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Publication Metadata only Synthetic algocyanobacterial consortium as an alternative to chemical fertilizers(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2023) Sadvakasova, Assemgul K.; Bauenova, Meruyert O.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Huang, Zhiyong; Wang, Jingjing; Balouch, Huma; Alharby, Hesham F.; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityThe use of unregulated pesticides and chemical fertilizers can have detrimental effects on biodiversity and human health. This problem is exacerbated by the growing demand for agricultural products. To address these global challenges and promote food and biological security, a new form of agriculture is needed that aligns with the principles of sustainable development and the circular economy. This entails developing the biotechnology market and maximizing the use of renewable and eco-friendly resources, including organic fertilizers and biofertilizers. Phototrophic microorganisms capable of oxygenic photosynthesis and assimilation of molecular nitrogen play a crucial role in soil microbiota, interacting with diverse microflora. This suggests the potential for creating artificial consortia based on them. Microbial consortia offer advantages over individual organisms as they can perform complex functions and adapt to variable conditions, making them a frontier in synthetic biology. Multifunctional consortia overcome the limitations of monocultures and produce biological products with a wide range of enzymatic activities. Biofertilizers based on such consortia present a viable alternative to chemical fertilizers, addressing the issues associated with their usage. The described capabilities of phototrophic and heterotrophic microbial consortia enable effective and environmentally safe restoration and preservation of soil properties, fertility of disturbed lands, and promotion of plant growth. Hence, the utilization of algo-cyanobacterial consortia biomass can serve as a sustainable and practical substitute for chemical fertilizers, pesticides, and growth promoters. Furthermore, employing these bio-based organisms is a significant stride towards enhancing agricultural productivity, which is an essential requirement to meet the escalating food demands of the growing global population. Utilizing domestic and livestock wastewater, as well as CO2 flue gases, for cultivating this consortium not only helps reduce agricultural waste but also enables the creation of a novel bioproduct within a closed production cycle.Publication Metadata only Biotechnological production of hydrogen: Design features of photobioreactors and improvement of conditions for cultivating cyanobacteria(PERGAMON-ELSEVIER SCIENCE LTD, 2024) Kossalbayev, Bekzhan D.; Yilmaz, Girayhan; Sadvakasova, Asemgul K.; Zayadan, Bolatkhan K.; Belkozhayev, Ayaz M.; Kamshybayeva, Gulzhanay K.; Sainova, Gaukhar A.; Bozieva, Ayshat M.; Alharby, Hesham F.; Tomo, Tatsuya; Allakhverdiev, Suleyman I.; Satbayev University; Satbayev University; Al-Farabi Kazakh National University; Bahcesehir University; Aitkhozhin Institute of Molecular Biology & Biochemistry; Akhmet Yassawi International Kazakh-Turkish University; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; King Abdulaziz University; Tokyo University of ScienceOver the last five decades, solar-based hydrogen (H2) production has been intensively studied. Specifically, the study of biophotolysis by cyanobacteria has received great attention to produce H2, and promising research approaches have been established. To date, numerous photobioreactors (PBRs) have been built to collect cyanobacterial biomass and generate bioenergy. Additionally, different PBR parameters were adjusted to increase the product yield. PBR development holds great potential not only for cell biomass but also for biological H2 production. This review aimed to examine the mechanisms involved in H2 production by cyanobacteria, explore the factors influencing the process, and describe five distinct PBRs known for their high H2 production. This article examines the pros and cons of the most efficient PBRs for H2 production and offers insights into strategies for (c) 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Genetic engineering contribution to developing cyanobacteria-based hydrogen energy to reduce carbon emissions and establish a hydrogen economy(PERGAMON-ELSEVIER SCIENCE LTD, 2024) Kamshybayeva, Gulzhanay K.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Kakimova, Ardak B.; Bauenova, Meruyert O.; Zayadan, Bolatkhan K.; Lan, Chi-Wei; Alwasel, Saleh; Tomo, Tatsuya; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Yuan Ze University; King Saud University; Tokyo University of Science; Tunghai University; Tunghai University; National Cheng Kung University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; King Abdulaziz University; Bahcesehir UniversityGrowing concerns over greenhouse gas emissions and energy insecurity caused by the depletion of conventional fuels have led to a search for sustainable fuel alternatives. As an alternative energy carrier, hydrogen (H2) is particularly attractive as only water is released during combustion. The process of H2 production from genetically engineered phototrophic microorganisms through biophotolysis leads the way to solve energy shortages. Genetically engineered cyanobacteria species are potential candidates due to their superior properties for reducing greenhouse gases and using solar energy as an energy source. The review discusses the mechanisms and enzymes involved in H2 production by cyanobacteria and applications of genetic engineering. A critical analysis of the fundamental issues attributed to the technical advancement of photobiological cyanobacteria-based H2 production is provided, as well as the perspectives for future research to reduce carbon dioxide emissions through the creation of waste-free technology. (c) 2022 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Prospects of cyanobacterial pigment production: Biotechnological potential and optimization strategies(ELSEVIER, 2022) Sandybayeva, Sandugash K.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Sadvakasova, Asem K.; Bolatkhan, Kenzhegul; Zadneprovskaya, Elena, V; Kakimov, Ardak B.; Alwasel, Saleh; Leong, Yoong Kit; Allakhverdiev, Suleyman I.; Chang, Jo-Shu; Al-Farabi Kazakh National University; Satbayev University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; King Saud University; Tunghai University; Russian Academy of Sciences; Bahcesehir University; Tunghai University; National Cheng Kung University; Yuan Ze UniversityIncreasing awareness of the harmful effects of synthetic colorants has led consumers to favor the use of natural alternatives such as plant or microbial pigments in food and cosmetics. Cyanobacteria are a rich source of many natural biopigments that are of high commercial value. In the market, bio-based pigments are usually sold as extracts to reduce purification costs. Various cell disruption methods are used for pigment extraction, such as sonication, homogenization, high pressure, supercritical CO2 extraction, enzymatic extraction, as well as other promising novel extraction methods that make the production of cyanobacterial pigments economically viable. In addition, a continuous cultivation system is considered the most suitable cultivation mode for large-scale biomass production. However, a major limitation in the large-scale production of cyanobacterial pigments is the installation and operation costs. Thus, basic and applied research is still needed to overcome such limitations and enable cyanobacteria to enter the global market. This review focuses on various cyanobacterial pigments, their applications, and current biotechnological approaches to increase the production of biopigments for their potential use in the pharmaceutical, food, and cosmetic industries. The current state of production technologies based on either open pond systems or closed photobioreactors was compared. The potential of scientific and technological advances to increase yield and reduce production costs of cyanobacteria biomass-based pigments was also discussed.Publication Metadata only Effect of the photosynthesis inhibitors on hydrogen production by non-heterocyst cyanobacterial strains(PERGAMON-ELSEVIER SCIENCE LTD, 2024) Kamshybayeva, Gulzhanay K.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Bauenova, Meruyert O.; Zayadan, Bolatkhan K.; Krapivina, Anastasia A.; Sainova, Gaukhar A.; Alharby, Hesham F.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Akhmet Yassawi International Kazakh-Turkish University; King Abdulaziz University; Russian Academy of Sciences; Bahcesehir UniversityThe energy of cyanobacterial hydrogen (H2) produced via bio-photolysis is being investigated as a potential solution to early-century environmental challenges. The main limiting factors of cyanobacterial H2 photoproduction are the availability of electrons for [NiFe]hydrogenase (H2ase) and the suppression of bidirectional H2ase activity induced by O2 acquired from water molecules splitting in photosystem II. The current study investigated how photosynthetic inhibitors (PIs) affected H2 production in non-N2-fixing cyanobacteria. Study findings revealed a rather high H2 yield in Synechocystis sp. PSU 1262, as well as a beneficial (14.2-fold) influence of 500 mmol KCN on the H2 production by the aforesaid strain. A 12/6-h light/dark cycle increased H2 production by 80.3% in cells supplemented with 500 mmol KCN. Under the optimised conditions, the photobiological H2 production of Synechocystis sp. PSU 1262 increased from 49.6 to 1552 nmol H2 mg-1 Chl a h-1. PIs suppressed chlorophyll a concentration under illumination, lowering the O2 levels, which enhanced bidirectional H2ase activity in Synechocystis sp. PSU 1262 cells. Applying varied light modes, preceded by the incorporation of PIs at optimal concentrations in H2 production by research cyanobacterial strains, improved the H2 yield and contributed signif (c) 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Prospects of cyanobacterial pigment production: Biotechnological potential and optimization strategies(Elsevier B.V., 2022) Sandybayeva, Sandugash K.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Sadvakasova, Asemgul K.; Bolatkhan, K.; Zadneprovskaya, Elena V.; Kakimova, Ardak B.; Alwasel, Salah Hamad; Leong, Yoong Kit; Allakhverdiev, Suleyman I.; Sandybayeva, Sandugash K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Kossalbayev, Bekzhan D., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan, Department of Chemical and Biochemical Engineering, Satbayev University, Almaty, Kazakhstan; Zayadan, Bolatkhan K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Sadvakasova, Asemgul K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Bolatkhan, K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Zadneprovskaya, Elena V., Controlled Photobiosynthesis Laboratory, Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation; Kakimova, Ardak B., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Alwasel, Salah Hamad, College of Sciences, Riyadh, Saudi Arabia; Leong, Yoong Kit, Department of Chemical and Materials Engineering, Tunghai University, Taichung, Taiwan; Allakhverdiev, Suleyman I., Controlled Photobiosynthesis Laboratory, Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation, Institute of Fundamental Problems of Biology of the Russian Academy of Sciences, Pushchino, Russian Federation, Faculty of Engineering and Natural Sciences, Bahçeşehir Üniversitesi, Istanbul, TurkeyIncreasing awareness of the harmful effects of synthetic colorants has led consumers to favor the use of natural alternatives such as plant or microbial pigments in food and cosmetics. Cyanobacteria are a rich source of many natural biopigments that are of high commercial value. In the market, bio-based pigments are usually sold as extracts to reduce purification costs. Various cell disruption methods are used for pigment extraction, such as sonication, homogenization, high pressure, supercritical CO2 extraction, enzymatic extraction, as well as other promising novel extraction methods that make the production of cyanobacterial pigments economically viable. In addition, a continuous cultivation system is considered the most suitable cultivation mode for large-scale biomass production. However, a major limitation in the large-scale production of cyanobacterial pigments is the installation and operation costs. Thus, basic and applied research is still needed to overcome such limitations and enable cyanobacteria to enter the global market. This review focuses on various cyanobacterial pigments, their applications, and current biotechnological approaches to increase the production of biopigments for their potential use in the pharmaceutical, food, and cosmetic industries. The current state of production technologies based on either open pond systems or closed photobioreactors was compared. The potential of scientific and technological advances to increase yield and reduce production costs of cyanobacteria biomass-based pigments was also discussed. © 2022 Elsevier B.V., All rights reserved.Publication Metadata only Synthetic algocyanobacterial consortium as an alternative to chemical fertilizers(Academic Press Inc., 2023) Sadvakasova, Asemgul K.; Bauenova, Meruyert O.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Huang, Zhiyong; Wang, Jingjing; Balouch, Huma; Alharby, Hesham Fasial; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Sadvakasova, Asemgul K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Bauenova, Meruyert O., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Kossalbayev, Bekzhan D., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan, Department of Chemical and Biochemical Engineering, Satbayev University, Almaty, Kazakhstan; Zayadan, Bolatkhan K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Huang, Zhiyong, Tianjin Institute of Industrial Biotechnology, Tianjin, China; Wang, Jingjing, Tianjin Institute of Industrial Biotechnology, Tianjin, China; Balouch, Huma, Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Alharby, Hesham Fasial, Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Chang, Jo-Shu, Department of Chemical and Materials Engineering, Tunghai University, Taichung, Taiwan, Research Center for Smart Sustainable Circular Economy, Tunghai University, Taichung, Taiwan, National Cheng Kung University, Tainan, Taiwan, Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, Taiwan; Allakhverdiev, Suleyman I., Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation, Institute of Fundamental Problems of Biology of the Russian Academy of Sciences, Pushchino, Russian Federation, Faculty of Engineering and Natural Sciences, Bahçeşehir Üniversitesi, Istanbul, TurkeyThe use of unregulated pesticides and chemical fertilizers can have detrimental effects on biodiversity and human health. This problem is exacerbated by the growing demand for agricultural products. To address these global challenges and promote food and biological security, a new form of agriculture is needed that aligns with the principles of sustainable development and the circular economy. This entails developing the biotechnology market and maximizing the use of renewable and eco-friendly resources, including organic fertilizers and biofertilizers. Phototrophic microorganisms capable of oxygenic photosynthesis and assimilation of molecular nitrogen play a crucial role in soil microbiota, interacting with diverse microflora. This suggests the potential for creating artificial consortia based on them. Microbial consortia offer advantages over individual organisms as they can perform complex functions and adapt to variable conditions, making them a frontier in synthetic biology. Multifunctional consortia overcome the limitations of monocultures and produce biological products with a wide range of enzymatic activities. Biofertilizers based on such consortia present a viable alternative to chemical fertilizers, addressing the issues associated with their usage. The described capabilities of phototrophic and heterotrophic microbial consortia enable effective and environmentally safe restoration and preservation of soil properties, fertility of disturbed lands, and promotion of plant growth. Hence, the utilization of algo-cyano-bacterial consortia biomass can serve as a sustainable and practical substitute for chemical fertilizers, pesticides, and growth promoters. Furthermore, employing these bio-based organisms is a significant stride towards enhancing agricultural productivity, which is an essential requirement to meet the escalating food demands of the growing global population. Utilizing domestic and livestock wastewater, as well as CO2 flue gases, for cultivating this consortium not only helps reduce agricultural waste but also enables the creation of a novel bioproduct within a closed production cycle. © 2023 Elsevier B.V., All rights reserved.Publication Metadata only Effect of the photosynthesis inhibitors on hydrogen production by non-heterocyst cyanobacterial strains(Elsevier Ltd, 2024) Kamshybayeva, Gulzhanay K.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Bauenova, Meruyert O.; Zayadan, Bolatkhan K.; Krapivina, Anastasia A.; Sainova, Gaukhar Askerovna; Alharby, Hesham Fasial; Allakhverdiev, Suleyman I.; Kamshybayeva, Gulzhanay K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan, Department of Chemical and Biochemical Engineering, Satbayev University, Almaty, Kazakhstan; Kossalbayev, Bekzhan D., Department of Chemical and Biochemical Engineering, Satbayev University, Almaty, Kazakhstan; Sadvakasova, Asemgul K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Bauenova, Meruyert O., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Zayadan, Bolatkhan K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Krapivina, Anastasia A., Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation; Sainova, Gaukhar Askerovna, Ecology Research Institute, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan; Alharby, Hesham Fasial, Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Allakhverdiev, Suleyman I., Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation, Institute of Fundamental Problems of Biology of the Russian Academy of Sciences, Pushchino, Russian Federation, Faculty of Engineering and Natural Sciences, Bahçeşehir Üniversitesi, Istanbul, TurkeyThe energy of cyanobacterial hydrogen (H2) produced via bio-photolysis is being investigated as a potential solution to early-century environmental challenges. The main limiting factors of cyanobacterial H2 photoproduction are the availability of electrons for [NiFe]-hydrogenase (H2ase) and the suppression of bidirectional H2ase activity induced by O2 acquired from water molecules splitting in photosystem II. The current study investigated how photosynthetic inhibitors (PIs) affected H2 production in non-N2-fixing cyanobacteria. Study findings revealed a rather high H2 yield in Synechocystis sp. PSU 1262, as well as a beneficial (14.2-fold) influence of 500 μmol KCN on the H2 production by the aforesaid strain. A 12/6-h light/dark cycle increased H2 production by 80.3% in cells supplemented with 500 μmol KCN. Under the optimised conditions, the photobiological H2 production of Synechocystis sp. PSU 1262 increased from 49.6 to 1552 nmol H2 mg−1 Chl a h−1. PIs suppressed chlorophyll a concentration under illumination, lowering the O2 levels, which enhanced bidirectional H2ase activity in Synechocystis sp. PSU 1262 cells. Applying varied light modes, preceded by the incorporation of PIs at optimal concentrations in H2 production by research cyanobacterial strains, improved the H2 yield and contributed significantly to the research originality. © 2023 Elsevier B.V., All rights reserved.Publication Metadata only Combating Phytopathogens by Integration of Metagenomics and Phototrophic Biotechnologies: Toward Sustainable Agricultural Practices(Taylor and Francis Ltd., 2025) Sadvakasova, Asemgul K.; Kossalbayev, Bekzhan D.; Zaletova, Dilnaz E.; Bauenova, Meruyert O.; Huang, Zhiyong; Zharmukhamedov, Sergei K.; Shabala, Sergey Nikolayevich; Allakhverdiev, Suleyman I.; Sadvakasova, Asemgul K., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Kossalbayev, Bekzhan D., Department of Chemical and Biochemical Engineering, Satbayev University, Almaty, Kazakhstan, Ecology Research Institute, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan; Zaletova, Dilnaz E., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Bauenova, Meruyert O., Faculty of Biology and Biotechnology, Al Farabi Kazakh National University, Almaty, Kazakhstan; Huang, Zhiyong, Tianjin Institute of Industrial Biotechnology, Tianjin, China; Zharmukhamedov, Sergei K., Institute of Fundamental Problems of Biology of the Russian Academy of Sciences, Pushchino, Russian Federation; Shabala, Sergey Nikolayevich, School of Biological Sciences, The University of Western Australia, Perth, Australia; Allakhverdiev, Suleyman I., Institute of Fundamental Problems of Biology of the Russian Academy of Sciences, Pushchino, Russian Federation, Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russian Federation, Faculty of Engineering and Natural Sciences, Bahçeşehir Üniversitesi, Istanbul, TurkeyRising global food demand amid climate change presents unprecedented challenges for modern agriculture. The spread of phytopathogens and the degradation of agroecosystems necessitate the development of innovative plant protection solutions. Traditional chemical pesticides are losing their effectiveness due to the emergence of resistant pathogens and their adverse environmental impacts, thereby intensifying interest in biological control methods. This study examines the integration of metagenomic analysis and phototrophic biotechnology as a promising approach to biocontrol. Metagenomics enables the precise identification of phytopathogens and beneficial microorganisms, laying the groundwork for the development of targeted biopesticides. Phototrophic microorganisms, including microalgae and cyanobacteria, exhibit antimicrobial properties and contribute to the restoration of soil ecosystems. The convergence of these technologies offers opportunities to form adaptive microbial consortia that ensure the long-term sustainability of agroecosystems. The paper discusses key challenges, including data processing complexities, the scalability of technologies, and regulatory barriers, and underscores the need for standardized methodologies and interdisciplinary collaboration. The integration of metagenomics and phototrophic biotechnology represents a promising direction for creating environmentally safe and sustainable agricultural production systems. © 2025 Elsevier B.V., All rights reserved.