Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Metadata only Isolated infantile myofibroma of the calvarium: Report of a case with a literature review (Jan, 10.1007/s00381-024-06289-9, 2024)(SPRINGER, 2024) Demir, Mustafa Kemal; Yapicier, Ozlem; Celik, Ozgur; Ertem, Onder; Kilic, Deniz; Bahcesehir University; Medical Park Hospitals Group; Bahcesehir University; Medical Park Hospitals Group; Near East UniversityPublication Metadata only Alterations in cerebral artery flow velocity acceleration pattern correlate with cognitive impairment in diabetes mellitus(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2025) Tas, Ahmet; Bayhan, Muhammed Ikbal; Yildiz, Mehlika; Alan, Yaren; Atay, Zeynep; Sezer, Fatih; Kitapli, Cagla; Tas, Ilke Kara; Umman, Sabahattin; Sezer, Murat; Istanbul University; Bogazici University; Bahcesehir University; Istanbul University; Gonen Balikesir State HospitalIntroduction: Flow velocity acceleration pattern is related to shear stress, pressure changes, cardiovascular risk factors, diabetes mellitus, hypertension, endothelial dysfunction and arterial stiffness. Considering the hemodynamic alterations in cognitive impairment, perturbations in cerebral artery flow acceleration pattern may correlate with cognitive impairment, which could enhance our understanding of how cardiovascular risk factors drive cognitive decline from a mechanistic point of view. Method: The first derivative of middle cerebral artery flow velocity waveforms obtained via transcranial Doppler were computed to visualize acceleration/deceleration waves (a,b,c,d,e) in ensemble-averaged signals. Vascular Aging Index was calculated per its definition (VAI:(b-c-d-e)/a). Relationship between multiple cognitive domains and VAI was evaluated with standard statistical tests. Results: VAI was significantly correlated with HVLT total recall (Hopkins Verbal Learning Test-revised) (r: -0.310 p: 0.046, n: 42), delayed recall (r: -0.396 p: 0.009), % Retention (r: -0.305 p: 0.050) and components of RCFT(Rey-Osterrieth Complex Figure Test), namely raw copy score (r: -0.524 p < 0.001), immediate recall (r: -0.323 p: 0.037). Controlling for age, body mass index, gray matter volume and diabetes duration yielded stronger correlations but lower group numbers due to missing data. Correlation coefficients for VAI with HVLT delayed recall and % Retention were -0.439 (p: 0.012) and -0.444(p: 0.011 n: 36) respectively. Likewise the adjusted correlations of VAI with RCFT components were improved (Raw Copy r: -0.557 p < 0.001, Immediate Recall r: -0.440 p: 0.012, Delayed Recall (r: -0.358 p: 0.044). Conclusion: In patients with diabetes, cerebral artery flow velocity acceleration pattern correlates with cognitive performance in visuo-constructional and verbal cognitive domains. Computational fluid dynamics may aid developing a better mechanistic understanding of arterial hemodynamics-cortical function coupling.Publication Metadata only Comprehensive Evaluation of Serpentine Aneurysms: a Systematic Review and Meta-analysis with a Subanalysis for Treatment Approaches(SPRINGER HEIDELBERG, 2024) Cinar, Celal; Elek, Alperen; Allahverdiyev, Irshad; Ozcinar, Kenan Kerem; Yazici, Adem C.; Kusbeci, Mahmut; Ozturk, Egemen; Oran, Ismail; Ege University; Istanbul University; Bahcesehir UniversityPurposeThis systematic review and meta-analysis aimed to systematically evaluate and enhance the understanding of optimal management strategies for serpentine aneurysms.MethodsA systematic search was conducted in Medline, Scopus, and Cochrane databases up to July 8, 2024, using relevant keywords. Studies included were case series, prospective or retrospective cohorts, or randomized controlled trials with data on clinical and angiographic outcomes of intracranial serpentine aneurysms. Data extraction and quality assessment were performed independently by two authors. Statistical analysis was conducted using R, with pooled estimates under a random-effects model.ResultsTen studies comprising 70 patients with 71 serpentine aneurysms were included. The majority (92.9%) were giant aneurysms. The overall rate of procedure-related complications was 33%, morbidity was 13%, and mortality was 13%. Good neurological outcomes were achieved in 76% of cases. For unruptured aneurysms, the complication rate was 34%, while no complications were observed in ruptured aneurysms. Comparative analysis between ruptured and unruptured aneurysms showed no significant differences in outcomes or complications. The technical success rate was 91%. Reconstructive methods showed a slightly higher rate of good neurological outcomes (77%) compared to deconstructive methods (70%), though complication rates were similar.ConclusionBoth reconstructive and deconstructive endovascular treatments for serpentine aneurysms are effective, with high rates of good neurological outcomes and acceptable complication rates.Publication Metadata only Isolated infantile myofibroma of the calvarium: Report of a case with a literature review(SPRINGER, 2024) Demir, Mustafa Kemal; Yapicier, Ozlem; Celik, Ozgurcelikj; Ertem, Onder; Kilic, Deniz; Medical Park Hospitals Group; Bahcesehir University; Bahcesehir University; Medical Park Hospitals Group; Near East UniversityObjectiveInfantile myofibromatosis is a rare entity of childhood characterized by benign myofibroblastic tumors in the soft tissues, the bones, and occasionally the viscera. Solitary skeletal lesions are relatively uncommon. Calvarial involvement should be distinguished from more aggressive tumors for appropriate treatment.MethodsWe reviewed solitary infantile myofibroma of the calvarium and discussed the relevant computed tomography and magnetic resonance imaging findings along with differential diagnosis. A case study of the frontal bone in a 5-month-old girl was also presented.ResultsFourteen cases were reviewed, including the current case. Of the 13 cases with known sex, eight were male and five female. The mean age was 3.03 with an age range of 0.41-9 years. Nine of the 14 tumors were in the frontal bone. The lesions were intradiploic with tabula interna and/or externa of the calvaria involvement. The mean largest diameter was 22.3 mm. Upon computed tomography, all the lesions were expansile and lytic, and hypoattenuated, isoattenuated or occasionally hyperatenuated. Calcification was not seen. On magnetic resonance imaging, most neoplasms were hypointense on T1-weighted and T2-weighted images. Neoplasms showed hypointense signal on diffusion-weighted imaging and hyperintense on apparent diffusion coefficient, without restricted diffusion in three cases. All lesions were intensely enhanced after gadolinium administration. Treatment was total surgical resection and recurrence was not observed during follow-up.ConclusionsInfantile myofibromas are rare, typically intradiploic expansile lytic lesions with tabula interna and/or externa involvement. Distinctive imaging features include the presence of hipointense signals on T2-weighted magnetic resonance images without restricted diffusion on diffusion-weighted imaging. A slow-growing, firm, painless, and nontender mass with supportive imaging findings should raise suspicion of the disease.Publication Metadata only Reduced false memory in the second language of Turkish-English bilinguals(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2024) Sitki, Merve; Ikier, Simay; Sener, Nilufer; Bahcesehir University; Marmara University; Istanbul Kultur University; Bahcesehir UniversityIn the Deese-Roediger-McDermott (DRM) paradigm, studying a list of semantically related words leads to false memory for the critical non-studied word that is related to all the words in the study list. Previous studies questioning whether bilinguals are more prone to false memory in their first language (L1) or second language (L2) in the DRM paradigm revealed mixed results. The present study investigated the same question with Turkish-English bilinguals. The revised hierarchical model proposes that the link between the lexicon and the semantic system is weaker in L2 than in L1, suggesting that false memory in the DRM paradigm that relies on semantic relatedness would be higher in L1 than in L2. Furthermore, previous studies showed that L2 is more resistant to errors in decision-making when the two languages are dissimilar, but not when they are similar, and Turkish and English are historically distant and typologically dissimilar languages. We tested Turkish-English bilingual participants whose L1 is Turkish with Turkish and English DRM word lists that had similar prior norms for generating false recognition. In the recognition test, some of the studied items and the critical non-studied items were presented and participants identified the studied items. False recognition for the critical non-studied items was lower and correct recognition for studied items was higher in L2 than in L1. The results suggest that L2 is more resistant to false memory due to its weaker lexicon and semantic system associations, at least when the two languages spoken by the bilingual are dissimilar.Publication Metadata only Mechanical thrombectomy for the treatment of large vessel occlusion due to cancer-related cerebral embolism: A systematic review(SAGE PUBLICATIONS INC, 2024) Toruno, Michelle; Al-Janabi, Omar; Karaman, Irem; Ghozy, Sherief; Senol, Yigit Can; Kobeissi, Hassan; Kadirvel, Ramanathan; Ashdown, Boyd; Kallmes, David F.; Mayo Clinic; University of Arizona; Bahcesehir University; Mayo Clinic; Mayo ClinicBackground Cancer-related cerebral embolism due to direct tumor embolization results in a rare acute ischemic stroke with large vessel occlusion (LVO). Despite the established status of mechanical thrombectomy (MT) in LVO management, its effectiveness and safety remains inadequately explored in this specific patient group.Methods We conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the Nested Knowledge AutoLit software, encompassing databases like Embase, PubMed, Scopus, and Web of Science, from their inception up to 9 May 2023.Results In the review of 35 studies encompassing 37 cases, mean patient age was 52 years, and 30% were female. Cardiac myxoma (29.7%), cardiac papillary fibroelastoma (16.2%), and squamous cell carcinoma of the lung (8.1%) were the most frequent underlying cancers. The left middle cerebral artery was the most commonly affected occlusion site (24.3%). Of the patients, 67.5% underwent MT alone, while 32.5% received MT combined with intravenous thrombolysis. Successful reperfusion (thrombolysis in cerebral infarction (TICI) 2b-3) was achieved in 89.1% of cases, with 59.4% reaching TICI 3. Functional independence was observed in 29.7% of patients.Conclusion While limitations exist, this comprehensive study highlights the potential benefits of MT in a patient group historically excluded from major trials, warranting further investigation.Publication Metadata only Too late to save: The national surge in ruptured arteriovenous malformations and the decline in endovascular utilization from 2016 to 2022(SAGE PUBLICATIONS INC, 2025) Gajjar, Avi A.; Goyal, Aditya Dev; Custozzo, Amanda; Boulos, Alan S.; Kayir, Ilayda; Fantauzzi, John; Feustel, Paul J.; Field, Nicholas C.; Dalfino, John C.; Paul, Alexandra R.; Albany Medical College; Albany Medical College; Bahcesehir University; Albany Medical CollegeIntroduction The ARUBA trial has influenced a shift towards more conservative management of small, unruptured cerebral arteriovenous malformations (AVMs), leading to less aggressive treatment approaches among neurointerventionalists. However, with evolving endovascular techniques, it is important to assess whether national practice changes have impacted rupture rates and outcomes.Methods Data from the Nationwide Inpatient Sample (NIS) for 2016-2022 regarding clinical characteristics, cost, morbidity, and mortality endovascularly treated AVMs was analyzed. Trends were evaluated using multivariable regression modeling, controlling for patient and hospital characteristics.Results A total of 8,935 patients underwent endovascular treatment for cerebral AVMs (6,500 unruptured and 2,435 ruptured). Endovascular treatment for unruptured AVMs declined significantly from 1195 cases in 2016 to 780 in 2022 (-34.7%, p = 0.020). Over the same period, the proportion of AVMs presenting ruptured increased from 15.7% to 25.7%, a 63.7% relative increase (p = 0.015). Multivariable analysis confirmed rising odds of rupture over time among endovascularly treated patients (OR = 1.12, 95% CI 1.00-1.25, p = 0.042). Among 11,205 ruptured AVM patients, the in-hospital mortality rate of thosewho did not undergo surgery rose 67.2% over time (6.7% in 2016 to 11.2% in 2022, p = 0.006).Conclusion The study reveals an increase in the probability of patients presenting with ruptured AVMs and being observed with a consequent increase in in-hospital mortality. This may be an unintended consequence of less aggressive strategies following the ARUBA trial, prompting a need to reevaluate current management techniques amidst rising costs, morbidity, and mortality.