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Publication Open Access Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents(Elsevier Inc. [email protected], 2020) Hoyt, Taylor; Feldman, Marc David; Okutucu, Sercan; Lendel, Vasili; Marmagkiolis, Konstantinos; McIntosh, Victoria; Ates, Ismail; Kose, Gulcan; Mego, David M.; Paixao, Andre R.M.; Hoyt, Taylor, The University of Texas Health Science Center at San Antonio, San Antonio, United States; Feldman, Marc David, The University of Texas Health Science Center at San Antonio, San Antonio, United States; Okutucu, Sercan, Ankara Numune Hospital, Ankara, Turkey; Lendel, Vasili, Arkansas Heart Hospital, Little Rock, United States; Marmagkiolis, Konstantinos, Florida Hospital, Orlando, United States; McIntosh, Victoria, Arkansas Heart Hospital, Little Rock, United States; Ates, Ismail, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kose, Gulcan, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Mego, David M., Arkansas Heart Hospital, Little Rock, United States; Paixao, Andre R.M., Arkansas Heart Hospital, Little Rock, United StatesPurpose: Zilver PTX nitinol self-expanding drug-eluting stent with paclitaxel coating is effective for treatment of superficial femoral artery (SFA) disease. However, as with any stent, it induces a measure of vascular inflammatory response. The current clinical trial (NCT02734836) aimed to assess vascular patency, remodeling, and inflammatory markers with intravascular optical coherence tomography (OCT) in patients with SFA disease treated with Zilver PTX stents. Methods: Serial OCT examinations were performed in 13 patients at baseline and 12-month follow-up. Variables evaluated included neointimal area, luminal narrowing, thrombus area, stent expansion as well as measures of inflammation including, peri-strut low-intensity area (PLIA), macrophage arc, neovascularization, stent strut apposition and coverage. Results: Percentage of malapposed struts decreased from 10.3 ± 7.9% post-intervention to 1.1 ± 2.2% at 12-month follow-up, but one patient showed late-acquired stent malapposition (LASM). The percent of uncovered struts at follow-up was 3.0 ± 4.5%. Average expansion of stent cross-sectional area from baseline to follow-up was 35 ± 19%. The average neointimal area was 7.8 ± 3.8 mm2. Maximal luminal narrowing was 61.1 ± 25.0%, and average luminal narrowing was 35.4 ± 18.2%. Average peri-strut low-intensity area (PLIA) per strut was 0.017 ± 0.018 mm2. Average number of neovessels per mm of stent was 0.138 ± 0.181. Average macrophage angle per frame at follow-up was 7 ± 11°. Average thrombus area at follow-up was 0.0093 ± 0.0184 mm2. Conclusion: At 12-month follow-up, OCT analysis of Zilver PTX stent shows outward remodeling and minimal neointimal growth, but evidence of inflammation including PLIA, neovessels, thrombus and macrophages. Thirteen patients with PAD had paclitaxel-coated stents implanted in their SFAs and were then imaged with OCT at baseline and 12-month follow-up. OCT proxy metrics of inflammation were quantified. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis(Elsevier Espana S.L., 2020) Aktaş Karabay, Ezgi; Demir, Damla; Aksu Çerman, Asli; Aktaş Karabay, Ezgi, Department of Dermatology and Venereology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Demir, Damla, Department of Dermatology and Venereology, University of Health Sciences, Istanbul, Turkey; Aksu Çerman, Asli, Department of Dermatology and Venereology, University of Health Sciences, Istanbul, TurkeyBackground: Psoriasis is a chronic immune-mediated inflammatory skin disease that is associated with cardiovascular comorbidities. Objectives: The objective of this retrospective study is to assess the C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio as inflammatory markers in patients with psoriasis and to search for a relationship between these parameters and psoriasis severity, as defined by the psoriasis area and severity index. Methods: There were 94 patients with psoriasis and 118 healthy controls enrolled in the study. The C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio values of two groups were retrospectively evaluated. Results: Statistically significant differences were observed in terms of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio between the patient and control groups (p = 0.001, p = 0.003, p = 0.038, and p = 0.007, respectively). Positive correlations were found between the psoriasis area and severity index and the values of C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio (r: 0.381, p < 0.01, r: 0.203, p < 0.05, r: 0.268, p < 0.01, r: 0.374, p < 0.01, r: 0.294, p < 0.01, respectively). Study limitations: The small sample size and the retrospective design of the study are limitations. Conclusion: Elevated C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly associated with psoriasis. A positive correlation between C-reactive protein and monocyte-to-high-density-lipoprotein ratio leads to the suggestion that monocyte-to-high-density-lipoprotein ratio might be a reliable parameter in psoriasis during the follow-up. The relationship between the diasease and inflammatory parameters might provide early detection of cardiovascular morbidities in psoriasis patients. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Effect of refractive error on color vision(Gazi Universitesi, 2020) Arslan, Esin; Diremsizoglu, Umut; Barut, Cagatay; Arslan, Esin, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Diremsizoglu, Umut, School of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Barut, Cagatay, Department of Anatomy, Bahsesehir University, Kadikoy, TurkeyPurpose: Prevalance of refractive error is increasing and without correct color perception everyday tasks such as matching or distinguishing color is a challenge. The aim is to determine the effect of refractive error on the color matching of red, green and blue appearing surfaces and how this color matching changes with refractive correction with glasses. Method: In this interventional single center study, 127 medical students from Bahcesehir University were enrolled. In a well-lit room (4794 lumen), an A4 paper sized color was placed on a tripod 4 meters away from the participant. They were asked to match the shown color to the scale. The scale consisted of five shades of three main colors (red, green, blue). Answers were categorized as correct or false. Categorical independent data were analyzed with Chi-square tests and for categorical paired data, McNemar tests were used. Results: 127 students consisted of sixty-four males (Mean: 19.70 ± 1.136) and sixty-three (Mean: 19.49 ± 0.965) females. 60 participants had refractive error and 67 participants had healthy vision. When emmetropes were compared to participants with refractive error, for only red color, emmetropes had significantly lower error rates (9%) compared to participants with refractive error (25%) (p=0.015). 60 participants with refractive error had lowered error rates in red (14%), green (10%) and blue (20%) color after correction. The decreases in error rates were not significant except blue was insignificant on the edge. P values for red, green and blue respectively are p=0.096, p=0.286 and p=0.050. Conclusion: The study found that refractive error negatively effects color perception and correcting the underlying health problem decreases the error rate in color perception. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Multicenter study of levodopa carbidopa intestinal gel in Parkinson’s disease: The Turkish experience(Turkiye Klinikleri Talapapa Bulvary no. 102 Hamammonu 1 06230, 2020) Gültekin, Murat; Ulukan, Çağrı; Tezcan, Sabiha; Dog̃u, Okan; Hanaĝasi, Haşmet Ayhan; Bilgiç, Başar Gar; Bora Tokcaer, Ayse; Çakmur, Raif; Elibol, Bülent; Mirza, Meral; Gültekin, Murat, Department of Neurology, Erciyes Üniversitesi, Kayseri, Turkey; Ulukan, Çağrı, Department of Neurology, Ankara Üniversitesi, Ankara, Turkey; Tezcan, Sabiha, Department of Neurology, Ankara Üniversitesi, Ankara, Turkey; Dog̃u, Okan, Department of Neurology, Mersin Üniversitesi, Mersin, Turkey; Hanaĝasi, Haşmet Ayhan, Department of Neurology, Istanbul Üniversitesi, Istanbul, Turkey; Bilgiç, Başar Gar, Department of Neurology, Istanbul Üniversitesi, Istanbul, Turkey; Bora Tokcaer, Ayse, Department of Neurology, Gazi Üniversitesi, Ankara, Turkey; Çakmur, Raif, Department of Neurology, Dokuz Eylül Üniversitesi, Izmir, Turkey; Elibol, Bülent, Department of Neurology, Hacettepe Üniversitesi, Ankara, Turkey; Mirza, Meral, Department of Neurology, Erciyes Üniversitesi, Kayseri, TurkeyBackground/aim: Our purpose was to determine the efficacy of levodopa carbidopa intestinal gel (LCIG) in a series of Turkish patients with Parkinson’s disease (PD). Materials and methods: We had telephone calls with 54 patients from 11 neurology centers who were on LCIG treatment, and 44 patients or their caregivers were included in an eight-item survey between September 2015 and June 2016. The reliability and validity of the survey were evaluated with intraclass correlation coefficients for every question separately. Results: Average age of the patients were 63.48 and the duration of PD was 12.79 years. Average LCIG treatment period was 15.63 months. Percentages of the patients who reported they were ‘better’ after LCIG treatment were as follows: 80% for time spent off, 55% for dyskinesia, 65% for tremor, 85% for gait disorder, 50% for pain, 50% for sleep disorders, 42.5% for depression, 32.5% for incontinence, and 70% for activities of daily living. Cronbach’s alpha was 0.795 and the intraclass correlation coefficient was reliable for the items. Conclusion: As detected by a survey performed by telephone calls with good interrater reliability, patients with PD improve with LCIG treatment in many aspects of the disease. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Assessment of spatiotemporal gait parameters in patients with lumbar disc herniation and patients with chronic mechanical low back pain(Turkish Neurosurgical Society, 2020) Amir Rashedi Bonab, Masoud; Kuru Colak, Tuǧba; Toktaş, Zafer Orkun; Konya, Deniz; Amir Rashedi Bonab, Masoud, Department of Physiotherapy and Rehabilitation, Marmara Üniversitesi, Istanbul, Turkey, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kuru Colak, Tuǧba, Department of Physiotherapy and Rehabilitation, Marmara Üniversitesi, Istanbul, Turkey, Department of Physiotherapy and Rehabilitation, Marmara Üniversitesi, Istanbul, Turkey; Toktaş, Zafer Orkun, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Konya, Deniz, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyAIM: To assess spatiotemporal gait parameters in patients with lumbar disc herniation (LDH) and chronic mechanical low back pain (CMLBP), and compare with healthy control group. MATERIAL and METHODS: A total of 70 patients was enrolled in this prospective, controlled cross-sectional study, of which 25 with LDH, 25 with CMLBP and 20 healthy individuals as the control group. Participants completed 10 passes on the WIN-TRACK Gait Analysis Platform at their self-selected walking speed. The arithmetic mean of the five flawless walking data was used for analysis. Pain intensity is assessed by the Visual Analog Scale (VAS). RESULTS: The spatiotemporal gait parameters were significantly decreased in LDH and CMLBP groups than the healthy control group, particularly in LDH groups (p≥0.001). It was found that pain intensity is negatively correlated to step and stride length, cadence and velocity (p<0.001). Results of linear regression analysis showed that 10% of the changes in gait cycle duration of the left extremity and 74% of the changes in the velocity were associated with pain intensity. CONCLUSION: Pain intensity can affect the spatiotemporal gait parameters in patients with Low Back Pain (LBP). Rehabilitation programs with gait optimization should be considered in the management of patients with LDH and CMLBP. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Clinical and radiological outcomes of high tibial osteotomy with combined fixator-assisted nailing and subtubercle tibial osteotomy(AVES, 2020) Bayam, L.; Erdem, Mehmet; Gülabi, Deniz; Erdem, Ahmet Can; Uyar, Ahmet Çagrı; Kochai, Alauddin; Bayam, L., Department of Orthopaedics and Traumatology, Sakarya Üniversitesi, Serdivan, Turkey; Erdem, Mehmet, Department of Orthopaedics and Traumatology, Sakarya Üniversitesi, Serdivan, Turkey; Gülabi, Deniz, Department of Orthopaedics, Bahçeşehir Üniversitesi, Istanbul, Turkey; Erdem, Ahmet Can, Vakıf Guraba University Hospital, Istanbul, Turkey; Uyar, Ahmet Çagrı, Department of Orthopaedics and Traumatology, Sakarya Üniversitesi, Serdivan, Turkey; Kochai, Alauddin, Department of Orthopaedics and Traumatology, Sakarya Üniversitesi, Serdivan, TurkeyObjective: The aim of this study was to assess the clinical and radiological results of our high tibial osteotomy technique combining fixator-assisted nailing and subtubercle tibial osteotomy in varus malalignment. Methods: This was a retrospective study of a consecutive series of 32 knees in 32 patients (‘2 follow-up loss’ 12 males and 18 females, mean age at the time of operation: 50.6±7.8 (36–62) years) operated on between 2014 and 2016. Radiographic and clinical measurements were assessed pre-and postoperatively. Kolmogorov-Smirnov, paired t and Wilcoxon rank tests were used in the statistical analyses. Results: The mean follow-up period was 36.1±8.15 (31–53) months, the mean duration of the hospital stay was 3.6±0.1 (2–6) days, and the mean Kellgren-Lawrence score was 2.4±0.6 (2–4). Time to bony union was an average of 16.17 (12–29) weeks. Compared to the preoperative mechanical medial proximal tibial angle, femorotibial angle and mechanical axis deviation measurements, all the postoperative values showed significant changes (p<0.01). However, there was no statistical difference between the preoperative and postoperative tibial slopes (p>0.05), and the postoperative Caton-Deschamps index did not show a meaningful change (p>0.05). The postoperative visual analog scale, Knee Society Score, and Modified Hospital for Special Surgery Knee Scoring System measures showed significant improvement compared to the preoperative values (p<0.01). The postoperative walking distance increased to 1137.50±845.1 meters, from 359.4±306.2 meters (p<0.01). Conclusion: This percutaneous technique is minimally invasive, corrects the alignment in two planes, and does not affect patellar height. We believe that this technique could be a promising alternative to other knee preserving surgeries in correcting varus malalignment. Level of Evidence: Level IV, Therapeutic Study. © 2023 Elsevier B.V., All rights reserved.Publication Open Access The Impact of Auricular Vagus Nerve Stimulation on Pain and Life Quality in Patients with Fibromyalgia Syndrome(Hindawi Limited 410 Park Avenue, 15th Floor, 287 pmb New York NY 10022, 2020) Kutlu, Nazli; Özden, Ali Veysel; Alptekin, Hasan Kerem; Öncü, Jülide; Bernardo-Filho, Mário M.; Kutlu, Nazli, Physiotherapy and Rehabilitation Department, Beykoz State Hospital, Malatya, Turkey; Özden, Ali Veysel, Health Sciences Institute, Bahçeşehir Üniversitesi, Istanbul, Turkey; Alptekin, Hasan Kerem, Health Sciences Institute, Bahçeşehir Üniversitesi, Istanbul, Turkey; Öncü, Jülide, Department of Physical Medicine and Rehabilitation, Sisli Etfal Hospital, Istanbul, Turkey; Bernardo-Filho, Mário M.,The purpose of this study is to evaluate the impact of auricular vagus nerve stimulation, applied in conjunction with an exercise treatment program, on pain and life quality in patients with fibromyalgia syndrome (FMS). To achieve the study objectives, 60 female patients between the ages 18 and 50, with diagnosed FMS according to the American College of Rheumatology (ACR) 2010 diagnostic criteria, were randomly divided into 2 groups of 30. The first group was assigned 20 sessions of a home-based exercise program, while the second group was assigned 20 sessions of auricular vagus nerve stimulation and 20 sessions of a home-based exercise program. Patients were assessed before and after the treatments using the Visual Analog Scale (VAS) for pain, Beck Depression Scale for depression, Beck Anxiety Scale for anxiety, Fibromyalgia Impact Questionnaire (FIQ) for functional evaluation, and Short Form-36 (SF-36) for life quality. In this randomized controlled trial, comparisons within the groups revealed that both groups had statistically significant improvements in pain, depression, anxiety, functionality, and life quality scores (p<0.05), while comparisons across the groups revealed that the group experiencing the vagus nerve stimulation had no statistically significant differences between the baseline scores, except for those of SF-36's subparameters of physical function, social functionality, and pain. In fact, comparisons across the groups after the interventions revealed that the group experiencing the vagus nerve stimulation had better scores but not statistically significant. From analysis of this data, we observed that vagus nerve stimulation in FMS treatment did not give additional benefit together with exercise, except for three subparameters of SF-36. It was identified that further studies which separately investigate the effects of vagus nerve stimulation and exercise on FMS with longer follow-up periods and an increased number of patients are needed. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Effects of outdoor natural light exposure on sleep quality in the elderly(Geriatrics Society, 2020) Şansal, Kenan Eren; Tanrıöver, Sezin Hatice; Aka, Başak Türküler; Şansal, Kenan Eren, Bahçeşehir Üniversitesi, Istanbul, Turkey; Tanrıöver, Sezin Hatice, Bahçeşehir Üniversitesi, Istanbul, Turkey; Aka, Başak Türküler, Bahçeşehir Üniversitesi, Istanbul, TurkeyIntroduction: One of the serious outcomes associated with ageing is the high prevalence of age-related sleep disturbances detrimentally influencing general well-being in the elderly. Whilst underexposure to diurnal bright light appears to be a reason for disturbed sleep in old age, further empirical evidence is required to confirm such a relationship. Materials and Method: In order to contribute to our current understanding of the subject, a study was conducted in a long-term care facility in Istanbul, Turkey. Participating elderly residents (N = 39) were exposed to natural light outdoors (> 10,000 lx) for 40 minutes in the morning on 17–21 June and 1–5 July 2019, and they were asked to report on their sleep quality by completing various questionnaires throughout the study. Results: The results of the study demonstrated a significant difference (p < 0.05) between the pre- and post-treatment scores of the participants. Moreover, the participants reported significantly less (p < 0.05) disturbed sleep in the second period during which they were exposed to approximately 63% more natural light. Conclusion: Based on our findings and those of other research groups, it is possible to conclude that light, or more specifically natural light, should be considered as an independent factor affecting sleep and, thus, general well-being in old age. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Prognostic Value of Pretreatment Systemic Immune-Inflammation Index in Glioblastoma Multiforme Patients Undergoing Postneurosurgical Radiotherapy plus Concurrent and Adjuvant Temozolomide(Hindawi Limited 410 Park Avenue, 15th Floor, 287 pmb New York NY 10022, 2020) Topkan, Erkan; Beşen, Ali Ayberk; Özdemir, Yurday; Kucuk, Ahmet; Mertsoylu, Hüseyin; Pehlivan, Berrin; Selek, Uǧur; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Beşen, Ali Ayberk, Department of Medical Oncology, Başkent Üniversitesi, Ankara, Turkey; Özdemir, Yurday, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Kucuk, Ahmet, Radiation Oncology Clinics, Mersin City Hospital, Mersin, Turkey; Mertsoylu, Hüseyin, Department of Medical Oncology, Başkent Üniversitesi, Ankara, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, Turkey, Department of Radiation Oncology, University of Texas Health Science Center at Houston, Houston, United StatesObjectives. To evaluate the potential prognostic utility of pretreatment systemic immune-inflammation index (SII) in newly diagnosed glioblastoma multiforme (GBM) patients who underwent postneurosurgical radiotherapy and concurrent plus adjuvant temozolomide. Methods. The retrospective data of GBM patients who underwent postneurosurgical radiotherapy and concurrent plus adjuvant temozolomide were analyzed. For each patient, SII was calculated using the platelet, neutrophil, and lymphocyte measures obtained on the first day of treatment: SII=platelets×neutrophils/lymphocytes. The receiver operating characteristic (ROC) curve analysis was utilized for the evaluation of optimal cut-off values for SII those linked with the outcomes. Primary and secondary endpoints constituted the overall (OS) and progression-free survival (PFS) per conveyance SII group. Results. A total of 167 patients were included. The ROC curve analysis identified the optimum SII cut-off at a rounded 565 value that significantly interacted with the PFS and OS and stratified patients into two groups: low-SII (SII<565, n=71) and high-SII (SII≥565, n=96), respectively. Comparative survival analyses exhibited that the high-SII cohort had significantly shorter median PFS (6.0 versus 16.6 months, P<0.001) and OS (11.1 versus 22.9 months, P<0.001) than the low-SII cohort. The relationship between the high-SII and poorer PFS (P<0.001) and OS (P<0.001) further retained its independent significance in multivariate analysis, as well. Conclusions. The outcomes displayed here qualified the pretreatment SII as a novel independent prognostic index for predicting survival outcomes of newly diagnosed GBM patients undergoing postneurosurgical radiotherapy and concurrent plus adjuvant temozolomide. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Prognostic Value of C-Reactive Protein to Albumin Ratio in Glioblastoma Multiforme Patients Treated with Concurrent Radiotherapy and Temozolomide(Hindawi Limited 410 Park Avenue, 15th Floor, 287 pmb New York NY 10022, 2020) Topkan, Erkan; Beşen, Ali Ayberk; Mertsoylu, Hüseyin; Kucuk, Ahmet; Pehlivan, Berrin; Selek, Uǧur; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Beşen, Ali Ayberk, Department of Medical Oncology, Başkent Üniversitesi, Ankara, Turkey; Mertsoylu, Hüseyin, Department of Medical Oncology, Başkent Üniversitesi, Ankara, Turkey; Kucuk, Ahmet, Radiation Oncology Clinics, Mersin City Hospital, Mersin, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, Turkey, Department of Radiation Oncology, University of Texas Health Science Center at Houston, Houston, United StatesObjective. We investigated the prognostic impact of C-reactive protein to albumin ratio (CRP/Alb) on the survival outcomes of newly diagnosed glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (TMZ). Methods. The pretreatment CRP and Alb records of GBM patients who underwent RT and concurrent plus adjuvant TMZ were retrospectively analyzed. The CRP/Alb was calculated by dividing serum CRP level by serum Alb level obtained prior to RT. The availability of significant cutoff value for CRP/Alb that interacts with survival was assessed with the receiver-operating characteristic (ROC) curve analysis. The primary endpoint was the association between the CRP/Alb and the overall survival (OS). Results. A total of 153 patients were analyzed. At a median follow-up of 14.7 months, median and 5-year OS rates were 16.2 months (95% CI: 12.5-19.7) and 9.5%, respectively, for the entire cohort. The ROC curve analysis identified a significant cutoff value at 0.75 point (area under the curve: 74.9%, sensitivity: 70.9%, specificity: 67.7%, P<0.001) for CRP/Alb that interacts with OS and grouped the patients into two: CRP/Alb <0.75 (n = 61) and ≥0.75 (n = 92), respectively. Survival comparisons revealed that the CRP/Alb <0.75 was associated with a significantly superior median (22.5 versus 15.7 months, P<0.001) and 5-year (20% versus 0%) rates than the CRP/Alb ≥0.75, which retained its independent significance in multivariate analysis (P<0.001). Conclusion. Present results suggested the pretreatment CRP/Alb as a significant and independent inflammation-based index which can be utilized for further prognostic lamination of GBM patients. © 2020 Elsevier B.V., All rights reserved.