The Correlation Between Systemic Inflammatory Response And Survival in Patients with Metachronous and Synchronous Liver Metastatic Colorectal Cancer

Abstract

Objectives: Recent data suggest that a low lymphocyte count in a colorectal tumor is associated with poor prognosis.The NLR has been shown to be an effective prognostic factor for survival in colorectal and ovarian cancer. It has beensuggested that the preoperative NLR may be a simple method to identify patients with a poor prognosis of colorectalcancer. The aim of this study was to evaluate the effect of the NLR on survival in patients with colorectal cancer whounderwent liver metastasectomy.Methods: The study included 76 patients who were admitted to the Medical Oncology Outpatient Clinic of Kartal Dr.Lutfi Kırdar Training and Research Hospital, who underwent liver metastasectomy and were followed up for colorectalcancer and whose clinical data and pre-metastasectomy laboratory values could be retrieved. The SPSS 17.0 softwarepackage was used in the analysis of the study. The mean, standard deviation, minimum-maximum, median, rate andfrequency values were used for the descriptive statistics of the data. The distribution of the variables was assessed bythe Kolmogorov Smirnov test. The independent samples t-test and Mann-Whitney U test were used for the analysis ofquantitative data. The chi-square test was used for analysis of qualitative data. The Cox regression and Kaplan-Meiersurvival analysis were used for survival analyses. Spearman’s correlation analysis was used for correlation analyses.Results: Age had a significant effect on survival time in the univariate model (p<0.05). Sex, colonic localization, lymphnode involvement, histological grade, metastatic status, surgical margin, diameter of metastases, number of metastases, leukocytes, neutrophils, lymphocytes, NLR, CRP, albumin and CEA parameters had no significant effect on survivalin the univariate model (p>0.05).Conclusion: In our study, when a survival analysis was carried out on all variables, the only variable affecting survivalwas age. The mean age of the metasynchronous group was 56.2±10.6 years, and the mean age of the synchronousgroup was 61.3±11.1 years. Despite the numerical difference, there was no statistical significance (p=0.055). Althoughthe mean age of the synchronous group was numerically higher, the survival was longer. This may be due to the shortfollow-up time and the small sample size