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Publication Metadata only Combating Phytopathogens by Integration of Metagenomics and Phototrophic Biotechnologies: Toward Sustainable Agricultural Practices(TAYLOR & FRANCIS INC, 2025) Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; Zaletova, Dilnaz; Bauenova, Meruyert O.; Huang, Zhiyong; Zharmukhamedov, Sergey K.; Shabala, Sergey; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Russian Academy of Sciences; University of Western Australia; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityRising global food demand amid climate change presents unprecedented challenges for modern agriculture. The spread of phytopathogens and the degradation of agroecosystems necessitate the development of innovative plant protection solutions. Traditional chemical pesticides are losing their effectiveness due to the emergence of resistant pathogens and their adverse environmental impacts, thereby intensifying interest in biological control methods. This study examines the integration of metagenomic analysis and phototrophic biotechnology as a promising approach to biocontrol. Metagenomics enables the precise identification of phytopathogens and beneficial microorganisms, laying the groundwork for the development of targeted biopesticides. Phototrophic microorganisms, including microalgae and cyanobacteria, exhibit antimicrobial properties and contribute to the restoration of soil ecosystems. The convergence of these technologies offers opportunities to form adaptive microbial consortia that ensure the long-term sustainability of agroecosystems. The paper discusses key challenges, including data processing complexities, the scalability of technologies, and regulatory barriers, and underscores the need for standardized methodologies and interdisciplinary collaboration. The integration of metagenomics and phototrophic biotechnology represents a promising direction for creating environmentally safe and sustainable agricultural production systems.Publication Metadata only Spectral insights: Navigating the frontiers of biomedical and microbiological exploration with Raman spectroscopy(ELSEVIER SCIENCE SA, 2024) Allakhverdiev, Elvin S.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Bauenova, Meruyert O.; Belkozhayev, Ayaz M.; Rodnenkov, Oleg, V; Martynyuk, Tamila, V; Maksimov, Georgy, V; Allakhverdiev, Suleyman I.; National Medical Research Center of Cardiology; Lomonosov Moscow State University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Aitkhozhin Institute of Molecular Biology & Biochemistry; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Bahcesehir UniversityRaman spectroscopy (RS), a powerful analytical technique, has gained increasing recognition and utility in the fields of biomedical and biological research. Raman spectroscopic analyses find extensive application in the field of medicine and are employed for intricate research endeavors and diagnostic purposes. Consequently, it enjoys broad utilization within the realm of biological research, facilitating the identification of cellular classifications, metabolite profiling within the cellular milieu, and the assessment of pigment constituents within microalgae. This article also explores the multifaceted role of RS in these domains, highlighting its distinct advantages, acknowledging its limitations, and proposing strategies for enhancement.Publication Metadata only MicroRNAs in Plant Genetic Regulation of Drought Tolerance and Their Function in Enhancing Stress Adaptation(MDPI, 2025) Zhakypbek, Yryszhan; Belkozhayev, Ayaz M.; Kerimkulova, Aygul; Kossalbayev, Bekzhan D.; Murat, Toktar; Tursbekov, Serik; Turysbekova, Gaukhar; Tursunova, Alnura; Tastambek, Kuanysh T.; Allakhverdiev, Suleyman I.; Satbayev University; Satbayev University; Al-Farabi Kazakh National University; Akhmet Yassawi International Kazakh-Turkish University; Al-Farabi Kazakh National University; Uspanov Kazakh Research Institute of Soil Science & Agrochemistry; Satbayev University; Kazakh Scientific Research Institute of Plant Protection & Quarantine of Zh.Zhienbaev; Lomonosov Moscow State University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityAdverse environmental conditions, including drought stress, pose a significant threat to plant survival and agricultural productivity, necessitating innovative and efficient approaches to enhance their resilience. MicroRNAs (miRNAs) are recognized as key elements in regulating plant adaptation to drought stress, with a notable ability to modulate various physiological and molecular mechanisms. This review provides an in-depth analysis of the role of miRNAs in drought response mechanisms, including abscisic acid (ABA) signaling, reactive oxygen species (ROS) detoxification, and the optimization of root system architecture. Additionally, it examines the effectiveness of bioinformatics tools, such as those employed in in silico analyses, for studying miRNA-mRNA interactions, as well as the potential for their integration with experimental methods. Advanced methods such as microarray analysis, high-throughput sequencing (HTS), and RACE-PCR are discussed for their contributions to miRNA target identification and validation. Moreover, new data and perspectives are presented on the role of miRNAs in plant responses to abiotic stresses, particularly drought adaptation. This review aims to deepen the understanding of genetic regulatory mechanisms in plants and to establish a robust scientific foundation for the development of drought-tolerant crop varieties.Publication Metadata only Assessing the Efficacy of Cyanobacterial Strains as Oryza sativa Growth Biostimulants in Saline Environments(MDPI, 2024) Bauenova, Meruyert O.; Sarsekeyeva, Fariza K.; Sadvakasova, Asemgul K.; Kossalbayev, Bekzhan D.; Mammadov, Ramazan; Token, Aziza I.; Balouch, Huma; Pashkovskiy, Pavel; Leong, Yoong Kit; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Akhmet Yassawi International Kazakh-Turkish University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Bahcesehir UniversitySoil salinity, which affects plant photosynthesis mechanisms, significantly limits plant productivity. Soil microorganisms, including cyanobacteria, can synthesize various exometabolites that contribute to plant growth and development in several ways. These microorganisms can increase plant tolerance to salt stress by secreting various phytoprotectants, therefore, it is highly relevant to study soil microorganisms adapted to high salinity and investigate their potential to increase plant resistance to salt stress. This study evaluated the antioxidant activity of four cyanobacterial strains: Spirulina platensis Calu-532, Nostoc sp. J-14, Trichormus variabilis K-31, and Oscillatoria brevis SH-12. Among these, Nostoc sp. J-14 presented the highest antioxidant activity. Their growth-stimulating effects under saline conditions were also assessed under laboratory conditions. These results indicate that Nostoc sp. J-14 and T. variabilis K-31 show significant promise in mitigating the harmful effects of salinity on plant size and weight. Both strains notably enhanced the growth of Oryza sativa plants under saline conditions, suggesting their potential as biostimulants to improve crop productivity in saline environments. This research underscores the importance of understanding the mechanisms by which cyanobacteria increase plant tolerance to salt stress, paving the way for sustainable agricultural practices in saline areas.Publication Metadata only Development and Transfer of Microbial Agrobiotechnologies in Contrasting Agrosystems: Experience of Kazakhstan and China(MDPI, 2025) Nygymetova, Aimeken M.; Sadvakasova, Assemgul K.; Zaletova, Dilnaz E.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Wang, Jingjing; Huang, Zhiyong; Sarsekeyeva, Fariza K.; Kirbayeva, Dariga K.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Bahcesehir University; Russian Academy of Sciences; Russian Academy of Sciences; Timiryazev Institute of Plant PhysiologyThe development and implementation of microbial consortium-based biofertilizers represent a promising direction in sustainable agriculture, particularly in the context of the ongoing global ecological and agricultural crisis. This article examines the agroecological and economic impacts of applying microbial consortiums and explores the mechanisms of technology transfer using the example of two countries with differing levels of scientific and technological advancement-China and Kazakhstan. The analysis of the Chinese experience reveals that the successful integration of microbial biofertilizers into agricultural practice is made possible by a well-established institutional framework that includes strong governmental support for R&D, a robust scientific infrastructure, and effective coordination with the private sector. In contrast, Kazakhstan, despite its favorable agroecological conditions and growing interest among farmers in environmentally friendly technologies, faces several challenges from limited funding to a fragmented technology transfer system. The comparative study demonstrates that adapting Chinese models requires consideration of local specificities and the strengthening of intergovernmental cooperation. The article concludes by emphasizing the need to establish a multi-level innovation ecosystem encompassing the entire cycle of development and deployment of microbial biofertilizers, as a prerequisite for improving agricultural productivity and ensuring food security in countries at different stages of economic development.Publication Metadata only Microalgae as a key tool in achieving carbon neutrality for bioproduct production(ELSEVIER, 2023) Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Balouch, Huma; Leong, Yoong Kit; Zayadan, Bolatkhan K.; Huang, Zhiyong; Alharby, Hesham F.; Tomo, Tatsuya; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Tunghai University; Tunghai University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Tokyo University of Science; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Lomonosov Moscow State University; Bahcesehir UniversityThe upcoming global climate change as a result of anthropogenic action is now increasingly attracting the attention of scientific communities. Over the past three decades, researchers and industries around the world have spent a lot of time and effort developing various carbon capture and storage technologies, which, despite their promise, are still economically complex, with unclear long-term consequences to the environment. As an alternative, biological carbon sequestration is considered an attractive method of atmospheric CO2 fixation with the production of biomass, which, in turn, can be used as a readily renewable feedstock for the production of biofuels and other valuable products. This review focuses on the latest data of microalgae research in terms of key carbon footprint minimization strategies, which include features of the carbon concentrating mechanism (CCM) in microalgae, the main range of biofuels and the possibility of obtaining valuable metabolites based on them, such as bioplastics, biofertilizers, and biologically active compounds.Publication Metadata only Synthetic algocyanobacterial consortium as an alternative to chemical fertilizers(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2023) Sadvakasova, Assemgul K.; Bauenova, Meruyert O.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Huang, Zhiyong; Wang, Jingjing; Balouch, Huma; Alharby, Hesham F.; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityThe use of unregulated pesticides and chemical fertilizers can have detrimental effects on biodiversity and human health. This problem is exacerbated by the growing demand for agricultural products. To address these global challenges and promote food and biological security, a new form of agriculture is needed that aligns with the principles of sustainable development and the circular economy. This entails developing the biotechnology market and maximizing the use of renewable and eco-friendly resources, including organic fertilizers and biofertilizers. Phototrophic microorganisms capable of oxygenic photosynthesis and assimilation of molecular nitrogen play a crucial role in soil microbiota, interacting with diverse microflora. This suggests the potential for creating artificial consortia based on them. Microbial consortia offer advantages over individual organisms as they can perform complex functions and adapt to variable conditions, making them a frontier in synthetic biology. Multifunctional consortia overcome the limitations of monocultures and produce biological products with a wide range of enzymatic activities. Biofertilizers based on such consortia present a viable alternative to chemical fertilizers, addressing the issues associated with their usage. The described capabilities of phototrophic and heterotrophic microbial consortia enable effective and environmentally safe restoration and preservation of soil properties, fertility of disturbed lands, and promotion of plant growth. Hence, the utilization of algo-cyanobacterial consortia biomass can serve as a sustainable and practical substitute for chemical fertilizers, pesticides, and growth promoters. Furthermore, employing these bio-based organisms is a significant stride towards enhancing agricultural productivity, which is an essential requirement to meet the escalating food demands of the growing global population. Utilizing domestic and livestock wastewater, as well as CO2 flue gases, for cultivating this consortium not only helps reduce agricultural waste but also enables the creation of a novel bioproduct within a closed production cycle.Publication Metadata only In silico design of biomass-to-hydrogen Pathways: A review(PERGAMON-ELSEVIER SCIENCE LTD, 2025) Kakimova, Ardak B.; Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; V. Zadneprovskaya, Elena; Xu, Tao; Zaletova, Dilnaz; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Xi'an University of Science & Technology; Bahcesehir UniversityHydrogen production from biomass has emerged as a promising renewable energy solution. However, significant challenges such as thermodynamic inefficiencies, high raw material costs, low hydrogen molar yields, and difficulties in using lignocellulosic feedstocks hinder its large-scale implementation. Conventional methods have not been able to effectively address these issues, which makes modern approaches, such as in silico strategies, essential. This review explores the role of computational models like genome-scale metabolic modeling, synthetic biology, and metabolic pathway reconstruction in overcoming these barriers. By utilizing vast genomic databases and advanced computational tools, researchers can optimize microbial systems, improve hydrogen yields, and design more efficient biohydrogen production processes. These in silico methods provide a pathway to enhance the efficiency of biomass processing and enable the development of scalable and sustainable hydrogen production technologies. The review highlights recent advancements and discusses the potential of in silico approaches to address key technological and economic limitations, paving the way for the future of biohydrogen energy.Publication Metadata only Microalgae- and cyanobacteria-derived phytostimulants for mitigation of salt stress and improved agriculture(ELSEVIER, 2024) Sarsekeyeva, Fariza K.; Sadvakasova, Asemgul K.; Sandybayeva, Sandugash K.; Kossalbayev, Bekzhan D.; Huang, Zhiyong; Zayadan, Bolatkhan K.; Akmukhanova, Nurziya R.; Leong, Yoong Kit; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Bahcesehir UniversitySoil salinization poses severe abiotic stress that adversely affects plant growth and development, ultimately threatening global food security by inducing physiological abnormalities. In response to escalating nutrient demands, with global requirements quantified at 76 % for nitrogen and 87 % for phosphorus, modern agriculture is increasingly adopting sustainable practices to enhance nutrient recycling and reduce reliance on external inputs. Emerging sources of plant phytostimulants, such as microalgal and cyanobacterial biomass, show promise in augmenting crop yields and bolstering plant resistance to various abiotic factors, including salt stress. The efficacy of these microorganisms stems from their simplistic cellular structure, superior photosynthetic efficiency, capacity for heterotrophic growth, adaptability to varying environmental conditions, potential for metabolic engineering, and the abundance of valuable biomolecules (such as soluble amino acids, micronutrients, polysaccharides, and phytohormones) within their biomass. This review provides an analysis of the current research landscape concerning microalgae- and cyanobacteria-derived phytostimulants, highlighting their promise as an innovative and sustainable alternative to synthetic fertilizers in the agricultural sector. Moreover, it identifies various adaptive responses of plants to salinity stress and assesses the potential and challenges associated with the use of microalgae and cyanobacteria-based metabolites for developing new sustainable strategies to enhance crop tolerance to salinity stress.Publication Metadata only Progress and innovation in key technologies for converting biomass to hydrogen(PERGAMON-ELSEVIER SCIENCE LTD, 2025) Kamshybayeva, Gulzhanay K.; Sadvakasova, Asemgul K.; Belkozhayev, Ayaz M.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Zharmukhamedov, Sergey K.; Hou, Harvey J. M.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Russian Academy of Sciences; Alabama State University; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Bahcesehir UniversityThe growing demand for clean energy has spotlighted biomass as a promising resource for sustainable hydrogen production, providing a carbon-neutral alternative to traditional fossil fuels. This review examines the latest advancements in converting biomass to hydrogen, focusing on thermochemical methods like gasification and pyrolysis, catalyst development, and biotechnological approaches such as dark fermentation and biophotolysis. While these methods offer substantial environmental benefits, including waste reduction and renewable energy generation, challenges persist in optimizing feedstock diversity, enhancing catalyst stability, and achieving costeffective scalability. Innovations in plasma-assisted reforming, advanced nanocatalysts, and integrated reactor designs show promise in overcoming these barriers. By fostering collaboration across academia, industry, and government, these advancements can pave the way for a viable, sustainable hydrogen economy and contribute significantly to reducing global carbon emissions.