Publication:
Subclinical Left Ventricular Dysfunction in Patients with Psoriasis Assessed Using Speckle Tracking Echocardiography

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dc.contributor.authorEzgi Aktaş
dc.contributor.authorAsli Aksu Çerman
dc.contributor.authorDamla Demir
dc.contributor.authorIlknur Kivanc Altunay
dc.contributor.authorMutlu Cagan Sumerkan
dc.contributor.institutionBAHÇEŞEHİR ÜNİVERSİTESİ
dc.contributor.institutionSAĞLIK BİLİMLERİ ÜNİVERSİTESİ
dc.contributor.institutionT.C. SAĞLIK BAKANLIĞI
dc.contributor.institutionSAĞLIK BİLİMLERİ ÜNİVERSİTESİ
dc.contributor.institutionSAĞLIK BİLİMLERİ ÜNİVERSİTESİ
dc.date.accessioned2025-09-20T19:59:55Z
dc.date.issued2019
dc.date.submitted22.09.2020
dc.description.abstractAmaç: Kronik, inflamatuar bir hastalık olan psöriyazis artmış kardiyovasküler (KV) hastalık (KVH) riski ile ilişkilidir. Şu anda, psöriyazis hastalarında subklinik KV disfonksiyonu inceleyen bir yöntem bulunmamaktadır. Bu çalışmanın amacı, tedavi almayan ve KVH gelişimi açısından hiçbir risk faktörü bulunmayan psöriyazisli hastalarda sol ventrikül fonksiyonunu incelemektir. Gereç ve Yöntemler: Bilinen KVH öyküsü veya KVH gelişimi için hiçbir risk faktörü bulunmayan 30 psöriyazis hastası ve yaş ve cinsiyet açısından uyumlu 20 sağlıklı kontrol çalışmaya dahil edildi. Tüm hastalara speckle traking derivasyonlar da dahil olmak üzere detaylı transtorasik ekokardiyografi yapıldı. Bulgular: Speckle traking ekokardiyografi ile global sirkümferensiyal gerilme, psöriyazis hastalarında kontrollere göre belirgin olarak daha düşük saptandı (ortalama ±SS: -23,34±%6,74 vs.-27,53±%4,11, sırasıyla, p<0,001). Global longitudinal gerilme, aort akım hızı, pulmoner arter akım hızı, sol ventrikül sistolsonu hacmi, sol ventrikül ejeksiyon fraksiyonu, erken diyastolik akım hızı (E) ve geç diyastolik (A) akım hızı tepe noktası sistol sonu volüm, E⁄A oranı ve C-reaktif protein de dahil olmak üzere biyokimyasal parametreler açısından psöriyazis hastaları ve kontrol grubu arasında anlamlı fark saptanmadı (p>0,05). Sonuç: Kardiyovasküler hastalık gelişimi açısından geleneksel risk faktörü bulunmayan psöriyazis hastalarında iki-boyutlu gerilme görüntüleme kullanılarak subklinik myokard disfonksiyonu saptandı. Bu görüntüleme tekniğinin psöriyazis hastalarında KVH gelişimini erken dönemde belirlemek açısından faydalı olabileceğini düşünmekteyiz.
dc.identifier.doi10.5336/dermato.2019-70951
dc.identifier.endpage57
dc.identifier.issn2146-9016
dc.identifier.issue2
dc.identifier.startpage51
dc.identifier.urihttps://hdl.handle.net/20.500.14719/5248
dc.identifier.volume29
dc.language.isoen
dc.relation.journalTürkiye Klinikleri Dermatoloji Dergisi
dc.subjectDermatoloji
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleSubclinical Left Ventricular Dysfunction in Patients with Psoriasis Assessed Using Speckle Tracking Echocardiography
dc.typeResearch Article
dcterms.references1. Boehncke WH, Schön MP. Psoriasis. Lancet. 2015,386(9997):983-94. [Crossref] [PubMed],2. McDonald CJ. Cardiovascular disease in psoriasis. J Invest Dermatol. 1989,92(4):646-7. [Crossref] [PubMed],3. Wakkee M, Thio HB, Prens EP, Sijbrands EJ, Neumann HA. Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients. Atherosclerosis. 2007,190(1):1-9. [Crossref] [PubMed],4. Singh VP, Le B, Khode R, Baker KM, Kumar R. Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes. 2008,57(12):3297-306. [Crossref] [PubMed] [PMC],5. Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006,296(14):1735-41. [Crossref] [PubMed],6. Ludwig RJ, Herzog C, Rostock A, Ochsendorf FR, Zollner TM, Thaci D, et al. Psoriasis: a possible risk factor for development of coronary artery calcification. Br J Dermatol. 2007,156(2):271-6. [Crossref] [PubMed],7. Zhao CT, Yeung CK, Siu CW, Tam S, Chan J, Chen Y, et al. Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis. J Eur Acad Dermatol Venereol. 2014,28(4):461-8. [Crossref] [PubMed],8. Ardic I, Kaya MG, Yarlioglues M, Karadag Z, Dogan A, Yildiz H, et al. Impaired aortic elastic properties in normotensive patients with psoriasis. Blood Press. 2010,19(6):351-8. [Crossref] [PubMed],9. Karadag AS, Yavuz B, Ertugrul DT, Akin KO, Yalcin AA, Deveci OS, et al. Is psoriasis a preatherosclerotic disease? Increased insulin resistance and impaired endothelial function in patients with psoriasis. Int J Dermatol. 2010,49(6):642-6. [Crossref] [PubMed],10. Shang Q, Tam LS, Yip GW, Sanderson JE, Zhang Q, Li EK, et al. High prevalence of subclinical left ventricular dysfunction in patients with psoriatic arthritis. J Rheumatol. 2011,38(7):1363-70. [Crossref] [PubMed],11. Bülbül Şen B, Ekiz Ö, Rifaioğlu EN, Büyükkaya E, Karakaş MF, Büyükkaya Ş, et al. Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: a Speckle Tracking Study. Int J Dermatol. 2016,55(2):158-64. [Crossref] [PubMed],12. Thomas G. Response to “non-Doppler two-dimensional strain imaging by echocardiography– from technical considerations to clinical applications.” J Am Soc Echocardiogr. 2007,20(8):1020. [Crossref] [PubMed],13. Blessberger H, Binder T. NON-invasive imaging: two dimensional speckle tracking echocardiography: basic principles. Heart. 2010,96(9):716-22. [Crossref] [PubMed],14. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, et al. Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: sclerosis: relationship to functional capacity and ventricular arrhythmias. Arthritis Rheum. 2011,63(12):3969-78. [Crossref] [PubMed],15. Sitia S, Tomasoni L, Cicala S, Atzeni F, Ricci C, Gaeta M, et al. Detection of preclinical impairment of myocardial function in rheumatoid arthritis patients with short disease duration by speckle tracking echocardiography. Int J Cardiol. 2012,160(1):8-14. [Crossref] [PubMed],16. Fredriksson T, Pettersson U. Severe psoriasis-- oral therapy with a new retinoid. Dermatologica. 1978,157(4):238-44. [Crossref] [PubMed],17. Delgado V, Ypenburg C, van Bommel RJ, Tops LF, Mollema SA, Marsan NA, et al. Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy. J Am Coll Cardiol. 2008,51(20):1944-52. [PubMed],18. Samarasekera EJ, Neilson JM, Warren RB, Parnham J, Smith CH. Incidence of cardiovascular disease in individuals with psoriasis: a systematic review and meta-analysis. J Invest Dermatol. 2013,133(10):2340-6. [Crossref] [PubMed],19. Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and the risk of diabetes mellitus: a systematic review and meta-analysis. JAMA Dermatol. 2013,149(1):84-91. [Crossref] [PubMed],20. Alexandroff AB, Pauriah M, Camp RD, Lang CC, Struthers AD, Armstrong DJ. More than skin deep: atherosclerosis as a systemic manifestation of psoriasis. Br J Dermatol. 2009,161(1):1-7. [Crossref] [PubMed],21. Ahlehoff O, Hansen PR, Gislason GH, Frydland M, Bryld LE, Elming H, et al. Myocardial function and effects of biologic therapy in patients with severe psoriasis: a prospective echocardiographic study. J Eur Acad Dermatol Venereol. 2016,30(5):819-23. [Crossref] [PubMed],22. Yilmazer B, Sahin T, Cefle A. Impaired myocardial deformation in psoriatic arthritis patients assessment by speckle trackingechocardiography. Acta Reumatol Port. 2016, 41(2):131-7. [PubMed],23. Kimball AB, Gladman D, Gelfand JM, Gordon K, Horn EJ, Korman NJ, et al, National Psoriasis Foundation. National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J Am Acad Dermatol. 2008,58(6): 1031-42. [Crossref] [PubMed] [PMC],24. El-Mongy S, Fathy H, Abdelaziz A, Omran E, George S, Neseem N, et al. Subclinical atherosclerosis in patients with chronic psoriasis: a potential association. J Eur Acad Dermatol Venereol. 2010,24(6):661-6. [Crossref] [PubMed],25. Channual J, Wu JJ, Dann FJ. Effects of tumor necrosis factor-alpha blockade on metabolic syndrome components in psoriasis and psoriatic arthritis and additional lessons learned from rheumatoid arthritis. Dermatol Ther. 2009,22(1):61-73. [Crossref] [PubMed] [PMC],26. Herron MD, Hinckley M, Hoffman MS, Papenfuss J, Hansen CB, Callis KP, et al. Impact of obesity and smoking on psoriasis presentation and management. Arch Dermatol. 2005,141(12):1527-34. [Crossref] [PubMed],27. Qureshi AA, Choi HK, Setty AR, Curhan GC. Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses. Arch Dermatol. 2009,145(4):379-82. [Crossref] [PubMed] [PMC],28. Prodanovich S, Kirsner RS, Kravetz JD, Ma F, Martinez L, Federman DG. Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. Arch Dermatol. 2009,145(6):700-3. [Crossref] [PubMed],29. Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J. 2010,31(8):1000-6. [Crossref] [PubMed] [PMC],30. Hahn BH, Grossman J, Chen W, McMahon M. The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. J Autoimmun. 2007,28(2-3):67-75. [Crossref] [PubMed],31. Herédi E, Végh J, Pogácsás L, Gáspár K, Varga J, Kincse G, et al. Subclinical cardiovascular disease and it’s improvement after long-term TNF-a inhibitor therapy in severe psoriatic patients. J Eur Acad Dermatol Venereol. 2016,30(9):1531-6. [Crossref] [PubMed]
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