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Publication Metadata only Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation(Bentham Science Publishers P.O. Box 294 Bussum 1400 AG, 2020) Baǧdaş, Deniz; Gül, Zülfiye; Meade, Julie A.; Cam, Betul; Çinkılıç, Nilüfer; Gürün, Mine Sibel; Baǧdaş, Deniz, Yale School of Medicine, New Haven, United States, Yale School of Medicine, New Haven, United States; Gül, Zülfiye, Department of Pharmacology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Meade, Julie A., Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, United States; Cam, Betul, Department of Physiology, Bursa Uludağ Üniversitesi, Bursa, Turkey; Çinkılıç, Nilüfer, Department of Biology, Bursa Uludağ Üniversitesi, Bursa, Turkey; Gürün, Mine Sibel, Department of Pharmacology, Bursa Uludağ Üniversitesi, Bursa, TurkeyBackground: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Successful WATCHMAN Device Implantation in a Patient with IVC Filter Thrombosis and Iliac Vein Occlusions(Elsevier Inc. [email protected], 2020) Okutucu, Sercan; Ates, Ismail; Marmagkiolis, Konstantinos; Kose, Gulcan; Iliescu, Cesar Angi; Ci̧lingiroǧlu, Mehmet; Okutucu, Sercan, Department of Cardiology, Ankara Numune Hospital, Ankara, Turkey; Ates, Ismail, Department of Cardiology, Medical Park Hospitals, Antalya, Turkey; Marmagkiolis, Konstantinos, Florida Hospital, Orlando, United States; Kose, Gulcan, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Iliescu, Cesar Angi, UT Houston, The University of Texas MD Anderson Cancer Center, Houston, United States; Ci̧lingiroǧlu, Mehmet, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey, Arkansas Heart Hospital, Little Rock, United StatesPercutaneous left atrial appendage occlusion has been shown to be a safe and cost-effective treatment for stroke prevention in patients with nonvalvular atrial fibrillation with increased stroke and bleeding risk. Venous system might be occluded from prior procedures or have structural abnormalities. Herein, we present a successful WATCHMAN device implantation in a patient with inferior vena cava filter thrombosis and iliac vein occlusions. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Automated Insulin Delivery in Children with Type 1 Diabetes(W.B. Saunders, 2020) Cengiz, Eda; Cengiz, Eda, Yale School of Medicine, New Haven, United States, Bahçeşehir Üniversitesi, Istanbul, TurkeyThe advent of insulin pump therapy marked an important milestone in diabetes treatment in the past few decades and has become the tipping point for the development of automated insulin delivery systems (AID). Standalone insulin pump systems have evolved over the course of years and have been replaced by modern high-technology insulin pumps with continuous glucose monitor interface allowing real-time insulin dose adjustment to optimize treatment. This review summarizes evidence from AID studies conducted in children with type 1 diabetes and discusses the outlook for future generation AID systems from a pediatric treatment perspective. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only The pros and cons of digital health communication tools in neurosurgery: a systematic review of literature(Springer, 2020) Nanah, Abdelrahman; Bayoumi, Ahmed B.; Nanah, Abdelrahman, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bayoumi, Ahmed B., Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, TurkeyEffective communication is critical in healthcare facilitation. Our aim is to illustrate the impact of digital communication tools in the field of neurosurgery based on the cumulative recently published reports to show an evidence-based review of both benefits and limitations. We performed a systematic review of records published from January 2003 to March 2018. A specific set of keywords such as digital and communication were used on PubMed database to conduct a thorough online search. 13 articles, out of 52, were comprehensively studied after complying with our inclusion and exclusion criteria. Many of the reviewed studies reported several applications of digital health communication tools in neurosurgery including 46% (6/13) in the Emergency Room and 23% (3/13) in the Operating Room. 38.5% (5/13) were applied in teaching hospitals. Reviewed studies were divided into two groups according to their applications (interventional (3/13) and non-interventional (10/13)). In the Emergency Room, digital health tools facilitated timely diagnosis and management, while in the operating room it permitted revolutionary robotic surgery. It showed potential for no-risk learning at academic institutions. While the fruitful impacts were convincing of the digital communication tools’ ability to enhance healthcare in neurosurgery, proper adherence to regulations against data loss and theft, two potential complications of digital tool misuse, must be maintained. Additionally, both time efficiency and the necessity of waiting for better implementation of communication tools proved to be obstacles to consistent digital tool integration. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Spine Metastasis of Thymic Carcinoma in a Pediatric Patient: A Case Report and Comprehensive Literature Review(S. Karger AG, 2020) Oktay, Kadir; Güzel, Ebru; Baykara, Okay; Akbaba, Mevlana; Sarí, Ibrahim; Güzel, Aslan I.; Oktay, Kadir, Department of Neurosurgery, Çukurova Üniversitesi Tip Fakültesi, Adana, Turkey; Güzel, Ebru, Department of Radiology, Medical Park Hospital, Bursa, Turkey; Baykara, Okay, Department of Neurosurgery, Çukurova Üniversitesi Tip Fakültesi, Adana, Turkey; Akbaba, Mevlana, Department of Neurosurgery, Çukurova Üniversitesi Tip Fakültesi, Adana, Turkey; Sarí, Ibrahim, Department of Pathology, Patomer Pathology Laboratory, Gaziantep, Turkey; Güzel, Aslan I., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyIntroduction: Thymic carcinoma metastases of the spinal column are very rare, especially in pediatric patients. To our knowledge, this is the first such pediatric case in the literature. Case Presentation: We report the case of a 14-year-old male patient with T12 and L1 metastases of thymic carcinoma. He had history of thymectomy and intrathoracic tumor resection 7 months previously. The patient's neurological condition deteriorated, therefore, tumor resection and decompression of the spinal canal were performed. He underwent instrumentation and fusion procedures to prevent spinal instability. Conclusion: The main purpose of the treatment is gross total resection of the thymic carcinoma. However, adjuvant methods such as radiotherapy and chemotherapy should be added to the treatment protocol in patients who have higher stage diseases or those in whom total tumor resection cannot be achieved. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Hypertension in Kidney Transplant Recipients: Where Are We Today?(Springer, 2021) Ari, Elif Merve; Fici, Francesco; Robles Perez-Monteoliva, Nicolás Roberto; Ari, Elif Merve, Department of Nephrology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Fici, Francesco, Cardiovascular Risk Chair, Universidad de Salamanca, Salamanca, Spain; Robles Perez-Monteoliva, Nicolás Roberto, Department of Nephrology, Hospital Clínico Universitario de Salamanca, Salamanca, SpainPurpose of Review: Cardiovascular disease is the leading cause of death and allograft loss among kidney transplant recipients, and hypertension is an independent risk factor for cardiovascular morbidity of this patient population. The etiology of hypertension is multifactorial, including pre-transplant volume overload, post-transplant recipient and donor-associated variables, and transplant-specific causes (immunosuppressive medications, allograft dysfunction and surgical complications such as transplant artery stenosis). Recent Findings: No randomized controlled trials have assessed the optimal blood pressure targets and explored the best antihypertensive regimen for kidney transplant recipients. According to the large observational studies, it is reasonable to achieve a blood pressure goal of equal to or less than 130/80 mmHg in the long-term follow-up for minimizing the cardiovascular morbidity. The selection of antihypertensive agents should be based on the patient’s co-morbidities, however, the initial choice could be calcium channel blockers especially in the first few months of transplantation. In patients with cardiovascular indications of renin-angiotensin-aldosterone system inhibition, given the well-described benefits in diabetic and proteinuric patients, it is reasonable to consider the use of renin-angiotensin-aldosterone system inhibitors. Summary: There is a need for future prospective trials in the transplant population to define optimal blood pressure goals and therapies. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Paralytic strabismus in turkish children examined at three tertiary care services: A retrospective cohort study(Slack Incorporated, 2021) Usta, Gülşah; Karaca, Umut; Keskinbora, Kadircan H.; Gönen, Tansu; Usta, Gülşah, Department of Ophthalmology, Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey; Karaca, Umut, Department of Ophthalmology, Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey; Keskinbora, Kadircan H., Department of Medical Ethics and History of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Gönen, Tansu, Department of Ophthalmology, Tekirdağ Namık Kemal Üniversitesi, Tekirdag, TurkeyPurpose: To assess the etiology and distribution of pediatric ocular motor nerve palsy manifesting as paralytic strabismus. Methods: The authors retrospectively examined the medical files of patients younger than 18 years who were suspected to have strabismus between January 1999 and June 2012 in three Turkish clinics and followed up for at least 6 months. Patients with paralytic strabismus were stratified according to age, sex, affected cranial nerve, and etiology (congenital, traumatic, neoplastic, post-viral, vascular, undetermined, or other), and compared the proportions between groups. Results: Paralytic strabismus was observed in 33 of 1,263 patients (2.6%), with a mean age of 5.9 ± 4.4 years (range: 6 months to 16 years). Seventeen patients (51.5%) were boys and 16 (48.5%) were girls. Twelve patients (36.4%) had congenital paralytic strabismus, and 21 patients (63.6%) had acquired strabismus. The most prevalent cause of acquired paralytic strabismus was trauma in 11 patients (52.4%), undetermined in 6 patients (28.6%), post-viral cranial nerve paralysis in 3 patients (14.3%), and a history of hydrocephalus in 1 patient (9.1%). The fourth cranial nerve was the most frequently affected (45.5% [15 of 33]), followed by the sixth (39.4% [13 of 33]) and the third (15.2% [5 of 33]). Conclusions: Evaluating the incidence and etiology of paralytic strabismus in children in a clinical setting may improve disease management and reduce unnecessary invasive examinations. This study will assist clinicians in understanding the clinic-based distribution of pediatric paralytic strabismus. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Could gas-filled pseudocyst mimick extruded disc herniation?(Churchill Livingstone, 2021) Ekşi̇, Murat Şakir; Ece Özcan-Ekşi, Emel; Orhun, Omer; Akkaş, Alper; Harun Yaşar, Ahmet; Zarbizada, Maftun; Canbolat, Cagri; Güdük, Mustafa; Bozkurt, Baran; İmre Usseli, Murat; Ekşi̇, Murat Şakir, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Ece Özcan-Ekşi, Emel, Department of Physical Medicine and Rehabilitation, Bahçeşehir Üniversitesi, Istanbul, Turkey; Orhun, Omer, School of Medicine, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Akkaş, Alper, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Harun Yaşar, Ahmet, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Zarbizada, Maftun, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Canbolat, Cagri, Neurosurgery Clinic, Memorial Hizmet Hospital, Istanbul, Turkey; Güdük, Mustafa, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Bozkurt, Baran, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; İmre Usseli, Murat, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, TurkeyThere are case reports and small case series in the literature reporting gas-filled pseudocysts (GFP). However, a systematic review presenting overall view of the disease and its management is still lacking. In the present study, we aimed to make a systematic review of GFP cases, and present an exemplary case of ours. Our second aim was to discuss current theories for pathogenesis of GFP. A systematic review of GFP was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Two large-scaled data search engines were used. A total of 53 articles were retrieved from the literature and presented with an exemplary case of ours. Mean age of the historical cohort was 59.47 years. There were 66 male (54.1%) and 56 female (45.9%) patients. The most prevalent clinical presentation was radicular sign/symptom in lower limbs with (29.1%) or without low back pain (LBP) (67%). Gas-filled pseudocyst has most commonly been diagnosed at the lower lumbar spine (L4-L5, 45.3%, L5-S1, 37.7%). Surgery was the treatment of choice in most of the patients (80%). In the whole cohort, 79.1% of the patients had complete recovery. Gas-filled pseudocysts are rarely observed in daily practice. They present mostly in men at the age of 60s. Precise differential diagnosis determination using appropriate imaging would help clinicians treat the patients properly. Gas-filled pseudocysts should be treated similarly to other spinal pathologies causing nerve root compression. © 2022 Elsevier B.V., All rights reserved.Publication Metadata only Interventional Strategies in Cancer-induced Cardiovascular Disease(Springer, 2021) Pushparaji, Bala; Donisan, Teodora; Bălănescu, D. V.; Palaskas, Nicolas L.; Kim, Peter Y.; Lopez-Mattei, Juan Carlos; Ci̧lingiroǧlu, Mehmet; Hassan, Saamir A.; Boudoulas, Konstantinos Dean; Marmagkiolis, Konstantinos; Pushparaji, Bala, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States, Department of Internal Medicine, Maimonides Medical Center, New York, United States; Donisan, Teodora, Department of Internal Medicine, Beaumont Hospital, Royal Oak, United States; Bălănescu, D. V., Department of Internal Medicine, Beaumont Hospital, Royal Oak, United States; Palaskas, Nicolas L., Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Kim, Peter Y., Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Lopez-Mattei, Juan Carlos, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Ci̧lingiroǧlu, Mehmet, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Hassan, Saamir A., Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States; Boudoulas, Konstantinos Dean, The Ohio State University Wexner Medical Center, Columbus, United States; Marmagkiolis, Konstantinos, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, United States, Northside Hospital, St Petersburg, United StatesPurpose of Review: To highlight the range of illnesses and procedures that the interventional onco-cardiologists face in their daily practice, along with the recent additions to anti-cancer therapies and their related cardiotoxicity. Recent findings: Immune checkpoint inhibitors (ICI) are not devoid of cardiotoxicity as thought earlier and lead to an increased incidence of myocarditis. Transcatheter valve replacement has been shown to be a safer alternative to surgical replacement in cancer patients. Summary: Interventional onco-cardiology is a novel field that addresses cardiovascular diseases in the setting of cancer. Traditionally excluding cancer patients from clinical trials has led to a dearth of information needed to tackle cardiac conditions like Takotsubo cardiomyopathy, malignant pericardial effusions, and radiation-induced vascular diseases encountered either exclusively or predominantly in this high-risk population. This review discusses the various treatment options available in the interventional armamentarium with a particular focus on ICI—myocarditis and transcatheter aortic valve replacement in cancer patients. © 2022 Elsevier B.V., All rights reserved.Publication Metadata only Effects of high intensity interval training and sprint interval training in patients with asthma: a systematic review(Taylor and Francis Ltd., 2022) Ertürk, Gamze; Günday, Çiçek; Evrendilek, Halenur; Sağır, Kübra; Aslan, Gökşen Kuran; Ertürk, Gamze, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkey, Department of Physiotherapy and Rehabilitation, T.C. Istanbul Kültür Üniversitesi, Istanbul, Turkey; Günday, Çiçek, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkey, Department of Physiotherapy and Rehabilitation, Bahçeşehir Üniversitesi, Istanbul, Turkey; Evrendilek, Halenur, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkey, Department of Physiotherapy and Rehabilitation, T.C. Istanbul Kültür Üniversitesi, Istanbul, Turkey; Sağır, Kübra, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkey, Department of Physiotherapy and Rehabilitation, İstinye Üniversitesi, Istanbul, Turkey; Aslan, Gökşen Kuran, Department of Physiotherapy and Rehabilitation, Istanbul University-Cerrahpasa, Istanbul, TurkeyObjective: The aim of this study is to review the effects of high-intensity interval training (HIIT)/sprint interval training (SIT) on asthma symptoms, cardiorespiratory functions, and other variables among asthmatic patients. Data sources: Randomized controlled trials published between January 2000 and January 2021 were searched in PubMed/MEDLINE, Web of Science, and Cochrane Library databases. Study selections: Following pre-specified inclusion criteria, this review included 7 randomized controlled studies that compare HIIT/SIT as an intervention with any other intervention and/or control group. Results: Of the included studies only four reported the chronic phase effects of the HIIT/SIT protocols. HIIT and SIT protocols applied in studies differ. HIIT improved forced expiratory volume in 1 s (FEV1) in the acute phase and maximal oxygen consumption (VO2max) in the chronic phase in the asthmatic patients (p < 0.05). Conclusion: To our knowledge, our systematic review is the first study evaluating the effects of HIIT/SIT protocols on asthma patients. HIIT/SIT protocols have beneficial effects on asthma patients. In order to better understand the results of these training procedures, studies that will be designed with high methodology are needed. © 2022 Elsevier B.V., All rights reserved.