Publication: Major Depresif Bozukluk Hastalarında Optik Koherens Tomografi ile Retinal Sinir Lifi Tabakası Kalınlığı Ölçümü
| dc.contributor.author | Ferdi Kosger | |
| dc.contributor.author | Ipek Sonmez | |
| dc.contributor.author | Umit Aykan | |
| dc.contributor.institution | ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ | |
| dc.contributor.institution | YAKIN DOĞU ÜNİVERSİTESİ | |
| dc.contributor.institution | BAHÇEŞEHİR ÜNİVERSİTESİ | |
| dc.date.accessioned | 2025-09-20T20:01:38Z | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 29.07.2022 | |
| dc.description.abstract | Amaç: Son yıllarda, nörodejeneratif hastalıklarda retinal sinir lifi tabakasındaki (RSLT) değişiklikleri araştıran çalışmalar artmaktadır. Bu çalışmada, bizim amacımız majör depresif bozukluğu olan hastalarda retinal sinir lifi tabakasındaki yapısal değişiklikleri saptamaktır Yöntem: Structured Clinical Interview for DSM (SCID) görüşmesi sonucundamajör depresif bozukluk tanısı konan 30 hasta ve yaş, cinsiyetaçısından hastalarla eşleştirilen 30 sağlıklı birey kontrol grubu olarak çalışmayadahil edilmiştir. Optik Koherens Tomografi (OKT) kullanılarak,majör depresif bozukluk hastalarında ve kontrol grubunda, retinal sinirlif tabakası (RSLT) kalınlığı her lokasyonda ölçülüp karşılaştırılmıştır.Bulgular: Majör depresif bozukluk tanılı hastaların RSLT kalınlığında,istatiksel olarak anlamlı bir azalma görülmemiştir.Sonuç: Çalışmamız, majör depresif bozukluk hastalarında RSLT kalınlığınınazalmadığını ve majör depresif bozukluk tanısında ve hastalığıngidişini izlemede OKT kullanımının uygun araç olmadığını göstermiştir.Bu çalışma unipolar depresyon patofizyolojisinin, nörodejeneratif hastalıklar,yaygın gelişimsel bozukluklar, şizofreni ve bipolar bozukluktanfarklı olabileceğini göstermektedir. | |
| dc.identifier.endpage | 66 | |
| dc.identifier.issn | 1309-4866 | |
| dc.identifier.issue | 1 | |
| dc.identifier.startpage | 62 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14719/5529 | |
| dc.identifier.volume | 54 | |
| dc.language.iso | tr | |
| dc.relation.journal | Nöropsikiyatri Arşivi | |
| dc.subject | Nörolojik Bilimler | |
| dc.subject | Psikiyatri | |
| dc.title | Major Depresif Bozukluk Hastalarında Optik Koherens Tomografi ile Retinal Sinir Lifi Tabakası Kalınlığı Ölçümü | |
| dc.type | Research Article | |
| dcterms.references | 1. Osby U, Brandt L, Correia N, Correia N, Ekbom A, Sparen P. Excess mortality in bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry 2001, 58: 844-850.,2. Price JL, Drevets WC. Neurocircuitry of mood disorders. Neuropsychopharmacology 2010, 35:192-216.,3. Maes M. Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 1995, 19:11-38.,4. Axer H, Keyserling DG. Mapping of fiber orientation in human internal capsule by means of polarized light and confocal scanning laser microscopy. J Neurosci Methods 2000, 94:165-175.,5. Van Heeringen C, Bijttebier S, Godfrin K. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev 2011, 35:688-698.,6. Young KA, Bonkale WL, Holcomb LA, Hicks PB, German DC. Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. Br J Psychiatry 2008, 192:285-289.,7. Bedwell JS, Miller LS, Brown JM, Yanasak NE. Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker. Int J Neurosci 2006, 116:881-894.,8. Chiu K, Chan TF, Wu A, Leung IY, So KF, Chang RC. Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina? Age 2012, 34:633-649.,9. Guo L, Duggan J, Cordeiro MF. Alzheimer's disease and retinal neurodegeneration. Curr Alzheimer Res 2010, 7:3-14.,10. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA. Optical coherence tomography. Science 1991, 254:1178-1181.,11. Rao NP, Venkatasubramanian G, Gangadhar BN. Proton magnetic resonance spectroscopy in depression. Indian J Psychiatry 2011, 53:307-311.,12. Wang Y, Jia Y, Xu G, Ling X, Liu S, Huang L. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study. J Affect Disorders 2012, 136:620-626.,13. Sanacora G, Banasr M. From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders. Biol Psychiatry 2013: 73:1172-1179.,14. Schroeter ML, Abdul-Khaliq H, Diefenbacher A. Blasig IE. S100B is increased in mood disorders and may be reduced by antidepressive treatment. Neuroreport 2002, 13:1675-1678.,15. Vecino E, Rodriguez FD, Ruzafa N, Pereiro X, Sharma SC. Glial-neuron interactions in the mammalian retina. Prog Retin Eye Res 2016, 51:1-40.,16. Paquet C, Boissonnot M, Roger F, Dighierro P, Gil R, Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett 2007, 420: 97-99.,17. Iseri PK, Altintaş O, Tokay T, Yuksel N. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. J Neuroophthalmol 2006, 26:18-24.,18. Berisha F, Feke GT, Trempe CL, McMeel JW, Schepens CL. Retinal abnormalities in early Alzheimer's disease. Invest Ophthalmol Vis Sci 2007, 48:2285- 2289.,19. Altintaş O, Işeri P, Ozkan B, Cağlar Y. Correlation between retinal morphological and functional findings and clinical severity in Parkinson's disease. Doc Ophthalmol 2007, 116:137-146.,20. van Koolwijk LM, Despriet DD, Van Duijn CM, Oostra BA, van Swieten JC, de Koning I, Klaver CC, Lemij HG. Association of cognitive functioning with retinal nevre fiber layer thickness. Investigative Ophthalmology and Visual Science 2009, 50:4576-4580.,21. Price MJ, Feldman RG, Adelberg D, Kayne H. Abnormalities in color vision and contrast sensitivity in Parkinson's disease. Neurology 1992, 42:887-890.,22. Butler PD, Harkavy-Friedman JM, Amador XF, Gorman JM. Backward masking in schizophrenia: relationship to medication status, neuropsychological functioning and dopamine metabolism. Biol Psychiatry 1996, 40:295-298.,23. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) Clinical Version. Washington DC, American Psychiatric Press, 1997.,24. Ozkurkcugil A, Aydemir O, Yıldız M, Esen A, Koroglu E. The adaptation and reliability study of Turkish version of Structured Clinical Interview for DSM IV Clinical Version. Medical Treatment Journal 1999, 12: 233-236.,25. Schuman JS, Pedut-Kloizman T, Hertzmark E, Hee MR, Wilkins JR, Coker JG, Puliafito CA, Fujimoto JG, Swanson EA. Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Ophthalmology 1996, 103:1889-1898.,26. de Souza MB, De Lemos RR, Da Cunha JE, De Lima Filho JL, De Oliveira JR. Searching for new genetic risk factors for neuropsychiatric disorders in expression databases. J Mol Neurosci 2010, 41:193-197,27. Gómez-Esteban JC, Tijero B, Somme J, Bilbao I, Fernández J, Boyero S, Velasco F, Lezcano E, Zarranz JJ. Application of depression criteria (DSM-IV) in patients with Parkinson's disease. Clin Neurol Neurosurg 2010, 111:665-669.,28. Fritze F, Ehrt U, Hortobagyi T, Ballard C, Aarsland D. Depressive symptoms in Alzheimer's disease and Lewy body dementia: a one-year follow-up study. Dement Geriatr Cogn Disord 2011, 32:143-149.,29. Perlis RH, Smoller JW, Mysore J, Sun M, Gillis T, Purcell S, Rietschel M, Nöthen MM, Witt S, Maier W, Iosifescu DV, Sullivan P, Rush AJ, Fava M, Breiter H, Macdonald M, Gusella J. Prevalance of incompletely penetrant Hungtinton's disease alleles among individuals with major depressive disorder. Am J Psychiatry 2010, 167:574-579.,30. Burgut FT, Benaur M, Hencliffe C. Late life depression: a neuropsychiatric approach. Expert Rev Neurother 2006, 6:65-72.,31. Rosso IM, Cintron CM, Steingard RJ, Renshaw PF, Young AD, Yurgelun-Todd DA. Amygdala and hippocampus volumes in pediatric major depression. Biol Psychiatry 2005, 57:21-26.,32. Manaye KF, Lei DL, Tizabi Y, Davila-Garcia MI, Mouton PR, Kelly PH. Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder. J Neuropathol Exp Neurol 2005, 64:224-229.,33. Tizabi Y, Hauser SR, Tyler KY, Getachew B, Madani R, Sharma Y, Manaye KF. Effects of nicotine on depressive-like behavior and hippocampal volume of female WKY rats. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34:62- 69.,34. Aykan U, Akdemir O, Yıldırım O, Varlıbas F. Screening for patients with mild Alzheimer Disease using Frequency Doubling Technology Perimetry. Neuro-Ophthalmology 2013, 37: 239-246.,35. Lima FB, Gracitelli CPB, Junior AP, Bresan RA. Evaluation of magnocellular pathway abnormalities in schizophrenia: a frequency doubling technology study and clinical implications. Arq Bras Oftalmol 2013, 76:85-89.,36. McCleery JP, Allman E, Carver LJ, Dobkins KR. Abnormal Magnocellular Pathway Visual Processing in Infants at risk for Autism. Biol Psychiatry 2007, 62:1007-1014.,37. Keri S, Benedek G, Janka Z. Vernier threshold and the parallel visual pathways in bipolar disorder: A follow-up study. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31:86-91.,38. Madness T, James AC, Goldberg I, Wine S, Dobinson J. A spatial frequency-doubling illusion-based pattern electroretinogram for glaucoma. Invest Ophthalmol Vis Sci 2000, 41:3818-3826.,39. Adolphs R, Baron-Cohen S, Tranel D. Impaired recognition of social emotions following amygdala damage. J Cogn Neurosci 2002, 14:1264-1274.,40. Whalen PJ, Rauch SL, Etcoff NL, Mclnerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998, 148:411-418.,41. Dobkins KR, Anderson CM, Lia B. Infant temporal contrast sensitivity functions (tCSFs) mature earlier for luminance than for chromatic stimuli: Evidence for precocious magnocellular development? Vision Res 1999, 39:3223- 3239.,42. Hammarrenger B, Lepore F, Lippe S, Labrosse M, Guillemot JP, Roy MS. Magnocellular and parvocellular developmental course in infants during the first year of life. Doc Ophthalmol 2003, 107:225-233.,43. Gudmundsson P, Olesen PJ, Simoni M, Pantoni L, Östling S, Kern S, Guo X, Skoog I. White matter lesions and temporal lobe atrophy related to incidence of both dementia and major depression in 70-year-olds followed over 10 years. Eur J Neurol 2015, 22:781-788. | |
| dspace.entity.type | Publication | |
| local.indexed.at | TRDizin |
