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Ni(II) complexes with 1,3,2,4-dithiadiphosphetane 2,4-disulfide-based ligands: Structural insights, theoretical studies, and anticancer activities

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dc.contributor.authorBulat, Elif
dc.contributor.authorSaǧlam, Ertugrul Gazi
dc.contributor.authorZeyrek, Celal Tuǧrul
dc.contributor.authorAkkoç, Senem
dc.contributor.authorZorlu, Yunus
dc.contributor.authorDal, Hakan
dc.contributor.institutionBulat, Elif, Department of Chemistry, Bozok Üniversitesi, Yozgat, Turkey, Department of Chemistry, Marmara Üniversitesi, Istanbul, Turkey
dc.contributor.institutionSaǧlam, Ertugrul Gazi, Department of Chemistry, Bozok Üniversitesi, Yozgat, Turkey, Department of Chemistry, Marmara Üniversitesi, Istanbul, Turkey
dc.contributor.institutionZeyrek, Celal Tuǧrul, Department of Medical Services and Techniques, Çankiri Karatekin Üniversitesi, Cankiri, Turkey
dc.contributor.institutionAkkoç, Senem, Department of Basic Sciences, Süleyman Demirel Üniversitesi, Isparta, Turkey, Faculty of Engineering and Natural Sciences, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionZorlu, Yunus, Department of Chemistry, Gebze Teknik Üniversitesi, Gebze, Turkey
dc.contributor.institutionDal, Hakan, Department of Medical Services and Techniques, Anadolu Üniversitesi, Eskisehir, Turkey
dc.date.accessioned2025-10-05T15:14:13Z
dc.date.issued2022
dc.description.abstractThe first synthesis of 2,4-bis(3,4-dimethoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (SAV-A1 reagent) was achieved. Seven oxo-alkyl esters (HLn) were synthesized thereof. Ni(II) complexes ([Ni(Ln)<inf>2</inf>]) of these ligands were prepared in ethanol. The structures were identified by spectral studies. Ni(II) complexes were unambiguously determined by X-ray crystallography. In addition, the ligands and their Ni(II) complexes were tested on two different human cancer cell lines, including liver and colon. Moreover, density functional theory (DFT) calculations of the Ni(II) complexes were performed, and the molecular docking studies of these compounds with liver cancer protein, PDB ID: 3WZE and colon cancer antigen proteins, ID 2HQ6 were presented to investigate and predict potential interactions. © 2022 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1002/aoc.6821
dc.identifier.issn02682605
dc.identifier.issn10990739
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85134509846
dc.identifier.urihttps://doi.org/10.1002/aoc.6821
dc.identifier.urihttps://hdl.handle.net/20.500.14719/8587
dc.identifier.volume36
dc.language.isoen
dc.publisherJohn Wiley and Sons Ltd
dc.relation.sourceApplied Organometallic Chemistry
dc.subject.authorkeywords2,4-diorganyl-1,3,2,4-dithiadiphosphetan-2,4-disulfide
dc.subject.authorkeywordsAnticancer
dc.subject.authorkeywordsDensity Functional Theory
dc.subject.authorkeywordsDithiophosphonato Complexes
dc.subject.authorkeywordsPerthiophosphonic Acid Anhydrides
dc.subject.authorkeywordsCell Culture
dc.subject.authorkeywordsChelation
dc.subject.authorkeywordsDensity Functional Theory
dc.subject.authorkeywordsDiseases
dc.subject.authorkeywordsNickel Compounds
dc.subject.authorkeywordsProteins
dc.subject.authorkeywordsSpectroscopic Analysis
dc.subject.authorkeywordsX Ray Crystallography
dc.subject.authorkeywords2,4-diorganyl-1,3,2,4-dithiadiphosphetan-2,4-disulphide
dc.subject.authorkeywordsAcid Anhydride
dc.subject.authorkeywordsAlkyl Esters
dc.subject.authorkeywordsAnticancer
dc.subject.authorkeywordsAnticancer Activities
dc.subject.authorkeywordsDensity-functional-theory
dc.subject.authorkeywordsDithiophosphonato Complex
dc.subject.authorkeywordsPerthiophosphonic Acid Anhydride
dc.subject.authorkeywordsStructural Insights
dc.subject.authorkeywordsTheoretical Study
dc.subject.authorkeywordsLigands
dc.subject.indexkeywordsCell culture
dc.subject.indexkeywordsChelation
dc.subject.indexkeywordsDensity functional theory
dc.subject.indexkeywordsDiseases
dc.subject.indexkeywordsNickel compounds
dc.subject.indexkeywordsProteins
dc.subject.indexkeywordsSpectroscopic analysis
dc.subject.indexkeywordsX ray crystallography
dc.subject.indexkeywords2,4-diorganyl-1,3,2,4-dithiadiphosphetan-2,4-disulphide
dc.subject.indexkeywordsAcid anhydride
dc.subject.indexkeywordsAlkyl esters
dc.subject.indexkeywordsAnticancer
dc.subject.indexkeywordsAnticancer activities
dc.subject.indexkeywordsDensity-functional-theory
dc.subject.indexkeywordsDithiophosphonato complex
dc.subject.indexkeywordsPerthiophosphonic acid anhydride
dc.subject.indexkeywordsStructural insights
dc.subject.indexkeywordsTheoretical study
dc.subject.indexkeywordsLigands
dc.titleNi(II) complexes with 1,3,2,4-dithiadiphosphetane 2,4-disulfide-based ligands: Structural insights, theoretical studies, and anticancer activities
dc.typeArticle
dcterms.referencesNizamov, Il'yas S., 2,4-Diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides, their structure and S-silyl dithiophosphonic derivatives, Phosphorus, Sulfur and Silicon and the Related Elements, 191, 11-12, pp. 1576-1577, (2016), J Chem Soc Dalton Trans, (1997), J Chem Soc Chem Commun, (1995), Chem Commun, (1997), Chem Commun, (1997), Dimitrov, Anton, 2,4-N,N′-Bis(dialkylamido)-2,4-dithioxo-1,3,2λ5, 4λ5-dithiadiphosphetanes, European Journal of Inorganic Chemistry, 19, pp. 3842-3845, (2004), Saǧlam, Ertugrul Gazi, The syntheses and characterization of new dithiophosphonates derived from novel 2,4-bis(Methoxytolyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfides and their ni(II) complexes, Journal of the Turkish Chemical Society, Section A: Chemistry, 7, 3, pp. 789-800, (2020), Org Synth, (1984), Lajoie, Gilles Andre, Facile regioselective formation of thiopeptide linkages from oligopeptides with new thionation reagents, Tetrahedron Letters, 24, 36, pp. 3815-3818, (1983), Yokoyama, Masataka, Improved O/S exchange reagents, Synthesis (Germany), NO. 10, pp. 827-829, (1984)
dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id57204558707
person.identifier.scopus-author-id36675689200
person.identifier.scopus-author-id56524421400
person.identifier.scopus-author-id55211930300
person.identifier.scopus-author-id24280865300
person.identifier.scopus-author-id6602816610

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