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Publication Metadata only Combating Phytopathogens by Integration of Metagenomics and Phototrophic Biotechnologies: Toward Sustainable Agricultural Practices(TAYLOR & FRANCIS INC, 2025) Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; Zaletova, Dilnaz; Bauenova, Meruyert O.; Huang, Zhiyong; Zharmukhamedov, Sergey K.; Shabala, Sergey; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Russian Academy of Sciences; University of Western Australia; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityRising global food demand amid climate change presents unprecedented challenges for modern agriculture. The spread of phytopathogens and the degradation of agroecosystems necessitate the development of innovative plant protection solutions. Traditional chemical pesticides are losing their effectiveness due to the emergence of resistant pathogens and their adverse environmental impacts, thereby intensifying interest in biological control methods. This study examines the integration of metagenomic analysis and phototrophic biotechnology as a promising approach to biocontrol. Metagenomics enables the precise identification of phytopathogens and beneficial microorganisms, laying the groundwork for the development of targeted biopesticides. Phototrophic microorganisms, including microalgae and cyanobacteria, exhibit antimicrobial properties and contribute to the restoration of soil ecosystems. The convergence of these technologies offers opportunities to form adaptive microbial consortia that ensure the long-term sustainability of agroecosystems. The paper discusses key challenges, including data processing complexities, the scalability of technologies, and regulatory barriers, and underscores the need for standardized methodologies and interdisciplinary collaboration. The integration of metagenomics and phototrophic biotechnology represents a promising direction for creating environmentally safe and sustainable agricultural production systems.Publication Metadata only Spectral insights: Navigating the frontiers of biomedical and microbiological exploration with Raman spectroscopy(ELSEVIER SCIENCE SA, 2024) Allakhverdiev, Elvin S.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Bauenova, Meruyert O.; Belkozhayev, Ayaz M.; Rodnenkov, Oleg, V; Martynyuk, Tamila, V; Maksimov, Georgy, V; Allakhverdiev, Suleyman I.; National Medical Research Center of Cardiology; Lomonosov Moscow State University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Aitkhozhin Institute of Molecular Biology & Biochemistry; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Bahcesehir UniversityRaman spectroscopy (RS), a powerful analytical technique, has gained increasing recognition and utility in the fields of biomedical and biological research. Raman spectroscopic analyses find extensive application in the field of medicine and are employed for intricate research endeavors and diagnostic purposes. Consequently, it enjoys broad utilization within the realm of biological research, facilitating the identification of cellular classifications, metabolite profiling within the cellular milieu, and the assessment of pigment constituents within microalgae. This article also explores the multifaceted role of RS in these domains, highlighting its distinct advantages, acknowledging its limitations, and proposing strategies for enhancement.Publication Metadata only Assessing the Efficacy of Cyanobacterial Strains as Oryza sativa Growth Biostimulants in Saline Environments(MDPI, 2024) Bauenova, Meruyert O.; Sarsekeyeva, Fariza K.; Sadvakasova, Asemgul K.; Kossalbayev, Bekzhan D.; Mammadov, Ramazan; Token, Aziza I.; Balouch, Huma; Pashkovskiy, Pavel; Leong, Yoong Kit; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Akhmet Yassawi International Kazakh-Turkish University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Bahcesehir UniversitySoil salinity, which affects plant photosynthesis mechanisms, significantly limits plant productivity. Soil microorganisms, including cyanobacteria, can synthesize various exometabolites that contribute to plant growth and development in several ways. These microorganisms can increase plant tolerance to salt stress by secreting various phytoprotectants, therefore, it is highly relevant to study soil microorganisms adapted to high salinity and investigate their potential to increase plant resistance to salt stress. This study evaluated the antioxidant activity of four cyanobacterial strains: Spirulina platensis Calu-532, Nostoc sp. J-14, Trichormus variabilis K-31, and Oscillatoria brevis SH-12. Among these, Nostoc sp. J-14 presented the highest antioxidant activity. Their growth-stimulating effects under saline conditions were also assessed under laboratory conditions. These results indicate that Nostoc sp. J-14 and T. variabilis K-31 show significant promise in mitigating the harmful effects of salinity on plant size and weight. Both strains notably enhanced the growth of Oryza sativa plants under saline conditions, suggesting their potential as biostimulants to improve crop productivity in saline environments. This research underscores the importance of understanding the mechanisms by which cyanobacteria increase plant tolerance to salt stress, paving the way for sustainable agricultural practices in saline areas.Publication Metadata only Development and Transfer of Microbial Agrobiotechnologies in Contrasting Agrosystems: Experience of Kazakhstan and China(MDPI, 2025) Nygymetova, Aimeken M.; Sadvakasova, Assemgul K.; Zaletova, Dilnaz E.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Wang, Jingjing; Huang, Zhiyong; Sarsekeyeva, Fariza K.; Kirbayeva, Dariga K.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Bahcesehir University; Russian Academy of Sciences; Russian Academy of Sciences; Timiryazev Institute of Plant PhysiologyThe development and implementation of microbial consortium-based biofertilizers represent a promising direction in sustainable agriculture, particularly in the context of the ongoing global ecological and agricultural crisis. This article examines the agroecological and economic impacts of applying microbial consortiums and explores the mechanisms of technology transfer using the example of two countries with differing levels of scientific and technological advancement-China and Kazakhstan. The analysis of the Chinese experience reveals that the successful integration of microbial biofertilizers into agricultural practice is made possible by a well-established institutional framework that includes strong governmental support for R&D, a robust scientific infrastructure, and effective coordination with the private sector. In contrast, Kazakhstan, despite its favorable agroecological conditions and growing interest among farmers in environmentally friendly technologies, faces several challenges from limited funding to a fragmented technology transfer system. The comparative study demonstrates that adapting Chinese models requires consideration of local specificities and the strengthening of intergovernmental cooperation. The article concludes by emphasizing the need to establish a multi-level innovation ecosystem encompassing the entire cycle of development and deployment of microbial biofertilizers, as a prerequisite for improving agricultural productivity and ensuring food security in countries at different stages of economic development.Publication Metadata only Microalgae as a key tool in achieving carbon neutrality for bioproduct production(ELSEVIER, 2023) Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Balouch, Huma; Leong, Yoong Kit; Zayadan, Bolatkhan K.; Huang, Zhiyong; Alharby, Hesham F.; Tomo, Tatsuya; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Tunghai University; Tunghai University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Tokyo University of Science; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Lomonosov Moscow State University; Bahcesehir UniversityThe upcoming global climate change as a result of anthropogenic action is now increasingly attracting the attention of scientific communities. Over the past three decades, researchers and industries around the world have spent a lot of time and effort developing various carbon capture and storage technologies, which, despite their promise, are still economically complex, with unclear long-term consequences to the environment. As an alternative, biological carbon sequestration is considered an attractive method of atmospheric CO2 fixation with the production of biomass, which, in turn, can be used as a readily renewable feedstock for the production of biofuels and other valuable products. This review focuses on the latest data of microalgae research in terms of key carbon footprint minimization strategies, which include features of the carbon concentrating mechanism (CCM) in microalgae, the main range of biofuels and the possibility of obtaining valuable metabolites based on them, such as bioplastics, biofertilizers, and biologically active compounds.Publication Metadata only Synthetic algocyanobacterial consortium as an alternative to chemical fertilizers(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2023) Sadvakasova, Assemgul K.; Bauenova, Meruyert O.; Kossalbayev, Bekzhan D.; Zayadan, Bolatkhan K.; Huang, Zhiyong; Wang, Jingjing; Balouch, Huma; Alharby, Hesham F.; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Tunghai University; Tunghai University; National Cheng Kung University; Yuan Ze University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Bahcesehir UniversityThe use of unregulated pesticides and chemical fertilizers can have detrimental effects on biodiversity and human health. This problem is exacerbated by the growing demand for agricultural products. To address these global challenges and promote food and biological security, a new form of agriculture is needed that aligns with the principles of sustainable development and the circular economy. This entails developing the biotechnology market and maximizing the use of renewable and eco-friendly resources, including organic fertilizers and biofertilizers. Phototrophic microorganisms capable of oxygenic photosynthesis and assimilation of molecular nitrogen play a crucial role in soil microbiota, interacting with diverse microflora. This suggests the potential for creating artificial consortia based on them. Microbial consortia offer advantages over individual organisms as they can perform complex functions and adapt to variable conditions, making them a frontier in synthetic biology. Multifunctional consortia overcome the limitations of monocultures and produce biological products with a wide range of enzymatic activities. Biofertilizers based on such consortia present a viable alternative to chemical fertilizers, addressing the issues associated with their usage. The described capabilities of phototrophic and heterotrophic microbial consortia enable effective and environmentally safe restoration and preservation of soil properties, fertility of disturbed lands, and promotion of plant growth. Hence, the utilization of algo-cyanobacterial consortia biomass can serve as a sustainable and practical substitute for chemical fertilizers, pesticides, and growth promoters. Furthermore, employing these bio-based organisms is a significant stride towards enhancing agricultural productivity, which is an essential requirement to meet the escalating food demands of the growing global population. Utilizing domestic and livestock wastewater, as well as CO2 flue gases, for cultivating this consortium not only helps reduce agricultural waste but also enables the creation of a novel bioproduct within a closed production cycle.Publication Metadata only Progress and innovation in key technologies for converting biomass to hydrogen(PERGAMON-ELSEVIER SCIENCE LTD, 2025) Kamshybayeva, Gulzhanay K.; Sadvakasova, Asemgul K.; Belkozhayev, Ayaz M.; Kossalbayev, Bekzhan D.; Bauenova, Meruyert O.; Zharmukhamedov, Sergey K.; Hou, Harvey J. M.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Russian Academy of Sciences; Alabama State University; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; Bahcesehir UniversityThe growing demand for clean energy has spotlighted biomass as a promising resource for sustainable hydrogen production, providing a carbon-neutral alternative to traditional fossil fuels. This review examines the latest advancements in converting biomass to hydrogen, focusing on thermochemical methods like gasification and pyrolysis, catalyst development, and biotechnological approaches such as dark fermentation and biophotolysis. While these methods offer substantial environmental benefits, including waste reduction and renewable energy generation, challenges persist in optimizing feedstock diversity, enhancing catalyst stability, and achieving costeffective scalability. Innovations in plasma-assisted reforming, advanced nanocatalysts, and integrated reactor designs show promise in overcoming these barriers. By fostering collaboration across academia, industry, and government, these advancements can pave the way for a viable, sustainable hydrogen economy and contribute significantly to reducing global carbon emissions.Publication Metadata only Optimising microalgae-derived butanol yield(PERGAMON-ELSEVIER SCIENCE LTD, 2024) Bauenova, Meruyert O.; Sadvakasova, Assemgul K.; Kossalbayev, Bekzhan D.; Yilmaz, Girayhan; Huang, Zhiyong; Wang, Jingjing; Balouch, Huma; Zaletova, Dilnaz E.; Lyaguta, Mariya A.; Alharby, Hesham F.; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Akhmet Yassawi International Kazakh-Turkish University; Bahcesehir University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; King Abdulaziz University; Timiryazev Institute of Plant Physiology; Russian Academy of SciencesRapid global urbanisation emphasises the necessity to explore sustainable energy resources to fulfill escalating energy demands. Biobutanol emerges as a promising biofuel due to heightened energy density and molecular similarity to petrol. Microalgae, rich in carbohydrates, offer a potential glucose source for biobutanol fermen-tation. The current study shows that varying CO2 concentrations affect carbohydrate content in the biomass of P. kessleri bh-2 and Scenedesmus sp.k-7. The introduction of 1% CO2 significantly improved carbohydrate pro-ductivity, reaching 74.5% for P. kessleri bh-2 and 71.0% for Scenedesmus sp.k-7. Enzymatic hydrolysis was found to be most effective for ABE fermentation, with optimal results obtained at enzyme loads of 8 mg g 1 cellulase and 2 mg g 1 amylase for both strains. When C. acetobutylicum cells were cultivated with pretreated P. kessleri bh-2 biomass, the biobutanol yield amounted to 4.8 gL-1 at a glucose concentration of 5.30 gL-1, demonstrating strain's superior performance compared to Scenedesmus sp.k-7.Publication Metadata only Genetic engineering contribution to developing cyanobacteria-based hydrogen energy to reduce carbon emissions and establish a hydrogen economy(PERGAMON-ELSEVIER SCIENCE LTD, 2024) Kamshybayeva, Gulzhanay K.; Kossalbayev, Bekzhan D.; Sadvakasova, Asemgul K.; Kakimova, Ardak B.; Bauenova, Meruyert O.; Zayadan, Bolatkhan K.; Lan, Chi-Wei; Alwasel, Saleh; Tomo, Tatsuya; Chang, Jo-Shu; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Satbayev University; Yuan Ze University; King Saud University; Tokyo University of Science; Tunghai University; Tunghai University; National Cheng Kung University; Russian Academy of Sciences; Timiryazev Institute of Plant Physiology; Russian Academy of Sciences; King Abdulaziz University; Bahcesehir UniversityGrowing concerns over greenhouse gas emissions and energy insecurity caused by the depletion of conventional fuels have led to a search for sustainable fuel alternatives. As an alternative energy carrier, hydrogen (H2) is particularly attractive as only water is released during combustion. The process of H2 production from genetically engineered phototrophic microorganisms through biophotolysis leads the way to solve energy shortages. Genetically engineered cyanobacteria species are potential candidates due to their superior properties for reducing greenhouse gases and using solar energy as an energy source. The review discusses the mechanisms and enzymes involved in H2 production by cyanobacteria and applications of genetic engineering. A critical analysis of the fundamental issues attributed to the technical advancement of photobiological cyanobacteria-based H2 production is provided, as well as the perspectives for future research to reduce carbon dioxide emissions through the creation of waste-free technology. (c) 2022 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Strategies for genetic modification of microalgae to improve the production efficiency of liquid biofuel(PERGAMON-ELSEVIER SCIENCE LTD, 2025) Kossalbayev, Bekzhan D.; Kakimova, Ardak B.; Sadvakasova, Assemgul K.; Bauenova, Meruyert O.; Balouch, Huma; Zaletova, Maria; Ahmad, Fiaz; Kirbayeva, Dariga K.; Ozgul, Sevim; Allakhverdiev, Suleyman I.; Al-Farabi Kazakh National University; Satbayev University; Akhmet Yassawi International Kazakh-Turkish University; Northwestern Polytechnical University; Bahcesehir University; Russian Academy of Sciences; Timiryazev Institute of Plant PhysiologyThe application of genetic engineering in biofuel production has advanced significantly, driven by developments in genetic tools and omics technologies. These advancements have enhanced our understanding of lipid and carbohydrate metabolism, opening new avenues for metabolic engineering to optimize biofuel production. This review explores genetic strategies to improve the lipid content and fatty acid profiles for biodiesel production, as well as innovations in engineering for one-step biobutanol synthesis using cyanobacteria. Strategies for carbohydrate accumulation are also examined, highlighting their role in biofuel production. Additionally, the review evaluates the environmental risks associated with large-scale fourth-generation biofuel production. The findings emphasize the potential of genetic engineering to transform microalgae into highly efficient biofuel platforms capable of producing biodiesel, biobutanol, and other liquid biofuels. By addressing critical challenges and leveraging cutting-edge technologies, this research contributes to the development of sustainable and economically viable biofuel production systems.
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