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Publication Metadata only Sex matters in CSU: Women face greater burden and poorer urticaria control, especially in midlife-CURE insights(WILEY, 2025) Kocaturk, Emek; Salameh, Pascale; Asero, Riccardo; Bizjak, Mojca; Gimenez-Arnau, Ana; Grattan, Clive; Pesque, David; Planella-Fontanillas, Nidia; Herzog, Leonie Shirin; Buttgereit, Thomas; Bonnekoh, Hanna; Fomina, Daria; Kovalkova, Elena; Lebedkina, Marina; Kasperska-Zajac, Alicja; Zajac, Magdalena; Zamlynsk, Mateusz; Kulthanan, Kanokvalai; Tuchinda, Papapit; Khoshkhui, Maryam; Hassanpour, Zohreh; Peter, Jonny; Du-Thanh, Aurelie; Meshkova, Raisa; Abuzakouk, Mohamed; Makris, Michael; Bouillet, Laurence; Bocquet, Alexis; Gregoriou, Stamatios; Thomsen, Simon Francis; Dissemond, Joachim; Staubach, Petra; Bauer, Andrea; Danilycheva, Inna; van Doorn, Martijn; Parisi, Claudio; Metz, Martin; Fluhr, Joachim W.; Zuberbier, Torsten; Weller, Karsten; Kolkhir, Pavel; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Bahcesehir University; Lebanese American University; University of Nicosia; University Clinic Golnik; Pompeu Fabra University; Hospital del Mar Research Institute; Hospital del Mar; Sechenov First Moscow State Medical University; Astana Medical University; Medical University of Silesia; Mahidol University; Mashhad University of Medical Sciences; Ahvaz Jundishapur University of Medical Sciences (AJUMS); University of Cape Town; Universite de Montpellier; Cleveland Clinic Foundation; National & Kapodistrian University of Athens; University Hospital Attikon; CHU Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); National & Kapodistrian University of Athens; University of Copenhagen; Copenhagen University Hospital; Bispebjerg Hospital; University of Copenhagen; University of Duisburg Essen; Johannes Gutenberg University of Mainz; Technische Universitat Dresden; Carl Gustav Carus University Hospital; NRC Institute of Immunology FMBA of Russia; Erasmus University Rotterdam; Erasmus MC; Hospital Italiano de Buenos Aires; University of Buenos Aires; University of Buenos Aires HospitalBackground: Chronic spontaneous urticaria (CSU), a disease predominantly affecting females, has limited information available on its differences between females and males of varying ages.Objective To investigate sex differences in age groups regarding disease activity, comorbidities, quality of life (QoL) and treatment patterns in CSU patients. Methods: We analysed Chronic Urticaria Registry (CURE) data, an international real-world registry for patients with chronic urticaria. Patients were recruited via an online platform using a standardized questionnaire. The data were analysed for demographics, age of onset, duration of urticaria, (Urticaria Activity Score [UAS], Urticaria Control Test [UCT], Chronic Urticaria Quality of Life Questionnaire [CU-Q2oL]), family history, systemic symptoms, aggravating factors, comorbidities, smoking and alcohol consumption, laboratory parameters, burden of disease, treatment distribution and response rates, compliance to treatment and adverse events. Comparisons were made among age groups <13, 13-17, 18-30, 31-50, 51-65 and >65 years. Results: Across 4136 CSU patients (from 58 sites across 29 countries), 2994 (72.4%) were female. Statistically significant female predominance started at age 31 (<0.001). Compared with males, females showed higher rates of angioedema (59.6 vs. 51.7%, p < 0.001), systemic symptoms (34.6 vs. 25.4%, p < 0.001), sleep disturbance (38.9 vs. 32.5%, p < 0.001), QoL impairment (CU-Q2oL score 32 vs. 27.7, p < 0.001) and lower rates of urticaria control than males in all medication categories (p < 0.05 for all). Females had more concomitant diseases, including asthma, thyroid disease, obesity, autoimmune disease, gastrointestinal disease and depression (p < 0.05 for all). The disease was especially more burdensome and refractory in females aged 51-65 years than males, evidenced by more angioedema and systemic symptoms, worse QoL, lower UCT scores and more emergency visits (p < 0.05 for all). However, these differences were not prominent in the elderly females (>65 years).Conclusion Compared with males, female CSU patients experience more burdensome disease, which gets worse in midlife.Publication Metadata only Mind the Gap: Perceived Economic Inequality and the Well-Being Gap around the Globe(SAGE PUBLICATIONS INC, 2025) Sanchez-Rodriguez, Angel; Gorski, Maciej R.; Joshanloo, Mohsen; Krys, Kuba; Tonnessen, Morten; Li, Liman Man Wai; Akaliyski, Plamen; Haas, Brian W.; Hussain, M. Azhar; Guemaz, Farida; Boussena, Mahmoud; Iter, Nuha; Vlasenko, Olha; Lun, Vivian Miu-Chi; Vignoles, Vivian L.; Aminnuddin, Nur Amali; Isik, Idil; Ngom-Dieng, Laina; Fulop, Marta; Igbokwe, David; Adamovic, Mladen; Garoarsdottir, Ragna Benedikta; Soboleva, Natalia; Teyssier, Julien; Gluckstad, Fumiko Kano; Park, Joonha; Zelenski, John; Yeung, Victoria Wai Lan; Yeung, June Chun; Yau, Eric Kenson; Yang, Jae-Won; Yakhlef, Belkacem; Xing, Cai; Wasiel, Arkadiusz; Vauclair, Christin-Melanie; van Tilburg, Wijnand; Turjacanin, Vladimir; Tra, Kieu Thi Thanh; Torres, Claudio; Sun, Chien-Ru; Sokolov, Boris; Sobhie, Rosita; Sirlopu, David; Selim, Heyla; Rocha, Ana Maria; Rizwan, Muhammad; Solcova, Iva Polackova; Pavlovic, Zoran; Palikot, Ewa; Olechowski, Mateusz; Okvitawanli, Ayu; Ochoa, Danielle; Nowak, Kaeolina; Nader, Martin; Myslinska-Szarek, Katarzyna; Murdock, Elke; Mosca, Oriana; Mosanya, Magdalena; Mokadem, Fatma; Mohammed, Linda; Malyonova, Arina; Malyonov, Alexander; Lee, Hannah; Lauri, Mary Anne; Kronberger, Nicole; Kocimska-Bortnowska, Agata; Kluzowicz, Maria; Kascakova, Natalia; Imran, Mostak Ahamed; Igou, Eric Raymond; Henk, Katharina; Hasanov, Rafail; Gjoneska, Biljana; Gavreliuc, Alin; Garvanova, Magdalena; Gamsakhurdia, Vladimer; Espinosa, Agustin; Dominguez Espinosa, Alejandra; Deltour, Jule; Costin, Vlad; Bolatov, Aidos; Baltin, Arno; Bakyono-Nabaloum, Rasmata; Asif, Resham; Appoh, Lily; Anic, Petra; Andrade, Laura; Almakaeva, Anna; Al-Zoubi, Marwan; Akello, Grace; Bond, Michael Harris; University of Salamanca; Polish Academy of Sciences; Institute of Psychology of the Polish Academy of Sciences; University of Warsaw; Keimyung University; Universitetet i Stavanger; Education University of Hong Kong (EdUHK); Lingnan University; University System of Georgia; University of Georgia; University of Sharjah; Roskilde University; Palestine Technical University - Kadoorie; University Osnabruck; University of Sussex; University Brunei Darussalam; Bahcesehir University; University Cheikh Anta Diop Dakar; University of London; King's College London; University of Iceland; HSE University (National Research University Higher School of Economics); Universite de Toulouse; Copenhagen Business School; Kyoto University; Carleton University; Catholic University of Korea; Ecole Normale Superieure de Constantine; Renmin University of China; Instituto Universitario de Lisboa; University of Essex; University of Banja Luka (UNIBL); Universidade de Brasilia; National Chengchi University; Anton de Kom Universiteit van Suriname; Universidad San Sebastian; King Saud University; Czech Academy of Sciences; Institute of Psychology of the Czech Academy of Sciences; University of Belgrade; Sebelas Maret University; University of the Philippines System; University of the Philippines Diliman; Universidad ICESI; University of Luxembourg; University of Cagliari; Dostoevsky Omsk State University; Indiana University System; Indiana University Northwest; University of Malta; Johannes Kepler University Linz; Palacky University Olomouc; Bangladesh Rural Advancement Committee BRAC; BRAC University; University of Limerick; University of Koblenz & Landau; Ministry of Education of Azerbaijan Republic; Baku State University; West University of Timisoara; University for Library Studies & Information Technology; Ivane Javakhishvili Tbilisi State University; Pontificia Universidad Catolica del Peru; Universidad Iberoamericana Ciudad de Mexico; Astana Medical University; Tallinn University; Universite Joseph Ki-Zerbo; Nord University; University of Rijeka; University of Jordan; Gulu University; Hong Kong Polytechnic UniversityThe link between economic inequality and individual well-being has been gaining increasing research attention. This study examines this relationship using data from 71 countries with diverse national incomes, addressing three key research gaps: (1) incorporating measures of both perceived and objective economic inequality, (2) extending analysis to multiple components of well-being beyond happiness, including meaning in life, harmony, and spirituality, and (3) assessing levels of both current and ideal well-being. Findings reveal that perceived economic inequality predicts personal well-being more strongly than objective inequality. In addition, perceived inequality is associated with a wider gap between current and ideal levels of happiness, meaning, harmony, and spirituality, although national income moderates the effects of meaning, harmony, and spirituality. We discuss the implications of these results, highlighting the need for more culturally sensitive studies on perceived economic inequality and well-being.Publication Metadata only Sex matters in CSU: Women face greater burden and poorer urticaria control, especially in midlife-CURE insights(WILEY, 2025) Kocaturk, Emek; Salameh, Pascale; Asero, Riccardo; Bizjak, Mojca; Gimenez-Arnau, Ana; Grattan, Clive; Pesque, David; Planella-Fontanillas, Nidia; Herzog, Leonie Shirin; Buttgereit, Thomas; Bonnekoh, Hanna; Fomina, Daria; Kovalkova, Elena; Lebedkina, Marina; Kasperska-Zajac, Alicja; Zajac, Magdalena; Zamlynsk, Mateusz; Kulthanan, Kanokvalai; Tuchinda, Papapit; Khoshkhui, Maryam; Hassanpour, Zohreh; Peter, Jonny; Du-Thanh, Aurelie; Meshkova, Raisa; Abuzakouk, Mohamed; Makris, Michael; Bouillet, Laurence; Bocquet, Alexis; Gregoriou, Stamatios; Thomsen, Simon Francis; Dissemond, Joachim; Staubach, Petra; Bauer, Andrea; Danilycheva, Inna; van Doorn, Martijn; Parisi, Claudio; Metz, Martin; Fluhr, Joachim W.; Zuberbier, Torsten; Weller, Karsten; Kolkhir, Pavel; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Bahcesehir University; Lebanese American University; University of Nicosia; University Clinic Golnik; Pompeu Fabra University; Hospital del Mar Research Institute; Hospital del Mar; Sechenov First Moscow State Medical University; Astana Medical University; Medical University of Silesia; Mahidol University; Mashhad University of Medical Sciences; Ahvaz Jundishapur University of Medical Sciences (AJUMS); University of Cape Town; Universite de Montpellier; Cleveland Clinic Foundation; National & Kapodistrian University of Athens; University Hospital Attikon; CHU Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); National & Kapodistrian University of Athens; University of Copenhagen; Copenhagen University Hospital; Bispebjerg Hospital; University of Copenhagen; University of Duisburg Essen; Johannes Gutenberg University of Mainz; Technische Universitat Dresden; Carl Gustav Carus University Hospital; NRC Institute of Immunology FMBA of Russia; Erasmus University Rotterdam; Erasmus MC; Hospital Italiano de Buenos Aires; University of Buenos Aires; University of Buenos Aires HospitalBackground: Chronic spontaneous urticaria (CSU), a disease predominantly affecting females, has limited information available on its differences between females and males of varying ages.Objective To investigate sex differences in age groups regarding disease activity, comorbidities, quality of life (QoL) and treatment patterns in CSU patients. Methods: We analysed Chronic Urticaria Registry (CURE) data, an international real-world registry for patients with chronic urticaria. Patients were recruited via an online platform using a standardized questionnaire. The data were analysed for demographics, age of onset, duration of urticaria, (Urticaria Activity Score [UAS], Urticaria Control Test [UCT], Chronic Urticaria Quality of Life Questionnaire [CU-Q2oL]), family history, systemic symptoms, aggravating factors, comorbidities, smoking and alcohol consumption, laboratory parameters, burden of disease, treatment distribution and response rates, compliance to treatment and adverse events. Comparisons were made among age groups <13, 13-17, 18-30, 31-50, 51-65 and >65 years. Results: Across 4136 CSU patients (from 58 sites across 29 countries), 2994 (72.4%) were female. Statistically significant female predominance started at age 31 (<0.001). Compared with males, females showed higher rates of angioedema (59.6 vs. 51.7%, p < 0.001), systemic symptoms (34.6 vs. 25.4%, p < 0.001), sleep disturbance (38.9 vs. 32.5%, p < 0.001), QoL impairment (CU-Q2oL score 32 vs. 27.7, p < 0.001) and lower rates of urticaria control than males in all medication categories (p < 0.05 for all). Females had more concomitant diseases, including asthma, thyroid disease, obesity, autoimmune disease, gastrointestinal disease and depression (p < 0.05 for all). The disease was especially more burdensome and refractory in females aged 51-65 years than males, evidenced by more angioedema and systemic symptoms, worse QoL, lower UCT scores and more emergency visits (p < 0.05 for all). However, these differences were not prominent in the elderly females (>65 years).Conclusion Compared with males, female CSU patients experience more burdensome disease, which gets worse in midlife.Publication Metadata only Global Andrology Forum Clinical Guidelines on the Relevance of Sperm DNA Fragmentation in Medicine(KOREAN SOC SEXUAL MEDICINE & ANDROLOGY, 2025) Cayan, Selahittin; Farkouh, Ala'a; Agarwal, Ashok; Atmoko, Widi; Wyns, Christine; Arafa, Mohamed; Zini, Armand; Shah, Rupin; Alipour, Hiva; Chung, Eric; Saleh, Ramadan; Pinggera, Germar-Michael; Konstantinidis, Charalampos; Al Hashimi, Manaf; Pescatori, Edoardo; Rambhatla, Amarnath; Toprak, Tuncay; Calogero, Aldo E.; Gul, Murat; Park, Hyun Jun; Altay, Baris; Falcone, Marco; Rashed, Ayman; Le, Tan V.; Bahar, Fahmi; Shatylko, Taras; Gorur, Sadik; El-Sakka, Ahmed I.; Saylam, Bari; Sarikaya, Selcuk; Smith, Ryan Patrick; Boeri, Luca; Efesoy, Ozan; Ceyhan, Erman; Russo, Giorgio Ivan; Ozer, Cevahir; Ho, Christopher Chee Kong; Gungor, Nur Dokuzeylul; Ozlu, Deniz Noyan; Molina, Juan Manuel Corral; Musa, Muhammad Ujudud; Tsujimura, Akira; Gokalp, Fatih; Mohamed, Mohamed Saeed; Okada, Keisuke; Khalafalla, Kareim; Kuroda, Shinnosuke; Binsaleh, Saleh; Motawi, Ahmad Tarek; Shamohammadi, Iman; Mogharabian, Nasser; Manh, Manh Truong; Taha, Emad Abdelraheem; Makarounis, Konstantinos; Mak, Siu King; Shedeed, Shedeed Ashour; Thomas, Charalampos; Mostafa, Taymour; Mersin University; Loma Linda University; Cleveland Clinic Foundation; University of Indonesia; Dr. Cipto Mangunkusumo National Public Hospital; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Universite Catholique Louvain; Egyptian Knowledge Bank (EKB); Cairo University; Hamad Medical Corporation; Qatar Foundation (QF); Weill Cornell Medical College Qatar; McGill University; Aalborg University; Princess Alexandra Hospital; University of Queensland; Egyptian Knowledge Bank (EKB); Sohag University; Medical University of Innsbruck; Khalifa University of Science & Technology; Henry Ford Health System; Henry Ford Hospital; Michigan State University; Michigan State University College of Human Medicine; University of Health Sciences Turkey; University of Catania; Selcuk University; Selcuk University; Pusan National University; Pusan National University; Pusan National University Hospital; Ege University; A.O.U. Citta della Salute e della Scienza di Torino; University of Turin; Biruni University; Egyptian Knowledge Bank (EKB); October 6 University (O6U); Hatay Mustafa Kemal University; Egyptian Knowledge Bank (EKB); Suez Canal University; Gulhane Training & Research Hospital; University of Health Sciences Turkey; University of Virginia; IRCCS Ca Granda Ospedale Maggiore Policlinico; Baskent University; University of Catania; Baskent University; Taylor's University; Bahcesehir University; University of Health Sciences Turkey; Bakirkoy Dr. Sadi Konuk Research & Training Hospital; University of Barcelona; Hospital Clinic de Barcelona; Juntendo University; Egyptian Knowledge Bank (EKB); Al Azhar University; Kobe University; Qatar University; Yokohama City University; King Saud University; Shiraz University of Medical Science; Shahroud University Medical Sciences; Egyptian Knowledge Bank (EKB); Assiut University; Egyptian Knowledge Bank (EKB); Assiut UniversityPurpose: To evaluate the evidence on sperm DNA fragmentation (SDF) and its clinical applications in reproductive medicine, highlighting benefits, limitations, and guidelines for its use to assist clinicians in objective decision-making. Materials and Methods: A multidisciplinary team of clinicians and reproductive experts from the Global Andrology Forum (GAF) reviewed the latest evidence on SDF, covering indications, testing methods, recurrent pregnancy loss, varicocele and its repair, assisted reproductive technologies (ART), treatment of associated conditions, antioxidant therapy, and sperm selection for ART. Expert statements and recommendations were developed and graded with the GRADE system using a modified Delphi process. Results: Based on the GAF surveys, systematic reviews, and meta-analyses related to SDF, 52 experts introduced and scored 24 statements and recommendations using the GRADE system. Of these, 87.5% (21/24) achieved strong ratings, reflecting broad consensus, while 12.5% (3/24) were rated weak. The guidelines provide evidence-based recommendations for clinical scenarios, including the role of SDF in infertility, recurrent pregnancy loss, and ART outcomes. Conclusions: While there is growing interest and evidence regarding the clinical benefit of SDF testing and its utility in managing male infertility, significant gaps in the literature limit its routine use in clinical practice. The guidelines offer a structured framework for integrating SDF testing into male infertility management, emphasizing a tailored approach based on individual clinical scenarios. Clinicians must balance the benefits and limitations of SDF testing and antioxidant treatment to optimize care in reproductive medicine. These guidelines are critical for advancing evidence-based practices in male infertility management.Publication Metadata only Dermatological Comorbidities Accompanying Rosacea and Their Relationship with Clinical and Demographic Features, Quality of Life, and Systemic Comorbidities: A Retrospective, Case-Controlled, Multicenter Survey(KARGER, 2025) Aksoy, Berna; Yildirim, Elif; Aktas, Ezgi; Polat, Mualla; Kelekci, Kiymet Handan; Tosun, Mustafa; Akturk, Aysun Sikar; Zindanci, Ilkin; Duygulu, Seniz; Colgecen, Emine; Serdar, Zehra Asiran; Kutlu, Omer; Izci, Neslihan Fisek; Karadag, Ayse Serap; Biruni University; Sanko University; Istanbul Okmeydani Training & Research Hospital; Abant Izzet Baysal University; Izmir Katip Celebi University; Cumhuriyet University; Kocaeli University; University of Health Sciences Turkey; Pamukkale University; Bozok University; Istanbul Yeni Yuzyil University; Tokat Gaziosmanpasa University; Bahcesehir University; Istanbul Arel UniversityIntroduction: As rosacea patients are generally light-skinned and photosensitized some sun-related skin findings are likely to be observed. This study aimed to determine which dermatological comorbidities accompany rosacea and evaluate their relationship with clinical, demographic, quality-of-life, and systemic comorbidities. Methods: This case-control multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Patient demographics, clinical findings, lifestyle data, medical history, and dermatological comorbidities were collected using a structured physician-administered questionnaire. All patients completed the Dermatology Life Quality Index. Results: The study included 922 rosacea patients and 799 controls without rosacea. Rosacea patients had higher dermatological comorbidities than controls. The prevalence of skin comorbidities increased as patient age and duration of rosacea increased. Additionally, these skin comorbidities negatively affected quality of life. Some dermatological comorbidities, especially civatte poikiloderma, had strongest predictive risk (odds ratio >= 3) of significant systemic comorbidities. Conclusion: Based on the present findings, clinicians should also assess rosacea patients for cutaneous dermatological comorbidities. Presence of skin comorbidities increased as patient age and duration of rosacea increased and might be predictive of systemic comorbidities. (c) 2025 S. Karger AG, BaselPublication Metadata only Sensitivity of frozen section analysis in patients with ovarian adult granulosa cell tumor, a multi-center study(SPRINGER HEIDELBERG, 2024) Ureyen, Isin; Toptas, Tayfun; Tokalioglu, Alp; Sahin, Mustafa; Oktar, Okan; Kole, Merve; Alci, Aysun; Ozturk, Cagatayhan; Ozmen, Fatma; Akturk, Selin Esen; Erdogan, Ozgur; Ersak, Burak; Kilic, Fatih; Bas, Sevda; Cakir, Caner; Kocak, Ozgur; Kilic, Cigdem; Ucar, Gokhan; Korkmaz, Vakkas; Narin, Mehmet Ali; Uncu, Dogan; Sanci, Muzaffer; Comert, Gunsu Kimyon; Ozdal, Bulent; Moralioglu, Ozlem Tekin; Ustun, Yaprak Engin; Boran, Nurettin; Taskin, Salih; Tasci, Tolga; Ortac, Firat; Turan, Taner; Antalya Training & Research Hospital; University of Health Sciences Turkey; University of Health Sciences Turkey; University of Health Sciences Turkey; Etlik Zubeyde Hanim Gynecology Education & Research Hospital; Ankara University; Adana Numune Training & Research Hospital; University of Health Sciences Turkey; University of Health Sciences Turkey; University of Health Sciences Turkey; Izmir Tepecik Training & Research Hospital; Hitit University; Dr. Zekai Tahir Burak Women's Health Research & Education Hospital; Bahcesehir UniversityIntroductionWe aimed to demonstrate the sensitivity of frozen section for patients with adult granulosa cell tumor (AGCT) and analyze the clinico-pathological factors that may be associated with sensitivity.Material methodsThis is a multicenter study including data of 10 Gynecological Oncology Departments. Frozen-section results of patients who had ovarian AGCT at the final pathology report were retrospectively analyzed. The relation between clinico-pathological characteristics such as age, tumor size, Ca-125 level, presence of ascites, omental metastasis, menopausal status and peritoneal cytology, and the sensitivity of frozen section in patients with AGCT were evaluated. The sensitivity of frozen section diagnosis was determined by comparing the frozen section result with the final pathological diagnosis.ResultsFrozen section results of 274 patients with AGCT were obtained. The median age of the patients was 52 years (range, 17-82 years). Totally, 144 (52.7%, n = 273) patients were postmenopausal. The median tumour size was 90 mm (range, 9-700 mm). The median preoperative Ca-125 level was 23 IU/mL (range, 2-995 IU/mL). The sensitivity of frozen section for detecting AGCT was 76.3%. Any association between the sensitivity of frozen section and menopausal status, presence of ascites, positive cytology, omental metastasis, tumor size, Ca-125 level, age could not be shown.ConclusionIt is important to know the diagnosis of AGCT intraoperatively, and we demonstrated the sensitivity of frozen-section for these tumors as 76.3%.Publication Metadata only Random unconditional convergence of Rademacher chaos in L∞ and sharp estimates for discrepancy of weighted graphs and hypergraphs(SPRINGER HEIDELBERG, 2025) Astashkin, Sergey V.; Lykov, Konstantin V.; Samara National Research University; Lomonosov Moscow State University; Bahcesehir University; National Academy of Sciences of Belarus (NASB); Institute of Mathematics of the National Academy of Sciences of Belarus; Belarusian State UniversityWe prove that both multiple Rademacher system and Rademacher chaos possess the property of random unconditional convergence in the space L-infinity. This fact combined with some intimate connections between L-infinity-norms of linear combinations of elements of these systems and some special norms of matrices of their coefficients allows us to establish novel sharp two-sided estimates for the discrepancy of edge-weighted graphs and hypergraphs. Some of these results extend the classical theorem proved by Erdos and Spencer in the unweighted case.Publication Metadata only Dysregulation of mTOR signalling is a converging mechanism in lissencephaly(NATURE PORTFOLIO, 2025) Zhang, Ce; Liang, Dan; Ercan-Sencicek, A. Gulhan; Bulut, Aybike S.; Cortes, Joelly; Cheng, Iris Q.; Henegariu, Octavian; Nishimura, Sayoko; Wang, Xinyuan; Peksen, A. Buket; Takeo, Yutaka; Caglar, Caner; Lam, TuKiet T.; Koroglu, Merve Nur; Narayanan, Anand; Lopez-Giraldez, Francesc; Miyagishima, Danielle F.; Mishra-Gorur, Ketu; Barak, Tanyeri; Yasuno, Katsuhito; Erson-Omay, E. Zeynep; Yalcinkaya, Cengiz; Wang, Guilin; Mane, Shrikant; Kaymakcalan, Hande; Guzel, Aslan; Caglayan, A. Okay; Tuysuz, Beyhan; Sestan, Nenad; Gunel, Murat; Louvi, Angeliki; Bilguvar, Kaya; Yale University; Yale University; Yale University; Yale University; Yale University; Acibadem University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Yale University; Yale University; Acibadem University; Yale University; Yale University; Yale University; Istanbul University - Cerrahpasa; Yale University; Acibadem University; Bahcesehir University; Dokuz Eylul University; Dokuz Eylul University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale New Haven Hospital; Acibadem University; Acibadem University; Bezmialem Vakif UniversityCerebral cortex development in humans is a highly complex and orchestrated process that is under tight genetic regulation. Rare mutations that alter gene expression or function can disrupt the structure of the cerebral cortex, resulting in a range of neurological conditions1. Lissencephaly ('smooth brain') spectrum disorders comprise a group of rare, genetically heterogeneous congenital brain malformations commonly associated with epilepsy and intellectual disability2. However, the molecular mechanisms underlying disease pathogenesis remain unknown. Here we establish hypoactivity of the mTOR pathway as a clinically relevant molecular mechanism in lissencephaly spectrum disorders. We characterized two types of cerebral organoid derived from individuals with genetically distinct lissencephalies with a recessive mutation in p53-induced death domain protein 1 (PIDD1) or a heterozygous chromosome 17p13.3 microdeletion leading to Miller-Dieker lissencephaly syndrome (MDLS). PIDD1-mutant organoids and MDLS organoids recapitulated the thickened cortex typical of human lissencephaly and demonstrated dysregulation of protein translation, metabolism and the mTOR pathway. A brain-selective activator of mTOR complex 1 prevented and reversed cellular and molecular defects in the lissencephaly organoids. Our findings show that a converging molecular mechanism contributes to two genetically distinct lissencephaly spectrum disorders.Publication Metadata only Omalizumab dosing patterns and drug survival in adult patients with chronic spontaneous urticaria(WILEY, 2025) Zhang, Ditte Georgina; Nielsen, Mia-Louise; Sorensen, Jennifer Astrup; Naassan, Somaia; Vestergaard, Christian; Kocatuerk, Emek; Ali, Zarqa; Thyssen, Jacob P.; Egeberg, Alexander; Thomsen, Simon Francis; University of Copenhagen; Bispebjerg Hospital; Copenhagen University Hospital; Aarhus University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Bahcesehir University; University of Copenhagen; University of CopenhagenBackgroundOmalizumab is an effective treatment for chronic spontaneous urticaria (CSU), but strategies and predictors for guiding long-term management and discontinuation remain limited.ObjectivesTo examine real-world treatment patterns, including dosing modifications and discontinuation, and identify potential predictive factors for these outcomes.MethodsThis was a retrospective, observational, real-life study of adult patients with CSU treated with omalizumab at a Urticaria Center of Reference and Excellence (UCARE) in Copenhagen, Denmark, between May 20, 2015, and April 4, 2024. The Kaplan-Meier estimator was used to visualize time to discontinuation and dose escalation/reduction (using standard label dosing as reference), and Cox-regressions with hazard ratios (HR) were used to investigate potential predictive variables.ResultsOf 430 patients initiated on omalizumab, 139 (32.4%) escalated treatment, 161 (37.5%) reduced treatment, and 90 (21.0%) discontinued treatment directly from the standard dose. The median survival time for dose escalation was 2 years (95% CI: 1.17-3.55), and the strongest predictor was a positive basophil histamine release assay (BHRA) (HR: 2.79, 95% CI: 1.69-4.61). Fast treatment response (HR: 0.50, 95% CI: 0.33-0.75) and higher baseline UCT scores (HR: 0.89, 95% CI: 0.82-0.97) decreased the risk of dose escalation. The median survival time to dose reduction was 1.2 years (95% CI: 0.98-1.49) and was more likely in males (HR: 1.68, 95% CI: 1.13-2.50) and patients with fast treatment response (HR: 1.66, 95% CI: 1.12-2.48). Median survival time to discontinuation (all reasons) of omalizumab was 3 years (95% CI: 2.35-3.64).ConclusionsA considerable proportion of patients with CSU require modifications to the recommended omalizumab dosing regimen. A positive BHRA was the strongest predictor for dose escalation, while male sex and fast treatment response were the strongest predictors for dose reduction. Our study highlights the need for individualized strategies in managing CSU.Publication Metadata only The Nexus of Identity, Emotions, and Agency in Virtual Exchanges Between Pre-Service Teachers From Türkiye and the United States(WILEY, 2025) Ustuk, Ozgehan; Yazan, Bedrettin; Uzum, Baburhan; Akayoglu, Sedat; Keles, Ufuk; Hong Kong Polytechnic University; University of Texas System; University of Texas at San Antonio (UTSA); Texas State University System; Sam Houston State University; Abant Izzet Baysal University; Bahcesehir UniversityThis study draws on data gleaned from multimodal identity tasks in an eight-week telecollaboration project involving 120 pre-service teachers from two teacher education programs in T & uuml,rkiye and the United States. The authors explore what emotions teachers expressed during their participation in telecollaboration and how their emotions intersected with their teacher agency and identity construction. The intersectionality of language teachers' identities and teachers' emotions as agency informed the study's conceptual framework. Utilizing multimodal critical discourse analysis, the authors found that pre-service teachers asserted projective agency by expressing emotions through multimodal and narrative identity tasks. The findings showed that the pre-service teachers' identity work was influenced by ecologically contextualized psycho-emotional circumstances throughout the project. Underscoring that teacher identity work cannot be conceptualized without attending to teachers' emotions and agency, the authors argue that when intentionally integrated into teacher education courses, identity tasks open experiential dimensions for pre-service teachers to engage in agentive and emotionally laden identity work. The study contributes to language teacher education research, highlighting the supranational, multicultural, and multilingual nature of the pre-service teachers' interactions while engaging in online synchronous and asynchronous activities. Bu makale T & uuml,rkiye ve Amerika Birle & scedil,ik Devletleri'ndeki iki & ouml,& gbreve,retmen e & gbreve,itimi program & imath,nda okuyan 120 & ouml,& gbreve,retmen aday & imath,n & imath,n d & acirc,hil oldu & gbreve,u sekiz haftal & imath,k uzaktan i & scedil, birli & gbreve,i (telecollaboration) projesinden elde edilen veriye dayanmaktad & imath,r. Ara & scedil,t & imath,rmac & imath,lar & ouml,& gbreve,retmenlerin uzaktan i & scedil, birli & gbreve,ine kat & imath,l & imath,mlar & imath, s & imath,ras & imath,nda dile getirdikleri duygular & imath, ve bu duygular & imath,n & imath,n & ouml,& gbreve,retmenlik etkenlikleri (agency) ile olu & scedil,turduklar & imath, kimlikleriyle kesi & scedil,imlerini incelemi & scedil,tir. Bu do & gbreve,rultuda & ccedil,ok bi & ccedil,imli ele & scedil,tirel s & ouml,ylem analizi kullanan ara & scedil,t & imath,rmac & imath,lar, & ouml,& gbreve,retmenlerin & ccedil,ok bi & ccedil,imli ve anlat & imath,ya dayal & imath, kimlik g & ouml,revleri ile duygular & imath,n & imath, ifade ederek izd & uuml,& scedil,& uuml,msel bir etkenlik ortaya koyduklar & imath,n & imath, g & ouml,zlemlemi & scedil,tir. Bulgular proje s & uuml,resince & ouml,& gbreve,retmen adaylar & imath,n & imath,n kimlik olu & scedil,umlar & imath, & ccedil,evresel olarak psiko-duygusal durumlar & imath,n etkisi alt & imath,nda kald & imath,& gbreve,& imath,n & imath, g & ouml,stermi & scedil,tir. Ara & scedil,t & imath,rmac & imath,lar, & ouml,& gbreve,retmenlerin kimlik & ccedil,al & imath,& scedil,malar & imath,n & imath,n (identity work), & ouml,& gbreve,retmen duygu ve etkenliklerinin incelenmeksizin kavramsalla & scedil,t & imath,r & imath,lamaya & gbreve,& imath,n & imath, belirtmi & scedil,lerdir. Ayr & imath,ca kimlik g & ouml,revleri, bilin & ccedil,li olarak & ouml,& gbreve,retmen e & gbreve,itimi derslerine dahil edildi & gbreve,inde, & ouml,& gbreve,retmen adaylar & imath, i & ccedil,in mesleki anlamda deneysel bir boyut olu & scedil,turarak onlar & imath,n etkensel ve duygu y & uuml,kl & uuml, kimlik & ccedil,al & imath,& scedil,mas & imath,nda bulunmalar & imath,n & imath, sa & gbreve,lam & imath,& scedil,t & imath,r. Bu & ccedil,al & imath,& scedil,ma, dil & ouml,& gbreve,retmeni e & gbreve,itiminde & ouml,& gbreve,retmen adaylar & imath,n & imath,n e & scedil,zamanl & imath, ve e & scedil,zamanl & imath, olmayan & ccedil,evrimi & ccedil,i etkinliklerde, ulusal s & imath,n & imath,rlar & imath,n & ouml,tesine & ccedil,& imath,kan, & ccedil,ok k & uuml,lt & uuml,rl & uuml, ve & ccedil,ok dilli etkile & scedil,imlerinin & ouml,neminin alt & imath,n & imath, & ccedil,izmektedir.