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Publication Metadata only Combating Phytopathogens by Integration of Metagenomics and Phototrophic Biotechnologies: Toward Sustainable Agricultural Practices(TAYLOR & FRANCIS INC, 2025) Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; Zaletova, Dilnaz; Bauenova, Meruyert O.; Huang, Zhiyong; Zharmukhamedov, Sergey K.; Shabala, Sergey; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Russian Academy of Sciences; University of Western Australia; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityRising global food demand amid climate change presents unprecedented challenges for modern agriculture. The spread of phytopathogens and the degradation of agroecosystems necessitate the development of innovative plant protection solutions. Traditional chemical pesticides are losing their effectiveness due to the emergence of resistant pathogens and their adverse environmental impacts, thereby intensifying interest in biological control methods. This study examines the integration of metagenomic analysis and phototrophic biotechnology as a promising approach to biocontrol. Metagenomics enables the precise identification of phytopathogens and beneficial microorganisms, laying the groundwork for the development of targeted biopesticides. Phototrophic microorganisms, including microalgae and cyanobacteria, exhibit antimicrobial properties and contribute to the restoration of soil ecosystems. The convergence of these technologies offers opportunities to form adaptive microbial consortia that ensure the long-term sustainability of agroecosystems. The paper discusses key challenges, including data processing complexities, the scalability of technologies, and regulatory barriers, and underscores the need for standardized methodologies and interdisciplinary collaboration. The integration of metagenomics and phototrophic biotechnology represents a promising direction for creating environmentally safe and sustainable agricultural production systems.Publication Metadata only Spectral insights: Navigating the frontiers of biomedical and microbiological exploration with Raman spectroscopy(ELSEVIER SCIENCE SA, 2024) Allakhverdiev, Elvin S.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Bauenova, Meruyert O.; Belkozhayev, Ayaz M.; Rodnenkov, Oleg, V; Martynyuk, Tamila, V; Maksimov, Georgy, V; Allakhverdiev, Suleyman I.; National Medical Research Center of Cardiology; Lomonosov Moscow State University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Aitkhozhin Institute of Molecular Biology & Biochemistry; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Bahcesehir UniversityRaman spectroscopy (RS), a powerful analytical technique, has gained increasing recognition and utility in the fields of biomedical and biological research. Raman spectroscopic analyses find extensive application in the field of medicine and are employed for intricate research endeavors and diagnostic purposes. Consequently, it enjoys broad utilization within the realm of biological research, facilitating the identification of cellular classifications, metabolite profiling within the cellular milieu, and the assessment of pigment constituents within microalgae. This article also explores the multifaceted role of RS in these domains, highlighting its distinct advantages, acknowledging its limitations, and proposing strategies for enhancement.Publication Metadata only MicroRNAs in Plant Genetic Regulation of Drought Tolerance and Their Function in Enhancing Stress Adaptation(MDPI, 2025) Zhakypbek, Yryszhan; Belkozhayev, Ayaz M.; Kerimkulova, Aygul; Kossalbayev, Bekzhan D.; Murat, Toktar; Tursbekov, Serik; Turysbekova, Gaukhar; Tursunova, Alnura; Tastambek, Kuanysh T.; Allakhverdiev, Suleyman I.; Satbayev University; Satbayev University; Al-Farabi Kazakh National University; Akhmet Yassawi International Kazakh-Turkish University; Al-Farabi Kazakh National University; Uspanov Kazakh Research Institute of Soil Science & Agrochemistry; Satbayev University; Kazakh Scientific Research Institute of Plant Protection & Quarantine of Zh.Zhienbaev; Lomonosov Moscow State University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityAdverse environmental conditions, including drought stress, pose a significant threat to plant survival and agricultural productivity, necessitating innovative and efficient approaches to enhance their resilience. MicroRNAs (miRNAs) are recognized as key elements in regulating plant adaptation to drought stress, with a notable ability to modulate various physiological and molecular mechanisms. This review provides an in-depth analysis of the role of miRNAs in drought response mechanisms, including abscisic acid (ABA) signaling, reactive oxygen species (ROS) detoxification, and the optimization of root system architecture. Additionally, it examines the effectiveness of bioinformatics tools, such as those employed in in silico analyses, for studying miRNA-mRNA interactions, as well as the potential for their integration with experimental methods. Advanced methods such as microarray analysis, high-throughput sequencing (HTS), and RACE-PCR are discussed for their contributions to miRNA target identification and validation. Moreover, new data and perspectives are presented on the role of miRNAs in plant responses to abiotic stresses, particularly drought adaptation. This review aims to deepen the understanding of genetic regulatory mechanisms in plants and to establish a robust scientific foundation for the development of drought-tolerant crop varieties.Publication Metadata only Development and Transfer of Microbial Agrobiotechnologies in Contrasting Agrosystems: Experience of Kazakhstan and China(MDPI, 2025) Nygymetova, Aimeken M.; Sadvakasova, Assemgul K.; Zaletova, Dilnaz E.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Wang, Jingjing; Huang, Zhiyong; Sarsekeyeva, Fariza K.; Kirbayeva, Dariga K.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Bahcesehir University; Russian Academy of Sciences; Russian Academy of Sciences; Timiryazev Institute of Plant PhysiologyThe development and implementation of microbial consortium-based biofertilizers represent a promising direction in sustainable agriculture, particularly in the context of the ongoing global ecological and agricultural crisis. This article examines the agroecological and economic impacts of applying microbial consortiums and explores the mechanisms of technology transfer using the example of two countries with differing levels of scientific and technological advancement-China and Kazakhstan. The analysis of the Chinese experience reveals that the successful integration of microbial biofertilizers into agricultural practice is made possible by a well-established institutional framework that includes strong governmental support for R&D, a robust scientific infrastructure, and effective coordination with the private sector. In contrast, Kazakhstan, despite its favorable agroecological conditions and growing interest among farmers in environmentally friendly technologies, faces several challenges from limited funding to a fragmented technology transfer system. The comparative study demonstrates that adapting Chinese models requires consideration of local specificities and the strengthening of intergovernmental cooperation. The article concludes by emphasizing the need to establish a multi-level innovation ecosystem encompassing the entire cycle of development and deployment of microbial biofertilizers, as a prerequisite for improving agricultural productivity and ensuring food security in countries at different stages of economic development.Publication Metadata only Fundamental properties, characterization techniques, and applications for photo(electro) catalysis: From Nanosized manganese oxides to manganese coordination compounds(ELSEVIER SCIENCE SA, 2025) Khosravi, Mehdi; Allakhverdiev, Suleyman I.; Eaton-Rye, Julian J.; Holynska, Malgorzata; Aro, Eva-Mari; Shen, Jian-Ren; Najafpour, Mohammad Mahdi; Institute for Advanced Studies in Basic Sciences (IASBS); Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Moscow Institute of Physics & Technology; Bahcesehir University; University of Otago; Philipps University Marburg; University of Turku; Okayama University; Sharif University of TechnologyThe excessive use of fossil fuels has led to significant environmental challenges, including global warming driven by carbon dioxide emissions and widespread air pollution. Essentially, focusing on sustainable and clean energy sources is necessary for the future of humanity and our planet. Through evolution, nature has solved this energy problem through the natural photosynthesis process. Manganese plays a crucial role in natural photosynthesis, specifically within the oxygen-evolving complex of photosystem II and therefore manganese has garnered significant interest for its potential use in catalytic, photocatalytic, and photoelectrochemical water oxidation, as well as in various other applications, due to its crucial role in natural photosynthesis. Therefore, This review focuses on the photocatalytic and photoelectrocatalytic properties of different manganese compounds and discusses various characterization techniques, with a special focus on electrochemical and photoelectrochemical methods used for assessing photoactive semiconductors. The primary goal of this text is to offer a comprehensive summary of the advancements in this area. Additionally, it sheds light on various approaches and strategies used in this field that could be applicable in related areas of interest. The review concludes with an outlook and final thoughts on the subject.Publication Metadata only Synthetic algocyanobacterial consortium as an alternative to chemical fertilizers(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2023) Sadvakasova, Assemgul K.; Bauenova, Meruyert O.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Huang, Zhiyong; Wang, Jingjing; Balouch, Huma; Alharby, Hesham F.; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityThe use of unregulated pesticides and chemical fertilizers can have detrimental effects on biodiversity and human health. This problem is exacerbated by the growing demand for agricultural products. To address these global challenges and promote food and biological security, a new form of agriculture is needed that aligns with the principles of sustainable development and the circular economy. This entails developing the biotechnology market and maximizing the use of renewable and eco-friendly resources, including organic fertilizers and biofertilizers. Phototrophic microorganisms capable of oxygenic photosynthesis and assimilation of molecular nitrogen play a crucial role in soil microbiota, interacting with diverse microflora. This suggests the potential for creating artificial consortia based on them. Microbial consortia offer advantages over individual organisms as they can perform complex functions and adapt to variable conditions, making them a frontier in synthetic biology. Multifunctional consortia overcome the limitations of monocultures and produce biological products with a wide range of enzymatic activities. Biofertilizers based on such consortia present a viable alternative to chemical fertilizers, addressing the issues associated with their usage. The described capabilities of phototrophic and heterotrophic microbial consortia enable effective and environmentally safe restoration and preservation of soil properties, fertility of disturbed lands, and promotion of plant growth. Hence, the utilization of algo-cyanobacterial consortia biomass can serve as a sustainable and practical substitute for chemical fertilizers, pesticides, and growth promoters. Furthermore, employing these bio-based organisms is a significant stride towards enhancing agricultural productivity, which is an essential requirement to meet the escalating food demands of the growing global population. Utilizing domestic and livestock wastewater, as well as CO2 flue gases, for cultivating this consortium not only helps reduce agricultural waste but also enables the creation of a novel bioproduct within a closed production cycle.Publication Metadata only Biotechnological production of hydrogen: Design features of photobioreactors and improvement of conditions for cultivating cyanobacteria(PERGAMON-ELSEVIER SCIENCE LTD, 2024) Kossalbayev, Bekzhan D.; Yilmaz, Girayhan; Sadvakasova, Asemgul K.; Zayadan, Bolatkhan K.; Belkozhayev, Ayaz M.; Kamshybayeva, Gulzhanay K.; Sainova, Gaukhar A.; Bozieva, Ayshat M.; Alharby, Hesham F.; Tomo, Tatsuya; Allakhverdiev, Suleyman I.; Satbayev University; Satbayev University; Al-Farabi Kazakh National University; Bahcesehir University; Aitkhozhin Institute of Molecular Biology & Biochemistry; Akhmet Yassawi International Kazakh-Turkish University; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; King Abdulaziz University; Tokyo University of ScienceOver the last five decades, solar-based hydrogen (H2) production has been intensively studied. Specifically, the study of biophotolysis by cyanobacteria has received great attention to produce H2, and promising research approaches have been established. To date, numerous photobioreactors (PBRs) have been built to collect cyanobacterial biomass and generate bioenergy. Additionally, different PBR parameters were adjusted to increase the product yield. PBR development holds great potential not only for cell biomass but also for biological H2 production. This review aimed to examine the mechanisms involved in H2 production by cyanobacteria, explore the factors influencing the process, and describe five distinct PBRs known for their high H2 production. This article examines the pros and cons of the most efficient PBRs for H2 production and offers insights into strategies for (c) 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Eco-friendly biopesticides derived from CO2-Fixing cyanobacteria(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2023) Akmukhanova, Nurziya R.; Leong, Yoong Kit; Seiilbek, Sandugash N.; Konysbay, Aigerim; Zayadan, Bolatkhan K.; Sadvakasova, Assemgul K.; Sarsekeyeva, Fariza K.; Bauenova, Meruyert O.; Bolatkhan, Kenzhegul; Alharby, Hesham F.; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Tunghai University; Tunghai University; King Abdulaziz University; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityThere is currently an escalating global demand for the utilization of plant and natural extracts as pesticides due to their minimal health risks. Cyanobacteria are highly valuable organisms with significant potential in agriculture and are of great interest for the development of agrochemical agents as biopesticides. The flexibility and adaptability of Cyanobacteria to various environmental conditions are facilitated by the presence of specialized enzymes involved in the production of biologically active diverse secondary metabolites, including alkaloids, lipopolysaccharides, non-protein amino acids, non-ribosomal peptides, polyketides, terpenoids, and others. This review focuses on the metabolites synthesized from cyanobacteria that have demonstrated effectiveness as antibacterial, antiviral, antifungal agents, insecticides, herbicides, and more. The potential role of cyanobacteria as an alternative to chemical pesticides for environmental conservation is discussed.Publication Metadata only Enhancing Photosynthesis and Plant Productivity through Genetic Modification(MDPI, 2024) Nazari, Mansoureh; Kordrostami, Mojtaba; Ghasemi-Soloklui, Ali Akbar; Eaton-Rye, Julian J.; Pashkovskiy, Pavel; Kuznetsov, Vladimir; Allakhverdiev, Suleyman I.; Ferdowsi University Mashhad; University of Otago; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityEnhancing crop photosynthesis through genetic engineering technologies offers numerous opportunities to increase plant productivity. Key approaches include optimizing light utilization, increasing cytochrome b6f complex levels, and improving carbon fixation. Modifications to Rubisco and the photosynthetic electron transport chain are central to these strategies. Introducing alternative photorespiratory pathways and enhancing carbonic anhydrase activity can further increase the internal CO2 concentration, thereby improving photosynthetic efficiency. The efficient translocation of photosynthetically produced sugars, which are managed by sucrose transporters, is also critical for plant growth. Additionally, incorporating genes from C4 plants, such as phosphoenolpyruvate carboxylase and NADP-malic enzymes, enhances the CO2 concentration around Rubisco, reducing photorespiration. Targeting microRNAs and transcription factors is vital for increasing photosynthesis and plant productivity, especially under stress conditions. This review highlights potential biological targets, the genetic modifications of which are aimed at improving photosynthesis and increasing plant productivity, thereby determining key areas for future research and development.Publication Metadata only Photosynthetic microbial fuel cells: practical applications of electron transfer chains(ND Zelinsky Inst Organic Chemistry, RAS - ZIOC RAS, 2023) Voloshin, Roman A.; Bozieva, Ayshat M.; Bruce, Barry D.; Allakhverdiev, Suleyman I.; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; University of Tennessee System; University of Tennessee Knoxville; Bahcesehir UniversityMembrane electron transfer underlies the central metabolic pathways for energy conversion. The photosynthetic and respiratory electron transport chains are complex apparatuses capable of generating a transmembrane proton gradient from sunlight or chemical energy. Recent exploitation of these apparatuses as energy convertors is of interest due to the availability and eco-friendliness of the biomaterial. Devices that utilize chemotrophic microorganisms to generate electricity have been known for over one hundred years. In these systems, called microbial fuel cells (MFC), one or more microorganisms catalyze charge transfer from a consumable substrate (acetate, glucose, etc.) to the electrode. Recently, MFCs based on phototrophic organisms have been actively developed. These devices, called photosynthetic microbial fuel cells (PMFC), still resemble the conventional MFC in that they also use living microbial cells to convert chemicals to electrical energy. However, the distinction between these two classes of fuel cells is that theMFCutilizes only the chemical energy of the organic substrate. At the same time, PMFCs are also capable of using solar energy. Common to both devices is the ability to utilize intrinsic electron transfer chains of bacterial metabolism as the primary mechanism of energy conversion. The widespread and accessible solar energy may permit PMFCs based on photosynthesis to become an inexpensive and efficient method for sunlight conversion. MFCs based on heterotrophs may be more promising in wastewater remediation and other ecological applications. This article reviews the latest advances in this field and emphasizes the remaining challenges. The bibliography includes 205 references.
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