Comparison of the diagnostic value of glucose-potassium ratio with insulin in women with polycystic ovary syndrome

Abstract

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects 12-23% of women of reproductive age. In this study, it was investigated whether serum Glucose to Potassium (Glu/K+) ratio has a diagnostic value in patients with PCOS. Materials and Methods: This research is a single-center, retrospective analysis study conducted. A PCOS group of 98 patients and 78 age-matched women was included in the study. Serum Glu/K+ was calculated by dividing serum fasting Glucose by serum potassium levels, and laboratory data were analyzed for the whole patient and control group. Results: A significant correlation was found in the correlation analysis between insulin and Glu/K+ ratio. The area under the ROC curve for the Glu/K+ ratio was found to be 0.775, close to the insulin. According to ROC analysis, Insulin cut-off value was found to be 9.1 with a sensitivity of 81% and a specificity of 75%, while the cutoff value of Glu/K+ ratio was calculated as 21.4 with a sensitivity of 74% and a specificity of 71%. Conclusion: Our results show that the serum Glu/K+ ratio is positive and closely related to insulin, which has diagnostic properties for PCOS. We found that the serum Glu/K+ ratio has sensitivity and specificity that can be used as a useful biomarker for PCOS.