Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Open Access Role of Serum HMGB1 in Prostate Cancer(2020) Çiçek, Hülya; Solakhan, Mehmet; Sever, Özlem Nuray; Yıldırım, Mustafa; Benlier, Necla; Yıldırım, Zeliha; Orhan, Nuri; Gaziantep Üniversitesi; Bahçeşehir Üniversitesi; Gaziantep Üniversitesi; Bahçeşehir Üniversitesi; Sanko Üniversitesi; Gaziantep Üniversitesi; T.C. Sağlık BakanlığıPurpose: In our study the diagnostic role of HMGB1 levels measured in serum were investigated in prostatitis and prostate carcinoma diagnosis and in the differential diagnosis of these two diseases. Material Method: Patients followed up for histopathologically verified diagnosis of prostate carcinoma and prostatitis in 20142017 at the Urology Clinic were included. HMGB1 measurement in serum was performed with the ELISA method. Results: A total of 78 subjects were included in the study, consisting of 30 (38.5%) prostatitis patients, 25 (32%) prostate carcinoma patients and 23 (29.5%) healthy subjects. HMGB1 was detected as 11.9±2.6 (Range 6.7-18.4) ng/ml in the prostatitis group, 15.1±4.5 (Range 8.4-24.8) ng/ml in the prostate carcinoma patients and as 9.2±3.1 (Range 4.7-18.7) ng/ml in the control group. The difference between the groups were investigated using the Friedman test as HMGB1 did not show normal distribution. Significant difference was detected between the three groups (p<0.001). When the groups were compared in pair, significant difference was detected between the prostatitis group and the control group (p=0.001). Significant difference was again detected between the prostate carcinoma group and the control group (p<0.001). Significant difference was detected between the prostatitis group and the prostate carcinoma group (p=0.006). Measurement of serum total prostate specific antigen (tPSA) levels were conducted automatically with the electro chemiluminescent method. A moderate level of (r=0.276) but a highly significant (p=0.009) positive correlation was found between PSA and HMGB1. Conclusion: In our study we showed that high PSA and high HMGB1 were highly correlated. HMGB1 measured in serum could be a useful marker in the differentiation of prostatitis and prostate carcinoma, in the early diagnosis of suspected prostate carcinoma and that HMGB1 value was significantly high in prostate carcinoma patients.Publication Open Access Comparison of Urinary Incontinence Subgroups according to Possible Risk Factors(2020) Solakhan, Mehmet; Kazımoğlu, Hatem; Topdağı, Yunus Emre; Güzel, Ali İrfan; Bahçeşehir Üniversitesi; Sanko Üniversitesi; Sanko Üniversitesi; T.C. Sağlık BakanlığıObjective: Urinary incontinence (UI) is involuntary urine flow that causes social and hygienic problems. The association between risks factors and UI in women was assessed. We compared the risk factors based on UI subtypes.Methods: The study included 470 women with different UI types (320 urge UI [UUI], 80 stress UI [SUI], and 70 mixed UI [MUI]).Age, educational level, urban/rural residence, parity, delivery type, diabetes mellitus (DM), and hypertension status, anyneurological abnormality, menopausal status, surgical history, and body mass index (BMI) were obtained.Results: Of all women, 320, 80, and 70 had UUI, SUI, and MUI, respectively. The groups did not differ significantly in terms ofage, hypertension status, neurological abnormality rate, smoking status, or surgical history (all p>0.05). Parity, episiotomy,DM status, delivery type, menopause status, hysterectomy history, and BMI differed significantly among the groups (allp<0.05).Conclusion: Our study found that parity, episiotomy, DM status, delivery type, menopause status, hysterectomy history, andBMI may be independent risk factors for different UI types.Publication Open Access Effects of Sperm Parameters on Pregnancy Rate in Patients Undergoing Intrauterine Insemination(2020) Solakhan, Mehmet; Demir, Mustafa; Bahçeşehir Üniversitesi; T.C. Sağlık BakanlığıOBJECTIVE: In this study, the effects of sperm parameters on the success of intrauterine insemination were investigated.STUDY DESIGN: The data from 309 infertile couples who were admitted between 2012-2018 without a female factor were analyzed retrospectively and included in the study. After the administration of go-nadotropin and hCG (5000-10000 IU), single insemination was performed in 36-40 hours in all cycles. All couples underwent routine infertility screening. The relationship between sperm parameters (motility, morphology, sperm count), patient age, duration of infertility with intrauterine insemination success was evaluated. RESULTS: There was no statistically significant difference between the two groups in terms of mean age and age related-parity. There was no statistically significant difference between male ages, lique-faction, and sperm volumes between the two groups (p=0.898, p=0.448, p=0.651). Before washing, There was a statistically significant difference between the sperm concentration, percentage of total motile sperm, percentage of progressive motility sperm, percentage of normal sperm morphology, and total sperm count between the two groups (p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.0001). After sperm washing, the results were similar to those obtained before washing. While statistically significant difference was observed between sperm volume and sperm concentrations (p=0.023, p=0.018), no sig-nificant difference was observed between the two groups in total sperm count (p=0.612). CONCLUSION: As a result, during the application of intrauterine insemination to infertile couples, total motile sperm count, progressive motility sperm count ratio and high sperm ratio with normal morphology used in order to increase pregnancy success can be considered as criteria that increase the chances of success.Publication Open Access Üretra Darlığında Endoskopik Cerrahi: Bıçağa Karşı Lazer(2020) Solakhan, Mehmet; Bayrak, Ömer; Bahçeşehir Üniversitesi; Gaziantep ÜniversitesiAmaç: Üretra darlığının endoskopik cerra-hisinde cold knife üretrotomi ile laser üretrot-ominin etkinliğini karşılaştırmayı amaçladık.Gereç ve Yöntemler: Toplam 171 hasta retrospektif olarak değerlerlendirildi. Çalışma kapsamında verileri tam olan 118 hasta 2 gruba ayrıldı (grup 1, n=53 cold knife üret-rotomi, grup 2, n= 65 lazer üretrotomi). Darlığın uzunluğu, operasyon süresi, preop-eratif ve postoperatif 3., 6. ve12. aylardaki Qmax değerleri, nüks olup olmadığı ve kom-plikasyon varlığı (kanama, extravazasyon, ateş gb) açısından iki grup karşılaştırıldı.Bulgular: Operasyon zamanının cold knife üretrotomi yapılan hastalarda daha kısa olduğu görüldü (14.01 ± 3.86 dk vs 25.03 ± 4.43 dk, p=0.001). Postoperatif 3., 6., ve 12. aylardaki Q max değerlerinin lazer üretrotomi yapılan hastalarda daha yüksek olduğu görüldü (p=0.03, p=0.001, p=0.001). Bir yıllık takip sonucunda grup-1’ de 28 (52.83%) hastada nüks saptanırken, grup-2’ de 12 (18.46%) has-tada nüks geliştiği gözlendi (p=0.01). Postop-eratif komplikasyonlar açısından her iki grup arasında istatiksel olarak anlamlı fark izlen-medi. (p=0.209).Sonuç: Yaptığımız bu çalışmada üretra darlığını endoskopik cerrahisinde, lazer üretro-tomi tekniğinin, cold knife üretrotomiye göre yüksek Qmax değerlerine ve daha düşük nüks oranına sahip olması nedeniyle daha başarılı bir cerrahi yöntem olduğu saptanmıştır. Sonuçların prospektif, randomize çalışmalarla desteklenmesi gerekmektedir.Publication Open Access Kronik Obstrüktif Akciğer Hastalığının Şiddeti Alt Üriner Sistem Semptomlarını ve Cinsel Fonksiyonu Etkilemektedir(2021) Solakhan, Mehmet; Kotuk, Mahir; Bahçeşehir Üniversitesi; T.C. Sağlık BakanlığıAmaç: Bu çalışmada, kronik obstrüktif akciğer hastalığı (KOAH) olan hastalarda alt üriner sistem semptomları, aşırı aktif mesane [overactive bladder (OAB)] sendromu ve erektil disfonksiyon (ED) görülme sıklığı araştırıldı. Gereç ve Yöntemler: Çalışmaya KOAH’lı toplam 707 erkek hasta dâhil edildi. Her hastaya Aşırı Aktif Mesane Anketi, Uluslararası Prostat Semptom Skoru [International Prostate Symptom Score (IPSS)] ve Uluslararası Erektil Fonksiyon İndeksi [International Index of Erectile Function (IIEF)] formu dolduruldu. Ek olarak, her hasta libido kaybı olup olmadığı konusunda da sorgulandı. Akciğer muayenesi, fizik muayene bulguları, spirometrik ölçümler ve arteriyel kan gazı analizleri ile yapıldı. Bulgular: Hastaların ortalama yaşı 52,5±10,6 yıl idi ve hasta yaşı ile ED ve alt üriner sistem semptomları arasında anlamlı bir ilişki bulundu (p=0,01). Ortalama beden kitle indeksi (BKİ) 33,2±5,6 kg/m2 idi. BKİ> 35 kg/m2 ile ED arasında anlamlı bir ilişki bulundu (p=0,042). Ortalama OAVBV8 skoru 7,71±4,44, ortalama IPSS skoru 10,3±5,7 ve ortalama IIEF skoru 11,6±6,44 bulundu. Şiddetli ve ileri KOAH ile acil ve idrar kaçırma da dâhil olmak üzere alt üriner sistem semptomları arasında anlamlı bir ilişki bulundu (sırasıyla p=0,035 ve p=0,021). KOAH şiddeti ile ED arasında anlamlı ilişki saptandı (p=0,001). Ayrıca, oksijen saturasyonu ≤90 olan hastalarda ED insidansı daha yüksek bulundu (p=0,044). Hastaların %91’inde normal libidonun normal olduğu görüldü. Sonuç: Sonuçlarımız şiddetli ve ileri şiddetli KOAH’lı hastalarda ED prevalansının arttığını ve KOAH hastalarında alt üriner sistem semptomlarının (özellikle urge inkontinans ve urgency) prevalansının daha yüksek olduğunu göstermiştir.Publication Open Access May Smoking and Alcohol Consumption Worsen the Spermiogram Results?(2021) Solakhan, Mehmet; Kazımoğlu, Hatem; Topdağı, Yunus Emre; Güzel, Ali İrfan; Bahçeşehir Üniversitesi; Sanko Üniversitesi; Sanko Üniversitesi; Sanko ÜniversitesiOBJECTIVE: In recent years, the number of infertile couples who desire pregnancy with assisted reproduction techniques is increasing. Smoking and alcohol consumption are important factors affectingthe treatment of fertility and assisted reproductive techniques. To evaluate the effect of smoking and alcohol consumption on spermiogram resultsSTUDY DESIGN: This prospective case-control study was conducted at current urology and infertilitydepartment in a tertiary research hospital and a total of 6171 cases included in the study. Data collectedand evaluated were age and sperm parameters (liquefaction, semen volume, sperm concentration, totalnumber, total motility, progressive motility, slow motility, non-progressive motility, morphology).RESULTS: Of 6171 patients, a total of 3247 men was smoker (n:3247, %52.6) and 3511 was alcoholusers (n:3511, %56.9). Mean age of the patients in the study group was 32.8±6.5 years. There was a statistically significant difference between the smoker and nonsmoker in terms of sperm concentration andslow motility (p <0.05). There was a statistically significant difference between alcohol consumption andno alcohol consumption in terms of, semen volume, sperm concentration, normal morphology (p <0.05).CONCLUSION: According to this study, smoking has a negative effect on sperm concentration and slowmotility. Alcohol consumption has a negative impact on semen volume, sperm concentration, normalmorphology. Smoking and alcohol consumption separately and combined were found to have a deleterious effect on sperm parameters. It is suggested that both habits may contribute to infertility problems.Publication Open Access Is Peyronie's an IgG4-related disease?(2021) Solakhan, Mehmet; Kısacık, Bünyamin; Bahçeşehir Üniversitesi; T.C. Sağlık BakanlığıObjective: We believe that IgG4 may have a role in the pathogenesis of Peyronie’s disease (PD), and this role could be particularly beneficial for developing new strategies, therefore, we aimed to investigate the role of IgG4 in PD. Methods: This study included 3 groups with a total of 139 subjects: (I) PD group (n=61), (II) control group (n=48), and (III) benign prostatic hyperplasia (BPH) group (n=30). IgG4 measurement was performed using the enzyme-linked immunosorbent assay. Plaque size, penile curvature, and the presence of concomitant impotence were evaluated in the PD group. Impotence was assessed based on the International Index of Erectile Function (IIEF). Results: A significant difference was observed between the PD and control groups and between the PD and BPH groups with regard to IgG4 levels, while no significant difference was found between the BPH and control groups (p=0.0001, p=0.002, and p=0.07, respectively). The IgG4 levels were significantly higher in the PD than in the other groups. The cutoff value determined between the groups was 87.5, 82, and 31.5, respectively. Mean plaque size was 2.0±1.01 cm, and a significant relationship was found between plaque size and IgG4 concentration (p=0.02). Mean penile curvature was 35.6±25.1°, and a significant relationship was found between penile curvature of >60° and IgG4 concentration (p=0.001). Mean IIEF score was 19 (range, 7-25). Moreover, no significant relationship was found between erectile dysfunction and IgG4 concentration. Penile pain was present in 24 (39.3%) patients with PD. Conclusion: The IgG4 levels were significantly increased in patients with PD, which implies that IgG4 may have a role in the pathogenesis of PD. This finding could be particularly beneficial for developing new strategies. Future studies with larger patient series are needed to substantiate our findings.