Publication:
Autoallergy and what the Allergist Needs to know

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dc.contributor.authorSteinert, Carolin
dc.contributor.authorPashuk, Margarita
dc.contributor.authorKolkhir, P. V.
dc.contributor.authorKocaturk Goncu, Emek Ozgur
dc.contributor.authorXiang, Yi Kui
dc.contributor.institutionSteinert, Carolin, Institute of Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany, Department of Biology, Freie Universität Berlin, Berlin, Germany
dc.contributor.institutionPashuk, Margarita, Institute of Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany, Department of Biology, Freie Universität Berlin, Berlin, Germany
dc.contributor.institutionKolkhir, P. V., Institute of Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany
dc.contributor.institutionKocaturk Goncu, Emek Ozgur, Institute of Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany, Department of Dermatology, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionXiang, Yi Kui, Institute of Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany, Tongji University School of Medicine, Shanghai, China
dc.date.accessioned2025-10-05T14:24:11Z
dc.date.issued2025
dc.description.abstractPurpose of the Review: This review aims to educate allergists about the concept of autoallergy by addressing five questions: 1) What is autoallergy and how does it differ from classical allergy? 2) How common is autoallergy? 3) Is autoallergy clinically relevant? 4) How can autoallergy be diagnosed? and 5) How is autoallergy treated? Recent Findings: In contrast to type I hypersensitivity against external allergens (allergy), autoallergy involves IgE autoantibodies targeting self-antigens. These are found in conditions like chronic spontaneous urticaria, atopic dermatitis, and asthma, with varying prevalence. While no standardized diagnostic tools exist, ELISA and basophil activation tests help identify the presence and function of IgE autoantibodies. Anti-IgE therapies have shown benefit, supporting their clinical relevance. Summary: Autoallergy is emerging as a distinct IgE-mediated mechanism that may contribute to chronic inflammation in immune-mediated diseases. Further investigation of this mechanism can improve disease stratification and enable more effective, targeted treatment strategies. © 2025 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1007/s11882-025-01215-8
dc.identifier.issn15297322
dc.identifier.issn15346315
dc.identifier.issue1
dc.identifier.pubmed40782271
dc.identifier.scopus2-s2.0-105012976413
dc.identifier.urihttps://doi.org/10.1007/s11882-025-01215-8
dc.identifier.urihttps://hdl.handle.net/20.500.14719/6080
dc.identifier.volume25
dc.language.isoen
dc.publisherSpringer
dc.relation.sourceCurrent Allergy and Asthma Reports
dc.subject.authorkeywordsAsthma
dc.subject.authorkeywordsAtopic Dermatitis
dc.subject.authorkeywordsAutoallergy
dc.subject.authorkeywordsAutoantibodies
dc.subject.authorkeywordsChronic Spontaneous Urticaria
dc.subject.authorkeywordsIge
dc.subject.authorkeywordsAtuzabrutinib
dc.subject.authorkeywordsBarzolvolimab
dc.subject.authorkeywordsBranebrutinib
dc.subject.authorkeywordsDupilumab
dc.subject.authorkeywordsFenebrutinib
dc.subject.authorkeywordsImmunoglobulin E
dc.subject.authorkeywordsOmalizumab
dc.subject.authorkeywordsRemibrutinib
dc.subject.authorkeywordsRilzabrutinib
dc.subject.authorkeywordsAllergens
dc.subject.authorkeywordsAutoantibodies
dc.subject.authorkeywordsAutoantigens
dc.subject.authorkeywordsImmunoglobulin E
dc.subject.authorkeywordsAllergen
dc.subject.authorkeywordsAtuzabrutinib
dc.subject.authorkeywordsBarzolvolimab
dc.subject.authorkeywordsBranebrutinib
dc.subject.authorkeywordsBruton Tyrosine Kinase Inhibitor
dc.subject.authorkeywordsDupilumab
dc.subject.authorkeywordsFenebrutinib
dc.subject.authorkeywordsImmunoglobulin E
dc.subject.authorkeywordsImmunoglobulin E Antibody
dc.subject.authorkeywordsOmalizumab
dc.subject.authorkeywordsRemibrutinib
dc.subject.authorkeywordsRilzabrutinib
dc.subject.authorkeywordsAutoantibody
dc.subject.authorkeywordsAutoantigen
dc.subject.authorkeywordsAllergic Asthma
dc.subject.authorkeywordsAllergic Bronchopulmonary Aspergillosis
dc.subject.authorkeywordsAllergy Test
dc.subject.authorkeywordsAntibody Titer
dc.subject.authorkeywordsAsthma
dc.subject.authorkeywordsAtopic Dermatitis
dc.subject.authorkeywordsAutoimmunity
dc.subject.authorkeywordsBasophil Activation Test
dc.subject.authorkeywordsBasophil Histamine Release Assay
dc.subject.authorkeywordsBullous Pemphigoid
dc.subject.authorkeywordsChronic Spontaneous Urticaria
dc.subject.authorkeywordsCross Reaction
dc.subject.authorkeywordsDirect Elisa
dc.subject.authorkeywordsDisease Activity
dc.subject.authorkeywordsDisease Severity
dc.subject.authorkeywordsDrug Efficacy
dc.subject.authorkeywordsDrug Protein Binding
dc.subject.authorkeywordsDrug Response
dc.subject.authorkeywordsDrug Safety
dc.subject.authorkeywordsEnzyme Linked Immunosorbent Assay
dc.subject.authorkeywordsFood Allergy
dc.subject.authorkeywordsHuman
dc.subject.authorkeywordsImmediate Type Hypersensitivity
dc.subject.authorkeywordsImmunoblotting
dc.subject.authorkeywordsImmunologist
dc.subject.authorkeywordsIndirect Elisa
dc.subject.authorkeywordsMedical Education
dc.subject.authorkeywordsMicroarray Analysis
dc.subject.authorkeywordsMilk Allergy
dc.subject.authorkeywordsNonhuman
dc.subject.authorkeywordsPathogenesis
dc.subject.authorkeywordsPollen Allergy
dc.subject.authorkeywordsPrick Test
dc.subject.authorkeywordsRadioimmunoassay
dc.subject.authorkeywordsReview
dc.subject.authorkeywordsSandwich Elisa
dc.subject.authorkeywordsSkin Test
dc.subject.authorkeywordsWestern Blotting
dc.subject.authorkeywordsDiagnosis
dc.subject.authorkeywordsHypersensitivity
dc.subject.authorkeywordsImmunology
dc.subject.authorkeywordsTherapy
dc.subject.authorkeywordsAllergens
dc.subject.authorkeywordsAllergists
dc.subject.authorkeywordsAutoantibodies
dc.subject.authorkeywordsAutoantigens
dc.subject.authorkeywordsHumans
dc.subject.authorkeywordsHypersensitivity
dc.subject.authorkeywordsImmunoglobulin E
dc.subject.indexkeywordsallergen
dc.subject.indexkeywordsatuzabrutinib
dc.subject.indexkeywordsbarzolvolimab
dc.subject.indexkeywordsbranebrutinib
dc.subject.indexkeywordsBruton tyrosine kinase inhibitor
dc.subject.indexkeywordsdupilumab
dc.subject.indexkeywordsfenebrutinib
dc.subject.indexkeywordsimmunoglobulin E
dc.subject.indexkeywordsimmunoglobulin E antibody
dc.subject.indexkeywordsomalizumab
dc.subject.indexkeywordsremibrutinib
dc.subject.indexkeywordsrilzabrutinib
dc.subject.indexkeywordsautoantibody
dc.subject.indexkeywordsautoantigen
dc.subject.indexkeywordsallergic asthma
dc.subject.indexkeywordsallergic bronchopulmonary aspergillosis
dc.subject.indexkeywordsallergy test
dc.subject.indexkeywordsantibody titer
dc.subject.indexkeywordsasthma
dc.subject.indexkeywordsatopic dermatitis
dc.subject.indexkeywordsautoimmunity
dc.subject.indexkeywordsbasophil activation test
dc.subject.indexkeywordsbasophil histamine release assay
dc.subject.indexkeywordsbullous pemphigoid
dc.subject.indexkeywordschronic spontaneous urticaria
dc.subject.indexkeywordscross reaction
dc.subject.indexkeywordsdirect ELISA
dc.subject.indexkeywordsdisease activity
dc.subject.indexkeywordsdisease severity
dc.subject.indexkeywordsdrug efficacy
dc.subject.indexkeywordsdrug protein binding
dc.subject.indexkeywordsdrug response
dc.subject.indexkeywordsdrug safety
dc.subject.indexkeywordsenzyme linked immunosorbent assay
dc.subject.indexkeywordsfood allergy
dc.subject.indexkeywordshuman
dc.subject.indexkeywordsimmediate type hypersensitivity
dc.subject.indexkeywordsimmunoblotting
dc.subject.indexkeywordsimmunologist
dc.subject.indexkeywordsindirect ELISA
dc.subject.indexkeywordsmedical education
dc.subject.indexkeywordsmicroarray analysis
dc.subject.indexkeywordsmilk allergy
dc.subject.indexkeywordsnonhuman
dc.subject.indexkeywordspathogenesis
dc.subject.indexkeywordspollen allergy
dc.subject.indexkeywordsprick test
dc.subject.indexkeywordsradioimmunoassay
dc.subject.indexkeywordsReview
dc.subject.indexkeywordssandwich ELISA
dc.subject.indexkeywordsskin test
dc.subject.indexkeywordsWestern blotting
dc.subject.indexkeywordsdiagnosis
dc.subject.indexkeywordshypersensitivity
dc.subject.indexkeywordsimmunology
dc.subject.indexkeywordstherapy
dc.subject.indexkeywordsAllergens
dc.subject.indexkeywordsAllergists
dc.subject.indexkeywordsAutoantibodies
dc.subject.indexkeywordsAutoantigens
dc.subject.indexkeywordsHumans
dc.subject.indexkeywordsHypersensitivity
dc.subject.indexkeywordsImmunoglobulin E
dc.titleAutoallergy and what the Allergist Needs to know
dc.typeReview
dcterms.referencesSvenningsen, Sarah, Asthma endotypes and an overview of targeted therapy for asthma, Frontiers in Medicine, 4, SEP, (2017), Otsuka, Atsushi, The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis, Immunological Reviews, 278, 1, pp. 246-262, (2017), Fyhrquist, Nanna, Endotypes of atopic dermatitis, Journal of Allergy and Clinical Immunology, 156, 1, pp. 24-40.e4, (2025), Zuberbier, Thorsten, The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria, Allergy: European Journal of Allergy and Clinical Immunology, 77, 3, pp. 734-766, (2022), Kolkhir, P. V., Autoimmune chronic spontaneous urticaria, Journal of Allergy and Clinical Immunology, 149, 6, pp. 1819-1831, (2022), Baker, Mary Grace, Food allergy endotypes revisited, Journal of Allergy and Clinical Immunology, 156, 1, pp. 1-16, (2025), Pawankar, Ruby U., The unmet global health need of severe and complex allergies: Meeting the challenge, World Allergy Organization Journal, 5, 2, pp. 20-21, (2012), Charles, Nicolas, Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases, Allergy: European Journal of Allergy and Clinical Immunology, 78, 12, pp. 3118-3135, (2023), Johansson, Siv Gunnar O., The discovery of IgE, Journal of Allergy and Clinical Immunology, 137, 6, pp. 1671-1673, (2016), Galli, Stephen Joseph, IgE and mast cells in allergic disease, Nature Medicine, 18, 5, pp. 693-704, (2012)
dspace.entity.typePublication
local.indexed.atScopus
person.identifier.scopus-author-id57221965707
person.identifier.scopus-author-id60036309300
person.identifier.scopus-author-id56076677500
person.identifier.scopus-author-id18437291300
person.identifier.scopus-author-id57221958792

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