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Advancing bone tissue engineering: multi-walled carbon nanotube-polylactic acid composites for enhanced regeneration

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dc.contributor.authorZahedah, Rola
dc.contributor.authorDinç, Bircan
dc.contributor.institutionZahedah, Rola, Department of Medical Biology, Istanbul University-Cerrahpasa, Istanbul, Turkey
dc.contributor.institutionDinç, Bircan, Department of Biophysics, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.date.accessioned2025-10-05T14:38:32Z
dc.date.issued2025
dc.description.abstractThe regeneration of bone tissues using a composite-based tissue engineering approach is a promising strategy for repairing and restoring their biological functions. This study extensively investigates the development and potential applications of Multi-Walled Carbon Nanotube-Polylactic Acid (MWCNT-PLA) composites for bone defect healing. The scaffolds were meticulously engineered and characterized to assess their material properties, structural compatibility, biodegradability, pH impact, water absorption, biocompatibility, cell viability, and cellular interactions. Composites were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Results showed a 15% increase in glass transition temperature, a 20% improvement in cell adhesion, and a 25% enhancement in mechanical strength compared to pure PLA. HOB cells demonstrated increased adhesion and proliferation on the composites, highlighting their biocompatibility. The findings revealed that incorporating MWCNTs enhances the thermal and mechanical properties of PLA, promotes cell adhesion, and influences the degradation behavior of the nanocomposites, marking significant progress in bone tissue engineering. © 2025 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1080/09276440.2025.2450158
dc.identifier.endpage419
dc.identifier.issn09276440
dc.identifier.issn15685543
dc.identifier.issue3
dc.identifier.scopus2-s2.0-105001948376
dc.identifier.startpage399
dc.identifier.urihttps://doi.org/10.1080/09276440.2025.2450158
dc.identifier.urihttps://hdl.handle.net/20.500.14719/6765
dc.identifier.volume32
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.sourceComposite Interfaces
dc.subject.authorkeywordsBiocompatibility
dc.subject.authorkeywordsBiodegradability
dc.subject.authorkeywordsHuman Osteoblast Cells
dc.subject.authorkeywordsMulti-walled Carbon Nanotube
dc.subject.authorkeywordsNanocomposite
dc.subject.authorkeywordsPolylactic Acid
dc.subject.authorkeywordsBone
dc.subject.authorkeywordsCarbon Carbon Composites
dc.subject.authorkeywordsCell Adhesion
dc.subject.authorkeywordsCell Engineering
dc.subject.authorkeywordsCell Proliferation
dc.subject.authorkeywordsHydroelasticity
dc.subject.authorkeywordsMultiwalled Carbon Nanotubes (mwcn)
dc.subject.authorkeywordsOsteoblasts
dc.subject.authorkeywordsScaffolds (biology)
dc.subject.authorkeywordsTissue Regeneration
dc.subject.authorkeywordsBiological Functions
dc.subject.authorkeywordsBone Defect Healing
dc.subject.authorkeywordsBone Tissue
dc.subject.authorkeywordsBone Tissue Engineering
dc.subject.authorkeywordsCells Adhesion
dc.subject.authorkeywordsHuman Osteoblasts Cells
dc.subject.authorkeywordsMulti-walled-carbon-nanotubes
dc.subject.authorkeywordsPolylactic Acid
dc.subject.authorkeywordsProperty
dc.subject.authorkeywordsTissues Engineerings
dc.subject.authorkeywordsFourier Transform Infrared Spectroscopy
dc.subject.indexkeywordsBone
dc.subject.indexkeywordsCarbon carbon composites
dc.subject.indexkeywordsCell adhesion
dc.subject.indexkeywordsCell engineering
dc.subject.indexkeywordsCell proliferation
dc.subject.indexkeywordsHydroelasticity
dc.subject.indexkeywordsMultiwalled carbon nanotubes (MWCN)
dc.subject.indexkeywordsOsteoblasts
dc.subject.indexkeywordsScaffolds (biology)
dc.subject.indexkeywordsTissue regeneration
dc.subject.indexkeywordsBiological functions
dc.subject.indexkeywordsBone defect healing
dc.subject.indexkeywordsBone tissue
dc.subject.indexkeywordsBone tissue engineering
dc.subject.indexkeywordsCells adhesion
dc.subject.indexkeywordsHuman osteoblasts cells
dc.subject.indexkeywordsMulti-walled-carbon-nanotubes
dc.subject.indexkeywordsPolylactic acid
dc.subject.indexkeywordsProperty
dc.subject.indexkeywordsTissues engineerings
dc.subject.indexkeywordsFourier transform infrared spectroscopy
dc.titleAdvancing bone tissue engineering: multi-walled carbon nanotube-polylactic acid composites for enhanced regeneration
dc.typeArticle
dcterms.referencesPolo-Corrales, Liliana, Scaffold design for bone regeneration, Journal of Nanoscience and Nanotechnology, 14, 1, pp. 15-56, (2014), O'Brien, Fergal J., Biomaterials & scaffolds for tissue engineering, Materials Today, 14, 3, pp. 88-95, (2011), Qu, Sshibin, Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma, Genomics Data, 5, pp. 385-387, (2015), Tyler, Betty Mae, Polylactic acid (PLA) controlled delivery carriers for biomedical applications, Advanced Drug Delivery Reviews, 107, pp. 163-175, (2016), de Moura, Nayara Koba, Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration, Materials Science and Engineering C, 117, (2020), Anderson, James M., Biodegradation and biocompatibility of PLA and PLGA microspheres, Advanced Drug Delivery Reviews, 28, 1, pp. 5-24, (1997), Feng, Kuanche, The influence of roughness on stem cell differentiation using 3D printed polylactic acid scaffolds, Soft Matter, 14, 48, pp. 9838-9846, (2018), Tsuji, Hideto, Poly(Lactic Acid), pp. 171-239, (2014), Wang, Guoyong, Crystallinity and Reinforcement in Poly-L-Lactic Acid Scaffold Induced by Carbon Nanotubes, Advances in Polymer Technology, 2019, (2019), Dinç, Bircan, Characterization of short-length multi-walled carbon nanotubes and cytotoxicity on MDA-MB-231 and HUVEC cell lines, Carbon Letters, 30, 2, pp. 143-153, (2020)
dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id59504799700
person.identifier.scopus-author-id57195263030

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