Publication:
The frequency of OPRK1 G36T and OPRM1 A118G opioid receptor gene polymorphisms in heroin-dependent individuals and nondependent healthy subjects in Turkey

Simple item page
dc.contributor.authorToker Uğurlu, Tuğçe
dc.contributor.authorAteşci, Figen
dc.contributor.authorDemircan, Günnur
dc.contributor.authorAkın, Demet
dc.contributor.authorZengin, Gülizar
dc.contributor.authorKepenek, Ata Onur
dc.contributor.authorBerk, Selim Can
dc.contributor.authorSaygın, Damla
dc.contributor.authorÖzliman, İdea Nehir
dc.contributor.institutionPamukkale Üniversitesi
dc.contributor.institutionİstanbul Demiroğlu Bilim Üniversitesi
dc.contributor.institutionBahçeşehir Üniversitesi
dc.contributor.institutionT.C. Sağlık Bakanlığı
dc.contributor.institutionİstanbul Üniversitesi
dc.contributor.institutionKocaeli Üniversitesi
dc.contributor.institutionKocaeli Üniversitesi
dc.contributor.institutionYabancı Kurumlar
dc.date.accessioned2025-09-20T19:55:07Z
dc.date.issued2023
dc.date.submitted22.08.2024
dc.description.abstractObjective: Polymorphisms of the Mu opioid receptor (MOR) gene (OPRM1), which encodes for the primary action site of heroin, have also been found to be associated with heroin addiction. The aim of this study was to investigate the relationships between heroin addiction and G36T OPRK1 and A118G OPRM1 receptor gene polymorphisms in a male population in Turkey. Method: 102 male patients with heroin use (without any other drug use) and 82 subjects without any history of opioid use were evaluated. The A118G and G36T SNPs on the MOR and Kappa opioid receptors (KOR) genes were assessed via TaqMan 5’-exonuclease allelic discrimination assays. Results: The mean duration of heroin use was 4.6±1.9 years. The G36T polymorphism and heterozygous genotype were both found to be more frequent in the patient group (OPRK1 gene). In the patient group, 79 (77.5%) patients had wild-type genotype and 23 (22.5%) patients had mutant genotype. In the control group, 76 (92.7 %) subjects had wild-type genotype and 6 (7.3 %) subjects had mutant genotype (p=0.005). Wild type allele frequency was determined to be 0.894 and mutant type allele frequency was 0.105. With regard to the A118G polymorphism, we found that there was no difference between groups in terms of genotype. Discussion: Our findings support a considerable role for OPRK1 in opioid addiction, however, in conflict with most studies, we did not determine a relationship with A118G in Turkish subjects. We suggest that further stu-dies should be conducted to ascertain the clinical implications of opioid gene polymorphisms in Turkey.
dc.identifier.doi10.5505/kpd.2023.73693
dc.identifier.endpage169
dc.identifier.issn1302-0099
dc.identifier.issn2146-7153
dc.identifier.issue3
dc.identifier.startpage163
dc.identifier.urihttps://hdl.handle.net/20.500.14719/4479
dc.identifier.volume26
dc.language.isoen
dc.relation.journalKlinik Psikiyatri Dergisi
dc.subjectMadde Bağımlılığı
dc.subjectGenetik ve Kalıtım
dc.subjectPsikoloji
dc.subjectFarmakoloji ve Eczacılık
dc.titleThe frequency of OPRK1 G36T and OPRM1 A118G opioid receptor gene polymorphisms in heroin-dependent individuals and nondependent healthy subjects in Turkey
dc.typeResearch Article
dcterms.references1. Kreek MJ, Levran O, Reed B, Schlussman SD, Zhou Y, Butelman ER. Opiate addiction and cocaine addiction: underly- ing molecular neurobiology and genetics. J Clin Invest 2012, 122:3387-3393.,2. Mistry CJ, Bawor M, Desai D, Marsh DC, Samaan Z. Genetics of opioid dependence: a review of the genetic contri- bution to opioid dependence. Curr Psychiatry Rev 2014, 10:156- 167.,3. Green J. Epidemiology of opioid abuse and addiction. J Emerg Nurs 2017, 43:106-113.,4. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 1998, 95:9608-9613.,5. Bozkaya O. Mutation and polymorphism for clinicians: medi- cal education. Turkiye Klinikleri J Pediatr 2009, 18:147-153.,6. Soleimani Asl S, Roointan A, Bergen H, Amiri S, Mardani P, Ashtari N, Shabani R, Mehdizadeh M. Opioid receptors gene polymorphism and heroin dependence in Iran. Basic Clin Neurosci 2018, 9:101-106.,7. Wang SC, Tsou HH, Chung RH, Chang YS, Fang CP, Chen CH, Ho IK, Kuo HW, Liu SC, Shih YH, Wu HY, Huang BH, Lin KM, Chen AC, Hsiao CF, Liu YL. The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance. J Clin Psychopharmacol 2014, 34:205- 211.,8. Kreek MJ. Opiate and cocaine addictions: challenge for phar- macotherapies. Pharmacol Biochem Behav 1997, 57:551-569.,9. Loh el W, Fann CS, Chang YT, Chang CJ, Cheng AT. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcohol Clin Exp Res 2004, 28:15-19.,10. Mayer P, Höllt V. Pharmacogenetics of opioid receptors and addiction. Pharmacogenet Genomics 2006, 16:1-7.,11. Zadina JE, Hackler L, Ge LJ, Kastin AJ. A potent and selec- tive endogenous agonist for the mu-opiate receptor. Nature 1997, 386:499-502.,12. Uhl GR, Sora I, Wang Z. The mu opiate receptor as a can- didate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci USA 1999, 96:7752-7755.,13. Chen D, Liu L, Xiao Y, Peng Y, Yang C, Wang Z. Ethnic- specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. Drug Alcohol Depend 2012, 123:1-6.,14. Kaya H, Kaya ÖB, Dilbaz N. Alkol kullanım bozukluğunun genetiği. Curr Addict Res 2017, 1:33-46.,15. Shi J, Hui L, Xu Y, Wang F, Huang W, Hu G. Sequence vari- ations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. Hum Mutat 2002, 19:459-460.,16. Türkan H, Karahalil B, Kadıoğlu E, Eren K, Gürol DT, Karakaya AE. The association between the OPRM1 A118G polymorphism and addiction in a Turkish population. Arh Hig Rada Toksikol 2019, 70:97-103.,17. Edenberg HJ, Wang J, Tian H, Pochareddy S, Xuei X, Wetherill L, Goate A, Hinrichs T, Kuperman S, Nurnberger JI Jr, Schuckit M, Tischfield JA, Foroud T. A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. Hum Mol Genet 2008, 17:1783-1789.,18. Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev 2005, 57:1-26.,19. Saito Y, Hanioka N, Maekawa K, Isobe T, Tsuneto Y, Nakamura R, Soyama A, Ozawa S, Tanaka-Kagawa T, Jinno H, Narimatsu S, Sawada J. Functional analysis of three CYP1A2 variants found in a Japanese population. Drug Metab Dispos 2005, 33:1905-1910.,20. Butelman ER, Yuferov V, Kreek MJ. κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci 2012, 35:587-596.,21. Pan ZZ. Mu-opposing actions of the kappa-opioid receptor. Trends Pharmacol Sci 1998, 19:94-98.,22. Bruchas MR, Land BB, Chavkin C. The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addic- tive behaviors. Brain Res 2010, 1314:44-55.,23. Zan GY, Wang Q, Wang YJ, Liu Y, Hang A, Shu XH, Liu JG. Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged mor- phine abstinence. Behav Brain Res 2015, 291:334-341.,24. Gerra G, Leonardi C, Cortese E, D'Amore A, Lucchini A, Strepparola G, Serio G, Farina G, Magnelli F, Zaimovic A, Mancini A, Turci M, Manfredini M, Donnini C. Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. Am J Med Genet B Neuropsychiatr Genet 2007, 144B:771-775.,25. Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenet Genomics 2004, 14:793-804.,26. Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol Psychiatry 2008, 13:531-543.,27. Kumar D, Chakraborty J, Das S. Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opi- oid receptor gene increase susceptibility to addiction in Indian population. Prog Neuropsychopharmacol Biol Psychiatry 2012, 36:225-230.,28. Laforge KS, Yuferov V, Kreek MJ. Opioid receptor and pep- tide gene polymorphisms: potential implications for addictions. Eur J Pharmacol 2000, 410:249-268.,29. Ahmed M, Ul Haq I, Faisal M, Waseem D, Taqi MM. Implication of OPRM1 A118G polymorphism in opioids addicts in Pakistan: in vitro and in silico analysis. J Mol Neurosci 2018, 65:472-479.,30. Tan EC, Tan CH, Karupathivan U, Yap EP. Mu opioid recep- tor gene polymorphisms and heroin dependence in Asian popu- lations. Neuroreport 2003, 14:569-572.,31. Mestek A, Hurley JH, Bye LS, Campbell AD, Chen Y, Tian M, Liu J, Schulman H, Yu L. The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin- dependent protein kinase and protein kinase C. J Neurosci 1995, 15:2396-2406.,32. Beer B, Erb R, Pavlic M, Ulmer H, Giacomuzzi S, Riemer Y, Oberacher H. Association of polymorphisms in pharmacoge- netic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. PLoS One 2013, 8:e75359.,33. Bart G, Heilig M, LaForge KS, Pollak L, Leal SM, Ott J, Kreek MJ. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry 2004, 9:547- 549.,34. Taqi MM, Faisal M, Zaman H. OPRM1 A118G polymor- phisms and its role in opioid addiction: implication on severity and treatment approaches. Pharmgenomics Pers Med 2019, 12:361-368.,35. Chartoff EH, Mavrikaki M. Sex differences in kappa opioid receptor function and their potential impact on addiction. Front Neurosci 2015, 9:466.,36. Rasakham K, Liu-Chen L-Y. Sex differences in kappa opioid pharmacology. Life Sci 2011, 88:2-16.
dspace.entity.typePublication
local.indexed.atTRDizin

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The frequency of OPRK1 G36T and OPRM1 A118G opioid receptor gene polymorphisms in heroin-dependent individuals and nondependent healthy subjects in Turkey.pdf
Size:
91.38 KB
Format:
Adobe Portable Document Format
Download

Collections

TR-Dizin İndeksli Yayınlar Koleksiyonu