Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
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Publication Open Access Primary Sonic Hedgehog–activated dorsal brainstem medulloblastoma and ipsilateral cerebellar atrophy in an adult(SAGE Publications Inc., 2020) Demir, Mustafa Kemal; Kurtkaya-Yapicier, Özlem Sahan; Mert, Başak; Alshareefi, Wiaam; Bozbuǧa, Mustafa; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kurtkaya-Yapicier, Özlem Sahan, Department of Pathology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Mert, Başak, Bahçeşehir Üniversitesi, Istanbul, Turkey; Alshareefi, Wiaam, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bozbuǧa, Mustafa, Department of Neurosurgery, Üsküdar Üniversitesi, Istanbul, TurkeyMedulloblastoma (MB) that arises outside the cerebellum from cells of the dorsal brainstem is rare. The most common subtype of MB in the dorsal brainstem is the Wingless (WNT) subtype that contains activating mutations in the WNT pathway effector CTNNB1. Ipsilateral cerebellar hemi-atrophy with a brainstem tumour is a finding that is usually documented with brainstem gangliogliomas as a possible specific imaging sign. We present a case of a 23-year-old female with progressive headache, imbalance on walking, double vision and difficulty in swallowing for a year. Magnetic resonance imaging demonstrated a mass with prominent restricted diffusion on the dorsal surface of the lower brainstem with ipsilateral cerebellar atrophy. The final histopathological diagnosis was a Sonic Hedgehog (SHH)-activated and TP53 wild-type primary lower dorsal brainstem MB. Primary SHH-activated TP53 wild-type dorsal brainstem MB is extremely rare, and as far as we know, the association of the tumour with ipsilateral cerebellar hemi-atrophy in an adult has never been reported. MB should be included in the differential diagnosis of focal dorsal brainstem tumours, even in the presence of ipsilateral cerebellar hemi-atrophy. © 2022 Elsevier B.V., All rights reserved.Publication Open Access Morphometry of common carotid artery and internal jugular vein in relation to gender and body side, Arteria Carotis Communis ve Vena Jugularis Interna'nin Cinsiyet ve Vücut Tarafina göre Morfometrisi(Gazi Universitesi [email protected], 2020) Ertem, Onder; Demir, Mustafa Kemal; Barut, Cagatay; Ertem, Onder, Bahçeşehir Üniversitesi, Istanbul, Turkey; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Barut, Cagatay, Department of Anatomy, Bahçeşehir Üniversitesi, Istanbul, TurkeyIntroduction: The common carotid arteries originate from brachiocephalic trunk on the right and directly from the aortic arch on the left. These arteries are contained within the carotid sheaths together with the internal jugular veins and vagus nerves. The structures enclosed in carotid sheath are of great importance, since they provide most of the vascular supply of the head and neck. They exhibit a great deal of variation and are related with a number of pathologic conditions and invasive procedures. Objectives: Thus we focused on morphology of the common carotid artery (CCA) and internal jugular vein (IJV) to determine these possible variations. Methods: Neck magnetic resonance images of 81 individuals (38 females and 43 males) were evaluated retrospectively. Diameter of the lumen of the common carotid artery (CD) and the diameters of the lumen of the internal jugular vein (ID) were measured at the same level that is one slice inferior to the slice in which the bifurcation of the CCA is observed firstly. CCA intima-media thickness (CIMT), IJV intima-media thickness (IIMT), CCA-midline distance (CMD) and IJV-midline distance (IMD) were also measured at the aforementioned level. The measurements were evaluated in relation to gender and asymmetry. Results: The values measured for Right CMD, Right IMD, Left CD, Left CMD and Left IMD of males were greater than those of females (p<0.05). The results stressed various morphometric parameters and topography of the IJV and CCA. Conclusion: The results are suggested to be helpful in determination of normal values in terms of diagnostic purposes and treatment planning. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Kidney Transplantation and COVID-19: Two Case Reports(Elsevier Inc., 2021) Tekin, Sabri; Özdoğan, Hatice; Demir, Mustafa Kemal; Soultan, Hagar Elsayed Akram; Zafar, Sadia; Tekin, Sabri, Department of Organ Transplantation, Bahçeşehir Üniversitesi, Istanbul, Turkey; Özdoğan, Hatice, Department of Internal Medicine, Ercis State Hospital, Van, Turkey; Demir, Mustafa Kemal, Department of Radiology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Soultan, Hagar Elsayed Akram, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, Turkey; Zafar, Sadia, Faculty of Medicine, Bahçeşehir Üniversitesi, Istanbul, TurkeyImmunocompromised populations are at great risk of the current 2020 global emergency of coronavirus disease 2019 (COVID-19), and treatment of kidney transplant recipients with COVID-19 is currently not declared. Hence, the purpose of the study is to set a clear treatment regimen. We report here a therapeutic course of 2 patients who underwent transplant surgery in March 2020 and got infected soon after. Since the transplant, these 2 patients have received triple maintenance immunosuppressive therapy with oral tacrolimus, mycophenolate mofetil (MMF), and prednisone, and they have been regularly followed up at our hospital. The tacrolimus trough level was between 10 and 12 ng/mL. After the diagnosis of COVID-19, MMF was stopped and the tacrolimus dose was reduced so that blood level was between 4 and 6 ng/mL. The first patient was a 30-year-old man who, despite being treated with hydroxychloroquine, favipiravir, oseltamivir, and azithromycin therapy, died because of the presence of other comorbidities. The second case was a 58-year-old man who fully recovered from COVID-19 pneumonia with treatment with methylprednisolone, MMF, azithromycin, favipiravir, hydroxychloroquine, and reduction in immunosuppression dosage. This reflects the importance of using glucocorticoids in the treatment of COVID-19 along with other medications and the decreased mortality rate associated with their use. © 2021 Elsevier B.V., All rights reserved.