Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Open Access Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy(Elsevier B.V., 2021) Yetkin-Arik, Bahar; Kastelein, Arnoud W.; Klaassen, Ingeborg; Jansen, Charlotte H.J.R.; Latul, Yani P.; Vittori, Miloš; Biri, Aydan Asyali; Kahraman, Korhan; Griffioen, Arjan W.; Amant, Frédéric C.H.; Yetkin-Arik, Bahar, Department of Ophthalmology, Universiteit van Amsterdam, Amsterdam, Netherlands, Department of Medical Biology, Universiteit van Amsterdam, Amsterdam, Netherlands; Kastelein, Arnoud W., Department of Obstetrics and Gynecology, Universiteit van Amsterdam, Amsterdam, Netherlands; Klaassen, Ingeborg, Department of Ophthalmology, Universiteit van Amsterdam, Amsterdam, Netherlands, Department of Medical Biology, Universiteit van Amsterdam, Amsterdam, Netherlands; Jansen, Charlotte H.J.R., Department of Obstetrics and Gynecology, Universiteit van Amsterdam, Amsterdam, Netherlands; Latul, Yani P., Department of Obstetrics and Gynecology, Universiteit van Amsterdam, Amsterdam, Netherlands; Vittori, Miloš, Biotechnical Faculty, Univerza v Ljubljani, Ljubljana, Slovenia; Biri, Aydan Asyali, Department of Obstetrics and Gynecology, Ankara Numune Hospital, Ankara, Turkey; Kahraman, Korhan, Department of Obstetrics and Gynecology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Griffioen, Arjan W., Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam, Netherlands; Amant, Frédéric C.H., Department of Oncology, KU Leuven, Leuven, Belgium, Center for Gynaecologic Oncology, Amsterdam, Netherlands, Center for Gynaecologic Oncology Amsterdam, The Netherlands Cancer Institute, Amsterdam, Netherlands, Center for Gynaecologic Oncology Amsterdam, Amsterdam UMC - University of Amsterdam, Amsterdam, NetherlandsAngiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development of anti-angiogenesis therapy in gynecological cancers and improvement of its efficacy have been a major focus of fundamental and clinical research. However, survival benefits of current anti-angiogenic agents, such as bevacizumab, in patients with gynecological cancer, are modest. Therefore, a better understanding of angiogenesis and the tumor microenvironment in gynecological cancers is urgently needed to develop more effective anti-angiogenic therapies, either or not in combination with other therapeutic approaches. We describe the molecular aspects of (tumor) blood vessel formation and the tumor microenvironment and provide an extensive clinical overview of current anti-angiogenic therapies for gynecological cancers. We discuss the different phenotypes of angiogenic endothelial cells as potential therapeutic targets, strategies aimed at intervention in their metabolism, and approaches targeting their (inflammatory) tumor microenvironment. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only An autopsy series: Lightning-related deaths in van and hakkâri provinces, Turkey(University of the West Indies, 2021) Hekimoglu, Yavuz; Aşırdizer, Mahmut; Demir, Ugur; Gur, A.; Etli, Yasin; Gumus, Orhan; Kartal, Erhan; Hekimoglu, Yavuz, Department of Forensic Medicine, Tekirdağ Namık Kemal Üniversitesi, Tekirdag, Turkey; Aşırdizer, Mahmut, Department of Forensic Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Demir, Ugur, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; Gur, A., Hakkari Forensic Medicine Branch Directorate of Forensic Medicine Institute, Hakkari, Turkey; Etli, Yasin, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; Gumus, Orhan, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; Kartal, Erhan, Department of Forensic Medicine, Van Yüzüncü Yıl Üniversitesi, Van, TurkeyObjective: To report the largest series of lightning-related deaths in Turkey, to review the literature on this subject, and to identify similarities and differences between the autopsy findings in this study and the information available in literature. Methods: In this study, autopsy reports and crime scene investigation data on 11 lightningrelated fatalities that occurred in the Van and Hakkâri Provinces, Turkey, from January 1, 2011 to December 31, 2015 were retrospectively reviewed. Results: Of the 1699 fatalities, 11 (2.53%) evaluated by medico-legal autopsy in the Van and Hakkâri Province in a 5-year period died from lightning strikes. Of these cases, 10 (90.1%) were males and 1 (9.9%) was female (p < 0.05). All cases were in the 11 to 33 years age group. All cases were injured outdoors. Conclusion: We concluded that deaths due to lightning strikes are relatively rare in Turkey, and may be reduced with precautions such as avoiding staying under trees or in the vicinity of high towers, refraining from touching metal objects, avoiding lying on the ground, leaning on walls, and crouching outdoors. © 2021 Elsevier B.V., All rights reserved.Publication Open Access Application of machine learning to improve dairy farm management: A systematic literature review(Elsevier B.V., 2021) Slob, Naftali; Catal, Cagatay; Kassahun, Ayalew; Slob, Naftali, Information Technology Group, Wageningen University & Research, Wageningen, Netherlands; Catal, Cagatay, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kassahun, Ayalew, Information Technology Group, Wageningen University & Research, Wageningen, NetherlandsIn recent years, several researchers and practitioners applied machine learning algorithms in the dairy farm context and discussed several solutions to predict various variables of interest, most of which were related to incipient diseases. The objective of this article is to identify, assess, and synthesize the papers that discuss the application of machine learning in the dairy farm management context. Using a systematic literature review (SLR) protocol, we retrieved 427 papers, of which 38 papers were determined as primary studies and thus were analysed in detail. More than half of the papers (55 %) addressed disease detection. The other two categories of problems addressed were milk production and milk quality. Seventy-one independent variables were identified and grouped into seven categories. The two prominent categories that were used in more than half of the papers were milking parameters and milk properties. The other categories of independent variables were milk content, pregnancy/calving information, cow characteristics, lactation, and farm characteristics. Twenty-three algorithms were identified, which we grouped into four categories. Decision tree-based algorithms are by far the most used followed by artificial neural network-based algorithms. Regression-based algorithms and other algorithms that do not belong to the previous categories were used in 13 papers. Twenty-three evaluation parameters were identified of which 7 were used 3 or more times. The three evaluation parameters that were used by more than half of the papers are sensitivity, specificity, RMSE. The challenges most encountered were feature selection and unbalanced data and together with problem size, overfitting/estimating, and parameter tuning account for three-quarters of the challenges identified. To the best of our knowledge, this is the first SLR study on the use of machine learning to improve dairy farm management, and to this end, this study will be valuable not only for researchers but also practitioners in dairy farms. © 2021 Elsevier B.V., All rights reserved.Publication Open Access Oat intake and risk of type 2 diabetes, cardiovascular disease and all-cause mortality: A systematic review and meta-analysis(MDPI, 2021) Wehrli, Faina; Taneri, Petek Eylul; Bano, Arjola; Bally, Lia; Blekkenhorst, Lauren C.; Bussler, Weston W.; Metzger, Brandon T.; Minder, Beatrice; Glisic, Marija; Muka, Taulant; Wehrli, Faina, Institute of Social and Preventive Medicine, Bern, Switzerland; Taneri, Petek Eylul, Institute of Social and Preventive Medicine, Bern, Switzerland, Department Istanbul, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bano, Arjola, Institute of Social and Preventive Medicine, Bern, Switzerland, University Hospital Bern, Bern, Switzerland; Bally, Lia, Department of Diabetes, University of Bern, Bern, Switzerland; Blekkenhorst, Lauren C., School of Medical and Health Sciences, Edith Cowan University, Perth, Australia, The University of Western Australia, Perth, Australia; Bussler, Weston W., Standard Process Nutrition Innovation Center, Kannapolis, United States; Metzger, Brandon T., Standard Process Nutrition Innovation Center, Kannapolis, United States; Minder, Beatrice, Public Health & Primary Care Library, University of Bern, Bern, Switzerland; Glisic, Marija, Institute of Social and Preventive Medicine, Bern, Switzerland; Muka, Taulant, Institute of Social and Preventive Medicine, Bern, SwitzerlandCardiovascular disease (CVD) and type 2 diabetes (T2D) remain the top disease and mortality burdens worldwide. Oats have been shown to benefit cardiovascular health and improve insulin resistance. However, the evidence linking oat consumption with CVD, T2D and all-cause mortality remains inconclusive. We conducted a comprehensive systematic review and meta-analysis of prospective cohort studies to evaluate the associations between oat consumption and risks of T2D, CVD and all-cause mortality in the general population. Five electronic databases were searched until September, 2020. Study specific relative risks (RR) were meta-analyzed using random effect models. Of 4686 relevant references, we included 9 articles, based on 8 unique studies and 471,157 participants. Comparing oat consumers versus non-consumers, RRs were 0.86 (95% CI 0.72– 1.03) for T2D incidence and 0.73 (95% CI 0.5–1.07) for combined CVD incidence. Comparing participants with highest versus lowest oat intake, RRs were 0.78 (95% CI 0.74–0.82) for T2D incidence, 0.81 (95% CI 0.61–1.08) for CHD incidence and 0.79 (95% CI 0.59–1.07) for stroke. For all-cause mortality one study based on three cohorts found RR for men and women were 0.76 (95% CI 0.69–0.85) and 0.78 (95% CI 0.70–0.87), respectively. Most studies (n = 6) were of fair to good quality. This meta-analysis suggests that consumption of oat could reduce the risk for T2D and all-cause mortality, while no significant association was found for CVD. Future studies should address a lack of standardized methods in assessing overall oat intake and type of oat products, and investigate a dose-dependent response of oat products on cardiometabolic outcomes in order to introduce oat as preventive and treatment options for the public. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Paralytic strabismus in turkish children examined at three tertiary care services: A retrospective cohort study(Slack Incorporated, 2021) Usta, Gülşah; Karaca, Umut; Keskinbora, Kadircan H.; Gönen, Tansu; Usta, Gülşah, Department of Ophthalmology, Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey; Karaca, Umut, Department of Ophthalmology, Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey; Keskinbora, Kadircan H., Department of Medical Ethics and History of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Gönen, Tansu, Department of Ophthalmology, Tekirdağ Namık Kemal Üniversitesi, Tekirdag, TurkeyPurpose: To assess the etiology and distribution of pediatric ocular motor nerve palsy manifesting as paralytic strabismus. Methods: The authors retrospectively examined the medical files of patients younger than 18 years who were suspected to have strabismus between January 1999 and June 2012 in three Turkish clinics and followed up for at least 6 months. Patients with paralytic strabismus were stratified according to age, sex, affected cranial nerve, and etiology (congenital, traumatic, neoplastic, post-viral, vascular, undetermined, or other), and compared the proportions between groups. Results: Paralytic strabismus was observed in 33 of 1,263 patients (2.6%), with a mean age of 5.9 ± 4.4 years (range: 6 months to 16 years). Seventeen patients (51.5%) were boys and 16 (48.5%) were girls. Twelve patients (36.4%) had congenital paralytic strabismus, and 21 patients (63.6%) had acquired strabismus. The most prevalent cause of acquired paralytic strabismus was trauma in 11 patients (52.4%), undetermined in 6 patients (28.6%), post-viral cranial nerve paralysis in 3 patients (14.3%), and a history of hydrocephalus in 1 patient (9.1%). The fourth cranial nerve was the most frequently affected (45.5% [15 of 33]), followed by the sixth (39.4% [13 of 33]) and the third (15.2% [5 of 33]). Conclusions: Evaluating the incidence and etiology of paralytic strabismus in children in a clinical setting may improve disease management and reduce unnecessary invasive examinations. This study will assist clinicians in understanding the clinic-based distribution of pediatric paralytic strabismus. © 2021 Elsevier B.V., All rights reserved.Publication Open Access COVID-19-associated mucormycosis: Case report and systematic review(Elsevier Inc., 2021) Dilek, Ahmet; Özaras, Reŝat; Özkaya, Şevket; Sünbül, Mustafa; Sen, Elif Itir; Leblebicioglu, Hakan; Dilek, Ahmet, Intensive Care Unit, Samsun Medicalpark Hospital, Samsun, Turkey, İstinye Üniversitesi, Istanbul, Turkey; Özaras, Reŝat, Department of Infectious Diseases, Medilife Health Group, Istanbul, Turkey; Özkaya, Şevket, Department of Pulmonology, Samsun Medicalpark Hospital, Samsun, Turkey, Department of Pulmonology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sünbül, Mustafa, Department of Infectious Diseases, Samsun Liv Hospital, Samsun, Turkey; Sen, Elif Itir, Bahçeşehir Üniversitesi, Istanbul, Turkey; Leblebicioglu, Hakan, Department of Infectious Diseases, Samsun Medicalpark Hospital, Samsun, TurkeyBackground: Increasing number of patients with COVID-19-associated mucormycosis have been reported, especially from India recently. We have described a patient with COVID-19-associated mucormycosis and, searched and analyzed current medical literature to delineate the characteristics of COVID-19-associated mucormycosis. Method: We reported a patient developed mucormycosis during post-COVID period. We searched literature to describe the incidence, clinical features, and outcomes of COVID-19-associated mucormycosis. Demographic features, risk factors, clinical features, diagnostic methods, treatment and outcome were analyzed. Results: We describe a 54-year-old male, hospitalized due to severe COVID-19 pneumonia. He was given long-term, high doses of systemic steroids. He developed maxillo-fascial mucormycosis and died of sepsis. Our literature search found 30 publications describing 100 patients including present case report. The majority (n = 68) were reported from India. 76% were male. The most commonly seen risk factors were corticosteroid use (90.5%), diabetes (79%), and hypertension (34%). Also, excessive use of broad-spectrum antibiotics were noted in cases. Most frequent involvements were rhino-orbital (50%), followed by rhino-sinusal (17%), and rhino-orbito-cerebral (15%). Death was reported as 33 out of 99 patients (33,3%). Conclusions: Steroid use, diabetes, environmental conditions, excessive use of antibiotics, and hypoxia are main risk factors. Despite medical and surgical treatment, mortality rate is high. A multidisciplinary approach is essential to improve the conditions facilitating the emergence of COVID-19-associated mucormycosis. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Could gas-filled pseudocyst mimick extruded disc herniation?(Churchill Livingstone, 2021) Ekşi̇, Murat Şakir; Ece Özcan-Ekşi, Emel; Orhun, Omer; Akkaş, Alper; Harun Yaşar, Ahmet; Zarbizada, Maftun; Canbolat, Cagri; Güdük, Mustafa; Bozkurt, Baran; İmre Usseli, Murat; Ekşi̇, Murat Şakir, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Ece Özcan-Ekşi, Emel, Department of Physical Medicine and Rehabilitation, Bahçeşehir Üniversitesi, Istanbul, Turkey; Orhun, Omer, School of Medicine, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Akkaş, Alper, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Harun Yaşar, Ahmet, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Zarbizada, Maftun, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Canbolat, Cagri, Neurosurgery Clinic, Memorial Hizmet Hospital, Istanbul, Turkey; Güdük, Mustafa, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; Bozkurt, Baran, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkey; İmre Usseli, Murat, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, TurkeyThere are case reports and small case series in the literature reporting gas-filled pseudocysts (GFP). However, a systematic review presenting overall view of the disease and its management is still lacking. In the present study, we aimed to make a systematic review of GFP cases, and present an exemplary case of ours. Our second aim was to discuss current theories for pathogenesis of GFP. A systematic review of GFP was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Two large-scaled data search engines were used. A total of 53 articles were retrieved from the literature and presented with an exemplary case of ours. Mean age of the historical cohort was 59.47 years. There were 66 male (54.1%) and 56 female (45.9%) patients. The most prevalent clinical presentation was radicular sign/symptom in lower limbs with (29.1%) or without low back pain (LBP) (67%). Gas-filled pseudocyst has most commonly been diagnosed at the lower lumbar spine (L4-L5, 45.3%, L5-S1, 37.7%). Surgery was the treatment of choice in most of the patients (80%). In the whole cohort, 79.1% of the patients had complete recovery. Gas-filled pseudocysts are rarely observed in daily practice. They present mostly in men at the age of 60s. Precise differential diagnosis determination using appropriate imaging would help clinicians treat the patients properly. Gas-filled pseudocysts should be treated similarly to other spinal pathologies causing nerve root compression. © 2022 Elsevier B.V., All rights reserved.Publication Open Access An Update on the Status of Vaccine Development for SARS-CoV-2 Including Variants. Practical Considerations for COVID-19 Special Populations(SAGE Publications Inc., 2022) Kantarcioglu, Bulent; Iqbal, Omer M.; Lewis, Joseph; Carter, Charles A.; Singh, Meharvan; Lievano, Fabio A.; Ligocki, Mark A.; Jeske, Walter P.; Adıgüzel, Cafer; Gerotziafas, Grigorios T.; Kantarcioglu, Bulent, Health Sciences Division, Loyola University Chicago, Chicago, United States; Iqbal, Omer M., Health Sciences Division, Loyola University Chicago, Chicago, United States; Lewis, Joseph, Health Sciences Division, Loyola University Chicago, Chicago, United States; Carter, Charles A., Campbell University, Buies Creek, United States; Singh, Meharvan, Stritch School of Medicine, Maywood, United States; Lievano, Fabio A., AbbVie, North Chicago, United States; Ligocki, Mark A., Ligocki Dental Group, Oak Brook, United States; Jeske, Walter P., Health Sciences Division, Loyola University Chicago, Chicago, United States; Adıgüzel, Cafer, Bahçeşehir Üniversitesi, Istanbul, Turkey; Gerotziafas, Grigorios T., Thrombosis Center, Sorbonne Université, Paris, FranceThe progress in the development of various vaccine platforms against SARS-CoV-2 have been rather remarkable owing to advancement in molecular and biologic sciences. Most of the current vaccines and those in development focus on targeting the viral spike proteins by generating antibodies of varying spectrum. These vaccines represent a variety of platforms including whole virus vaccines, viral vector vaccines, nucleic acid vaccines representing RNA, DNA, and their hybrid forms. The therapeutic efficacy of these vaccines varies owing to their pharmacodynamic individualities. COVID-19 variants are capable of inducing different pathologic responses and some of which may be resistant to antibodies generated by current vaccines. The current clinical use of these vaccines has been through emergency use authorization until recently. Moreover, the efficacy and safety of these vaccines have been tested in substantial numbers of individuals but studies in special populations that better reflect the global population are pending results. These specialized populations include young children, immunocompromised patients, pregnant individuals, and other specialized groups. Combination approaches, molecularly modified vaccination approaches, and vaccines conferring longer periods of immunity are being currently being investigated, as well as pharmacovigilance studies. The continual transformation of SARS-CoV-2 and its variants are of concern along with the breakthrough infections. These considerations pose new challenges for the development of vaccination platforms. For this purpose, booster doses, combination vaccine approaches, and other modalities are being discussed. This review provides an updated account of currently available vaccines and those in advanced development with reference to their composition and mechanisms of action. A discussion on the use of vaccines in special populations including immunocompromised patients, pregnant women and other specialized populations are also included. © 2022 Elsevier B.V., All rights reserved.Publication Open Access Dietary factors and onset of natural menopause: A systematic review and meta-analysis(Elsevier Ireland Ltd, 2022) Grisotto, Giorgia; Farago, Julian S.; Taneri, Petek Eylul; Wehrli, Faina; Roa-Díaz, Zayne Milena; Minder, Beatrice; Glisic, Marija; Gonzalez-Jaramillo, Valentina; Voortman, Trudy G.; Marques-Vidal, P. Manuel; Grisotto, Giorgia, University of Bern, Bern, Switzerland, Graduate School for Health Sciences, University of Bern, Bern, Switzerland, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, United States; Farago, Julian S., University of Bern, Bern, Switzerland; Taneri, Petek Eylul, University of Bern, Bern, Switzerland, Department of Public Health, Bahçeşehir Üniversitesi, Istanbul, Turkey; Wehrli, Faina, University of Bern, Bern, Switzerland; Roa-Díaz, Zayne Milena, University of Bern, Bern, Switzerland, Graduate School for Health Sciences, University of Bern, Bern, Switzerland; Minder, Beatrice, Public Health & Primary Care Library, University of Bern, Bern, Switzerland; Glisic, Marija, University of Bern, Bern, Switzerland, Swiss Paraplegic Centre, Nottwil, Switzerland; Gonzalez-Jaramillo, Valentina, University of Bern, Bern, Switzerland, Graduate School for Health Sciences, University of Bern, Bern, Switzerland; Voortman, Trudy G., Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands, Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands; Marques-Vidal, P. Manuel, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, SwitzerlandBackground: Diet has been suggested to play a role in determining the age at natural menopause, however, the evidence is inconsistent. Objective: We systematically reviewed and evaluated published research about associations between diet and onset of natural menopause (ONM). Methods: We searched 6 databases (Medline, Embase, Cochrane, PubMed, Web of Science and Google Scholar) through January 21,2021 to identify prospective studies assessing the association between diet and ONM. Two independent reviewers extracted data using a predesigned data-collection form. Pooled hazard risks (HRs) were calculated using random effect models. Results: Of the 6,137 eligible references we reviewed, we included 15 articles in our final analysis. Those 15 articles included 91,554 women out of 298,413 who experienced natural menopause during follow-up. Overall, there were 89 food groups investigated, 38 macronutrients and micronutrients, and 6 dietary patterns. Among the food groups, higher intake of green and yellow vegetables was associated with earlier age of ONM, while high intakes of some dairy products, such as low-fat, skimmed milk, and low intake of alcohol were associated with a later onset. We observed no consistent association between macronutrient and micronutrient intake and ONM. Our results suggests that a vegetarian diet could be associated with early ONM, we did not observe any other consistent effect from other dietary patterns. Limitations included the number of studies, lack of replication studies and the research being of an observational nature, most studies (11/15) were at medium risk of bias. Conclusion: Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial. Prospero id: CRD42021232087 © 2021 Elsevier B.V., All rights reserved.Publication Open Access Association Between Ultra-Processed Food Intake and All-Cause Mortality: A Systematic Review and Meta-Analysis(Oxford University Press, 2022) Taneri, Petek Eylul; Wehrli, Faina; Roa-Díaz, Zayne Milena; Itodo, Oche Adam; Salvador, Dante Jr; Raeisi-Dehkordi, Hamidreza; Bally, Lia; Minder, Beatrice; Kiefte-De-Jong, Jessica Christina Kiefte De; Laine, Jessica E.; Taneri, Petek Eylul, Institute of Social and Preventive Medicine, Bern, Switzerland, Public Health Department, Bahçeşehir Üniversitesi, Istanbul, Turkey; Wehrli, Faina, Institute of Social and Preventive Medicine, Bern, Switzerland; Roa-Díaz, Zayne Milena, Graduate School for Health Sciences, University of Bern, Bern, Switzerland, Institute of Social and Preventive Medicine, Bern, Switzerland; Itodo, Oche Adam, Swiss Paraplegic Centre, Nottwil, Switzerland, Graduate School for Health Sciences, University of Bern, Bern, Switzerland, Institute of Social and Preventive Medicine, Bern, Switzerland; Salvador, Dante Jr, Graduate School for Health Sciences, University of Bern, Bern, Switzerland, Institute of Social and Preventive Medicine, Bern, Switzerland; Raeisi-Dehkordi, Hamidreza, Graduate School for Health Sciences, University of Bern, Bern, Switzerland, Institute of Social and Preventive Medicine, Bern, Switzerland; Bally, Lia, Department of Diabetes, University Hospital Bern, Bern, Switzerland; Minder, Beatrice, Public Health & Primary Care Library, University of Bern, Bern, Switzerland; Kiefte-De-Jong, Jessica Christina Kiefte De, Department of Public Health and Primary Care, Leids Universitair Medisch Centrum, Leiden, Netherlands; Laine, Jessica E., Institute of Social and Preventive Medicine, Bern, SwitzerlandConsumption of ultra-processed foods (UPF) has increased worldwide during the last decades because they are hyperpalatable, cheap, and ready-to-consume products. However, uncertainty exists about their impact on health. We conducted a systematic review and meta-analysis evaluating the association of UPF consumption with all-cause mortality risk. Five bibliographic databases were searched for relevant studies. Random effects models were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). Of 6,951 unique citations, 40 unique prospective cohort studies comprising 5,750,133 individuals were included, publication dates ranged from 1984 to 2021. Compared with low consumption, highest consumption of UPF (RR = 1.29, 95% CI: 1.17, 1.42), sugar-sweetened beverages (RR = 1.11, 95% CI, 1.04, 1.18), artificially sweetened beverages (RR = 1.14, 95% CI, 1.05, 1.22), and processed meat/red meat (RR = 1.15, 95% CI, 1.10, 1.21) were significantly associated with increased risk of mortality. However, breakfast cereals were associated with a lower mortality risk (RR = 0.85, 95% CI, 0.79, 0.92). This meta-analysis suggests that high consumption of UPF, sugar-sweetened beverages, artificially sweetened beverages, processed meat, and processed red meat might increase all-cause mortality, while breakfast cereals might decrease it. Future studies are needed to address lack of standardized methods in UPF categorization. © 2022 Elsevier B.V., All rights reserved.
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