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Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient

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dc.contributor.authorMusmula, Müge
dc.contributor.authorAkkoç, Senem
dc.contributor.institutionMusmula, Müge, Department of Pharmacology, Süleyman Demirel University, Faculty of Medicine, Isparta, Turkey
dc.contributor.institutionAkkoç, Senem, Department of Basic Sciences, Süleyman Demirel Üniversitesi, Isparta, Turkey, Faculty of Engineering and Natural Sciences, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.date.accessioned2025-10-05T14:37:18Z
dc.date.issued2025
dc.description.abstractApoptosis is the programmed death of cells that have lost their function, have been damaged, or are no longer needed in the organism. Genes that control this process are overexpressed in some tumors. Carvacrol, a terpenoid, has been shown to inhibit tumor growth and induce apoptosis in cancerous cells, increasing caspase activity, DNA fragmentation, and the expression of the Bax protein, while decreasing Bcl-2 expression. In this review, the effects of carvacrol on various cancers and its potential as a drug are summarized. © 2025 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1080/10286020.2025.2517669
dc.identifier.issn14772213
dc.identifier.issn10286020
dc.identifier.scopus2-s2.0-105008352400
dc.identifier.urihttps://doi.org/10.1080/10286020.2025.2517669
dc.identifier.urihttps://hdl.handle.net/20.500.14719/6707
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.sourceJournal of Asian Natural Products Research
dc.subject.authorkeywordsAnticancer Agents
dc.subject.authorkeywordsApoptosis
dc.subject.authorkeywordsCancer
dc.subject.authorkeywordsCarvacrol
dc.subject.authorkeywordsCarvacrol
dc.subject.authorkeywordsAntineoplastic Agent
dc.subject.authorkeywordsCarvacrol
dc.subject.authorkeywordsProtein Bax
dc.subject.authorkeywordsApoptosis
dc.subject.authorkeywordsCancer Cell
dc.subject.authorkeywordsDna Fragmentation
dc.subject.authorkeywordsHuman
dc.subject.authorkeywordsNonhuman
dc.subject.authorkeywordsReview
dc.subject.indexkeywordsantineoplastic agent
dc.subject.indexkeywordscarvacrol
dc.subject.indexkeywordsprotein Bax
dc.subject.indexkeywordsapoptosis
dc.subject.indexkeywordscancer cell
dc.subject.indexkeywordsDNA fragmentation
dc.subject.indexkeywordshuman
dc.subject.indexkeywordsnonhuman
dc.subject.indexkeywordsreview
dc.titleApoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient
dc.typeReview
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dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id59949491900
person.identifier.scopus-author-id55211930300

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