The Effect of Bacterial Cellulose in the Prevention of Leakage after Sleeve Gastrectomy-An Experimental Study

Abstract

Background: One of the most important complications of sleeve gastrectomy (SG), a frequently used method in the surgical treatment of obesity, is gastric sleeve leak. The prevention of gastric sleeve leak will contribute to the prevention of mortality subsequent to SG. In this study, bacterial cellulose (BC) was used to prevent leak after SG. Materials and Methods: In our study, SG was performed on 20 Sprague-Dawley rats. They were divided into two groups, one with primary suture only, and the other with BC cover along the suture line. After 7 days, suture line bursting pressure was measured and histopathological examinations were performed. Results: According to the findings of our study, the bursting pressure increased with BC application. As a result of histopathological examinations, BC group showed a significant increase in the fibroblast, eosinophil density, and inflammatory cell infiltration. Conclusion: BC has been shown to accelerate wound healing mechanically and histopathologically. Besides, our study will shed light on the advanced clinical studies to be conducted on the effect of BC preventing gastric leak after SG, and we suggest that BC may be used for this purpose in the near future. © 2022 Elsevier B.V., All rights reserved.