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Start date: 2020End date: 2026Type: search.filters.itemtype.Proceedings PaperAuthor: search.filters.author.Islam, Md BaharulAuthor: search.filters.author.Alimanov, AlnurSubject: search.filters.subject.Computer Science, Interdisciplinary Applications

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    Advancing Retinal Image Segmentation: A Denoising Diffusion Probabilistic Model Perspective
    (IEEE COMPUTER SOC, 2024) Alimanov, Alnur; Islam, Md Baharul; Bahcesehir University; State University System of Florida; Florida Gulf Coast University
    Retinal images and vessel trees play a crucial role in aiding ophthalmologists to identify and diagnose various illnesses related to the eyes, blood vessels, and brain. However, manual retinal image segmentation is a laborious and highly skilled procedure, posing challenges in terms of both difficulty and time consumption. This study proposes a novel approach to retinal image segmentation, leveraging the Denoising Diffusion Probabilistic Model (DDPM) for precise performance. To our best knowledge, DDPM is being applied in this domain for the first time. Our approach incorporates a novel constraint to prevent DDPM from generating vessel structures that not present in the original retinal images during the segmentation process. Additionally, our model is not limited to the original DDPM size of 64 x 64 pixels. Instead, we train it to effectively segment images sized 256 x 256 pixels. This is a significant advancement since the original DDPM works exclusively with 64x64 image sizes and is primarily designed for generating random image samples. In our work, we address both limitations with a novel, efficient approach for accurate retinal image segmentation. A comprehensive evaluation of our methodology includes both quantitative and qualitative assessments. Our proposed method demonstrates competitive performance compared to state-of-the-art techniques, as indicated by both qualitative and quantitative scores. The source code of our method can be accessed at https://github.com/AAleka/DDPM-segmentation.
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    Denoising Diffusion Probabilistic Model for Retinal Image Generation and Segmentation
    (IEEE, 2023) Alimanov, Alnur; Islam, Md Baharul; Bahcesehir University
    Experts use retinal images and vessel trees to detect and diagnose various eye, blood circulation, and brain-related diseases. However, manual segmentation of retinal images is a time-consuming process that requires high expertise and is difficult due to privacy issues. Many methods have been proposed to segment images, but the need for large retinal image datasets limits the performance of these methods. Several methods synthesize deep learning models based on Generative Adversarial Networks (GAN) to generate limited sample varieties. This paper proposes a novel Denoising Diffusion Probabilistic Model (DDPM) that outperformed GANs in image synthesis. We developed a Retinal Trees (ReTree) dataset consisting of retinal images, corresponding vessel trees, and a segmentation network based on DDPM trained with images from the ReTree dataset. In the first stage, we develop a two-stage DDPM that generates vessel trees from random numbers belonging to a standard normal distribution. Later, the model is guided to generate fundus images from given vessel trees and random distribution. The proposed dataset has been evaluated quantitatively and qualitatively. Quantitative evaluation metrics include Frechet Inception Distance (FID) score, Jaccard similarity coefficient, Cohen's kappa, Matthew's Correlation Coefficient (MCC), precision, recall, F1-score, and accuracy. We trained the vessel segmentation model with synthetic data to validate our dataset's efficiency and tested it on authentic data. Our developed dataset and source code is available at https://github.com/AAleka/retree.