Publication:
Strong association between serotonin transporter 5-httvntr variant and psychoactive substance (Nicotine) use in the turkish cypriot population

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dc.contributor.authorKandemiş, Emine
dc.contributor.authorTuncel, Gülten
dc.contributor.authorAşut, Özen
dc.contributor.authorTemel, Şehime Gülsün
dc.contributor.authorErgoren, M. C.
dc.contributor.institutionKandemiş, Emine, Department of Molecular Biology and Genetics, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionTuncel, Gülten, Department of Medical Biology, Yakın Doğu Üniversitesi, Nicosia, Cyprus, DESAM Research Institute, Yakın Doğu Üniversitesi, Nicosia, Cyprus
dc.contributor.institutionAşut, Özen, Department of Public Health, Yakın Doğu Üniversitesi, Nicosia, Cyprus
dc.contributor.institutionTemel, Şehime Gülsün, Department of Public Health, Yakın Doğu Üniversitesi, Nicosia, Cyprus, Department of Medical Genetics, Bursa Uludağ Üniversitesi, Bursa, Turkey
dc.contributor.institutionErgoren, M. C., Department of Medical Biology, Yakın Doğu Üniversitesi, Nicosia, Cyprus, DESAM Research Institute, Yakın Doğu Üniversitesi, Nicosia, Cyprus
dc.date.accessioned2025-10-05T15:52:52Z
dc.date.issued2020
dc.description.abstractBackground: The use of psychoactive substances is one of the most dangerous social problems worldwide. Nicotine dependence results from the interaction between neurobiological, environmental and genetic factors. Serotonin is a neurotransmitter that has a wide range of central nervous system activities. The serotonin transporter gene has been previously linked to psychological traits. Objective: A variable number of tandem repeats within the serotonin transporter-linked polymorphic gene region are believed to alter the transcriptional efficiency of the 5-HTT gene. Therefore, we aimed to investigate the association between this polymorphic site and smoking behavior in the Turkish Cypriot population. Methods: A total of 259 (100 smokers, 100 non-smokers and 59 ex-smokers) Turkish Cypriots were included in this population-based cross-sectional study. Genomic DNA was extracted from peripheral blood samples and the 5-HTTVNTR2 polymorphisms were determined by the PCR-RFLP. Results: The allelic frequency and genotype distribution results of this study showed a strong association (P<0.0001) between smokers and non-smokers. No statistical significance was found between non-smokers and ex-smokers. Conclusion: This is the first genetic epidemiology study to investigate the allelic frequencies of 5-HTTVNTR2 polymorphisms associated with smoking behavior in the Turkish Cypriot population. Based on the results of this study, genome-wide association studies should be designed for preventive medicine in this population. © 2021 Elsevier B.V., All rights reserved.
dc.identifier.doi10.2174/1389200221666200620201348
dc.identifier.endpage470
dc.identifier.issn18755453
dc.identifier.issn13892002
dc.identifier.issue6
dc.identifier.pubmed32562520
dc.identifier.scopus2-s2.0-85090608933
dc.identifier.startpage466
dc.identifier.urihttps://doi.org/10.2174/1389200221666200620201348
dc.identifier.urihttps://hdl.handle.net/20.500.14719/10762
dc.identifier.volume21
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.sourceCurrent Drug Metabolism
dc.subject.authorkeywordsCyprus
dc.subject.authorkeywordsNeurotransmitter Agents
dc.subject.authorkeywordsNicotine
dc.subject.authorkeywordsSerotonin
dc.subject.authorkeywordsSmoking
dc.subject.authorkeywordsTobacco
dc.subject.authorkeywordsNicotine
dc.subject.authorkeywordsNicotine
dc.subject.authorkeywordsSerotonin Plasma Membrane Transport Proteins
dc.subject.authorkeywordsSlc6a4 Protein, Human
dc.subject.authorkeywordsHigh Density Lipoprotein Cholesterol
dc.subject.authorkeywordsLow Density Lipoprotein Cholesterol
dc.subject.authorkeywordsNicotine
dc.subject.authorkeywordsPsychotropic Agent
dc.subject.authorkeywordsSerotonin Transporter
dc.subject.authorkeywordsTriacylglycerol
dc.subject.authorkeywordsSlc6a4 Protein, Human
dc.subject.authorkeywords5 Htt Gene
dc.subject.authorkeywords5 Httvnt Gene
dc.subject.authorkeywordsAdult
dc.subject.authorkeywordsArticle
dc.subject.authorkeywordsBody Mass
dc.subject.authorkeywordsCholesterol Blood Level
dc.subject.authorkeywordsCross-sectional Study
dc.subject.authorkeywordsDiastolic Blood Pressure
dc.subject.authorkeywordsDna Extraction
dc.subject.authorkeywordsDna Polymorphism
dc.subject.authorkeywordsEx-smoker
dc.subject.authorkeywordsFemale
dc.subject.authorkeywordsGene
dc.subject.authorkeywordsGene Frequency
dc.subject.authorkeywordsGenetic Association
dc.subject.authorkeywordsGenetic Epidemiology
dc.subject.authorkeywordsGenetic Polymorphism
dc.subject.authorkeywordsGenetic Variability
dc.subject.authorkeywordsGenome-wide Association Study
dc.subject.authorkeywordsHuman
dc.subject.authorkeywordsMale
dc.subject.authorkeywordsNon-smoker
dc.subject.authorkeywordsPolymerase Chain Reaction Restriction Fragment Length Polymorphism
dc.subject.authorkeywordsSmoking
dc.subject.authorkeywordsSmoking Cessation
dc.subject.authorkeywordsSystolic Blood Pressure
dc.subject.authorkeywordsVariable Number Of Tandem Repeat
dc.subject.authorkeywordsGenetic Predisposition
dc.subject.authorkeywordsGenetics
dc.subject.authorkeywordsGenotyping Technique
dc.subject.authorkeywordsMetabolism
dc.subject.authorkeywordsMiddle Aged
dc.subject.authorkeywordsTobacco Dependence
dc.subject.authorkeywordsTurkey (bird)
dc.subject.authorkeywordsAdult
dc.subject.authorkeywordsCross-sectional Studies
dc.subject.authorkeywordsEx-smokers
dc.subject.authorkeywordsFemale
dc.subject.authorkeywordsGene Frequency
dc.subject.authorkeywordsGenetic Predisposition To Disease
dc.subject.authorkeywordsGenotyping Techniques
dc.subject.authorkeywordsHumans
dc.subject.authorkeywordsMale
dc.subject.authorkeywordsMiddle Aged
dc.subject.authorkeywordsNicotine
dc.subject.authorkeywordsNon-smokers
dc.subject.authorkeywordsPolymorphism, Genetic
dc.subject.authorkeywordsSerotonin Plasma Membrane Transport Proteins
dc.subject.authorkeywordsSmokers
dc.subject.authorkeywordsTobacco Use Disorder
dc.subject.authorkeywordsTurkey
dc.subject.indexkeywordshigh density lipoprotein cholesterol
dc.subject.indexkeywordslow density lipoprotein cholesterol
dc.subject.indexkeywordsnicotine
dc.subject.indexkeywordspsychotropic agent
dc.subject.indexkeywordsserotonin transporter
dc.subject.indexkeywordstriacylglycerol
dc.subject.indexkeywordsSLC6A4 protein, human
dc.subject.indexkeywords5 HTT gene
dc.subject.indexkeywords5 HTTVNT gene
dc.subject.indexkeywordsadult
dc.subject.indexkeywordsArticle
dc.subject.indexkeywordsbody mass
dc.subject.indexkeywordscholesterol blood level
dc.subject.indexkeywordscross-sectional study
dc.subject.indexkeywordsdiastolic blood pressure
dc.subject.indexkeywordsDNA extraction
dc.subject.indexkeywordsDNA polymorphism
dc.subject.indexkeywordsex-smoker
dc.subject.indexkeywordsfemale
dc.subject.indexkeywordsgene
dc.subject.indexkeywordsgene frequency
dc.subject.indexkeywordsgenetic association
dc.subject.indexkeywordsgenetic epidemiology
dc.subject.indexkeywordsgenetic polymorphism
dc.subject.indexkeywordsgenetic variability
dc.subject.indexkeywordsgenome-wide association study
dc.subject.indexkeywordshuman
dc.subject.indexkeywordsmale
dc.subject.indexkeywordsnon-smoker
dc.subject.indexkeywordspolymerase chain reaction restriction fragment length polymorphism
dc.subject.indexkeywordssmoking
dc.subject.indexkeywordssmoking cessation
dc.subject.indexkeywordssystolic blood pressure
dc.subject.indexkeywordsvariable number of tandem repeat
dc.subject.indexkeywordsgenetic predisposition
dc.subject.indexkeywordsgenetics
dc.subject.indexkeywordsgenotyping technique
dc.subject.indexkeywordsmetabolism
dc.subject.indexkeywordsmiddle aged
dc.subject.indexkeywordstobacco dependence
dc.subject.indexkeywordsturkey (bird)
dc.subject.indexkeywordsAdult
dc.subject.indexkeywordsCross-Sectional Studies
dc.subject.indexkeywordsEx-Smokers
dc.subject.indexkeywordsFemale
dc.subject.indexkeywordsGene Frequency
dc.subject.indexkeywordsGenetic Predisposition to Disease
dc.subject.indexkeywordsGenotyping Techniques
dc.subject.indexkeywordsHumans
dc.subject.indexkeywordsMale
dc.subject.indexkeywordsMiddle Aged
dc.subject.indexkeywordsNicotine
dc.subject.indexkeywordsNon-Smokers
dc.subject.indexkeywordsPolymorphism, Genetic
dc.subject.indexkeywordsSerotonin Plasma Membrane Transport Proteins
dc.subject.indexkeywordsSmokers
dc.subject.indexkeywordsTobacco Use Disorder
dc.subject.indexkeywordsTurkey
dc.titleStrong association between serotonin transporter 5-httvntr variant and psychoactive substance (Nicotine) use in the turkish cypriot population
dc.typeArticle
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dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id56627015700
person.identifier.scopus-author-id57203268806
person.identifier.scopus-author-id57201504674
person.identifier.scopus-author-id6507885442
person.identifier.scopus-author-id56731124900

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