Publication:
Does transient hypothyroxinemia influence metabolic bone disease of prematurity?

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dc.contributor.authorDemirel, Utku
dc.contributor.authorÖzek, Eren
dc.contributor.authorBereket, Abdullah
dc.contributor.authorDemirel, Bilge
dc.contributor.authorTopuzoǧlu, Ahmet
dc.contributor.authorAkman, Ipek Özkan
dc.contributor.institutionDemirel, Utku, Department of Neonatology, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionÖzek, Eren, Department of Neonatology, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey
dc.contributor.institutionBereket, Abdullah, Pediatric Endocrinology, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey
dc.contributor.institutionDemirel, Bilge, Department of Neonatolgy, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey
dc.contributor.institutionTopuzoǧlu, Ahmet, Department of Public Health, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey
dc.contributor.institutionAkman, Ipek Özkan, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.date.accessioned2025-10-05T16:38:53Z
dc.date.issued2013
dc.description.abstractObjective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP). Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age ≤34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T4, total T4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level <4.5mg/dl and/or ALP >900IU/l. THOP was defined as a serum free and/or total thyroxine level lower than-1 SD for gestational age at the 7th postnatal day. Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age. Conclusion: The risk of MBD does not increase significantly in babies with THOP. © 2013 Informa UK Ltd. © 2013 Elsevier B.V., All rights reserved.
dc.identifier.doi10.3109/14767058.2013.804051
dc.identifier.endpage1849
dc.identifier.issn14764954
dc.identifier.issn14767058
dc.identifier.issue18
dc.identifier.pubmed23672243
dc.identifier.scopus2-s2.0-84887940254
dc.identifier.startpage1844
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.804051
dc.identifier.urihttps://hdl.handle.net/20.500.14719/13133
dc.identifier.volume26
dc.language.isoen
dc.relation.sourceJournal of Maternal-Fetal and Neonatal Medicine
dc.subject.authorkeywordsAlkaline Phosphatase
dc.subject.authorkeywordsMetabolic Bone Disease
dc.subject.authorkeywordsPrematurity
dc.subject.authorkeywordsThyroid Hormones
dc.subject.authorkeywordsTransient Hypothyroxinemia
dc.subject.authorkeywordsPhosphate
dc.subject.authorkeywordsThyrotropin
dc.subject.authorkeywordsThyroxine
dc.subject.authorkeywordsPhosphate
dc.subject.authorkeywordsThyrotropin
dc.subject.authorkeywordsThyroxine
dc.subject.authorkeywordsAlkaline Phosphatase Blood Level
dc.subject.authorkeywordsArticle
dc.subject.authorkeywordsClinical Feature
dc.subject.authorkeywordsControlled Study
dc.subject.authorkeywordsDisease Association
dc.subject.authorkeywordsGestational Age
dc.subject.authorkeywordsHuman
dc.subject.authorkeywordsHypothyroidism
dc.subject.authorkeywordsInfant
dc.subject.authorkeywordsLow Birth Weight
dc.subject.authorkeywordsMajor Clinical Study
dc.subject.authorkeywordsMetabolic Bone Disease
dc.subject.authorkeywordsParenteral Nutrition
dc.subject.authorkeywordsPerinatal Period
dc.subject.authorkeywordsPhosphate Blood Level
dc.subject.authorkeywordsPrematurity
dc.subject.authorkeywordsPriority Journal
dc.subject.authorkeywordsThyrotropin Blood Level
dc.subject.authorkeywordsTransient Hypothyroxinemia Of Prematurity
dc.subject.authorkeywordsTurkey (republic)
dc.subject.authorkeywordsBirth Weight
dc.subject.authorkeywordsBone Diseases, Metabolic
dc.subject.authorkeywordsCongenital Hypothyroidism
dc.subject.authorkeywordsFemale
dc.subject.authorkeywordsGestational Age
dc.subject.authorkeywordsHumans
dc.subject.authorkeywordsInfant, Newborn
dc.subject.authorkeywordsInfant, Premature, Diseases
dc.subject.authorkeywordsLength Of Stay
dc.subject.authorkeywordsParenteral Nutrition
dc.subject.authorkeywordsRespiration, Artificial
dc.subject.authorkeywordsThyroid Function Tests
dc.subject.authorkeywordsThyroxine
dc.subject.indexkeywordsphosphate
dc.subject.indexkeywordsthyrotropin
dc.subject.indexkeywordsthyroxine
dc.subject.indexkeywordsalkaline phosphatase blood level
dc.subject.indexkeywordsarticle
dc.subject.indexkeywordsclinical feature
dc.subject.indexkeywordscontrolled study
dc.subject.indexkeywordsdisease association
dc.subject.indexkeywordsgestational age
dc.subject.indexkeywordshuman
dc.subject.indexkeywordshypothyroidism
dc.subject.indexkeywordsinfant
dc.subject.indexkeywordslow birth weight
dc.subject.indexkeywordsmajor clinical study
dc.subject.indexkeywordsmetabolic bone disease
dc.subject.indexkeywordsparenteral nutrition
dc.subject.indexkeywordsperinatal period
dc.subject.indexkeywordsphosphate blood level
dc.subject.indexkeywordsprematurity
dc.subject.indexkeywordspriority journal
dc.subject.indexkeywordsthyrotropin blood level
dc.subject.indexkeywordstransient hypothyroxinemia of prematurity
dc.subject.indexkeywordsTurkey (republic)
dc.subject.indexkeywordsBirth Weight
dc.subject.indexkeywordsBone Diseases, Metabolic
dc.subject.indexkeywordsCongenital Hypothyroidism
dc.subject.indexkeywordsFemale
dc.subject.indexkeywordsGestational Age
dc.subject.indexkeywordsHumans
dc.subject.indexkeywordsInfant, Newborn
dc.subject.indexkeywordsInfant, Premature, Diseases
dc.subject.indexkeywordsLength of Stay
dc.subject.indexkeywordsParenteral Nutrition
dc.subject.indexkeywordsRespiration, Artificial
dc.subject.indexkeywordsThyroid Function Tests
dc.subject.indexkeywordsThyroxine
dc.titleDoes transient hypothyroxinemia influence metabolic bone disease of prematurity?
dc.typeArticle
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dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id36536682400
person.identifier.scopus-author-id6701418969
person.identifier.scopus-author-id7004903391
person.identifier.scopus-author-id56533529600
person.identifier.scopus-author-id8685203400
person.identifier.scopus-author-id6603684367

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