Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Metadata only Letter to the Editor: Radiotherapy Increases aMMP-8 Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study(SAGE PUBLICATIONS INC, 2023) Yilmaz, Busra; Topkan, Erkan; Pehlivan, Berrin; Selek, Ugur; Bahcesehir University; Baskent University; Bahcesehir University; Koc UniversityPublication Metadata only Letter to the Editor regarding Radiologic findings of osteonecrosis, osteoradionecrosis, osteomyelitis and jaw metastatic disease with cone beam CT(ELSEVIER IRELAND LTD, 2023) Yilmaz, Busra; Topkan, Erkan; Bahcesehir University; Baskent UniversityPublication Metadata only Comment on: Planned dose of intensity modulated proton beam therapy versus volumetric modulated arch therapy to tooth-bearing regions(ELSEVIER, 2023) Yilmaz, Busra; Topkan, Erkan; Bahcesehir University; Baskent UniversityPublication Metadata only Letter to the editor: trismus, health-related quality of life, and trismus-related symptoms up to 5 years post-radiotherapy for head and neck cancer treated between 2007 and 2012(SPRINGER, 2023) Yilmaz, Busra; Topkan, Erkan; Bahcesehir University; Baskent UniversityPublication Metadata only Letter to the editor: preoperative evaluation of oral hygiene may predict the overall survival of patients with esophageal cancer(SPRINGER JAPAN KK, 2024) Topkan, Erkan; Yilmaz, Busra; Somay, Efsun; Baskent University; Bahcesehir University; Baskent UniversityPublication Metadata only Radiation therapy for cT1-2 carcinoma of the palatine tonsil diagnosed via a simple tonsillectomy: Dosimetry and patterns of care in the IMRT era(ELSEVIER, 2023) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; Baskent University; Baskent University; Bahcesehir University; Baskent UniversityPublication Metadata only Comments on Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment(ELSEVIER IRELAND LTD, 2024) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Baskent University; Bahcesehir University; Baskent University; Baskent UniversityPublication Metadata only Hemoglobin-to-platelet ratio in predicting the incidence of trismus after concurrent chemoradiotherapy(WILEY, 2023) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Kucuk, Ahmet; Haksoyler, Veysel; Pehlivan, Berrin; Selek, Ugur; Araz, Kenan; Baskent University; Baskent University; Baskent University; Medline Health Group; Bahcesehir University; Koc University; University of Texas System; UTMD Anderson Cancer Center; University of Texas Health Science Center HoustonObjective The significance of pre-hemoglobin-to-platelet ratio (HPR) in predicting the occurrence of radiation-induced trismus (RIT) in locally advanced nasopharyngeal carcinoma patients (LA-NPC) who received concurrent chemoradiotherapy (C-CRT). Methods The records of LA-NPC patients with oral examination before and after C-CRT were analyzed. Maximum mouth openings (MMO) were measured before and after C-CRT to confirm RIT status, with an MMO of <= 35 mm defined as RIT. HPR values were calculated on the first day of C-CRT. The relationship between the HPR values and RIT status was discovered using the receiver operating characteristic curve analysis. Results A total of 43 patients RIT cases among 198 individuals were diagnosed. The optimal HPR cutoff that stratified the patients into two groups was 0.54. RIT incidence was found to be significantly higher in the HPR <= 0.54 group than its HPR >0.54 counterpart(p < 0.001). Univariately T3-4 stage, mean masticator apparatus dose>57.2Gy, and pre-C-CRT MMO <= 40.7 mm were found as the other significant correlates of increased RIT rates(p < 0.05). All four variables seemed to be independently connected to greater RIT incidence in multivariate analysis (p < 0.05, for each). Conclusion The risk of post-C-CRT RIT may be significantly increased when pre-treatment HPR levels are low.Publication Metadata only Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer(WILEY, 2024) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Ozdemir, Beyza Sirin; Ozturk, Duriye; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, Ugur; Baskent University; Bahcesehir University; Baskent University; Medical Park Hospitals Group; Afyonkarahisar Health Sciences University; Istinye University; Koc UniversityPurpose. To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for the prevalence of radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA-NPC) receiving concurrent chemoradiotherapy (CCRT). Methods. Data from 228 LA-NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs <= 35 mm. Complete blood test results from the first day of CCRT were used to calculate PIV/Hb levels. A potential relationship between pretreatment PIV/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis. Results. Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%, specificity: 86.4%, sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group than in the PIV/Hb < 68 group (58.8% vs. 3.8%, P<0.001). Multivariate logistic regression analysis showed that a pre-CCRT PIV > 68 was independently associated with significantly higher rates of RIT. Conclusion. Higher pretreatment levels of the novel PIV/Hb index predict increased RIT rates following definitive CCRT for LA-NPCs.Publication Metadata only The predictive usefulness of the novel combined hemoglobin-to-platelet ratio and maximum mouth opening index on prevalence of radiation induced trismus in patients with nasopharyngeal cancer(WILEY, 2023) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Kucuk, Ahmet; Pehlivan, Berrin; Selek, Ugur; Baskent University; Baskent University; Baskent University; Bahcesehir University; Koc University; University of Texas System; University of Texas Health Science Center Houston; UTMD Anderson Cancer Center; Baskent UniversityObjectivesTo explore how well a unique combination of hemoglobin-to-platelet ratio (HPR) and pretreatment maximum mouth opening (MMO) predicts the prevalence of radiation-induced trismus (RIT). Patients and methodsHPR and MMO cutoff values (0.54 and 40.7 mm) divided patients into two groups. To develop the novel HPR-MMO index, four combinations of these factors were tested for predictive power: Group 1: HPR > 0.54 and MMO > 40.7 mm, Group 2: HPR <= 0.54 but MMO > 40.7 mm, Group 3: HPR > 0.54 but MMO <= 40.7 mm, Group 4: HPR <= 0.54 and MMO <= 40.7 mm. ResultsData of 198 patients with LA-NPC was analyzed retrospectively. RIT rates for Groups 1 to 4 were 10.2%, 15.2%, 25%, and 59.4%. Groups 2 and 3 were merged to generate HPR-MMO index because of statistically equivalent RIT rates: Low-risk: HPR > 0.54 and MMO > 40.7 mm, Intermediate-risk: HPR <= 0.54 but MMO > 40.7 mm or, HPR > 0.54 but MMO <= 40.7 mm, High-risk: HPR <= 0.54 and MMO <= 40.7 mm. It was revealed that the low-, high-, and intermediate-risk group's RIT rates, 10.2%, 59.4%, and 19.2%, respectively. ConclusionThe novel HPR-MMO index may to classify LA-NPC patients into low, intermediate, and high-risk RIT groups.