Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Metadata only Mapping the Implementation of the United Nations Sustainable Development Goals(WILEY, 2025) Leal Filho, Walter; Wall, Tony; Salvia, Amanda Lange; Ozuyar, Pinar; Brandli, Luciana Londero; Azul, Anabela Marisa; Sharifi, Ayyoob; Manchester Metropolitan University; Hochschule Angewandte Wissenschaft Hamburg; Liverpool John Moores University; University of Liverpool; Bahcesehir University; Universidade de Passo Fundo; Universidade de Coimbra; Universidade de Coimbra; Universidade de Coimbra; Hiroshima University; Hiroshima UniversityThe implementation of the United Nations' Sustainable Development Goals (SDGs) is a process, which has been mobilizing the international community-and resources-in an unprecedented way. However, even though this worldwide movement is expected to mobilize stakeholders from across all society, it remains unclear how this process is yielding the expected results. In an attempt to address this knowledge gap, this study examines the literature on the implementation of the SDGs and performs a mapping of the extent to which they are being implemented. This study combines a bibliometric analysis using the major scientific databases, with a critical appraisal of the experiences and progresses documented in the Encyclopedia of the UN SDGs. The results show that whereas significant progress has been seen in implementing some SDGs, other goals remain under-prioritized or under-resourced. Also, some goals such as SDG13 (Climate action), SDG 3 (Health and Well Being), and SDG 16 (Peace, Justice, and Strong Institutions) are more prominently present in the literature, when compared with the others. Based on the findings, the paper outlines some of the research needs, which should be met, so as to address the implementation problems the mapping has identified.Publication Metadata only Comprehensive Evaluation of Serpentine Aneurysms: a Systematic Review and Meta-analysis with a Subanalysis for Treatment Approaches(SPRINGER HEIDELBERG, 2024) Cinar, Celal; Elek, Alperen; Allahverdiyev, Irshad; Ozcinar, Kenan Kerem; Yazici, Adem C.; Kusbeci, Mahmut; Ozturk, Egemen; Oran, Ismail; Ege University; Istanbul University; Bahcesehir UniversityPurposeThis systematic review and meta-analysis aimed to systematically evaluate and enhance the understanding of optimal management strategies for serpentine aneurysms.MethodsA systematic search was conducted in Medline, Scopus, and Cochrane databases up to July 8, 2024, using relevant keywords. Studies included were case series, prospective or retrospective cohorts, or randomized controlled trials with data on clinical and angiographic outcomes of intracranial serpentine aneurysms. Data extraction and quality assessment were performed independently by two authors. Statistical analysis was conducted using R, with pooled estimates under a random-effects model.ResultsTen studies comprising 70 patients with 71 serpentine aneurysms were included. The majority (92.9%) were giant aneurysms. The overall rate of procedure-related complications was 33%, morbidity was 13%, and mortality was 13%. Good neurological outcomes were achieved in 76% of cases. For unruptured aneurysms, the complication rate was 34%, while no complications were observed in ruptured aneurysms. Comparative analysis between ruptured and unruptured aneurysms showed no significant differences in outcomes or complications. The technical success rate was 91%. Reconstructive methods showed a slightly higher rate of good neurological outcomes (77%) compared to deconstructive methods (70%), though complication rates were similar.ConclusionBoth reconstructive and deconstructive endovascular treatments for serpentine aneurysms are effective, with high rates of good neurological outcomes and acceptable complication rates.Publication Metadata only Recent Advances in the Multifunctional Properties and Applications of Carbon Nanotube/Graphene Hybrid Polymer Nanocomposites(WILEY, 2025) Navidfar, Amir; Trabzon, Levent; Bahcesehir University; Istanbul Technical University; Samarkand State UniversityGraphene and carbon nanotubes (CNTs) have emerged as highly regarded carbon fillers in the field of polymer nanocomposites (PNCs), owing to their exceptional structural and functional characteristics. Achieving a high-quality nanofiller dispersion inside the polymer matrix is critical for developing top-performing PNCs. Combining CNTs and graphene with varied dimensions could prove to be the most favorable nanofillers in the preparation of high-performance nanocomposites, owing to their synergistic outcome through the development of an effective three-dimensional (3D) structure. The issues related to nanofillers and their functionalization techniques were first discussed. Then, commercially feasible fabrication methods of PNCs, including melt compounding, solution mixing, in situ polymerization, and layer-by-layer (LbL) assembly, were briefly summarized. This paper mainly reviews the effectiveness of hybrid CNT/graphene on mechanical, thermal, electrical, and EMI-shielding properties and applications of PNCs. The primary motivations for ternary nanocomposites are to (1) achieve greater performance improvement through synergistic effects, (2) attain multifunctionality, (3) improve scalability, and (4) lower manufacturing costs.Publication Metadata only Review on polylactic acid and Polycaprolactone composites with Carbon-Based reinforcements: CNTs and GNPs integration(SPRINGERNATURE, 2025) Caylak, Sena; Navidfar, Amir; Trabzon, Levent; Istanbul Technical University; Istanbul Technical University; Bahcesehir University; Istanbul Technical University; Samarkand State UniversityPoly(lactic acid)/Polycaprolactone (PLA/PCL) blend-based nanocomposites reinforced with carbon-based fillers that are both biocompatible and biodegradable have received considerable attention for numerous applications. Their exceptional electrical, mechanical, and thermal properties, along with their low toxicity, low cost, and renewability, have sparked substantial research to assess their potential as polymer composites. In this work, we provided an overview of the recent progress on the current trends of employing carbon-based nanofillers in PLA/PCL blends. The properties of these individual polymers and the blending of PCL with PLA enhance the properties of the polymer structure are mentioned first. Then, the comprehensive review particularly focuses on the addition of the most commonly used carbon-based nanofillers such as graphene nanoplateles (GNPs) and carbon nanotubes (CNTs) into PLA/PCL blends, and its effect on the composite performance is also discussed. In conclusion, the potential applications to develop PLA/PCL biocomposites with the impact of emphasis on carbon-based filler are also presented and future expectations are summarized.Publication Metadata only Mechanical thrombectomy for the treatment of large vessel occlusion due to cancer-related cerebral embolism: A systematic review(SAGE PUBLICATIONS INC, 2024) Toruno, Michelle; Al-Janabi, Omar; Karaman, Irem; Ghozy, Sherief; Senol, Yigit Can; Kobeissi, Hassan; Kadirvel, Ramanathan; Ashdown, Boyd; Kallmes, David F.; Mayo Clinic; University of Arizona; Bahcesehir University; Mayo Clinic; Mayo ClinicBackground Cancer-related cerebral embolism due to direct tumor embolization results in a rare acute ischemic stroke with large vessel occlusion (LVO). Despite the established status of mechanical thrombectomy (MT) in LVO management, its effectiveness and safety remains inadequately explored in this specific patient group.Methods We conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the Nested Knowledge AutoLit software, encompassing databases like Embase, PubMed, Scopus, and Web of Science, from their inception up to 9 May 2023.Results In the review of 35 studies encompassing 37 cases, mean patient age was 52 years, and 30% were female. Cardiac myxoma (29.7%), cardiac papillary fibroelastoma (16.2%), and squamous cell carcinoma of the lung (8.1%) were the most frequent underlying cancers. The left middle cerebral artery was the most commonly affected occlusion site (24.3%). Of the patients, 67.5% underwent MT alone, while 32.5% received MT combined with intravenous thrombolysis. Successful reperfusion (thrombolysis in cerebral infarction (TICI) 2b-3) was achieved in 89.1% of cases, with 59.4% reaching TICI 3. Functional independence was observed in 29.7% of patients.Conclusion While limitations exist, this comprehensive study highlights the potential benefits of MT in a patient group historically excluded from major trials, warranting further investigation.Publication Metadata only Nano Carrier Systems in Increasing Drug Effectiveness(SPRINGERNATURE, 2025) Musmula, Muge; Akkoc, Senem; Suleyman Demirel University; Suleyman Demirel University; Bahcesehir UniversityThe utilization of nanocarrier systems enables the targeted delivery of therapeutic drugs to specific tissues and organs through binding to the surfaces or cores of nanoparticles. The ability to sustain optimal drug levels within the body is contingent upon the controlled release of therapeutic medications. These substances have the capacity to enhance the bioavailability of poorly soluble drugs by increasing their solubility. Furthermore, they can protect sensitive therapeutic agents from degradation, thereby maintaining their effectiveness until they reach their target. A range of nanopharmaceutical systems, designed for various therapeutic applications, have undergone rigorous evaluation in preclinical and clinical studies, yielding encouraging results. This review examines the role of nanocarrier systems in enhancing the efficacy of pharmaceuticals used to treat various diseases. Finally, the challenges encountered in the production and application of nanocarriers, and future research opportunities are also presented. [GRAPHICS]Publication Metadata only Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient(TAYLOR & FRANCIS LTD, 2025) Musmula, Muge; Akkoc, Senem; Suleyman Demirel University; Suleyman Demirel University; Bahcesehir UniversityApoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown to inhibit tumor growth and induce apoptosis in cancerous cells, increasing caspase activity, DNA fragmentation, and the expression of the Bax protein, while decreasing Bcl-2 expression. In this review, the effects of carvacrol on various cancers and its potential as a drug are summarized.Publication Metadata only Artificial Intelligence and Machine Learning in Diabetic Foot Ulcer Care: Advances in Diagnosis, Treatment, Prognosis, and Novel Therapeutic Strategies(SAGE PUBLICATIONS INC, 2025) Misir, Abdulhamit; Bahcesehir UniversityBackground: Diabetic foot ulcers (DFUs) affect 19% to 34% of individuals with diabetes during their lifetime and account for over one million nontraumatic lower-limb amputations annually. Standard care often fails to detect early, subclinical changes, leading to delayed intervention and high mortality rates. This review examines how artificial intelligence (AI) and machine learning (ML) can extract complex patterns from diverse data modalities to advance DFU care.Methods: We examined AI/ML applications in DFU care across four domains: diagnosis (automated image and thermogram classification, biomechanical risk stratification), treatment optimization (AI-driven offloading prescriptions, tele-rehabilitation, molecularly informed wound care), prognosis (neural network and random forest models for risk assessment), and novel strategy development (generative AI, transcriptomic target discovery, wearable digital biomarkers).Results: Artificial intelligence/ML methodologies have demonstrated promising results in DFU image and thermogram analysis, with reported accuracies ranging from 81-97% across different studies. Biomechanical ML models show potential for dynamic risk stratification, and prognostic models achieve moderate performance with area under the curve values around 0.74-0.82. Generative AI approaches have shown promise for data augmentation, improving segmentation performance in limited datasets.Conclusion: Despite promising advances, several challenges impede clinical translation, including data standardization, model explainability, regulatory compliance, clinical workflow integration, prospective validation, and equitable implementation. Collaborative efforts among clinicians, data scientists, regulators, and patients are essential to translate AI-driven innovations into routine DFU management, potentially reducing amputations and improving outcomes for this global health burden.