Publication:
Reducing Virulence and Biofilm of Pseudomonas aeruginosa by Potential Quorum Sensing Inhibitor Carotenoid: Zeaxanthin

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dc.contributor.authorGökalsın, Barış
dc.contributor.authorAksoydan, Busecan
dc.contributor.authorErman, Burak R.
dc.contributor.authorSesal, Nüzhet Cenk
dc.contributor.institutionGökalsın, Barış, Department of Biology, Marmara Üniversitesi, Istanbul, Turkey
dc.contributor.institutionAksoydan, Busecan, Department of Biophysics, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionErman, Burak R., Chemical and Biological Engineering Department, Koç Üniversitesi, Istanbul, Turkey
dc.contributor.institutionSesal, Nüzhet Cenk, Department of Biology, Marmara Üniversitesi, Istanbul, Turkey
dc.date.accessioned2025-10-05T16:16:05Z
dc.date.issued2017
dc.description.abstractPseudomonas aeruginosa can regulate its virulence gene expressions by using a signal system called quorum sensing. It is known that inhibition of quorum sensing can block biofilm formation and leave the bacteria defenseless. Therefore, it is necessary to determine natural sources to obtain potential quorum sensing inhibitors. This study aims to investigate an alternative treatment approach by utilizing the carotenoid zeaxanthin to reduce the expressions of P. aeruginosa virulence factors through quorum sensing inhibition. The inhibition potential of zeaxanthin was determined by in silico screening from a library of 638 lichen metabolites. Fluorescent monitor strains were utilized for quorum sensing inhibitor screens, and quantitative reverse-transcriptase PCR assay was performed for evaluating gene expression. Results indicate that zeaxanthin is a better inhibitor than the lichen secondary metabolite evernic acid, which was previously shown to be capable of inhibiting P. aeruginosa quorum sensing systems. © 2017 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1007/s00248-017-0949-3
dc.identifier.endpage473
dc.identifier.isbn9780470048177
dc.identifier.issn1432184X
dc.identifier.issn00953628
dc.identifier.issue2
dc.identifier.pubmed28255686
dc.identifier.scopus2-s2.0-85014086296
dc.identifier.startpage466
dc.identifier.urihttps://doi.org/10.1007/s00248-017-0949-3
dc.identifier.urihttps://hdl.handle.net/20.500.14719/12016
dc.identifier.volume74
dc.language.isoen
dc.publisherSpringer New York LLC barbara.b.bertram@gsk.com
dc.relation.sourceMicrobial Ecology
dc.subject.authorkeywordsBiofilm
dc.subject.authorkeywordsMolecular Docking
dc.subject.authorkeywordsPseudomonas Aeruginosa
dc.subject.authorkeywordsQuorum Sensing
dc.subject.authorkeywordsZeaxanthin
dc.subject.authorkeywordsZeaxanthin
dc.subject.authorkeywordsAnti-bacterial Agents
dc.subject.authorkeywordsZeaxanthins
dc.subject.authorkeywordsAntiinfective Agent
dc.subject.authorkeywordsZeaxanthin
dc.subject.authorkeywordsBiofilm
dc.subject.authorkeywordsDrug Effects
dc.subject.authorkeywordsPathogenicity
dc.subject.authorkeywordsPseudomonas Aeruginosa
dc.subject.authorkeywordsQuorum Sensing
dc.subject.authorkeywordsVirulence
dc.subject.authorkeywordsAnti-bacterial Agents
dc.subject.authorkeywordsBiofilms
dc.subject.authorkeywordsQuorum Sensing
dc.subject.authorkeywordsVirulence
dc.subject.authorkeywordsZeaxanthins
dc.subject.indexkeywordsantiinfective agent
dc.subject.indexkeywordszeaxanthin
dc.subject.indexkeywordsbiofilm
dc.subject.indexkeywordsdrug effects
dc.subject.indexkeywordspathogenicity
dc.subject.indexkeywordsPseudomonas aeruginosa
dc.subject.indexkeywordsquorum sensing
dc.subject.indexkeywordsvirulence
dc.subject.indexkeywordsAnti-Bacterial Agents
dc.subject.indexkeywordsBiofilms
dc.subject.indexkeywordsQuorum Sensing
dc.subject.indexkeywordsVirulence
dc.subject.indexkeywordsZeaxanthins
dc.titleReducing Virulence and Biofilm of Pseudomonas aeruginosa by Potential Quorum Sensing Inhibitor Carotenoid: Zeaxanthin
dc.typeArticle
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dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id57189220818
person.identifier.scopus-author-id57193457339
person.identifier.scopus-author-id56243116800
person.identifier.scopus-author-id57188835410

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