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The Effects of Corticosteroid Injection in the Healthy and Damaged Achilles Tendon Model: Histopathological and Biomechanical Experimental Study in Rats

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dc.contributor.authorIstemi YÜCEL
dc.contributor.authorTurhan Beyza ÖZTÜRK
dc.contributor.authorNazım KARAHAN
dc.contributor.authorMehmet Müfit Orak
dc.contributor.authorAhmet Midi
dc.contributor.authorilyas arslan
dc.contributor.institutionT.C. SAĞLIK BAKANLIĞI
dc.contributor.institutionTanımlanmamış Kurum
dc.contributor.institutionT.C. SAĞLIK BAKANLIĞI
dc.contributor.institutionBAHÇEŞEHİR ÜNİVERSİTESİ
dc.contributor.institutionBAHÇEŞEHİR ÜNİVERSİTESİ
dc.contributor.institutionT.C. SAĞLIK BAKANLIĞI
dc.date.accessioned2025-09-20T19:59:21Z
dc.date.issued2020
dc.date.submitted10.11.2020
dc.description.abstractObjective: To show the effects of corticosteroids on inflammatory reactions in the injured Achilles tendon in rats.Material and Method: Thirty-two adult Wistar Albino rats were used in the study. The rats were divided into 4 groups. In the first group (IntactSaline), saline solution was injected to the intact Achilles tendon. In the second group (Intact Corticosteroid), corticosteroid was injected tothe intact tendon. In the third group (Injured Saline), saline solution was injected to the injured Achilles tendon. In the fourth group (InjuredCorticosteroid), corticosteroid was injected to the injured tendon. All groups were sacrificed on day 30 and Achilles tendons were taken andprepared for histological and biomechanical evaluation.Results: According to the biomechanical test, mean load-to-failure of the Intact Saline group was significantly lower than the Intact Corticosteroid(p=0.016), Injured Saline (p=0.001) and Injured Corticosteroid) (p=0.012) groups. According to the histopathological evaluation, tenocytemean of the Intact Saline group was statistically lower than the Injured Saline and Injured Corticosteroid groups. Tenocyte mean of the IntactCorticosteroid group was statistically significantly lower than the Injured Saline and Injured Corticosteroid groups. The ground substancemean of the Intact Saline group was significantly lower than the Injured Saline and Injured Corticosteroid groups. The ground substance meanof the Intact Corticosteroid group was significantly lower than the Injured Saline and Injured Corticosteroid groups. There was no statisticallysignificant difference between the groups in terms of calcification.Conclusion: It has been found that there is biomechanical and histopathological significant benefit of intra-tendon corticosteroid administrationin the experimentally generated Achilles tendon injury model.
dc.identifier.doi10.5146/tjpath.2019.01468
dc.identifier.endpage47
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue1
dc.identifier.startpage39
dc.identifier.urihttps://hdl.handle.net/20.500.14719/5156
dc.identifier.volume36
dc.language.isoen
dc.relation.journalTürk Patoloji Dergisi
dc.subjectPatoloji
dc.titleThe Effects of Corticosteroid Injection in the Healthy and Damaged Achilles Tendon Model: Histopathological and Biomechanical Experimental Study in Rats
dc.typeResearch Article
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