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Publication Metadata only Encephalomyelitis associated with Covid-19 infection: case report(Taylor and Francis Ltd, 2020) Demirci Otluoglu, Gulden; Yener, Ulaş; Demir, Mustafa Kemal; Yilmaz, Baran; Demirci Otluoglu, Gulden, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yener, Ulaş, Department of Neurosurgery, University of Virginia, Charlottesville, United States; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yilmaz, Baran, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyWe describe a COVID-19 patient who presented with persistent headache and anosmia that was related to viral encephalomyelitis with acute lesions on MRI in both the brain and upper cervical cord. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Primary Sonic Hedgehog–activated dorsal brainstem medulloblastoma and ipsilateral cerebellar atrophy in an adult(SAGE Publications Inc., 2020) Demir, Mustafa Kemal; Kurtkaya-Yapicier, Özlem Sahan; Mert, Başak; Alshareefi, Wiaam; Bozbuǧa, Mustafa; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kurtkaya-Yapicier, Özlem Sahan, Department of Pathology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Mert, Başak, Bahçeşehir Üniversitesi, Istanbul, Turkey; Alshareefi, Wiaam, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bozbuǧa, Mustafa, Department of Neurosurgery, Üsküdar Üniversitesi, Istanbul, TurkeyMedulloblastoma (MB) that arises outside the cerebellum from cells of the dorsal brainstem is rare. The most common subtype of MB in the dorsal brainstem is the Wingless (WNT) subtype that contains activating mutations in the WNT pathway effector CTNNB1. Ipsilateral cerebellar hemi-atrophy with a brainstem tumour is a finding that is usually documented with brainstem gangliogliomas as a possible specific imaging sign. We present a case of a 23-year-old female with progressive headache, imbalance on walking, double vision and difficulty in swallowing for a year. Magnetic resonance imaging demonstrated a mass with prominent restricted diffusion on the dorsal surface of the lower brainstem with ipsilateral cerebellar atrophy. The final histopathological diagnosis was a Sonic Hedgehog (SHH)-activated and TP53 wild-type primary lower dorsal brainstem MB. Primary SHH-activated TP53 wild-type dorsal brainstem MB is extremely rare, and as far as we know, the association of the tumour with ipsilateral cerebellar hemi-atrophy in an adult has never been reported. MB should be included in the differential diagnosis of focal dorsal brainstem tumours, even in the presence of ipsilateral cerebellar hemi-atrophy. © 2022 Elsevier B.V., All rights reserved.Publication Metadata only A diagnostic dilemma in the emergency room: intracranial hemorrhages in acute myeloblastic leukemia with hyperleukocytosis(Springer, 2020) Demir, Mustafa Kemal; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Metadata only Mesial temporal lobe rosette-forming glioneuronal tumor : an unusual location for a rare tumor(Springer, 2020) Kurtkaya-Yapicier, Özlem Sahan; Demir, Mustafa Kemal; Jaafar, Ebrahim; Bozbuǧa, Mustafa; Kurtkaya-Yapicier, Özlem Sahan, Department of Pathology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Jaafar, Ebrahim, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bozbuǧa, Mustafa, Department of Neurosurgery, Üsküdar Üniversitesi, Istanbul, Turkey[No abstract available]Publication Metadata only Cerebral hydatid disease with serpent sign, calcifications, and peripheral enhancement(Springer Science and Business Media Deutschland GmbH info@springer-sbm.com, 2020) Demir, Mustafa Kemal; Kurtkaya-Yapicier, Özlem Sahan; Jameel, Muslim Ageel; Bozbuǧa, Mustafa; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kurtkaya-Yapicier, Özlem Sahan, Department of Pathology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Jameel, Muslim Ageel, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bozbuǧa, Mustafa, Department of Neurosurgery, Üsküdar Üniversitesi, Istanbul, Turkey[No abstract available]Publication Metadata only Red cell distribution width levels in Parkinson’s disease patients(Springer Science and Business Media Deutschland GmbH info@springer-sbm.com, 2020) Kenangil, Gülay Ozgen; Ari, Buse Cagla; Kaya, Fatma Altuntaş; Demir, Mustafa Kemal; Mayda-Domaç, Füsun; Kenangil, Gülay Ozgen, Department of Neurology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Ari, Buse Cagla, Department of Neurology, Erenköy Mental Health and Neurological Diseases Training and Research Hospital, Istanbul, Turkey; Kaya, Fatma Altuntaş, Department of Neurology, Erenköy Mental Health and Neurological Diseases Training and Research Hospital, Istanbul, Turkey; Demir, Mustafa Kemal, Department of Neurology, Erenköy Mental Health and Neurological Diseases Training and Research Hospital, Istanbul, Turkey; Mayda-Domaç, Füsun, Department of Neurology, Erenköy Mental Health and Neurological Diseases Training and Research Hospital, Istanbul, TurkeyParkinson’s disease (PD) is a neurodegenerative disorder with motor and non-motor impairment. It has been known for a while that oxidative stress, protein changes and mitochondrial dysfunction have the role of contribution to the pathogenesis. Disturbance of red blood cell function may play a role in the pathophysiology of neurodegenerative diseases such as Huntington’s, Parkinson’s and Alzheimer’s disease. RDW was found to be strongly associated with inflammatory markers in diseases such as acute pancreatitis, myocardial injury and hepatocellular carcinoma. The data about RDW levels and PD are scarce. In this study, we aimed to investigate the RDW values and their relationship with the severity of the disease in patients with Parkinson’s disease. 94 patients with Parkinson’s disease were included into the study, 97 healthy individuals without history of PD were considered as control group. The United Parkinson’s Disease Rating Scale (UPDRS) and the modified Hoehn and Yahr staging scale were used to assess the severity of PD. Although RDW levels were significantly higher than the healthy subjects, there was not any relation between the severity of PD, duration of the disease, RDW levels, other blood parameters, mean UPDRS score or mean mH&Y score. In conclusion, RDW levels are higher than the healthy subjects in PD patients but there is no relation between RDW levels and disease duration. Larger studies are needed to explain the role of RDW as an inflammatory marker. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Intracranial extra-axial mesenchymal chondrosarcoma in a 16-month-old patient with a literature review of pediatric patients(Springer Science and Business Media Deutschland GmbH, 2021) Kurtkaya-Yapicier, Özlem Sahan; Nanah, Abdelrahman; Taşkapılıoğlu, Mevlüt Özgür; Demir, Mustafa Kemal; Kurtkaya-Yapicier, Özlem Sahan, Department of Pathology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Nanah, Abdelrahman, Bahçeşehir Üniversitesi, Istanbul, Turkey; Taşkapılıoğlu, Mevlüt Özgür, Department of Neurosurgery, Bursa Uludağ Üniversitesi, Bursa, Turkey; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, TurkeyMesenchymal chondrosarcoma is a rare high-grade malignant subtype of chondrosarcoma that is characterized by undifferentiated, round, or spindled mesenchymal cells, interspersed with islands of hyaline cartilage. We report a primary intracranial extra-axial mesenchymal chondrosarcoma in a 16-month-old patient with a review of the literature focusing on intracranial extra-axial MCs with or without skull involvement in pediatric patients, including differential diagnosis. The patient was admitted with a swelling in the right temporooccipital region. There was intracranial extra-dural extension of the mass, which abuts the neural parenchyma without any invasion. A complete tumor resection was performed. Pathological diagnosis was mesenchymal chondrosarcoma. The patient was free of symptoms after surgery. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Sellar spine: a rare osseous anomaly(Springer Science and Business Media Deutschland GmbH, 2021) Demir, Mustafa Kemal; Toktaş, Zafer Orkun; Kilic, Turker D.; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey,; Toktaş, Zafer Orkun, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kilic, Turker D., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Open Access Kidney Transplantation and COVID-19: Two Case Reports(Elsevier Inc., 2021) Tekin, Sabri; Özdoğan, Hatice; Demir, Mustafa Kemal; Soultan, Hagar Elsayed Akram; Zafar, Sadia; Tekin, Sabri, Department of Organ Transplantation, Bahçeşehir Üniversitesi, Istanbul, Turkey; Özdoğan, Hatice, Department of Internal Medicine, Ercis State Hospital, Van, Turkey; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Soultan, Hagar Elsayed Akram, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Zafar, Sadia, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, TurkeyImmunocompromised populations are at great risk of the current 2020 global emergency of coronavirus disease 2019 (COVID-19), and treatment of kidney transplant recipients with COVID-19 is currently not declared. Hence, the purpose of the study is to set a clear treatment regimen. We report here a therapeutic course of 2 patients who underwent transplant surgery in March 2020 and got infected soon after. Since the transplant, these 2 patients have received triple maintenance immunosuppressive therapy with oral tacrolimus, mycophenolate mofetil (MMF), and prednisone, and they have been regularly followed up at our hospital. The tacrolimus trough level was between 10 and 12 ng/mL. After the diagnosis of COVID-19, MMF was stopped and the tacrolimus dose was reduced so that blood level was between 4 and 6 ng/mL. The first patient was a 30-year-old man who, despite being treated with hydroxychloroquine, favipiravir, oseltamivir, and azithromycin therapy, died because of the presence of other comorbidities. The second case was a 58-year-old man who fully recovered from COVID-19 pneumonia with treatment with methylprednisolone, MMF, azithromycin, favipiravir, hydroxychloroquine, and reduction in immunosuppression dosage. This reflects the importance of using glucocorticoids in the treatment of COVID-19 along with other medications and the decreased mortality rate associated with their use. © 2021 Elsevier B.V., All rights reserved.Publication Metadata only Allogeneic hematopoietic stem cell transplantation in patients with childhood cerebral adrenoleukodystrophy: A single-center experience Better prognosis in earlier stage(John Wiley and Sons Inc, 2021) Yalçin, Koray; Çelen, Suna S.; Daloǧlu, Hayriye; Demir, Mustafa Kemal; Öztürkmen, Seda Irmak; Pasayev, Dayanat; Zhumatayev, Suleimen; Uygun, Vedat; Hazar, Volkan; Tezcan-Karasu, Gülsün; Yalçin, Koray, Medicalpark Goztepe Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey; Çelen, Suna S., Medicalpark Goztepe Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey; Daloǧlu, Hayriye, Medicalpark Antalya Hospital Pediatric Stem Cell Transplantation Unit, Antalya, Turkey; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Öztürkmen, Seda Irmak, Medicalpark Antalya Hospital Pediatric Stem Cell Transplantation Unit, Antalya, Turkey; Pasayev, Dayanat, Medicalpark Goztepe Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey; Zhumatayev, Suleimen, Medicalpark Goztepe Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey; Uygun, Vedat, Medicalpark Antalya Hospital Pediatric Stem Cell Transplantation Unit, Antalya, Turkey; Hazar, Volkan, Medicalpark Goztepe Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey; Tezcan-Karasu, Gülsün, Medicalpark Goztepe Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey, Medicalpark Antalya Hospital Pediatric Stem Cell Transplantation Unit, Antalya, TurkeyBackground: ALD is a rare X-linked peroxisomal metabolic disorder with many distinct phenotypes of disease that emerge on a wide scale from adrenal insufficiency to fatal cALD which progresses to a vegetative state within a few years. Currently, HSCT is the only treatment method known to stabilize disease progression in patients with cALD. In this study, we aim to report our HSCT experience in patients with cALD and the factors that determine the success of HSCT, as a single-center experience. Methods: The study cohort involves 23 boys with cALD and three patients with ALD trait and new-onset abnormal behavior who underwent allogeneic HSCT between January 2012 and September 2019 in our transplantation center. Loes scoring, NFS, scale and MFD were performed for evaluating the severity of the cerebral disease. The study cohort was divided into two groups according to baseline NFS and Loes score: early-stage (NFS ≤ 1 and Loes score <9) and advanced stage (NFS > 1 or Loes score ≥9). Results: The pretransplant stage of disease impacted both OS and MFD-free survival. The estimated OS and MFD-free survival at 3 years in patients with advanced disease were 46.1% (95% CI 19.0–73.2) and 23.1% (95% CI 0.2–46.0), respectively, and all patients with the early disease were alive (p:.004) and MFD-free (p <.001) at 3 years. Conclusion: This study demonstrated that early HSCT is vital in patients with cALD. The early-stage disease had a significant survival advantage and free from disease progression after HSCT. © 2021 Elsevier B.V., All rights reserved.
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