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Publication Metadata only Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation(Bentham Science Publishers P.O. Box 294 Bussum 1400 AG, 2020) Baǧdaş, Deniz; Gül, Zülfiye; Meade, Julie A.; Cam, Betul; Çinkılıç, Nilüfer; Gürün, Mine Sibel; Baǧdaş, Deniz, Yale School of Medicine, New Haven, United States, Yale School of Medicine, New Haven, United States; Gül, Zülfiye, Department of Pharmacology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Meade, Julie A., Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, United States; Cam, Betul, Department of Physiology, Bursa Uludağ Üniversitesi, Bursa, Turkey; Çinkılıç, Nilüfer, Department of Biology, Bursa Uludağ Üniversitesi, Bursa, Turkey; Gürün, Mine Sibel, Department of Pharmacology, Bursa Uludağ Üniversitesi, Bursa, TurkeyBackground: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Successful WATCHMAN Device Implantation in a Patient with IVC Filter Thrombosis and Iliac Vein Occlusions(Elsevier Inc. [email protected], 2020) Okutucu, Sercan; Ates, Ismail; Marmagkiolis, Konstantinos; Kose, Gulcan; Iliescu, Cesar Angi; Ci̧lingiroǧlu, Mehmet; Okutucu, Sercan, Department of Cardiology, Ankara Numune Hospital, Ankara, Turkey; Ates, Ismail, Department of Cardiology, Medical Park Hospitals, Antalya, Turkey; Marmagkiolis, Konstantinos, Florida Hospital, Orlando, United States; Kose, Gulcan, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Iliescu, Cesar Angi, UT Houston, The University of Texas MD Anderson Cancer Center, Houston, United States; Ci̧lingiroǧlu, Mehmet, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey, Arkansas Heart Hospital, Little Rock, United StatesPercutaneous left atrial appendage occlusion has been shown to be a safe and cost-effective treatment for stroke prevention in patients with nonvalvular atrial fibrillation with increased stroke and bleeding risk. Venous system might be occluded from prior procedures or have structural abnormalities. Herein, we present a successful WATCHMAN device implantation in a patient with inferior vena cava filter thrombosis and iliac vein occlusions. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Automated Insulin Delivery in Children with Type 1 Diabetes(W.B. Saunders, 2020) Cengiz, Eda; Cengiz, Eda, Yale School of Medicine, New Haven, United States, Bahçeşehir Üniversitesi, Istanbul, TurkeyThe advent of insulin pump therapy marked an important milestone in diabetes treatment in the past few decades and has become the tipping point for the development of automated insulin delivery systems (AID). Standalone insulin pump systems have evolved over the course of years and have been replaced by modern high-technology insulin pumps with continuous glucose monitor interface allowing real-time insulin dose adjustment to optimize treatment. This review summarizes evidence from AID studies conducted in children with type 1 diabetes and discusses the outlook for future generation AID systems from a pediatric treatment perspective. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only State-of-the-art Review: Interventional Onco-Cardiology(Springer, 2020) Pushparaji, Bala; Marmagkiolis, Konstantinos; Miller, Cameron K.; Aziz, Moez Karim; Bălănescu, D. V.; Donisan, Teodora; Palaskas, Nicolas L.; Kim, Peter Y.; Lopez-Mattei, Juan Carlos; Ci̧lingiroǧlu, Mehmet; Pushparaji, Bala, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Marmagkiolis, Konstantinos, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States, Northside Hospital, St Petersburg, United States; Miller, Cameron K., Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Aziz, Moez Karim, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States, University of Texas Health Science Center at Houston, Houston, United States; Bălănescu, D. V., Department of Internal Medicine, Beaumont Hospital, Royal Oak, United States; Donisan, Teodora, Department of Internal Medicine, Beaumont Hospital, Royal Oak, United States; Palaskas, Nicolas L., Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Kim, Peter Y., Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Lopez-Mattei, Juan Carlos, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Ci̧lingiroǧlu, Mehmet, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, TurkeyPurpose of review: To discuss invasive cardiovascular procedures as they relate to onco-cardiology, as well as recent additions to anti-cancer therapies and their subsequent effect on cardiovascular toxicity. Recent findings: The development of immune checkpoint inhibitors and chimeric antigen receptor T cell therapy has been linked to cardiotoxicity and represents an emerging area of concern. Recent advances in transcatheter valve replacement have shown benefits compared with surgical management regardless of malignancy type, stage, or treatment. Summary: With the increasing use of immunotherapy and increasing recognition of cardiotoxicity, there is a need for identifying mortality-improving strategies. The use of a transcatheter approach for aortic valve replacement looks to be a safer alternative when compared with surgical replacement despite the presence of cancer. Pericardial disease is frequent in the cancer population and pericardiocentesis represents a valid option for the treatment of significant pericardial effusions. Endomyocardial biopsy is performed for various indications in the cancer population and is the gold standard for diagnosing myocarditis and infiltrative diseases. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only The pros and cons of digital health communication tools in neurosurgery: a systematic review of literature(Springer, 2020) Nanah, Abdelrahman; Bayoumi, Ahmed B.; Nanah, Abdelrahman, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bayoumi, Ahmed B., Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, TurkeyEffective communication is critical in healthcare facilitation. Our aim is to illustrate the impact of digital communication tools in the field of neurosurgery based on the cumulative recently published reports to show an evidence-based review of both benefits and limitations. We performed a systematic review of records published from January 2003 to March 2018. A specific set of keywords such as digital and communication were used on PubMed database to conduct a thorough online search. 13 articles, out of 52, were comprehensively studied after complying with our inclusion and exclusion criteria. Many of the reviewed studies reported several applications of digital health communication tools in neurosurgery including 46% (6/13) in the Emergency Room and 23% (3/13) in the Operating Room. 38.5% (5/13) were applied in teaching hospitals. Reviewed studies were divided into two groups according to their applications (interventional (3/13) and non-interventional (10/13)). In the Emergency Room, digital health tools facilitated timely diagnosis and management, while in the operating room it permitted revolutionary robotic surgery. It showed potential for no-risk learning at academic institutions. While the fruitful impacts were convincing of the digital communication tools’ ability to enhance healthcare in neurosurgery, proper adherence to regulations against data loss and theft, two potential complications of digital tool misuse, must be maintained. Additionally, both time efficiency and the necessity of waiting for better implementation of communication tools proved to be obstacles to consistent digital tool integration. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Spine Metastasis of Thymic Carcinoma in a Pediatric Patient: A Case Report and Comprehensive Literature Review(S. Karger AG, 2020) Oktay, Kadir; Güzel, Ebru; Baykara, Okay; Akbaba, Mevlana; Sarí, Ibrahim; Güzel, Aslan I.; Oktay, Kadir, Department of Neurosurgery, Çukurova Üniversitesi Tip Fakültesi, Adana, Turkey; Güzel, Ebru, Department of Radiology, Medical Park Hospital, Bursa, Turkey; Baykara, Okay, Department of Neurosurgery, Çukurova Üniversitesi Tip Fakültesi, Adana, Turkey; Akbaba, Mevlana, Department of Neurosurgery, Çukurova Üniversitesi Tip Fakültesi, Adana, Turkey; Sarí, Ibrahim, Department of Pathology, Patomer Pathology Laboratory, Gaziantep, Turkey; Güzel, Aslan I., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyIntroduction: Thymic carcinoma metastases of the spinal column are very rare, especially in pediatric patients. To our knowledge, this is the first such pediatric case in the literature. Case Presentation: We report the case of a 14-year-old male patient with T12 and L1 metastases of thymic carcinoma. He had history of thymectomy and intrathoracic tumor resection 7 months previously. The patient's neurological condition deteriorated, therefore, tumor resection and decompression of the spinal canal were performed. He underwent instrumentation and fusion procedures to prevent spinal instability. Conclusion: The main purpose of the treatment is gross total resection of the thymic carcinoma. However, adjuvant methods such as radiotherapy and chemotherapy should be added to the treatment protocol in patients who have higher stage diseases or those in whom total tumor resection cannot be achieved. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Ultra-widefield imaing in age-related macular degeneration(Gazi Eye Foundation, 2021) Kurt, Rengin Aslihan; Mestanoglu, Mert; Kurt, Rengin Aslihan, Ophthalmology Department Istanbul, Başkent Üniversitesi, Ankara, Turkey, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Mestanoglu, Mert, Ophthalmology Department Istanbul, Başkent Üniversitesi, Ankara, Turkey, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, TurkeyAge related macular degeneration accounts for 8.7% of all blindness worldwide and is the major cause of blindness in the developed world. The projected number of people with the disease will be 288 million in 2040, deserving the effort for early detection and treatment. In many different studies the peripheral retinal changes had been demonstrated clinically and pathologically in age related macular degeneration. Retinal imaging had a huge development within the last century and now it is easier to detect and document the peripheral retinal changes. Ultra-widefi eld imaging with many different commercially available devices will be one of the most important tools of retinal imaging. In this review our aim is to discuss the diagnostic, therapeutic and predictive value of ultra-widefi eld imaging in age related macular degeneration. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only An autopsy series: Lightning-related deaths in van and hakkâri provinces, Turkey(University of the West Indies, 2021) Hekimoglu, Yavuz; Aşırdizer, Mahmut; Demir, Ugur; Gur, A.; Etli, Yasin; Gumus, Orhan; Kartal, Erhan; Hekimoglu, Yavuz, Department of Forensic Medicine, Tekirdağ Namık Kemal Üniversitesi, Tekirdag, Turkey; Aşırdizer, Mahmut, Department of Forensic Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Demir, Ugur, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; Gur, A., Hakkari Forensic Medicine Branch Directorate of Forensic Medicine Institute, Hakkari, Turkey; Etli, Yasin, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; Gumus, Orhan, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; Kartal, Erhan, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, TurkeyObjective: To report the largest series of lightning-related deaths in Turkey, to review the literature on this subject, and to identify similarities and differences between the autopsy findings in this study and the information available in literature. Methods: In this study, autopsy reports and crime scene investigation data on 11 lightningrelated fatalities that occurred in the Van and Hakkâri Provinces, Turkey, from January 1, 2011 to December 31, 2015 were retrospectively reviewed. Results: Of the 1699 fatalities, 11 (2.53%) evaluated by medico-legal autopsy in the Van and Hakkâri Province in a 5-year period died from lightning strikes. Of these cases, 10 (90.1%) were males and 1 (9.9%) was female (p < 0.05). All cases were in the 11 to 33 years age group. All cases were injured outdoors. Conclusion: We concluded that deaths due to lightning strikes are relatively rare in Turkey, and may be reduced with precautions such as avoiding staying under trees or in the vicinity of high towers, refraining from touching metal objects, avoiding lying on the ground, leaning on walls, and crouching outdoors. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Hypertension in Kidney Transplant Recipients: Where Are We Today?(Springer, 2021) Ari, Elif Merve; Fici, Francesco; Robles Perez-Monteoliva, Nicolás Roberto; Ari, Elif Merve, Department of Nephrology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Fici, Francesco, Cardiovascular Risk Chair, Universidad de Salamanca, Salamanca, Spain; Robles Perez-Monteoliva, Nicolás Roberto, Department of Nephrology, Hospital Clínico Universitario de Salamanca, Salamanca, SpainPurpose of Review: Cardiovascular disease is the leading cause of death and allograft loss among kidney transplant recipients, and hypertension is an independent risk factor for cardiovascular morbidity of this patient population. The etiology of hypertension is multifactorial, including pre-transplant volume overload, post-transplant recipient and donor-associated variables, and transplant-specific causes (immunosuppressive medications, allograft dysfunction and surgical complications such as transplant artery stenosis). Recent Findings: No randomized controlled trials have assessed the optimal blood pressure targets and explored the best antihypertensive regimen for kidney transplant recipients. According to the large observational studies, it is reasonable to achieve a blood pressure goal of equal to or less than 130/80 mmHg in the long-term follow-up for minimizing the cardiovascular morbidity. The selection of antihypertensive agents should be based on the patient’s co-morbidities, however, the initial choice could be calcium channel blockers especially in the first few months of transplantation. In patients with cardiovascular indications of renin-angiotensin-aldosterone system inhibition, given the well-described benefits in diabetic and proteinuric patients, it is reasonable to consider the use of renin-angiotensin-aldosterone system inhibitors. Summary: There is a need for future prospective trials in the transplant population to define optimal blood pressure goals and therapies. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Virtual articulators, virtual occlusal records and virtual patients in dentistry(Ondokuz Mayis Universitesi, 2021) Özdemir, Gökhan; Albayrak, Berkman; Yüzbaşıoğlu, Emir; Us, Yeşim Olçer; Özdemir, Gökhan, Department of Prosthodontics, Bahçeşehir Üniversitesi, Istanbul, Turkey; Albayrak, Berkman, Department of Prosthodontics, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yüzbaşıoğlu, Emir, Department of Prosthodontics, Bahçeşehir Üniversitesi, Istanbul, Turkey, Department of Dentistry, BAU International University, Batumi, Georgia; Us, Yeşim Olçer, Department of Prosthodontics, Bahçeşehir Üniversitesi, Istanbul, TurkeyDigital technology is broadly used in almost every part of medicine. As tools of digital technology, augmented reality and virtual reality have been adopted in all disciplines of dentistry and dental education. In particular, virtual articulators have allowed for a full analysis of occlusion with dental models that can simulate all mandibular movements in static and dynamic positions. When combined with additional software, virtual articulators can also enhance education and practice, allow for quicker and more precise individualized diagnoses and enable discussions of dental treatment planning options with patients during their first appointment. This article reviews the requirements for virtual articulators and occlusal recordings and assesses their advantages and disadvantages in various aspects. © 2021 Elsevier B.V., All rights reserved.