Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
Permanent URI for this communityhttps://hdl.handle.net/20.500.14719/1741
Browse
19 results
Search Results
Publication Open Access Letter to the Editor: Radiotherapy Increases aMMP-8 Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study(SAGE Publications Ltd, 2023) Yilmaz, Busra; Topkan, Erkan; Pehlivan, Berrin; Selek, Uǧur; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, Turkey[No abstract available]Publication Metadata only Pre-chemoradiotherapy low hemoglobin levels indicate increased osteoradionecrosis risk in locally advanced nasopharyngeal cancer patients(Springer Science and Business Media Deutschland GmbH, 2023) Yilmaz, Busra; Somay, Efsun; Topkan, Erkan; Pehlivan, Berrin; Selek, Uǧur; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Somay, Efsun, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, Turkey, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United StatesPurpose: We aimed to determine whether pretreatment hemoglobin (Hb) levels can predict the risk of osteoradionecrosis (ORN) in patients receiving concurrent chemoradiotherapy (CCRT) for locally advanced nasopharyngeal carcinoma (LA-NPC). Methods: ORN cases were identified from the records of LA-NPCs who had oral exams before and after CCRT. All Hb measurements were obtained on the first day of treatment. Receiving operating characteristic curve analysis was used to determine the relationship between Hb levels and ORN rates. The relationship between pretreatment Hb levels and ORN rates served as the primary endpoint, and secondary endpoints included the discovery of additional potential ORN risk factors. Results: Among the 263 eligible LA-NPCs, we identified 8.7% ORN cases. The ideal cutoff Hb before CCRT was 10.6 g/dL. It was revealed that HPR ≤ 10.6 group had a significantly higher ORN rate (32.5% vs. 1.5% for Hb > 10.6, P < 0.001). The mandibular V59.8 ≥ 36% Gy, pre-CCRT ≥ 4 tooth extractions, the presence of post-CCRT tooth extractions, and the time of post-CCRT tooth extractions > 8 months were the other factors associated with significantly increased ORN rates (P < 0.05 for each). Conclusion: Low pre-CCRT Hb levels appeared to be independently linked to significantly higher ORN rates. Pretreatment Hb levels may be used to establish preventive measures and predict ORN. © 2023 Elsevier B.V., All rights reserved.Publication Metadata only Comment on: Planned dose of intensity modulated proton beam therapy versus volumetric modulated arch therapy to tooth-bearing regions(Elsevier Ltd, 2023) Yilmaz, Busra; Topkan, Erkan; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey[No abstract available]Publication Metadata only The predictive usefulness of the novel combined hemoglobin-to-platelet ratio and maximum mouth opening index on prevalence of radiation induced trismus in patients with nasopharyngeal cancer(John Wiley and Sons Inc, 2023) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Kucuk, Ahmet; Pehlivan, Berrin; Selek, Uǧur; Somay, Efsun, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Kucuk, Ahmet, Department of Radiation Oncology, Mersin City Hospital, Mersin, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, Turkey, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United StatesObjectives: To explore how well a unique combination of hemoglobin-to-platelet ratio (HPR) and pretreatment maximum mouth opening (MMO) predicts the prevalence of radiation-induced trismus (RIT). Patients and methods: HPR and MMO cutoff values (0.54 and 40.7 mm) divided patients into two groups. To develop the novel HPR-MMO index, four combinations of these factors were tested for predictive power: Group 1: HPR > 0.54 and MMO > 40.7 mm, Group 2: HPR ≤ 0.54 but MMO > 40.7 mm, Group 3: HPR > 0.54 but MMO ≤ 40.7 mm, Group 4: HPR ≤ 0.54 and MMO ≤ 40.7 mm. Results: Data of 198 patients with LA-NPC was analyzed retrospectively. RIT rates for Groups 1 to 4 were 10.2%, 15.2%, 25%, and 59.4%. Groups 2 and 3 were merged to generate HPR-MMO index because of statistically equivalent RIT rates: Low-risk: HPR > 0.54 and MMO > 40.7 mm, Intermediate-risk: HPR ≤ 0.54 but MMO > 40.7 mm or, HPR > 0.54 but MMO ≤ 40.7 mm, High-risk: HPR ≤ 0.54 and MMO ≤ 40.7 mm. It was revealed that the low-, high-, and intermediate-risk group's RIT rates, 10.2%, 59.4%, and 19.2%, respectively. Conclusion: The novel HPR-MMO index may to classify LA-NPC patients into low, intermediate, and high-risk RIT groups. © 2023 Elsevier B.V., All rights reserved.Publication Metadata only Hemoglobin-to-platelet ratio in predicting the incidence of trismus after concurrent chemoradiotherapy(John Wiley and Sons Inc, 2023) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Kucuk, Ahmet; Haksöyler, Veysel; Pehlivan, Berrin; Selek, Uǧur; Araz, Kenan; Somay, Efsun, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Yilmaz, Busra, Department of Dentomaxillofacial Radiology, Başkent Üniversitesi, Ankara, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Kucuk, Ahmet, Department of Radiation Oncology, Mersin City Hospital, Mersin, Turkey; Haksöyler, Veysel, Department of Medical Oncology, Medline Hospital, Adana, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, Turkey, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States; Araz, Kenan, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, TurkeyObjective: The significance of pre-hemoglobin-to-platelet ratio (HPR) in predicting the occurrence of radiation-induced trismus (RIT) in locally advanced nasopharyngeal carcinoma patients (LA-NPC) who received concurrent chemoradiotherapy (C-CRT). Methods: The records of LA-NPC patients with oral examination before and after C-CRT were analyzed. Maximum mouth openings (MMO) were measured before and after C-CRT to confirm RIT status, with an MMO of ≤35 mm defined as RIT. HPR values were calculated on the first day of C-CRT. The relationship between the HPR values and RIT status was discovered using the receiver operating characteristic curve analysis. Results: A total of 43 patients RIT cases among 198 individuals were diagnosed. The optimal HPR cutoff that stratified the patients into two groups was 0.54. RIT incidence was found to be significantly higher in the HPR ≤0.54 group than its HPR >0.54 counterpart(p < 0.001). Univariately T3-4 stage, mean masticator apparatus dose>57.2Gy, and pre-C-CRT MMO ≤40.7 mm were found as the other significant correlates of increased RIT rates(p < 0.05). All four variables seemed to be independently connected to greater RIT incidence in multivariate analysis (p < 0.05, for each). Conclusion: The risk of post-C-CRT RIT may be significantly increased when pre-treatment HPR levels are low. © 2023 Elsevier B.V., All rights reserved.Publication Metadata only Letter to the Editor regarding Radiologic findings of osteonecrosis, osteoradionecrosis, osteomyelitis and jaw metastatic disease with cone beam CT(Elsevier Ireland Ltd, 2023) Yilmaz, Busra; Topkan, Erkan; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey[No abstract available]Publication Metadata only Radiation therapy for cT1-2 carcinoma of the palatine tonsil diagnosed via a simple tonsillectomy: Dosimetry and patterns of care in the IMRT era(Elsevier Ltd, 2023) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Somay, Efsun, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Open Access The predictive value of pretreatment hemoglobin-to-platelet ratio on osteoradionecrosis incidence rates of locally advanced nasopharyngeal cancer patients managed with concurrent chemoradiotherapy(BioMed Central Ltd, 2023) Yilmaz, Busra; Somay, Efsun; Topkan, Erkan; Kucuk, Ahmet; Pehlivan, Berrin; Selek, Uǧur; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Somay, Efsun, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Kucuk, Ahmet, Department of Radiation Oncology, Mersin City Hospital, Mersin, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, TurkeyBackground: This retrospective study aimed to investigate whether the pretreatment hemoglobin-to-platelet ratio (HPR) could predict the risk of osteoradionecrosis (ORN) in patients receiving concurrent chemoradiotherapy (C-CRT) for locally advanced nasopharyngeal carcinoma (LA-NPC). Methods: ORN cases were reported from the records of LA-NPC patients who had oral examinations before and after C-CRT. The pretreatment HPR values were calculated on the first day of C-CRT. The connection between HPR values and ORN occurrences was determined using receiver operating characteristic curve analysis. The primary endpoint was the relationship between the pretreatment HPR values and post-C-CRT ORN incidence rates, while secondary endpoints included the identification of other putative ORN risk factors. Results: We distinguished 10.9% incidences of ORN during the post-C-CRT follow-up period among 193 LA-NPC patients. The optimal cutoff for pre-C-CRT HPR was 0.48 that grouped the patients into two HPR groups with fundamentally different post-C-CRT ORN incidence rates: Group 1: HPR ≤ 0.48 (N = 60), and Group 2: HPR > 0.48 (N = 133). The comparative analysis indicated a significantly higher ORN incidence in HPR ≤ 0.48 group (30%, P < 0.001). The other factors associated with meaningfully increased ORN rates included the presence of pre-C-CRT ≥ 5 teeth extractions, mandibular volume receiving ≥ 64 Gy, post-C-CRT tooth extractions, mean mandibular dose ≥ 50.6 Gy, and C-CRT to tooth extraction interval > 5.5 months. Conclusion: Low pretreatment HPR levels were independently and unequivocally linked to significantly increased incidence of ORN post-C-CRT. Pre-C-CRT HPR levels may be used to estimate the incidence of ORN and be useful for taking preventive and therapeutic measures in these patients such as monitoring oral hygiene with strict follow-up, avoidance of unnecessary tooth extractions, particularly after C-CRT, and use of more rigorous mandibular RT dose limits. © 2023 Elsevier B.V., All rights reserved.Publication Open Access Valero’s host index is useful in predicting radiation-induced trismus and osteoradionecrosis of the jaw risks in locally advanced nasopharyngeal carcinoma patients(BioMed Central Ltd, 2023) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; Pehlivan, Berrin; Selek, Uǧur; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey; Somay, Efsun, Department of Oral and Maxillofacial Surgery, Başkent Üniversitesi, Ankara, Turkey; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Pehlivan, Berrin, Department of Radiation Oncology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Selek, Uǧur, Department of Radiation Oncology, Koç Üniversitesi, Istanbul, TurkeyBackground: In the absence of previous research, we sought to assess the H-Index’s predictive significance for radiation-induced trismus (RIT) and osteoradionecrosis of the jaw (ORNJ) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving concurrent chemoradiotherapy (C-CRT). Patients and methods: The research comprised 295 LA-NPC patients who had C-CRT and pre- and post-C-CRT oral exams between June 2010 and December 2021. The H-Index was calculated using neutrophils, monocytes, lymphocytes, hemoglobin, and albumin measurements obtained on the first day of C-CRT. Patients were divided into three and two H-index groups, respectively, based on previously established cutoff values (1.5 and 3.5) and the cutoff value determined by our receiver operating characteristic (ROC) curve analysis. The primary objective was the presence of any significant connections between pretreatment H-Index groups and post-C-CRT RIT and ORNJ rates. Results: RIT and ORNJ was diagnosed in 46 (15.6%) and 13 (7.8%) patients, respectively. The original H-Index grouping could only categorize RIT and ORNJ risks at a cutoff value of 3.5, with no significant differences in RIT and ORNJ rates between groups with H-Index 1.5 and 1.5 to 3.5 (P < 0.05 for each). The ideal H-Index cutoff for both RIT and ORNJ rates was found to be 5.5 in ROC curve analysis, which divided the entire research population into two groups: H-Index ≤ 5.5 (N = 195) and H-Index > 5.5 (N = 110). Intergroup comparisons revealed that patients in the H-Index > 5.5 group had significantly higher rates of either RIT (31.8% vs. 5.9%, P < 0.001) or ORNJ (17.3% vs. 2.2%, P < 0.001) than their H-Index ≤ 5.5 counterparts. The results of the multivariate analysis showed that H-Index > 5.5 was independently linked to significantly higher RIT (P < 0.001) and ORNJ (P < 0.001) rates. Conclusion: Pre-C-CRT H-Index > 5.5 is associated with significantly increased RIT and ORNJ rates in LA-NPC patients receiving definitive C-CRT. © 2023 Elsevier B.V., All rights reserved.Publication Metadata only Letter to the editor: trismus, health‐related quality of life, and trismus‐related symptoms up to 5 years post‐radiotherapy for head and neck cancer treated between 2007 and 2012(Springer Science and Business Media Deutschland GmbH, 2023) Yilmaz, Busra; Topkan, Erkan; Yilmaz, Busra, Department of Oral and Maxillofacial Surgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Topkan, Erkan, Department of Radiation Oncology, Başkent Üniversitesi, Ankara, Turkey[No abstract available]