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Exosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?

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dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorMikati, Houda
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorYulug, Burak
dc.contributor.institutionOzansoy, Mehmet, Department of Physiology, Bahçeşehir Üniversitesi, Istanbul, Turkey, Neuroscience Program, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionMikati, Houda, Department of Physiology, Bahçeşehir Üniversitesi, Istanbul, Turkey, Neuroscience Program, Bahçeşehir Üniversitesi, Istanbul, Turkey
dc.contributor.institutionVelioglu, Halil Aziz, Karolinska Institutet, Stockholm, Sweden
dc.contributor.institutionYulug, Burak, Department of Neurology, Alanya Alaaddin Keykubat University, Alanya, Turkey
dc.date.accessioned2025-10-05T15:05:00Z
dc.date.issued2023
dc.description.abstractExosomes are potent mediators of physiological and pathological processes. In Alzheimer's disease and inflammatory disorders, due to exosomes' distinctive ability to cross the blood-brain barrier, a bidirectional communication between the periphery and the central nervous system exists. Since exosomes can carry various biochemical molecules, this review investigates the role of exosomes as possible mediators between chronic systemic inflammatory diseases and Alzheimer's disease. Exosomes carry pro-inflammatory molecules generated in the periphery, travel to the central nervous system, and target glial and neuronal cells. Microglia and astrocytes then become activated, initiating chronic neuroinflammation. As the aging brain is more susceptible to such changes, this state of neuroinflammation can stimulate neuropathologies, impair amyloid-beta clearance capabilities, and generate dysregulated microRNAs that alter the expression of genes critical in Alzheimer's disease pathology. These processes, individually and collectively, become significant risk factors for the development of Alzheimer's disease. © 2023 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1016/j.biopha.2022.114161
dc.identifier.issn07533322
dc.identifier.issn19506007
dc.identifier.pubmed36641928
dc.identifier.scopus2-s2.0-85146188932
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2022.114161
dc.identifier.urihttps://hdl.handle.net/20.500.14719/8094
dc.identifier.volume159
dc.language.isoen
dc.publisherElsevier Masson s.r.l.
dc.relation.oastatusAll Open Access
dc.relation.oastatusGold Open Access
dc.relation.sourceBiomedicine and Pharmacotherapy
dc.subject.authorkeywordsAlzheimer's Disease
dc.subject.authorkeywordsExosomes
dc.subject.authorkeywordsExtracellular Vesicles
dc.subject.authorkeywordsNeurodegenerative Diseases
dc.subject.authorkeywordsSystemic Chronic Inflammatory Diseases
dc.subject.authorkeywordsRna
dc.subject.authorkeywordsMicrornas
dc.subject.authorkeywordsCytokine
dc.subject.authorkeywordsRna
dc.subject.authorkeywordsMicrorna
dc.subject.authorkeywordsAlzheimer Disease
dc.subject.authorkeywordsAstrocyte
dc.subject.authorkeywordsAstrocytosis
dc.subject.authorkeywordsBlood Brain Barrier
dc.subject.authorkeywordsCell Activation
dc.subject.authorkeywordsChronic Inflammation
dc.subject.authorkeywordsDegenerative Disease
dc.subject.authorkeywordsExosome
dc.subject.authorkeywordsGenetic Modification
dc.subject.authorkeywordsGliosis
dc.subject.authorkeywordsHuman
dc.subject.authorkeywordsMicroglia
dc.subject.authorkeywordsNervous System Inflammation
dc.subject.authorkeywordsNeuropathology
dc.subject.authorkeywordsNonhuman
dc.subject.authorkeywordsReview
dc.subject.authorkeywordsWhite Matter
dc.subject.authorkeywordsGenetics
dc.subject.authorkeywordsInflammation
dc.subject.authorkeywordsMetabolism
dc.subject.authorkeywordsAlzheimer Disease
dc.subject.authorkeywordsExosomes
dc.subject.authorkeywordsHumans
dc.subject.authorkeywordsInflammation
dc.subject.authorkeywordsMicrornas
dc.subject.authorkeywordsNeuroinflammatory Diseases
dc.subject.indexkeywordscytokine
dc.subject.indexkeywordsRNA
dc.subject.indexkeywordsmicroRNA
dc.subject.indexkeywordsAlzheimer disease
dc.subject.indexkeywordsastrocyte
dc.subject.indexkeywordsastrocytosis
dc.subject.indexkeywordsblood brain barrier
dc.subject.indexkeywordscell activation
dc.subject.indexkeywordschronic inflammation
dc.subject.indexkeywordsdegenerative disease
dc.subject.indexkeywordsexosome
dc.subject.indexkeywordsgenetic modification
dc.subject.indexkeywordsgliosis
dc.subject.indexkeywordshuman
dc.subject.indexkeywordsmicroglia
dc.subject.indexkeywordsnervous system inflammation
dc.subject.indexkeywordsneuropathology
dc.subject.indexkeywordsnonhuman
dc.subject.indexkeywordsReview
dc.subject.indexkeywordswhite matter
dc.subject.indexkeywordsgenetics
dc.subject.indexkeywordsinflammation
dc.subject.indexkeywordsmetabolism
dc.subject.indexkeywordsAlzheimer Disease
dc.subject.indexkeywordsExosomes
dc.subject.indexkeywordsHumans
dc.subject.indexkeywordsInflammation
dc.subject.indexkeywordsMicroRNAs
dc.subject.indexkeywordsNeuroinflammatory Diseases
dc.titleExosomes: A missing link between chronic systemic inflammation and Alzheimer's disease?
dc.typeReview
dcterms.referencesKang, Taeyoung, Biogenesis of Extracellular Vesicles, Sub-cellular Biochemistry, 97, pp. 19-43, (2021), Anand, Sushma, Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles, Biochimica et Biophysica Acta - Proteins and Proteomics, 1867, 12, (2019), Johnstone, Rose M., Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)., Journal of Biological Chemistry, 262, 19, pp. 9412-9420, (1987), Pan, Bintao, Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes, Journal of Cell Biology, 101, 3, pp. 942-948, (1985), Zhang, Tongmei, The emerging role of exosomes in Alzheimer's disease, Ageing Research Reviews, 68, (2021), Rastogi, Simran, The evolving landscape of exosomes in neurodegenerative diseases: Exosomes characteristics and a promising role in early diagnosis, International Journal of Molecular Sciences, 22, 1, pp. 1-31, (2021), Song, Zhiqi, Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer’s Disease, Frontiers in Molecular Neuroscience, 13, (2020), Xie, Shenmin, Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications, Membranes, 12, 5, (2022), Caruso Bavisotto, Celeste, Extracellular vesicle-mediated cell–cell communication in the nervous system: Focus on neurological diseases, International Journal of Molecular Sciences, 20, 2, (2019), Gurunathan, Sangiliyandi, Biogenesis, membrane trafficking, functions, and next generation nanotherapeutics medicine of extracellular vesicles, International Journal of Nanomedicine, 16, pp. 3357-3383, (2021)
dspace.entity.typePublication
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person.identifier.scopus-author-id15849087500
person.identifier.scopus-author-id58062425000
person.identifier.scopus-author-id57216638864
person.identifier.scopus-author-id6507583384

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