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  • Publication
    Isolated infantile myofibroma of the calvarium: Report of a case with a literature review (Jan, 10.1007/s00381-024-06289-9, 2024)
    (SPRINGER, 2024) Demir, Mustafa Kemal; Yapicier, Ozlem; Celik, Ozgur; Ertem, Onder; Kilic, Deniz; Bahcesehir University; Medical Park Hospitals Group; Bahcesehir University; Medical Park Hospitals Group; Near East University
  • Publication
    Expanding the indication of living donor liver transplantation to recipients with PVT: Clinical advances and ongoing challenges
    (LIPPINCOTT WILLIAMS & WILKINS, 2025) Balci, Deniz; Gomez-Gavara, Concepcion; Hessheimer, Amelia J.; Bahcesehir University; Hospital Universitari Vall d'Hebron; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Hospital Universitario La Paz
  • Publication
    Predictive Value of Stone Management According to Size-Hardness (SMASH) Score for Post-Operative Fever after Ureteroscopy
    (MARY ANN LIEBERT, INC, 2025) Kayar, Ridvan; Kayar, Kemal; Ozsoy, Emrah; Artuk, Ilker; Demir, Samet; Tokuc, Emre; Ozturk, Metin; Istanbul Haydarpasa Numune Training & Research Hospital; University of Health Sciences Turkey; Bahcesehir University
    Purpose: Post-operative fever (POF) is a common infectious complication following ureteroscopy (URS). Early identification of high-risk patients may help reduce morbidity and optimize peri-operative management. This study aimed to evaluate the predictive value of the Stone Management According to Size-Hardness (SMASH) score-a composite index based on stone size and density-for forecasting POF after URS.Patients and Methods: We retrospectively analyzed 143 patients who underwent semi-rigid and flexible URS for unilateral ureteral stones between January 2023 and January 2025. Demographic, radiological, and operative parameters were recorded, including SMASH score, Hounsfield unit (HU), stone size and location, operative time, and hydronephrosis. POF was defined as a body temperature >= 38.3 degrees C with a positive urine culture. Comparative and receiver operating characteristic curve analyses were performed to assess predictors of POF.Results: POF occurred in 17 patients (11.9%). The febrile group had significantly higher SMASH scores (median: 8.08 vs. 5.09, p = 0.001), HU values (720 vs. 626, p = 0.006), and longer operative times (41 vs. 34 min, p = 0.001). Proximal stone location was also more common in the febrile group (p = 0.001). No significant differences were observed in age, gender, comorbidities, or hydronephrosis.Conclusions: Elevated SMASH scores, longer operative time, and proximal stone location were independently associated with POF after URS. The SMASH score may serve as a useful tool for pre-operative risk stratification, allowing for enhanced peri-operative precautions in high-risk patients.
  • Publication
    Effect of the Educational Intervention on the Balance of Diabetic Foot Amputees: A Randomized Controlled Study
    (SAGE PUBLICATIONS INC, 2023) Toygar, Ismail; Suceken, Sevda; Aslan, Fatma Eti; Celebi, Mehmet Emin; Batar, Suat; Mugla Sitki Kocman University; Bahcesehir University; Bahcesehir University; Istanbul Umraniye Training & Research Hospital; Mugla Sitki Kocman University
    This study aimed to evaluate the effect of educational intervention on the balance of diabetic foot amputees. There were 2 groups and 60 patients (30 in each group) in the study. The patients were divided into 2 groups using block randomization to provide equal distribution of the minor and major amputations in groups. An education program was prepared in line with Bandura's Social Cognitive Learning theory. Education was administered to the intervention group before the amputation. Three days after the education, the patients' balance was examined using Berg Balance Scale (BBS). There were not any statistically significant differences between the groups regarding the sociodemographic and disease-related characteristics except for marital status (P = .038). The mean BBS scores were 31.4 +/- 17.6 for the intervention group and 20.3 +/- 17.8 for the control group. We demonstrated that the intervention lowered fall risk after minor (P = .045) but not major amputation (P = .067). We recommend using education for the patients who will undergo amputation and further studies in larger and different populations.
  • Publication
    Comprehensive evaluation of management strategies and rupture status in partially thrombosed aneurysms: a systematic review and meta-analysis
    (BMJ PUBLISHING GROUP, 2024) Elek, Alperen; Allahverdiyev, Irshad; Ozcinar, Kenan Kerem; Yazici, Adem C.; Cinar, Celal; Kusbeci, Mahmut; Ozturk, Egemen; Oran, Ismail; Ege University; Istanbul University; Bahcesehir University
    Background This meta-analysis aims to evaluate and compare the clinical and angiographic outcomes of different management strategies for partially thrombosed intracranial aneurysms (PTIAs).Methods A systematic review was conducted using MEDLINE, Scopus, and Web of Science databases up to September 2024. Studies providing clinical and angiographic outcomes of PTIAs were included. Favorable outcomes were defined as those reported directly in the studies or, when the modified Rankin Scale (mRS) was available, as an mRS score of 0-2. Statistical analysis was conducted using R, with pooled estimates under a random-effects model.Results Eighteen studies involving 362 patients with 363 PTIAs were analyzed. Favorable neurological outcomes were observed in 76% of patients, while 20% experienced procedure-related complications. Recurrence occurred in 36% of cases, and retreatment was required in 23%. Mortality was low at 0.8%. Subgroup analysis revealed that reconstructive approaches were associated with higher rates of favorable outcomes (72%) and lower complication rates (21%) compared with deconstructive methods (60% and 28%, respectively). Among the reconstructive techniques, flow diverter stenting showed the highest rate of favorable outcomes (82%), while simple coiling had the lowest (71%). Additionally, unruptured PTIAs had a significantly better prognosis, with 69% achieving favorable outcomes, fewer complications (22% vs 51% for ruptured), and lower mortality (0.8% vs 27%) compared with ruptured aneurysms. Among the reconstructive techniques, flow diverter stenting showed the best outcomes.Conclusion PTIAs treated with reconstructive approaches that are unruptured, non-giant, and located in the anterior circulation show higher rates of favorable neurological outcomes with acceptable complications. However, outcomes, complications, and occlusion rates are slightly worse compared with typical non-thrombotic saccular aneurysms, indicating that these aneurysms pose a greater challenge.
  • Publication
    Isolated infantile myofibroma of the calvarium: Report of a case with a literature review
    (SPRINGER, 2024) Demir, Mustafa Kemal; Yapicier, Ozlem; Celik, Ozgurcelikj; Ertem, Onder; Kilic, Deniz; Medical Park Hospitals Group; Bahcesehir University; Bahcesehir University; Medical Park Hospitals Group; Near East University
    ObjectiveInfantile myofibromatosis is a rare entity of childhood characterized by benign myofibroblastic tumors in the soft tissues, the bones, and occasionally the viscera. Solitary skeletal lesions are relatively uncommon. Calvarial involvement should be distinguished from more aggressive tumors for appropriate treatment.MethodsWe reviewed solitary infantile myofibroma of the calvarium and discussed the relevant computed tomography and magnetic resonance imaging findings along with differential diagnosis. A case study of the frontal bone in a 5-month-old girl was also presented.ResultsFourteen cases were reviewed, including the current case. Of the 13 cases with known sex, eight were male and five female. The mean age was 3.03 with an age range of 0.41-9 years. Nine of the 14 tumors were in the frontal bone. The lesions were intradiploic with tabula interna and/or externa of the calvaria involvement. The mean largest diameter was 22.3 mm. Upon computed tomography, all the lesions were expansile and lytic, and hypoattenuated, isoattenuated or occasionally hyperatenuated. Calcification was not seen. On magnetic resonance imaging, most neoplasms were hypointense on T1-weighted and T2-weighted images. Neoplasms showed hypointense signal on diffusion-weighted imaging and hyperintense on apparent diffusion coefficient, without restricted diffusion in three cases. All lesions were intensely enhanced after gadolinium administration. Treatment was total surgical resection and recurrence was not observed during follow-up.ConclusionsInfantile myofibromas are rare, typically intradiploic expansile lytic lesions with tabula interna and/or externa involvement. Distinctive imaging features include the presence of hipointense signals on T2-weighted magnetic resonance images without restricted diffusion on diffusion-weighted imaging. A slow-growing, firm, painless, and nontender mass with supportive imaging findings should raise suspicion of the disease.
  • Publication
    Nasal Bone Anthropometric Analysis of 1022 Adult Turkish Patients Utilizing Three-Dimensional Computed Tomography: The Dorsal Profile Angle and Its Clinical Implications
    (SPRINGER, 2025) Tuncel, Umut; Kokten, Alperen Can; Lazovic, Goran; Bahcesehir University
    BackgroundAnthropometric analysis of the nasal bone can establish parameters that significantly contribute to rhinoplasty outcomes. Key anatomical landmarks situated along the nasal dorsum, including the sellion, rhinion, and kyphion, can have significant angular relationships. Among these elements, the dorsal profile angle (DPA) and its corresponding point have been the least investigated to date.Materials and MethodsA comprehensive review of nasal bone anthropometrics using three-dimensional computed tomography (3D-CT) images from 1022 randomly selected adult Turkish patients who applied for rhinoplasty at our clinic between 2022 and 2025 years was conducted. The inclusion criteria for this study consisted of cases seeking primary rhinoplasty, cases of secondary rhinoplasty and severe trauma were excluded from consideration. The measurements were meticulously performed on lateral views of the CT scans. Key points identified included the nasion, sellion, dorsal profile angle (hereinafter referred to as the gibbion point), kyphion, and rhinion points. The dorsal profile angle, nasofrontal angle (NFA), nasion angle (NA), and kyphion angle (KA) were calculated, along with measurements of nasal bone length and shape. Thus, S- and V-shape nasal bone anthropometrics were detected, and the correlations between all measurements were evaluated.ResultsThe mean age was 35.4 +/- 12.7 years. Of the cases, 501 were female, and the remaining were male. Seven hundred sixteen cases had an S-shaped nasal bone. In contrast, 306 had a V-shape. The DPA, NFA, and KA were 153.5 +/- 10.7 degrees, 125.7 +/- 7.1 degrees, and 160.7 +/- 6.5 degrees in the S-shape group, while they measured 157.5 +/- 7.3 degrees, 128.5 +/- 10.6 degrees, and 167 +/- 7.3 degrees in the V-shape group, respectively. There was a statistically significant difference between the measurements (p = 0.001). A low-level but positive correlation was found between the DPA with kyphion and nasofrontal angles.ConclusionsThe pivot point of the dorsal profile angle represents the origin of a prominent hump. This angle is more distinct in males and noses characterized by S-shaped nasal bones. Therefore, surgeons are advised to consider DPA when executing preservation rhinoplasty, as alterations to this angle may transform the nasal framework from an S-shape to a V-shape.Level of Evidence IIIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.