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Publication Metadata only Subclinical hypothyroidism: Is it important in intracytoplasmic sperm injection cycles?(GALENOS YAYINCILIK, 2017) Caliskan, Eray; Ergin, Rahime Nida; Oztekin, Deniz Can; Kars, Bulent; Cakir, Seda; Sofuoglu, Kenan; Bahcesehir University; Izmir Tepecik Training & Research Hospital; University of Health Sciences Turkey; Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital; University of Health Sciences Turkey; Istanbul Zeynep Kamil Maternity & Children's Diseases Training & Research HospitalObjective: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women. Materials and Methods: A retrospective case-control study was conducted. Out of 2529 ICSI cycles evaluated, 41 women with hypothyroidism, 28 women with hyperthyroidism, and 128 women with subclinical hyperthyroidism were excluded, and 2336 cycles were analyzed. Women were identified as having subclinical hypothyroidism (case group, n=105) in the presence of a thyroid-stimulating hormone level >4.5 mU/L and normal free T4 and compared with euthyroid controls (n=2231). Results: The mean age, body mass index, day 3 follicle-stimulating hormone level, and antral follicle count of the study patients were similar to the control group (p>0.5). The cycle cancellation rate of the study group was similar to the control group (13.3% vs. 7.6%, p=0.1). The clinical pregnancy rate was 21.2% in the study group, which was significantly lower than the 35.8% in the control group (p=0.04). The take-home baby rate was also significantly lower in the study group compared with the control groups (13.5% vs. 31.4% respectively, p=0.01). Conclusion: Both the clinical pregnancy rate and the take-home baby rate is lower in women with subclinical hypothyroidism at the time of ICSI cycle.Publication Metadata only The evaluation of analytical thinking skills and reaction tests on performance in female football players: their impact on in-game decision-making processes(SPRINGERNATURE, 2025) Yalcin, Gamze; Genc, Hazal; Bahcesehir University; Bahcesehir UniversityBackground Quick and accurate decision-making is crucial for individual and team success in football. Cognitive skills such as analytical thinking and reaction time enhance in-game performance. This study aimed to evaluate the effects of analytical thinking skills and reaction time on the performance of female football players and to explore their influence on decision-making processes during gameplay. Materials and methods A total of 40 female football players participated in the study. Decision-making simulations and selective reaction tests were used to assess cognitive performance, while reaction times to visual stimuli were measured using Blazepod devices. Physical performance was evaluated through the Y Balance Test to assess lower extremity dynamic balance and postural control. Additionally, the Tampa Scale for Kinesiophobia was administered to assess fear of injury and its potential impact on performance. Results A significant positive correlation was found between analytical thinking skills and in-game decision-making processes (r = 0.68, p < 0.01). A moderate-to-strong negative correlation was found between reaction time and decision-making time (r = - 0.52, p < 0.05). Multiple linear regression analysis indicated that the decision-making score significantly positively affected kinesiophobia (B = 1.101, p = 0.030), with the model explaining 24.7% of the variance in kinesiophobia scores (R-2 = 0.247). Conclusion These findings suggest that cognitive and physical parameters are associated with in-game performance in female football players. Monitoring and enhancing these components may contribute to developing more effective training and performance strategies.Publication Metadata only Fluorine determination in human and animal bones by particle-induced gamma-ray emission(Springer Verlag, 2001) Sastri, Chaturvedula S.; Lyengar, Venkatesh; Blondiaux, Gilbert B.; Tessier, Yves; Petri, Hermann; Hoffmann, Peter S.; Aras, Namik K.; Zaichick, Vladimir Ye; Ortner, Hugo Manfred; Sastri, Chaturvedula S., Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, Germany; Lyengar, Venkatesh, International Atomic Energy Agency, Vienna, Vienna, Austria; Blondiaux, Gilbert B., Centre de Recherches Internationales Sciences Po, Paris, France; Tessier, Yves, Centre de Recherches Internationales Sciences Po, Paris, France; Petri, Hermann, Forschungszentrum Jülich GmbH, Julich, Germany; Hoffmann, Peter S., Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, Germany; Aras, Namik K., Department of Chemistry, Middle East Technical University (METU), Ankara, Turkey, Bahçeşehir Üniversitesi, Istanbul, Turkey; Zaichick, Vladimir Ye, A. Tsyb Medical Radiological Research Center, Obninsk, Russian Federation; Ortner, Hugo Manfred, Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, GermanyFluorine was determined in the iliac crest bones of patients and in ribs collected from post-mortem investigations by particle-induced gamma-ray emission based on the 19F(p,p′y)19F reaction, using 2.0/2.5 MeV protons. The results indicate that for 68% of the human samples the F concentration is in the range 500-1999 μg g-1. For comparison purposes fluorine was also determined in some animal bones, in some animal tissues lateral profiles of fluorine were measured. © Springer-Verlag 2001. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Global variations in peak bone mass as studied by dual-energy X-ray absorptiometry(Akademiai Kiado Rt., 2004) McCloskey, Eugene V.; Dey, Abhijit; Parr, Robert M.; Aras, Namik K.; Balogh, Ádám; Bostock, J.; Borelli, Aurélio; Krishnan, Sivarama S.; Lobo, Gerald J.; Qin, Linlin; McCloskey, Eugene V., Who Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; Dey, Abhijit, Who Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; Parr, Robert M., International Atomic Energy Agency, Vienna, Vienna, Austria; Aras, Namik K., Bahçeşehir Üniversitesi, Istanbul, Turkey; Balogh, Ádám, Debreceni Egyetem, Debrecen, Hungary; Bostock, J., Who Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; Borelli, Aurélio, Hospital das Clinicas, Sao Paulo, Brazil; Krishnan, Sivarama S., Toronto General Hospital, Toronto, Canada; Lobo, Gerald J., Clínica Indisa, Santiago, Chile; Qin, Linlin, China-Japan Friendship Hospital, Beijing, ChinaIn 1994, the International Atomic Energy Agency (IAEA) initiated a 5-year Co-ordinated Research Project (CRP) to determine geographical and racial differences in peak bone mineral density (BMD) in men and women aged 15-49 years. The study demonstrates that there are distinct global differences in BMD at the hip and spine in both men and women approximating to one population standard deviation between populations with the highest and lowest BMD. These differences persist following adjustments for age, sex and body size. Such information is valuable in understanding the reasons for global differences in fracture rate and predicting future trends in fracture incidence. © 2025 Elsevier B.V., All rights reserved.Publication Metadata only Precision of a dual energy X-ray absorptiometry device(Akademiai Kiado Rt., 2004) Korkusuz, Feza; Işikh, S.; Akin, Sabire; Ungan, Mehmet; Şenköylü, Alpaslan; Aras, Namik K.; Korkusuz, Feza, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Işikh, S., Medical Center, Middle East Technical University (METU), Ankara, Turkey; Akin, Sabire, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Ungan, Mehmet, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Şenköylü, Alpaslan, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Aras, Namik K., Bahçeşehir Üniversitesi, Istanbul, TurkeyThe standard method to diagnose and follow-up osteoporosis is the measurement of bone mineral density (BMD) using dual X-ray absorptiometry (DEXA). Manufacturers' manuals of DEXA devices state the intrascanner coefficient of variance is less than 0.01 g/cm2. The aim of this study was to evaluate the in vivo coefficient of variance of a Lunar DPX scanner in male and female healthy adult subjects. Average BMD for females and males were 1.170±0.091 g/cm2 and 1.272±0.115 g/cm 2, respectively. Monthly phantom measurements provided and controlled by the manufacturer were 1.243±0.008 g/cm2 (range 1.222 to 1.257) and the coefficient of variance was 0.006. It is concluded that the in vivo coefficient of variance of DEXA devices can slightly be higher than that proposed by the manufacturer. © 2025 Elsevier B.V., All rights reserved.Publication Metadata only Relationship between general and context-specific attachment orientations in a Turkish sample(2006) Imamoǧlu, Selen; Olcay Imamoĝlu, E.; Imamoǧlu, Selen, Faculty of Communication, Bahçeşehir Üniversitesi, Istanbul, Turkey; Olcay Imamoĝlu, E., Department of Psychology, Middle East Technical University (METU), Ankara, TurkeyThe authors explored the relationship between general and context-specific attachment orientations involving family, peer, and romantic contexts. Participants were 110 Turkish university students (50 men, 60 women). The authors used the Turkish form of K. Bartholomew and L. M. Horowitz's (1991) Relationship Questionnaire (RQ) to measure participants' general and specific attachment orientations. Using 5-point Likert-type scales, participants specified the degree to which each of the 4 descriptions of RQ (i.e., of secure, preoccupied, dismissing, and fearful orientations) represented (a) how they generally felt in close relationships, and then how they felt in their (b) family relationships, (c) romantic relationships, and (d) peer relationships. The present results indicated that participants who were generally high rather than low on a particular attachment orientation tended to be so across the 3 contexts, thereby supporting the trait-like conceptualization of attachment styles. However, the present results also supported conceptualization of attachment orientations as specific context-related tendencies because regardless of their general orientations, participants reported feeling relatively more secure in some relationships (e.g., family) than in others (e.g., romantic). The authors discussed the present results as supporting (a) the coexistence of both general and specific attachment orientations in the cognitive system and (b) the cross-cultural validity of attachment orientations. Copyright © 2006 Heldref Publications. © 2009 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Prediction of cyclosporine A blood levels: An application of the adaptive-network-based fuzzy inference system (ANFIS) in assisting drug therapy(2008) Gören, Sezer; Karahoca, Adem; Onat, Filiz Yilmaz; Gören, Mehmet Zafer; Gören, Sezer, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karahoca, Adem, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Onat, Filiz Yilmaz, Department of Pharmacology and Clinical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey; Gören, Mehmet Zafer, Department of Pharmacology and Clinical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, TurkeyObjective: Therapeutic drug monitoring (TDM) is a procedure in which the levels of drugs are assayed in various body fluids with the aim of individualizing the dose of critical drugs, such as cyclosporine A. Cyclosporine A assays are performed in blood. Methods: We proposed the use of the Takagi and Sugeno-type adaptive-network-based fuzzy inference system (ANFIS) to predict the concentration of cyclosporine A in blood samples taken from renal transplantation patients. We implemented the ANFIS model using TDM data collected from 138 patients and 20 input parameters. Input parameters for the model consisted of concurrent use of drugs, blood levels, sampling time, age, gender, and dosing intervals. Results: Fuzzy modeling produced eight rules. The developed ANFIS model exhibited a root mean square error (RMSE) of 0.045 with respect to the training data and an error of 0.057 with respect to the checking data in the MATLAB environment. Conclusion: ANFIS can effectively assist physicians in choosing best therapeutic drug dose in the clinical setting. © 2008 Springer-Verlag. © 2009 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Organizational commitment of military physicians(Association of Military Surgeons of the US pubsvc.tsp@sheridan.com, 2009) Demir, Cesim; Şahin, Bayram; Tekef, Kadir; Uçar, Muharrem; Kursun, Olcay; Demir, Cesim, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Şahin, Bayram, Department of Health Care Management, Hacettepe Üniversitesi, Ankara, Turkey; Tekef, Kadir, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Uçar, Muharrem, Department of Medical History and Deontology, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Kursun, Olcay, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, TurkeyAn individual's loyalty or bond to his or her employing organization, referred to as organizational commitment, influences various organizational outcomes such as employee motivation, job satisfaction, performance, accomplishment of organizational goals, employee turnover, and absenteeism. Therefore, as in other sectors, employee commitment is crucial also in the healthcare market. This study investigates the effects of organizational factors and personal characteristics on organizational commitment of military physicians using structural equation modeling (SEM) on a self-report, cross-sectional survey that consisted of 635 physicians working in the 2 biggest military hospitals in Turkey. The results of this study indicate that professional commitment and organizational incentives contribute positively to organizational commitment, whereas conflict with organizational goals makes a significantly negative contribution to it. These results might help develop strategies to increase employee commitment, especially in healthcare organizations, because jobrelated factors have been found to possess greater impact on organizational commitment than personal characteristics. Reprint and Copyright © by Association of Military Surgeons of U.S., 2009. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Caregiving style, problem solving strategies, anger style and health status in women caregivers of alzheimer patients and healthy elderly, Alzhei̇mer hastalarina ve saǧlikli yaşlilara bakimveren kadin yakinlarda bakim verme tarzi, problem çözme strateji̇leri̇,öfke tarzlari ve saǧlik durumunun i̇ncelenmeṡi(2009) Korkut, Yeflim; Sertel-Berk, Hanife Özlem; Korkut, Yeflim, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sertel-Berk, Hanife Özlem, Psikoloji Anabilim Dali, Istanbul Üniversitesi, Istanbul, TurkeyIntroduction: The principle aim of this study is to investigate the caregiving style of the participants and the kind of support they receive, to compare anger levels, problem solving approaches and health problems of Alzheimer Disease (AD) patient female caregivers with a control group. This study further examines the effect of group, age, health status, anger style and problem solving style on depression. Materials and Method: 42 female caregivers (22 AD and 20 control) participated in the study. They were given a demographic questionnaire, Beck Depression Inventory-BDI, State-Trait Anger Scale-STAS and Problem Solving Inventory-PSI. Results: Results indicated that both AD and control group caregivers were similar in terms of caregiving style. Though AD and control group caregivers did not differ in terms PSI and BDI, there were significant differences between those who reported illness and those who did not in terms of impatient and thoughtful approach sub-tests of PSI. The regression analysis showed that age and repressed anger significantly explained the variation in BDI. Conclusion: Altogether results showed that in a relatively low at risk women caregivers group, regardless of being AD caregiver or not, age and repressed anger are important factors on depression levels. Health status of caregiver seems to be a determining factor on PSI. © 2009 Elsevier B.V., All rights reserved.Publication Metadata only Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations(2010) Bilgüvar, Kaya; Öztürk, Ali Kemal; Louvi, Angeliki; Kwan, Kenneth Y.; Choi, Murim; Tatlí, Burak; Yalnizoǧlu, Dilek; Tüysüz, Beyhan; Caglayan, Ahmet Okay; Gökben, Sarenur; Bilgüvar, Kaya, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Öztürk, Ali Kemal, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Louvi, Angeliki, Department of Neurosurgery, Yale School of Medicine, New Haven, United States, Department of Neurobiology, Yale School of Medicine, New Haven, United States, Department of Genetics, Yale School of Medicine, New Haven, United States; Kwan, Kenneth Y., Department of Neurobiology, Yale School of Medicine, New Haven, United States, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, United States; Choi, Murim, Department of Genetics, Yale School of Medicine, New Haven, United States; Tatlí, Burak, Department of Pediatrics, İstanbul Tıp Fakültesi, Istanbul, Turkey; Yalnizoǧlu, Dilek, Department of Pediatrics, Hacettepe Üniversitesi, Ankara, Turkey; Tüysüz, Beyhan, Department of Pediatrics, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; Caglayan, Ahmet Okay,; Gökben, Sarenur, Department of Pediatrics, Ege University Medical School, Izmir, TurkeyThe development of the human cerebral cortex is an orchestrated process involving the generation of neural progenitors in the periventricular germinal zones, cell proliferation characterized by symmetric and asymmetric mitoses, followed by migration of post-mitotic neurons to their final destinations in six highly ordered, functionally specialized layers1,2. An understanding of the molecular mechanisms guiding these intricate processes is in its infancy, substantially driven by the discovery of rare mutations that cause malformations of cortical development3-6. Mapping of disease loci in putative Mendelian forms of malformations of cortical development has been hindered by marked locus heterogeneity, small kindred sizes and diagnostic classifications that may not reflect molecular pathogenesis. Here we demonstrate the use of whole-exome sequencing to overcome these obstacles by identifying recessive mutations in WD repeat domain 62 (WDR62) as the cause of a wide spectrum of severe cerebral cortical malformations including microcephaly, pachygyria with cortical thickening as well as hypoplasia of the corpus callosum. Some patients with mutations in WDR62 had evidence of additional abnormalities including lissencephaly, schizencephaly, polymicrogyria and, in one instance, cerebellar hypoplasia, all traits traditionally regarded as distinct entities. In mice and humans, WDR62 transcripts and protein are enriched in neural progenitors within the ventricular and subventricular zones. Expression of WDR62 in the neocortex is transient, spanning the period of embryonic neurogenesis. Unlike other known microcephaly genes, WDR62 does not apparently associate with centrosomes and is predominantly nuclear in localization. These findings unify previously disparate aspects of cerebral cortical development and highlight the use of whole-exome sequencing to identify disease loci in settings in which traditional methods have proved challenging. © 2010 Macmillan Publishers Limited. All rights reserved. © 2012 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.