Publication:
Stres ile Uyarılmış Mesane Hasarına Karşı Montelukastın Koruyucu Etkileri

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dc.contributor.authorÇetinel, Şule
dc.contributor.authorErcan, Feriha
dc.contributor.authorÇikler Dülger, Esra
dc.contributor.authorErsoy Canillioğlu, Yasemin
dc.contributor.authorŞener, Göksel
dc.contributor.institutionMarmara Üniversitesi
dc.contributor.institutionMarmara Üniversitesi
dc.contributor.institutionİstanbul Demiroğlu Bilim Üniversitesi
dc.contributor.institutionBahçeşehir Üniversitesi
dc.contributor.institutionMarmara Üniversitesi
dc.date.accessioned2025-09-20T20:00:45Z
dc.date.issued2018
dc.date.submitted11.11.2020
dc.description.abstractAmaç: Bu çalışmanın amacı sisteinil lökotrien 1 reseptör antagonisti olan montelukastın (ML) sudan kaçınma stresi (SKS) ile uyarılmış sıçan mesane mukoza hasarı üzerine rolünü incelemek idi. Yöntemler: SKS grubundaki sıçanlara beş gün boyunca günde iki saat SKS uygulandı. SKS+ML grubundaki sıçanlara, beş gün boyunca SKS uygulamasından sonra ML ( 10 mg/kg, i.p.,) uygulandı. Kontrol grubundaki sıçanlara sadece çözücü solüsyon enjekte edildi. Mesanenin genel morfolojik özellikleri ışık mikrsokobu ile değerlendirildi. Mast hücre aktivasyonu ve üroplakin dağılımı immunohistokimya ile değerlendirildi. Glikozaminoglikan (GAG) dağılımı ve ürotelyum geçirgenliği rutenyum kırmızısı (RK) boyama tekniği uygulanarak geçirimli elektron mikroskopi ile, luminal ürotelyal hücreler taramalı electron mikrsokopi ile değerlendirildi. Doku malondialdehit (MDA) ve glutatyon (GSH) düzeyleri de analiz edildi. Bulgular: SKS grubunda, ürotelyum tabakasında düzensiz GAG tabakası ve üroplakin dağılımı, hücrelerarası boşluklara RK geçişi ve genişlemiş sıkı bağlantıların varlığı, enflamatuvar hücre infiltrasyonunda ve hem granüllü hem de degranüle olmuş mast hücre sayısında artış gözlendi. Kontrol grubu ile kıyaslandığında SKS grubunda mesanede anlamlı olarak MDA seviyesinde artış, GSH seviyesinde düşüş gözlendi. SKS+ML grubunda bir çok alanda oldukça düzenli GAG tabakası, üroplakin dağılımı ve sıkı bağlantıların varlığı, enflamatuvar hücre infiltrasyonunda ve hem granüllü hem de degranüle olmuş mast hücre sayısında düşüş gözlendi. İlaveten, bu grupta anlamlı bir şekilde MDA seviyesinde düşüş, GSH seviyesinde artış gözlendi. Sonuç: Montelukastın SKS ile uyarılmış mesane hasarı üzerine enflamtuvar ve oksidatif aktiviteyi engelleyerek koruyucu etki göstermeye çalıştığı görülmektedir.
dc.identifier.doi10.5152/clinexphealthsci.2017.691
dc.identifier.endpage216
dc.identifier.issn2459-1459
dc.identifier.issue3
dc.identifier.startpage211
dc.identifier.urihttps://hdl.handle.net/20.500.14719/5375
dc.identifier.volume8
dc.language.isoen
dc.relation.journalClinical and Experimental Health Sciences
dc.subjectGenel ve Dahili Tıp
dc.subjectÜroloji ve Nefroloji
dc.titleStres ile Uyarılmış Mesane Hasarına Karşı Montelukastın Koruyucu Etkileri
dc.typeResearch Article
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