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Publication Open Access A preliminary study of tracking B-cell kinetics in patients with lung transplantation by monitoring kappa-deleting recombination excision circles(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2022) Akbulut, Zeynep; Akdeniz, Tuba; Vayvada, Mustafa; Kalamanoğlu, Merih; Yeğinsu, Ali; Yanıkkaya Demirel, Gülderen; Kutlu, Cemal Asım; Maltepe University; Yeditepe University; Bahcesehir University; Istanbul Yeni Yuzyil University; Yeditepe University; Bahcesehir UniversityBackground: This study aims to evaluate humoral immune system response by measuring copy numbers of kappa-deleting recombination excision circles (KREC) gene segment from B lymphocytes in patients with lung transplantation. Methods: Between September 2015 and November 2016, a total of 11 patients (8 males, 3 females, mean age: 45.4 +/- 12.0 years, range, 23 to 59 years) who underwent lung transplantation with different primary indications were included. The copy numbers of KREC gene segment were quantified using real-time polymerase chain reaction method in peripheral blood samples collected pre- and post-transplantation. The samples of the patients were compared with the KREC levels in deoxyribonucleic acid extracted from blood samples of healthy children. Results: There was no significant change in KREC levels between pre- and post-operation (p=0.594 and p=0.657), although the median values indicated that the highest increase in the KREC levels (7x10(5)-12x10(5) , 85-170) was on Day 7 of transplantation. There was a positive correlation between the KREC levels (mL in blood) and lymphocytes at 24 h after transplantation (p=0.043) and between KREC copies per 10(6) of blood and age on Day 7. Conclusion: Our preliminary results suggest that KREC levels as an indicator of B lymphocyte production are elevated after lung transplantation. A prognostic algorithm by tracking B cell kinetics after post-transplantation for long-term follow-up can be developed following the confirmation of these preliminary results with more patient samples.Publication Open Access A mentorship model for teacher education: Young STEM researchers and practitioners program(MEHMET TEKEREK, 2022) Yabas, Defne; Bozoğlu, Hayriye Sinem; Bahçeşehir ÜniversitesiThe current research is about the impact of the young STEM researchers and practitioners program implemented within the STEM: Integrated teaching project. The aim of the program is to incorporate STEM integrated teaching knowledge in the teacher preparation period. In this phenomenological study, we explored five pre-school teachers' program experiences and their STEM conceptions. Data were collected with semi-structured interviews, including questions about the impact and elements of the program and participants' STEM conceptions. Content analysis showed that awareness for STEM education, development of integrated teaching knowledge, and program elements were the emergent themes about the program experience. Teacher candidates responded to the models that include real-world problems and engineering as contexts as most desirable when shown STEM education models to understand their STEM conceptions. The young STEM researchers and practitioners program can be evaluated as a developing model to be incorporated into teacher education programs. Further research can explore how pre-service teachers form their STEM conceptions and develop their integrated teaching knowledge.Publication Open Access Fizyoterapi ve Rehabilitasyon Öğrencilerinin Öğrenme Stili Tercihlerine Göre Akademik Başarı, Akademik Öz Güven ve Eğitim Ortamı Algısının Karşılaştırılması(2025) Açar, Görkem; Delibay, Aylin Aydoğdu; Kiloatar, Hümeyra; Turan, Onur; Bahçeşehir Üniversitesi; Kütahya Sağlık Bilimleri Üniversitesi; İstanbul Atlas ÜniversitesiBu çalışmanın amacı lisans düzeyindeki fizyoterapi ve rehabilitasyon öğrencilerinin farklı öğrenme stili tercihlerine göre akademik başarılarını, akademik özgüvenlerini ve öğrenme çevrelerini incelemekti. Çalışmaya lisans düzeyindeki 180 fizyoterapi ve rehabilitasyon öğrencisi dahil edilmiştir. Bireylerin öğrenme stili tercihleri Kolb Öğrenme Stili Envanteri-3 ile, öğrenme çevreleri Dundee Mevcut Eğitim Ortamı Değerlendirme Ölçeği (DREEM) ile, özgüvenleri ise Akademik Özgüven Ölçeği (AÖÖ) ile değerlendirilmiştir. Bireylerin akademik başarıları Genel Akademik Not Ortalamaları aracılığıyla değerlendirilmiştir. Farklı öğrenme stillerini tercih eden bireylerin Akademik Özgüven Ölçeği ile ölçülen akademik özgüvenleri benzerdi (p>0,05). Farklı öğrenme stillerini tercih eden bireylerin DREEM anketiyle ölçülen öğrenme çevresi algıları istatistiksel olarak farklıydı (p<0,05). Özümseyen öğrenme stilini tercih eden öğrencilerinin DREEM puanı ayrıştıran ve yerleştiren öğrenme stilini tercih eden bireylere göre daha düşük bulundu (p<0,05). Farklı öğrenme stillerini tercih eden bireylerin akademik başarıları istatistiksel olarak farklı bulundu (p<0,05). Değiştiren ve ayrıştıran öğrenme stillerine sahip öğrenciler arasında (χ² = 16.36, p = 0.0025), ayrıca yerleştiren ve ayrıştıran öğrenme stillerine sahip öğrenciler arasında (χ² = 16.37, p = 0.0025) istatistiksel olarak anlamlı farklılıklar bulunmuştur. Bu çalışma, fizyoterapi ve rehabilitasyon öğrencilerinde öğrenme stili tercihlerinin akademik başarı ve öğrenme ortamı algısı üzerinde anlamlı bir etkisi olduğunu ortaya koymuştur. Özümseyen öğrenme stiline sahip öğrencilerin eğitim ortamına yönelik memnuniyet düzeylerinin daha düşük olduğu, ayrıştırıcı öğrenme stiline sahip öğrencilerin ise akademik başarılarının daha düşük olduğu bulunmuştur. Buna karşılık, akademik özgüven düzeyleri öğrenme stilleri arasında anlamlı bir farklılık göstermemiştir. Bu bulgular, farklı öğrenme stillerine uygun eğitim stratejilerinin geliştirilmesinin, fizyoterapi ve rehabilitasyon eğitiminde öğrenci memnuniyetini ve akademik başarıyı artırabileceğini göstermektedir.Publication Open Access Popular Culture: From Being an Enemy of the Feminist Movement to a Tool for Women's Liberation?(John Wiley and Sons Inc, 1999) Kirca, Süheyla; Kirca, Süheyla, Public Relations Department, Bahçeşehir Üniversitesi, Istanbul, Turkey[No abstract available]Publication Open Access House mice with metacentric chromosomes in the Middle East(Mendelian Society of Lund, 2000) Gündüz, Islam; Tez, Cosslkun; Searle, Jeremy B.; Gündüz, Islam, Department of Biology, Bahçeşehir Üniversitesi, Istanbul, Turkey; Tez, Cosslkun, Department of Biology, Erciyes Üniversitesi, Kayseri, Turkey; Searle, Jeremy B., Department of Biology, University of York, York, United Kingdom[No abstract available]Publication Open Access The synthesis of novel crown ethers, part VII [1]. Coumarin derivatives of benzocrowns and cation binding from fluorescence spectra(Springer Netherlands, 2000) Erk, Çakil L.; Bulut, Mustafa; Göçen, Ayten; Erk, Çakil L., Department of Chemistry, İstanbul Teknik Üniversitesi, Istanbul, Turkey; Bulut, Mustafa, Department of Chemistry, Marmara Üniversitesi, Istanbul, Turkey; Göçen, Ayten, Department of Chemistry, Bahçeşehir Üniversitesi, Istanbul, Turkey4-[3-(1-benzopyran-2-one)] derivatives of benzo[12]crown-4, benzo[15]crown-5 and benzo-[18]crown-6 were synthesized from 4-[3-(1-benzopyran-2-one)]-1,2-dihydroxy-benzene reacting with bis-ethyleneglycol dihalides or pentaethylene glycol ditosylate in alkali carbonate/DMF/water. The original products were identified by high resolution EI-mass spectra as well us IR, 1H-NMR and 13C-NMR spectroscopy. The 1 : 1 binding constants of Mg2+, Li+, Na+ and K+ with the coumarin-benzocrowns were estimated using fluorescence emission spectroscopy in acetonitrile. The complexing enhanced quenching fluorescence spectra (CEQFS) and complexing enhanced fluorescence spectra (CEFS) exhibited the ion binding powers due to cationic recognition rules of the macrocycles. © 2020 Elsevier B.V., All rights reserved.Publication Open Access Cooling scheme based on the AF-F transition in Fe-Rh alloys induced by tensile stress(2002) Annaorazov, Murad P.; Nikitin, Sergey Aleksandrovich; Tyurin, A. L.; Akopyan, S. A.; Myndyev, R. W.; Annaorazov, Murad P., Faculty of Arts and Sciences, Bahçeşehir Üniversitesi, Istanbul, Turkey; Nikitin, Sergey Aleksandrovich, Department of Physics, Lomonosov Moscow State University, Moscow, Russian Federation; Tyurin, A. L., Department of Physics, Turkmen State University, Ashgabad, Turkmenistan; Akopyan, S. A., Department of Physics, Turkmen State University, Ashgabad, Turkmenistan; Myndyev, R. W., Department of Physics, Turkmen State University, Ashgabad, TurkmenistanA cooling scheme based on the first-order antiferromagnetism-ferromagnetism transition induced in the Fe-Rh alloy by one-dimensional tensile stress is proposed. Using the model S-T diagram for this alloy, the cooling cycles are drawn up based both on the latent heat of transition absorption and emission when the transition is induced isothermally and on the change in temperature of the alloy when the transition is induced adiabatically by applying tensile stress. The calculated values of the efficiency ε for the cycles are ∼35 at ΔT - 5 K and ∼27 at ΔT = 10 K, where ΔT is the difference between the temperature of the surroundings and that of the cooled body. These values are achieved using a tensile stress of ∼1 × 109 Pa. The high values of ε make it possible to consider Fe-Rh alloys near the equiatomic composition as an effective refrigerant for elastocaloric cooling near room temperature. © 2004 Elsevier Science B.V., Amsterdam. All rights reserved.Publication Open Access Safety of radial coronary angiography with uninterrupted direct-acting oral anticoagulant treatment(Turkish Society of Cardiology kareyayincilik@gmail.com, 2019) Tuǧba Kemaloǧlu, K.; Gürol, Tayfun; Sarıgül, Nedim Umutay; Arslan, Utku; Kobegenova, Maryam; Aydin, Alper; Soylu, Özer; Daǧdeviren, Bahadïr; Tuǧba Kemaloǧlu, K., Bahçeşehir Üniversitesi, Istanbul, Turkey; Gürol, Tayfun, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sarıgül, Nedim Umutay,; Arslan, Utku, Bahçeşehir Üniversitesi, Istanbul, Turkey; Kobegenova, Maryam, Bahçeşehir Üniversitesi, Istanbul, Turkey; Aydin, Alper, Bahçeşehir Üniversitesi, Istanbul, Turkey; Soylu, Özer, Bahçeşehir Üniversitesi, Istanbul, Turkey; Daǧdeviren, Bahadïr, Bahçeşehir Üniversitesi, Istanbul, TurkeyObjective: It is not known whether direct-acting oral anticoagulants (DOACs), such as dabigatran, apixaban, and rivaroxaban increase the risk of bleeding complications during or after coronary catheterization. The aim of this study was to investigate the safety of uninterrupted DOAC treatment during diagnostic radial coronary angiography (CAG). Methods: This study included 160 patients who underwent diagnostic radial cardiac catheterization. The 60 patients in the group who were using a DOAC (apixaban, rivaroxaban, or dabigatran) were enrolled in a Group A. Post-procedure results from patients in Group A were compared with those of an ageand sex-matched control group (Group B) that included 100 patients who underwent radial CAG who did not use a DOAC. Results: There was no significant difference in the procedure and compression times, creatinine level, or presence of hypertension, diabetes mellitus, smoking, alcohol use, vascular disease, or congestive heart failure between the 2 groups. During the 1 -month follow-up period, only 1 radial occlusion was registered in the control group (Group B). There was no case of a large hematoma (>5 cm or extending to the forearm), dissection, fistula, perforation, or compartment syndrome. Hematomas smaller than 5 cm were seen in 2 patients (1 in each group). No thrombotic events were observed during follow-up examinations. Conclusion: Performing radial CAG with uninterrupted DOAC treatment appears to carry no risk of increased early or short-term complications. The simple, uninterrupted DOAC strategy is comfortable, easy, and safe. © 2019 Elsevier B.V., All rights reserved.Publication Open Access Antidepressant prescriptions in neurosurgical practice: A survey of current trends(Turkish Neurosurgical Society, 2019) Bayoumi, Ahmed B.; Efe, Ibrahim Efecan; Ozturk, Özden Caglar; Yokus, Burhan; Uzuner, Ayse; Kilic, Turker D.; Bozkurt, Selma; Toktaş, Zafer Orkun; Bayoumi, Ahmed B., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Efe, Ibrahim Efecan, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey, Department of Neurosurgery, Charité – Universitätsmedizin Berlin, Berlin, Germany; Ozturk, Özden Caglar, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Yokus, Burhan, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Uzuner, Ayse, Faculty of Medicine, Marmara Üniversitesi, Istanbul, Turkey; Kilic, Turker D., Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, Turkey; Bozkurt, Selma, Department of Psychiatry, Bahçeşehir Üniversitesi, Istanbul, Turkey; Toktaş, Zafer Orkun, Department of Neurosurgery, Bahçeşehir Üniversitesi, Istanbul, TurkeyAIM: To better understand the indications and the impact of antidepressant drugs on the field of neurosurgery in terms of risks and benefits in Turkey. MATERIAL and METHODS: A national survey was conducted among neurosurgeons in current practice in Turkey to report routine prescription trends of antidepressant drugs. Gender, neurosurgical subspecialty, city, type of practice, years of experience, antidepressant agent, indications and reasons not to prescribe were ascertained. A brief review of literature was done to show clinical and research evidence. RESULTS: A total of 336 neurosurgeons took the survey, 53% of them prescribe antidepressants routinely, whereas 47% of them do not. Of the 72% non-prescribers prefer to refer their patients to a psychiatrist and 22% of them believe that antidepressants have no role in neurosurgery. Vascular and pediatric neurosurgeons as well as neurosurgeons at research hospitals showed the lowest prescription proportion, while general and brain tumor neurosurgeons and ones in private practice showed the highest prescription proportion. Surgeons with more than 20 year-experience had the lowest prescription proportion (43%). Type of practice and years of experience showed a statistically significant association with the prescription of antidepressant drugs across (p=0.002 and p=0.025, respectively). CONCLUSION: Type of practice and years of experience showed a statistically significant association with the proportion of antidepressants' prescribers in Turkish neurosurgery practice at the time of this survey. Non-prescriber neurosurgeons need to recognize the indications, whereas prescribers have to understand the risks of using antidepressants. © 2019 Elsevier B.V., All rights reserved.Publication Open Access Structural relationships among academic procrastination, academic motivation, and problem solving skill in prep class college students(Pegem Akademi Yayincilik Egitim Danismanlik Hizmetleri editoryrd@pegegog.net, 2019) Yurtseven, Nihal; Dogan, Selcuk; Yurtseven, Nihal, Faculty of Educational Sciences, Bahçeşehir Üniversitesi, Istanbul, Turkey; Dogan, Selcuk, Georgia Southern University, Statesboro, United StatesAcademic procrastination has been one of the major problems among students from different levels of education, specifically for college students. The purpose of this study is to examine the effect of problem solving skill, a kind of cognitive skill, as well as academic motivation on academic procrastination behaviors of university students. In this explanatory correlational research study, 509 college students who enrolled in an extensive English language program at a public university in Turkey were included. As data collection tools, Tuckman procrastination scale, academic motivation scale and problem solving skill inventory were used. After testing our proposed theory through Structural Equation Modelling (SEM), we found that problem solving skill had a strong effect on academic procrastination. We provided evidence showing that academic procrastination was a function of problem solving skill and academic motivation, rather than driven by intrinsic or extrinsic motivation. The current study emphasizes that academic procrastination behavior is related to the problem solving skill and presents a different perspective that should be taken into consideration in dealing with academic procrastination behaviors. © 2019 Elsevier B.V., All rights reserved.