutahya, Turkey; Gökdemir, Gonca, Department of Dermatology, Bahçeşehir Üniversitesi, Istanbul, TurkeyBackground: Topical onychomycosis therapies are usually inadequate, and patient compliance to systemic therapies is poor. Recently, interest in laser therapy for the treatment of onychomycosis has increased. We sought to investigate the efficacy of long-pulsed Nd:YAG laser therapy for onychomycosis. Methods: Thirty patients with mycologically confirmed onychomycosis received long-pulsed 1064-nm Nd:YAG laser therapy, moving the beam in a spiral pattern over the whole nail plate two times, with a 1-minute pause between passes. Laser therapy was performed with a spot diameter of 4 mm at a speed of 25 mm/sec once weekly for 4 weeks using fluencies ranging from 40 to 60 J/cm2, depending on the thickness of the nail plate. Patients were evaluated in terms of clinical improvement and mycologic cure. Results: Thirty patients started and 15 completed the study. Mycologic cure was achieved in nine patients (60%), of whom eight (89%) were infected with Trichophyton sp. Complete clinical improvement was achieved in seven patients (47%), all of whom were infected with Trichophyton sp. Mycologic cure was not achieved in one of two patients infected with Epidermophyton or in either patient in whom the agent was Candida or Aspergillus, complete clinical improvement did not occur in any of these patients. No serious adverse events were observed. Conclusions: Based on these results, long-pulsed Nd:YAG laser can be used as an effective treatment for onychomycosis, but further studies are needed to draw firmer conclusions. © 2017 Elsevier B.V., All rights reserved.Publication Open Access The role of EGFR, hepatocyte growth factor receptor (c-Met), c-ErbB2 (HER2-neu) and clinicopathological parameters in the pathogenesis and prognosis of chordoma(Federation of Turkish Pathology Societies [email protected], 2017) Tosuner, Zeynep; Bozkurt, Süheyla Uyar; Kilic, Turker D.; Yilmaz, Baran; Tosuner, Zeynep, Department of Pathology, Bezmiâlem Vakıf Üniversitesi, Istanbul, Turkey; Bozkurt, Süheyla Uyar, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey; Kilic, Turker D., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yilmaz, Baran, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyObjective: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to analyse the histopathological features of chordomas and the immunoexpression profiles of the three receptor tyrosine kinases of EGFR, c-Met and c-Erb-B2 in chordomas. We have correlated these results with recurrence and overall survival status of the patients. Material and Method: We studied 49 chordoma patients in order to evaluate the histopathological features and immunohistochemical stainings by EGFR, c-Met and c-ErbB2 antibodies. Of the 49 patients, follow up data was available for 40 patients. Clinical data of the patients were correlated with histopathological features and survival analysis was performed. Results: The immunostaining rate by EGFR and c-Met was 73.5% and 12.2% respectively. None of the cases showed immunoreactivity by c-ErbB2 (0%). Of the 40 cases, 17 cases showed recurrences. EGFR expression was detected in 14 recurrent (14/17) and 17 non-recurrent cases (17/23). Four of the 17 recurrent cases (4/17) were positive by c-Met, while none of the non-recurrent cases (0/23) were positive by this antibody. Significantly, all cases with positive c-Met expression showed recurrences (p<0.05). Conclusion: Our study indicates that EGFR expression is detected in the majority of chordoma cases. c-Met expression can be used as a prognostic indicator for chordoma. © 2018 Elsevier B.V., All rights reserved.