Publication:
Itraconazole-induced thrombocytopenia

Simple item page
dc.contributor.authorAksoy, Berna
dc.contributor.institutionAksoy, Berna, Department of Dermatology, Bahçeşehir Üniversitesi, Istanbul, Turkey, Dermatology Clinic, VM Medicalpark Hospital, Kocaeli, Turkey
dc.date.accessioned2025-10-05T16:16:27Z
dc.date.issued2017
dc.description.abstractItraconazole is one of the systemic treatment options for extensive tinea versicolor. A male patient who developed thrombocytopenia during the treatment of tinea versicolor by itraconazole is reported in this manuscript. He was diagnosed to develop thrombocytopenia on the third day of treatment. In the literature, there are two reports of itraconazole-induced thrombocytopenia both in malignancy patients. One report contained three patients who developed thrombocytopenia as a result of a drug interaction between bortezomib and itraconazole. The other report contained a patient who developed thrombocytopenia following six weeks of treatment with itraconazole. It is hypothesized by the author of this manuscript that this patient’s thrombocytopenia developed as a result of selective bone marrow suppression which is brought about by itraconazole’s effect on megakaryocytes. © 2017 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1080/15569527.2016.1257995
dc.identifier.endpage306
dc.identifier.issn15569535
dc.identifier.issn15569527
dc.identifier.issue3
dc.identifier.pubmed27903082
dc.identifier.scopus2-s2.0-85006893214
dc.identifier.startpage305
dc.identifier.urihttps://doi.org/10.1080/15569527.2016.1257995
dc.identifier.urihttps://hdl.handle.net/20.500.14719/12029
dc.identifier.volume36
dc.language.isoen
dc.publisherTaylor and Francis Ltd healthcare.enquiries@informa.com
dc.relation.sourceCutaneous and Ocular Toxicology
dc.subject.authorkeywordsAdverse Effect
dc.subject.authorkeywordsItraconazole
dc.subject.authorkeywordsMegakaryocyte
dc.subject.authorkeywordsPlatelet Production
dc.subject.authorkeywordsStat Proteins
dc.subject.authorkeywordsThrombopoietin
dc.subject.authorkeywordsBortezomib
dc.subject.authorkeywordsItraconazole
dc.subject.authorkeywordsKetoconazole
dc.subject.authorkeywordsOxiconazole
dc.subject.authorkeywordsPotassium Hydroxide
dc.subject.authorkeywordsBortezomib
dc.subject.authorkeywordsItraconazole
dc.subject.authorkeywordsKetoconazole
dc.subject.authorkeywordsOxiconazole
dc.subject.authorkeywordsPotassium Hydroxide
dc.subject.authorkeywordsShampoo
dc.subject.authorkeywordsAdult
dc.subject.authorkeywordsAerosol
dc.subject.authorkeywordsBone Marrow Biopsy
dc.subject.authorkeywordsCase Report
dc.subject.authorkeywordsDesquamation
dc.subject.authorkeywordsHuman
dc.subject.authorkeywordsHypopigmentation
dc.subject.authorkeywordsLaboratory Test
dc.subject.authorkeywordsLeukopenia
dc.subject.authorkeywordsMaintenance Therapy
dc.subject.authorkeywordsMale
dc.subject.authorkeywordsMegakaryocyte
dc.subject.authorkeywordsNote
dc.subject.authorkeywordsPetechia
dc.subject.authorkeywordsSkin Examination
dc.subject.authorkeywordsThrombocyte Count
dc.subject.authorkeywordsThrombocytopenia
dc.subject.authorkeywordsTinea Versicolor
dc.subject.authorkeywordsTreatment Duration
dc.subject.indexkeywordsbortezomib
dc.subject.indexkeywordsitraconazole
dc.subject.indexkeywordsketoconazole
dc.subject.indexkeywordsoxiconazole
dc.subject.indexkeywordspotassium hydroxide
dc.subject.indexkeywordsshampoo
dc.subject.indexkeywordsadult
dc.subject.indexkeywordsaerosol
dc.subject.indexkeywordsbone marrow biopsy
dc.subject.indexkeywordscase report
dc.subject.indexkeywordsdesquamation
dc.subject.indexkeywordshuman
dc.subject.indexkeywordshypopigmentation
dc.subject.indexkeywordslaboratory test
dc.subject.indexkeywordsleukopenia
dc.subject.indexkeywordsmaintenance therapy
dc.subject.indexkeywordsmale
dc.subject.indexkeywordsmegakaryocyte
dc.subject.indexkeywordsNote
dc.subject.indexkeywordspetechia
dc.subject.indexkeywordsskin examination
dc.subject.indexkeywordsthrombocyte count
dc.subject.indexkeywordsthrombocytopenia
dc.subject.indexkeywordstinea versicolor
dc.subject.indexkeywordstreatment duration
dc.titleItraconazole-induced thrombocytopenia
dc.typeNote
dcterms.referencesGupta, Aditya K., Systematic review of systemic treatments for tinea versicolor and evidence-based dosing regimen recommendations, Journal of Cutaneous Medicine and Surgery, 18, 2, pp. 79-90, (2014), Horst, Heinz August, Thrombocytopenia and leukopenia associated with itraconazole., Annals of Internal Medicine, 125, 2, pp. 156-157, (1996), Iwamoto, Takuya, Drug interaction between itraconazole and bortezomib: Exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib, Pharmacotherapy, 30, 7, pp. 661-665, (2010), Liebman, Howard A., Thrombocytopenia in cancer patients, Thrombosis Research, 133, SUPPL. 2, pp. S63-S69, (2014), Arnold, Donald M., Approach to the diagnosis and management of drug-induced immune thrombocytopenia, Transfusion Medicine Reviews, 27, 3, pp. 137-145, (2013), Kaushansky, Alexis, Systems biology of megakaryocytes, Advances in Experimental Medicine and Biology, 844, pp. 59-84, (2014), Hau, Carren Sy, Antimycotics suppress the Malassezia extract-induced production of CXC chemokine ligand 10 in human keratinocytes, Journal of Dermatology, 41, 2, pp. 124-134, (2014), Morris, Michèle Ileana, Posaconazole: A new oral antifungal agent with an expanded spectrum of activity, American Journal of Health-System Pharmacy, 66, 3, pp. 225-236, (2009)
dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id24342773300

Files

Collections

Scopus İndeksli Yayınlar Koleksiyonu