Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed
Permanent URI for this communityhttps://hdl.handle.net/20.500.14719/1741
Browse
2121 results
Search Results
Publication Metadata only Retrospective review of epidemic viral pneumonia cases in Turkey: A multicenter study(SPANDIDOS PUBL LTD, 2017) Cortuk, Mustafa; Acat, Murat; Yazici, Onur; Yasar, Zehra; Kiraz, Kemal; Ataman, Sena Yapicioglu; Tanriverdi, Elif; Zitouni, Burcak; Kirakli, Cenk; Ediboglu, Ozlem; Tuksavul, Fevziye; Dirican, Adem; Celik, Hale Kefeli; Ozkaya, Sevket; Cetinkaya, Erdogan; Karabuk University; Adnan Menderes University; Abant Izzet Baysal University; Antalya Ataturk State Hospital; Izmir Dr Suat Seren Chest Diseases & Thoracic Surgery Training & Research Hospital; Istanbul Yedikule Chest Diseases & Thoracic Surgery Training & Research Hospital; Medical Park Hospitals Group; Samsun Training & Research Hospital; Samsun Training & Research Hospital; Bahcesehir UniversityInfluenza A (H1N1) caused its first pandemic in 2009 in USA and Mexico. Since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. This is due in part to pandemic influenza A infection having greater impact on populations <65 years old than other viral strains, including seasonal influenza. Chest radiographies of those affected displayed a rapid progression of patchy infiltrates, and a large proportion of individuals required admission to intensive care units (ICU). Despite efforts, patients infected with the virus had a high mortality rate. The present multicenter study aimed to retrospectively evaluate the clinical, demographic and prognostic characteristics of patients diagnosed with epidemic viral pneumonia in Turkey. A total of 92 patients were included in the study. The Student's t-test and Chi-square tests were performed to analyze quantitative data, assuming a normal distribution, and to analyze qualitative data, respectively. Stepwise logistic regression was used to evaluate the effects of demographic variables and laboratory values on the virus mortality rate. The male/female ratio was 42/50 and the mean age was 48.74 +/- 16.65 years. A total of 69 (75%) patients were unvaccinated against influenza. The most common symptoms were cough (87%) and fever (63%). Chest computed tomography showed peripheral patchy areas of the lungs of ground glass density in 38 patients (41.3%). A total of 22 (59.4%) patients had H1N1, 5 (12.5%) patients had influenza B, and 38 (41.3%) patients met the criteria for admission to the ICU. Of these patients, 20 (52.63%) were monitored with a mechanical ventilator, with a noninvasive ventilator being adequate for 10 (26.32%) of patients. The length of stay in the ICU was 6.45 +/- 5.97 days and the duration of mechanical ventilation was 5.06 +/- 4.69 days. A total of 12 (13.04%) patients in the ICU succumbed. Logistic regression analysis revealed that among the parameters possibly associated with mortality, being an active smoker increased the risk of mortality 7.08-fold compared to other groups (P=0.005). In conclusion, viral pneumonia remains a significant health problem during the winter period. Considering the high number of ICU admissions and high rate of mortality for patients in the present study, earlier initiation of antiviral therapy is necessary. Active smoking increased mortality in viral pneumonia.Publication Metadata only The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy(WILEY, 2017) Gur-Ozmen, S.; Mula, M.; Agrawal, N.; Cock, H. R.; Lozsadi, D.; von Oertzen, T. J.; City St Georges, University of London; City St Georges, University of London; Bahcesehir UniversityBackground and purposePeople with epilepsy are at increased risk of accidents and injuries but, despite several studies on this subject, data regarding preventable causes are still contradictory. The aim of this study was to investigate the relationship between injuries, side effects of antiepileptic drugs (AEDs) and depression. MethodsData from a consecutive sample of adult patients with epilepsy attending the outpatient clinics at St George's University Hospital in London were included. All patients were asked if they had had any injury since the last clinic appointment and completed the Liverpool Adverse Event Profile (LAEP) and Neurological Disorders Depression Inventory for Epilepsy. ResultsAmong 407 patients (243 females, mean age 43.1years), 71 (17.4%) reported injuries since the last appointment. A two-step cluster analysis revealed two clusters with the major cluster (53.5% of the injured group) showing a total score for LAEP 45, a positive Neurological Disorders Depression Inventory for Epilepsy screening and presence of AED polytherapy. A total score for LAEP 45 was the most important predictor. ConclusionsAntiepileptic drug treatment should be reviewed in patients reporting injuries in order to evaluate the potential contribution and burden of AED side effects.Publication Metadata only Comparison of 28-Day Mortality Between Hospital- and Community-Acquired Influenza Patients(DOC DESIGN INFORMATICS CO LTD, 2023) Bilgin, Hueseyin; Basari, Tugce; Pazar, Nazli; Kucuker, Isil; Can-Sarinoglu, Rabia; Marmara University; Marmara University; Bahcesehir UniversityObjective: This study aimed to compare 28-day mortality between patients have hospital-acquired influenza (HAI) and those have community-acquired influenza (CAI) during the 2017-2019 influenza seasons in a tertiary care center in Istanbul, Turkiye.Materials and Methods: This retrospective cohort included all hospitalized patients who had confirmed influenza infection and were over 17 years old. HAI was defined as a case of influenza that tested negative in a PCR test or had no signs of influenza on admission but with a positive test result at any point after 72 hours of admission. CAI was defined as a case of influenza diagnosed within 72 hours of admission or before admission. The primary outcome was 28-day mortality after diagnosis. Biological sex, admission to the intensive care unit (ICU), presence of chronic obstructive pulmonary disease, cardiovascular and immunosuppressive comorbidities, influenza subtype, and other variables identified with univariate analyses (p<0.25) were entered into logistic regression analysis.Results: During the study period, 92 (46%) of 201 hospitalized patients who tested positive for influenza were identified as HAI, and the rest (109) were identified as CAI. Univariate analysis showed no differences between survivors and non-survivors in patient characteristics, except non-survivors were more likely to have an ICU admission. The multivariable logistic regression analysis results showed that HAI was associated with 5.6-fold increased odds of mortality (95% confidence interval [CI]=1.6-19.3, p=0.006, Figure 2), after adjustment for age, gender, comorbidity, and ICU admission. Conclusion: The results of this study revealed that patients who had HAI were more likely to die within 28 days compared to those who had CAI after controlling for key confounders. The high rate of HAI underscores the critical importance of robust infection control measures for hospital-acquired viral infections. Additional research and targeted interventions are necessary to improve the HAI prognosis.Publication Metadata only Fluorine determination in human and animal bones by particle-induced gamma-ray emission(Springer Verlag, 2001) Sastri, Chaturvedula S.; Lyengar, Venkatesh; Blondiaux, Gilbert B.; Tessier, Yves; Petri, Hermann; Hoffmann, Peter S.; Aras, Namik K.; Zaichick, Vladimir Ye; Ortner, Hugo Manfred; Sastri, Chaturvedula S., Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, Germany; Lyengar, Venkatesh, International Atomic Energy Agency, Vienna, Vienna, Austria; Blondiaux, Gilbert B., Centre de Recherches Internationales Sciences Po, Paris, France; Tessier, Yves, Centre de Recherches Internationales Sciences Po, Paris, France; Petri, Hermann, Forschungszentrum Jülich GmbH, Julich, Germany; Hoffmann, Peter S., Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, Germany; Aras, Namik K., Department of Chemistry, Middle East Technical University (METU), Ankara, Turkey, Bahçeşehir Üniversitesi, Istanbul, Turkey; Zaichick, Vladimir Ye, A. Tsyb Medical Radiological Research Center, Obninsk, Russian Federation; Ortner, Hugo Manfred, Fachbereich Material- und Geowissenschaften, Technische Universität Darmstadt, Darmstadt, GermanyFluorine was determined in the iliac crest bones of patients and in ribs collected from post-mortem investigations by particle-induced gamma-ray emission based on the 19F(p,p′y)19F reaction, using 2.0/2.5 MeV protons. The results indicate that for 68% of the human samples the F concentration is in the range 500-1999 μg g-1. For comparison purposes fluorine was also determined in some animal bones, in some animal tissues lateral profiles of fluorine were measured. © Springer-Verlag 2001. © 2020 Elsevier B.V., All rights reserved.Publication Metadata only Global variations in peak bone mass as studied by dual-energy X-ray absorptiometry(Akademiai Kiado Rt., 2004) McCloskey, Eugene V.; Dey, Abhijit; Parr, Robert M.; Aras, Namik K.; Balogh, Ádám; Bostock, J.; Borelli, Aurélio; Krishnan, Sivarama S.; Lobo, Gerald J.; Qin, Linlin; McCloskey, Eugene V., Who Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; Dey, Abhijit, Who Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; Parr, Robert M., International Atomic Energy Agency, Vienna, Vienna, Austria; Aras, Namik K., Bahçeşehir Üniversitesi, Istanbul, Turkey; Balogh, Ádám, Debreceni Egyetem, Debrecen, Hungary; Bostock, J., Who Collaborating Centre for Metabolic Bone Diseases, Sheffield, United Kingdom; Borelli, Aurélio, Hospital das Clinicas, Sao Paulo, Brazil; Krishnan, Sivarama S., Toronto General Hospital, Toronto, Canada; Lobo, Gerald J., Clínica Indisa, Santiago, Chile; Qin, Linlin, China-Japan Friendship Hospital, Beijing, ChinaIn 1994, the International Atomic Energy Agency (IAEA) initiated a 5-year Co-ordinated Research Project (CRP) to determine geographical and racial differences in peak bone mineral density (BMD) in men and women aged 15-49 years. The study demonstrates that there are distinct global differences in BMD at the hip and spine in both men and women approximating to one population standard deviation between populations with the highest and lowest BMD. These differences persist following adjustments for age, sex and body size. Such information is valuable in understanding the reasons for global differences in fracture rate and predicting future trends in fracture incidence. © 2025 Elsevier B.V., All rights reserved.Publication Metadata only Precision of a dual energy X-ray absorptiometry device(Akademiai Kiado Rt., 2004) Korkusuz, Feza; Işikh, S.; Akin, Sabire; Ungan, Mehmet; Şenköylü, Alpaslan; Aras, Namik K.; Korkusuz, Feza, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Işikh, S., Medical Center, Middle East Technical University (METU), Ankara, Turkey; Akin, Sabire, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Ungan, Mehmet, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Şenköylü, Alpaslan, Medical Center, Middle East Technical University (METU), Ankara, Turkey; Aras, Namik K., Bahçeşehir Üniversitesi, Istanbul, TurkeyThe standard method to diagnose and follow-up osteoporosis is the measurement of bone mineral density (BMD) using dual X-ray absorptiometry (DEXA). Manufacturers' manuals of DEXA devices state the intrascanner coefficient of variance is less than 0.01 g/cm2. The aim of this study was to evaluate the in vivo coefficient of variance of a Lunar DPX scanner in male and female healthy adult subjects. Average BMD for females and males were 1.170±0.091 g/cm2 and 1.272±0.115 g/cm 2, respectively. Monthly phantom measurements provided and controlled by the manufacturer were 1.243±0.008 g/cm2 (range 1.222 to 1.257) and the coefficient of variance was 0.006. It is concluded that the in vivo coefficient of variance of DEXA devices can slightly be higher than that proposed by the manufacturer. © 2025 Elsevier B.V., All rights reserved.Publication Metadata only Relationship between general and context-specific attachment orientations in a Turkish sample(2006) Imamoǧlu, Selen; Olcay Imamoĝlu, E.; Imamoǧlu, Selen, Faculty of Communication, Bahçeşehir Üniversitesi, Istanbul, Turkey; Olcay Imamoĝlu, E., Department of Psychology, Middle East Technical University (METU), Ankara, TurkeyThe authors explored the relationship between general and context-specific attachment orientations involving family, peer, and romantic contexts. Participants were 110 Turkish university students (50 men, 60 women). The authors used the Turkish form of K. Bartholomew and L. M. Horowitz's (1991) Relationship Questionnaire (RQ) to measure participants' general and specific attachment orientations. Using 5-point Likert-type scales, participants specified the degree to which each of the 4 descriptions of RQ (i.e., of secure, preoccupied, dismissing, and fearful orientations) represented (a) how they generally felt in close relationships, and then how they felt in their (b) family relationships, (c) romantic relationships, and (d) peer relationships. The present results indicated that participants who were generally high rather than low on a particular attachment orientation tended to be so across the 3 contexts, thereby supporting the trait-like conceptualization of attachment styles. However, the present results also supported conceptualization of attachment orientations as specific context-related tendencies because regardless of their general orientations, participants reported feeling relatively more secure in some relationships (e.g., family) than in others (e.g., romantic). The authors discussed the present results as supporting (a) the coexistence of both general and specific attachment orientations in the cognitive system and (b) the cross-cultural validity of attachment orientations. Copyright © 2006 Heldref Publications. © 2009 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Prediction of cyclosporine A blood levels: An application of the adaptive-network-based fuzzy inference system (ANFIS) in assisting drug therapy(2008) Gören, Sezer; Karahoca, Adem; Onat, Filiz Yilmaz; Gören, Mehmet Zafer; Gören, Sezer, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Karahoca, Adem, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, Turkey; Onat, Filiz Yilmaz, Department of Pharmacology and Clinical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey; Gören, Mehmet Zafer, Department of Pharmacology and Clinical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, TurkeyObjective: Therapeutic drug monitoring (TDM) is a procedure in which the levels of drugs are assayed in various body fluids with the aim of individualizing the dose of critical drugs, such as cyclosporine A. Cyclosporine A assays are performed in blood. Methods: We proposed the use of the Takagi and Sugeno-type adaptive-network-based fuzzy inference system (ANFIS) to predict the concentration of cyclosporine A in blood samples taken from renal transplantation patients. We implemented the ANFIS model using TDM data collected from 138 patients and 20 input parameters. Input parameters for the model consisted of concurrent use of drugs, blood levels, sampling time, age, gender, and dosing intervals. Results: Fuzzy modeling produced eight rules. The developed ANFIS model exhibited a root mean square error (RMSE) of 0.045 with respect to the training data and an error of 0.057 with respect to the checking data in the MATLAB environment. Conclusion: ANFIS can effectively assist physicians in choosing best therapeutic drug dose in the clinical setting. © 2008 Springer-Verlag. © 2009 Elsevier B.V., All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Publication Metadata only Organizational commitment of military physicians(Association of Military Surgeons of the US pubsvc.tsp@sheridan.com, 2009) Demir, Cesim; Şahin, Bayram; Tekef, Kadir; Uçar, Muharrem; Kursun, Olcay; Demir, Cesim, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Şahin, Bayram, Department of Health Care Management, Hacettepe Üniversitesi, Ankara, Turkey; Tekef, Kadir, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Uçar, Muharrem, Department of Medical History and Deontology, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Kursun, Olcay, Department of Computer Engineering, Bahçeşehir Üniversitesi, Istanbul, TurkeyAn individual's loyalty or bond to his or her employing organization, referred to as organizational commitment, influences various organizational outcomes such as employee motivation, job satisfaction, performance, accomplishment of organizational goals, employee turnover, and absenteeism. Therefore, as in other sectors, employee commitment is crucial also in the healthcare market. This study investigates the effects of organizational factors and personal characteristics on organizational commitment of military physicians using structural equation modeling (SEM) on a self-report, cross-sectional survey that consisted of 635 physicians working in the 2 biggest military hospitals in Turkey. The results of this study indicate that professional commitment and organizational incentives contribute positively to organizational commitment, whereas conflict with organizational goals makes a significantly negative contribution to it. These results might help develop strategies to increase employee commitment, especially in healthcare organizations, because jobrelated factors have been found to possess greater impact on organizational commitment than personal characteristics. Reprint and Copyright © by Association of Military Surgeons of U.S., 2009. © 2017 Elsevier B.V., All rights reserved.Publication Metadata only Caregiving style, problem solving strategies, anger style and health status in women caregivers of alzheimer patients and healthy elderly, Alzhei̇mer hastalarina ve saǧlikli yaşlilara bakimveren kadin yakinlarda bakim verme tarzi, problem çözme strateji̇leri̇,öfke tarzlari ve saǧlik durumunun i̇ncelenmeṡi(2009) Korkut, Yeflim; Sertel-Berk, Hanife Özlem; Korkut, Yeflim, Bahçeşehir Üniversitesi, Istanbul, Turkey; Sertel-Berk, Hanife Özlem, Psikoloji Anabilim Dali, Istanbul Üniversitesi, Istanbul, TurkeyIntroduction: The principle aim of this study is to investigate the caregiving style of the participants and the kind of support they receive, to compare anger levels, problem solving approaches and health problems of Alzheimer Disease (AD) patient female caregivers with a control group. This study further examines the effect of group, age, health status, anger style and problem solving style on depression. Materials and Method: 42 female caregivers (22 AD and 20 control) participated in the study. They were given a demographic questionnaire, Beck Depression Inventory-BDI, State-Trait Anger Scale-STAS and Problem Solving Inventory-PSI. Results: Results indicated that both AD and control group caregivers were similar in terms of caregiving style. Though AD and control group caregivers did not differ in terms PSI and BDI, there were significant differences between those who reported illness and those who did not in terms of impatient and thoughtful approach sub-tests of PSI. The regression analysis showed that age and repressed anger significantly explained the variation in BDI. Conclusion: Altogether results showed that in a relatively low at risk women caregivers group, regardless of being AD caregiver or not, age and repressed anger are important factors on depression levels. Health status of caregiver seems to be a determining factor on PSI. © 2009 Elsevier B.V., All rights reserved.