Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Open Access Multicenter study of levodopa carbidopa intestinal gel in Parkinson’s disease: the Turkish experience(2020) Bilgiç, Başar; Murat Gültekin; Erer Özbek, Çiğdem Sevda; Tezcan, Sabiha; Mirza, Meral; Yılmaz Kuşbeci, Özge; Çakmur, Raif; Akbostancı, Muhittin Cenk; Günal, Dilek; Hanağası, Haşmet Ayhan; Elibol, Bülent; Bora Tokcaer, Ayşe; Kenangil, Gülay; Doğu, Okan; Ulukan, Çağrı; İstanbul Üniversitesi; Erciyes Üniversitesi; Bursa Uludağ Üniversitesi; Ankara Üniversitesi; Erciyes Üniversitesi; T.C. Sağlık Bakanlığı; Dokuz Eylül Üniversitesi; Ankara Üniversitesi; Marmara Üniversitesi; İstanbul Üniversitesi; Hacettepe Üniversitesi; Gazi Üniversitesi; Bahçeşehir Üniversitesi; Mersin Üniversitesi; Ankara ÜniversitesiBackground/aim: Our purpose was to determine the efficacy of levodopa carbidopa intestinal gel (LCIG) in a series of Turkish patientswith Parkinson’s disease (PD).Materials and methods: We had telephone calls with 54 patients from 11 neurology centers who were on LCIG treatment, and 44patients or their caregivers were included in an eight-item survey between September 2015 and June 2016. The reliability and validity ofthe survey were evaluated with intraclass correlation coefficients for every question separately.Results: Average age of the patients were 63.48 and the duration of PD was 12.79 years. Average LCIG treatment period was 15.63months. Percentages of the patients who reported they were ‘better’ after LCIG treatment were as follows: 80% for time spent off, 55% fordyskinesia, 65% for tremor, 85% for gait disorder, 50% for pain, 50% for sleep disorders, 42.5% for depression, 32.5% for incontinence,and 70% for activities of daily living. Cronbach’s alpha was 0.795 and the intraclass correlation coefficient was reliable for the items.Conclusion: As detected by a survey performed by telephone calls with good interrater reliability, patients with PD improve with LCIGtreatment in many aspects of the disease.Publication Open Access Örgütsel Sinizmin Örgütsel Bağlılık Üzerine Etkisinin İncelenmesi: Hekimlere Yönelik Bir Araştırma(2020) Koçoğlu Sazkaya, Merve; Terzi, Cansu; Marmara Üniversitesi; Bahçeşehir ÜniversitesiBu araştırmanın literatür bölümünde örgütsel sinizm ve örgütsel bağlılık kavramları, boyutları ve sonuçları konularıele alınmıştır. Örgütsel sinizmin örgütsel bağlılık üzerine etkisini incelemek amacıyla yapılan bu çalışma İstanbul’dakamu ve özel hastanelerde çalışan 436 doktor üzerinde gerçekleştirilmiştir. Araştırma sonucuna göre hekimlerinörgütsel sinizm algılarının örgütsel bağlılık üzerinde negatif yönlü etkisi olduğu belirlenmiştir. Bu etkinin alt boyutlarıincelendiğinde de örgütsel sinizmin örgütsel bağlılığın alt boyutları olan duygusal bağlılık, devamlılık bağlılığı venormatif bağlılık üzerinde negatif yönlü etkisi olduğu tespit edilmiştir.Publication Open Access The effects of resveratrol treatment on caveolin-3 expression and $Na^+$ /$K^+$ ATPase activity in rats with isoproterenol-induced myocardial injury(2020) Özkan, Naziye; Akkiprik, Mustafa; Çetinel, Şule; Tetik, Şermin; Yiğiner, Ömer; Acar, Zehra; Aykaç, Aslı; Şehirli, Ahmet Özer; Çağlayan Yeğen, Berrak; Şener, Göksel; Tezcan, Mehmet; Marmara Üniversitesi; Marmara Üniversitesi; Marmara Üniversitesi; Marmara Üniversitesi; Bahçeşehir Üniversitesi; Marmara Üniversitesi; Yakın Doğu Üniversitesi; Yakın Doğu Üniversitesi; T.C. Sağlık Bakanlığı; Marmara Üniversitesi; T.C. Sağlık BakanlığıOBJECTIVE: The present study aims to investigate the therapeutic effects of resveratrol (RES) on isoproterenol (ISO) induced myocardial injury rat model.METHODS: Catecholamine-induced heart damage was induced by ISO treatment for 30 days. The rats were divided intofour groups as follows: the control group received saline, the ISO group received 5.0 mg/kg ISO, the RES group received 10mg/kg RES, and the ISO-RES group received 10 mg/kg RES and 5 mg/kg ISO treatments for 30 days. Following echocardiographic measurements and body weight recorded, the rats were decapitated. Plasma and cardiac tissue samples obtained bydecapitation were analyzed using biochemical, histopathological, molecular and immunohistochemical methods.RESULTS: In the ISO group, Na+/K+ ATPase activity and ATP content, GSH, and caveolin-3 levels were low. LDH, CK and lysosomal enzyme activities, MDA level, and MPO activity were found to be high. It was determined that GSH and MDA levels and MPO,Na+/K+ ATPase activity, ATP content caveolin-3 levels changes that arose from ISO treatment were suppressed by RES treatment.CONCLUSION: RES treatment has ameliorated all the functional and biochemical parameters. The results obtained in thisstudy suggest that RES is a promising supplement against catecholamine exposure as it improves antioxidant defense mechanisms in the heart. In the light of above-mentioned data, RES can be assumed as a promising agent in ameliorating theoxidative injury of the myocardium.Publication Open Access Correlation of Renal Colic Incidences with the Season, Gender and Age: Cross-Sectional Study(2020) Güner, Doğu; Ürkmez, Ahmet; Yüksel, Özgür Haki; Akan, Serkan; Yıldırım, Çağlar; Şahin, Aytaç; T.C. Sağlık Bakanlığı; Sağlık Bilimleri Üniversitesi; Bahçeşehir Üniversitesi; T.C. Sağlık Bakanlığı; T.C. Sağlık Bakanlığı; T.C. Sağlık BakanlığıIntroduction: In the present study, we researched whether meteorological changes affect the number of renal colic patientsadmitted to the hospital emergency department and whether this effect varies with gender and age.Methods: In this study, 5661 patients admitted to the emergency medicine clinic of Fatih Sultan Mehmet Training andResearch Hospital between the dates of January 2017 and December 2017 with renal colic complaints were retrospectivelyscanned with International Classification for Diseases- 10 (ICD 10) N23 (renal colic) code. Renal colic was diagnosed andtreated by emergency medicine physicians. Average temperature and humidity values according to months were acquiredfrom the Republic of Turkey Ministry of Forestry and Water Affairs General Directorate of Meteorology.Results: This study was conducted with a total number of 5661 cases between the ages of 2 and 91. 3344 (59.1%) of thepatients were male, and 2317 (40.9%) were female. The average examination age of the cases was 41.58±14.63. There was astatistically significant difference between the seasons in terms of the examination ages of the cases (p=0.001). As a result ofthe dual comparisons, the average examination age of the cases in the summer season was found to be lower at a statistically significant level than the averages of the cases in Winter (p=0.001), Spring (p=0.001) and Fall (p=0.045) seasons (p<0.05).Discussion and Conclusion: In our study, we detected that meteorological parameters have an effect on renal colic development, and this effect varies according to the age and gender of the patient. Especially in the warmer months, malepatients are more sensitive towards dehydration than female patients, probably due to the hormonal mechanisms, so therenal colic incidence is higher in these patients. Thus, the suggestion is to increase fluid intake and not to stay dehydrated.Publication Open Access Do Thyroid Hormones have any Effects on the Development of Retinopathy of Prematurity?(2020) Akman, İpek; Coşkun, Yeşim; Demirci, Eylem; Bayram, Tevfik; Yabaş Kızıloğlu, Özge; Bahçeşehir Üniversitesi; Bahçeşehir Üniversitesi; T.C. Sağlık Bakanlığı; Marmara Üniversitesi; Bahçeşehir ÜniversitesiIntroduction: Retinopathy of prematurity (ROP) is a disease characterized by abnormal vascularization of the retina inpreterm infants. The present study aims to investigate the relationship between ROP and serum thyroid hormones based onthe known effects of thyroid hormones on angiogenesis.Methods: This retrospective study included infants born <34 weeks of gestation between January 2011 and January 2019who were hospitalized from birth to at least the first month of life in the Neonatal Intensive Care Unit and who had regularROP examinations. The patients were divided into two groups as having ROP and no ROP. Patients diagnosed as ROP weredivided into two subgroups as follows: treated ROP and untreated ROP. Variables, such as gender, gestational age (GA), birthweight (BW), bronchopulmonary dysplasia (BPD), duration of mechanical ventilation, duration of oxygen therapy, necrotizing enterocolitis and intraventricular hemorrhage (IVH), together with serum-free T4 and TSH levels on postnatal 7th (sT4-1and TSH-1) and 28th days (sT4-2 and TSH-2), were examined.Results: One hundred ninety-three infants without ROP (Group 1) and 152 infants with ROP (Group 2) enrolled in this study.Among 152 patients with ROP, 114 infants did not receive ROP treatment (Group 2a), and 38 infants received ROP treatment(Group 2b). In Group 2, free T4-1 and TSH-2 were significantly lower than in Group 1 (p<0.001). The sT4-1 and sT4-2 levelsof Group 2b were significantly lower than those of Group 2a (p=0.042 and p=0.015, respectively). In the logistic regressionanalysis of risk factors, thyroid hormone levels were not found to be independently effective on the development of the ROP.Discussion and Conclusion: In this study, the findings suggest that thyroid hormones had no effect on ROP development.Larger and prospective studies may shed light on the effects of thyroid hormones on ROP development.Publication Open Access Obez Hastaların Obstrüktif Uyku Apnesinde Birinci Basamak Tedavi Yöntemi Olarak Kilo Yönetiminin Rolü(2020) Ayhan Başer, Duygu; Başer, Serdar; Adin Selçuk, Ayşe; Hacettepe Üniversitesi; T.C. Sağlık Bakanlığı; Bahçeşehir ÜniversitesiAmaç: Kilo kaybının, uyku apnesini iyileştirdiği kanıtlanmıştır ve bu hastalık için ilk tedavi seçeneği olarak kabul edilir. Bu çalışmanın amacı obez hastalarda kilo yönetimi stratejileri ile kilo kaybı ve obstrüktif uyku apnesi arasındaki ilişkiyi değerlendirmektir.Yöntemler: Prospektif tipteki çalışma, vücut kitle indeksleri 25'ten büyük, ardışık 50 obstrüktif uyku apnesi hastası üzerinde yapıldı. Anket formunun ve Epworth uykululuk skalasının ilk kısmı, hastaların Kasım 2017 ile Mayıs 2018 arasındaki ilk ziyaretinde yüzyüze görüşülerek uygulandı. Horlama polikliniğine başvuran tüm hastalara kilo vermesi önerildi. Anket formunun ve Epworth uykululuk skalasının ikinci kısmı hastalara 3 ay sonar uygulandı ve ağırlıkları da kaydedildi. İstatistiksel analiz için SPSS 15.0 programı kullanıldı.Bulgular: Tüm hastalara kilo vermeleri önerildi. Hastaların %26'sı sadece diyet, %12'si sadece egzersiz, % 12'si hem diyet hem de egzersiz uyguladı. Hastaların %50'si kilo vermek için hiçbir şey yapmadı. Diyet yapanların %76,9'u, egzersiz yapanların %100'ü ve diyet yapan ve egzersiz yapanların %83,3'ü kilo vermiştir. Kilo kaybı konusunda çaba gösteren hastaların başlangıç ve kontrol (3 ay sonra) vücut kitle indeksleri ve Epworth Uykululuk Skalası puanları arasında istatistiksel olarak anlamlı fark bulundu.Sonuç: Kilo kaybı hastanın kendi isteği ile olduğunda, takip ve bakımla birlikte uyumu daha yüksektir. Çalışmamızdaki örneklem sayısı genelleme yapmak için uygun olmasa da, kilo kaybının obstrüktif uyku apnesi üzerinde olumlu bir etkisi olduğunu doğruladık.Publication Open Access İstanbul, Türkiye’de Enfektif Endokardit Olguları: Enfektif Endokarditin Mikrobiyolojik Tanısında Bakteriyolojik, Serolojik ve Moleküler Yöntemlerin Değerlendirilmesi(2020) Özdemir, Sinem; Şimşek-Yavuz, Serap; Mamal Torun, Müzeyyen; İstanbul Üniversitesi - Cerrahpaşa; İstanbul Üniversitesi; Bahçeşehir ÜniversitesiAmaç:Düşük insidanslı enfeksiyöz bir hastalık olmasına rağmen, enfektif endokardit (IE) yüksek mortalite riskine sahiptir. Bu çalışmada, Türkiye'de enfektif endokardit tanısı için bakteriyolojik, serolojik ve moleküler yöntemlerin tanıdaki yerini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çok merkezli ve prospektif olarak tasarlanmış olan çalışmaya Ocak 2012 - Aralık 2016 tarihleri arasında, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Kardiyoloji Anabilim Dalı, İstanbul Üniversitesi Haseki Kardiyoloji Enstitüsü ve Siyami Ersek Kalp Damar Cerrahisi Hastanesi'ne yatırılan ve kesin enfektif endokardit tanısı alan 50 (14 yaş üstü) hasta dahil edildi. Enfektif endokarditin mikrobiyolojik tanısı için bakteriyolojik, serolojik ve moleküler yöntemler kullandı. Bulgular: Çalışmaya dahil edilen 50 IE olgusunun yaş ortalaması 47 idi. Otuz yedi hastada (%74) olağan mikroorganizmalar saptanrken, 13 (%26) hastada tanımlanamayan nedensel ajanlar tespit edildi. Etken olarak tanımlanan mikroorganizmalar, stafilokoklar (%28), streptokoklar (%12), enterokoklar (%8), Brucella melitensis (%4), Pseudomonas aeruginosa (%2), Aggregatibacter actinomycetemcomitans (%2), Peptostreptococcus anaerobius (%2), Candida parapsilosis (%4), Bartonella henselae (%8) and Chlamydophila pneumoniae (%4) olarak tespit edildi. Sonuç: Bu çalışmada, tespit edilen etiyolojik ajanların, 31’i (% 62) kültür-pozitif, 6’sı(% 12) kültür-negatif idi. Kültür-negatif vakaların oranını azaltmak için, kan kültürü örnekleri dikkatle toplanmalı ve yeni tanı teknikleri kullanılmalıdır.Publication Metadata only The effect of bone mineral density on development of Schmorl’s nodes in young patients(2020) Naciye Sinem Gezer; Özlem AKINCI; Ali BALCI; umut özdamarlar; DOKUZ EYLÜL ÜNİVERSİTESİ; T.C. SAĞLIK BAKANLIĞI; DOKUZ EYLÜL ÜNİVERSİTESİ; BAHÇEŞEHİR ÜNİVERSİTESİObjective: The aim of this study was to detect the relationship between the development of Schmorl’s nodes (SNs) and bonemineral density (BMD) in young patients.Methods: Computerized tomography (CT) images of the thoracolumbar vertebral column were retrospectively examinedby two experienced radiologists for SNs. The diagnostic criterion for SN was defined as a node size larger than one-third butnot more than two-thirds of the relevant vertebral endplate. Considering the eligibility criteria, a total of 74 individuals (60males and 14 females, mean age: 24.3 years, age range: 18-40 years) with SN at the thoracolumbar vertebrae were includedin the patient group, and a total of 38 age- and gender-matched individuals (30 males and 8 females, mean age: 25 years)with no evidence of SN were included in the control group. All these individuals were younger than 40 years. In the patientgroup, SNs were assessed in terms of the distribution of the thoracolumbar vertebrae, the location of the upper and lowerendplates, and the total number of lesions. In all individuals included in the study, BMD was measured from the axial CTsections by quantitative CT and then compared between the two groups.Results: The distribution of age and gender was comparable between the two groups (p=0.438). A total of 208 SNs wereidentified in the patient group. Of these, 92 (44%) were located at the thoracic vertebrae and 116 (56%) at the lumbar vertebrae.The mean BMD was 131.6 g/cm3 in the patient group and 140.7 g/cm3 in the control group (p=0.03). There was nosignificant relationship between the total number of SNs per patient and the mean BMD (p=0.156).Conclusion: Evidence from this study revealed that low BMD may be a predisposing factor for the development of SNs inpatients younger than 40 years.Publication Open Access Role of Serum HMGB1 in Prostate Cancer(2020) Çiçek, Hülya; Solakhan, Mehmet; Sever, Özlem Nuray; Yıldırım, Mustafa; Benlier, Necla; Yıldırım, Zeliha; Orhan, Nuri; Gaziantep Üniversitesi; Bahçeşehir Üniversitesi; Gaziantep Üniversitesi; Bahçeşehir Üniversitesi; Sanko Üniversitesi; Gaziantep Üniversitesi; T.C. Sağlık BakanlığıPurpose: In our study the diagnostic role of HMGB1 levels measured in serum were investigated in prostatitis and prostate carcinoma diagnosis and in the differential diagnosis of these two diseases. Material Method: Patients followed up for histopathologically verified diagnosis of prostate carcinoma and prostatitis in 20142017 at the Urology Clinic were included. HMGB1 measurement in serum was performed with the ELISA method. Results: A total of 78 subjects were included in the study, consisting of 30 (38.5%) prostatitis patients, 25 (32%) prostate carcinoma patients and 23 (29.5%) healthy subjects. HMGB1 was detected as 11.9±2.6 (Range 6.7-18.4) ng/ml in the prostatitis group, 15.1±4.5 (Range 8.4-24.8) ng/ml in the prostate carcinoma patients and as 9.2±3.1 (Range 4.7-18.7) ng/ml in the control group. The difference between the groups were investigated using the Friedman test as HMGB1 did not show normal distribution. Significant difference was detected between the three groups (p<0.001). When the groups were compared in pair, significant difference was detected between the prostatitis group and the control group (p=0.001). Significant difference was again detected between the prostate carcinoma group and the control group (p<0.001). Significant difference was detected between the prostatitis group and the prostate carcinoma group (p=0.006). Measurement of serum total prostate specific antigen (tPSA) levels were conducted automatically with the electro chemiluminescent method. A moderate level of (r=0.276) but a highly significant (p=0.009) positive correlation was found between PSA and HMGB1. Conclusion: In our study we showed that high PSA and high HMGB1 were highly correlated. HMGB1 measured in serum could be a useful marker in the differentiation of prostatitis and prostate carcinoma, in the early diagnosis of suspected prostate carcinoma and that HMGB1 value was significantly high in prostate carcinoma patients.Publication Open Access Comparison of Urinary Incontinence Subgroups according to Possible Risk Factors(2020) Solakhan, Mehmet; Kazımoğlu, Hatem; Topdağı, Yunus Emre; Güzel, Ali İrfan; Bahçeşehir Üniversitesi; Sanko Üniversitesi; Sanko Üniversitesi; T.C. Sağlık BakanlığıObjective: Urinary incontinence (UI) is involuntary urine flow that causes social and hygienic problems. The association between risks factors and UI in women was assessed. We compared the risk factors based on UI subtypes.Methods: The study included 470 women with different UI types (320 urge UI [UUI], 80 stress UI [SUI], and 70 mixed UI [MUI]).Age, educational level, urban/rural residence, parity, delivery type, diabetes mellitus (DM), and hypertension status, anyneurological abnormality, menopausal status, surgical history, and body mass index (BMI) were obtained.Results: Of all women, 320, 80, and 70 had UUI, SUI, and MUI, respectively. The groups did not differ significantly in terms ofage, hypertension status, neurological abnormality rate, smoking status, or surgical history (all p>0.05). Parity, episiotomy,DM status, delivery type, menopause status, hysterectomy history, and BMI differed significantly among the groups (allp<0.05).Conclusion: Our study found that parity, episiotomy, DM status, delivery type, menopause status, hysterectomy history, andBMI may be independent risk factors for different UI types.