Publication:
Ozon Oksidatif Ön Koşullandırmanın Subaraknoid Üzerine Etkileri Sıçan Serebral Vazospazm Modeli Yoluyla Kanama

Simple item page
dc.contributor.authorSüslü, Hüsnü
dc.contributor.authorSüslü, Hikmet Turan
dc.contributor.authorCeylan, Davut
dc.contributor.authorUyar Bozkurt, Süheyla
dc.contributor.authorGüçlü, Bülent
dc.contributor.authorTatarlı, Necati
dc.contributor.authorAvşar, Timuçin
dc.contributor.institutionMALTEPE ÜNİVERSİTESİ
dc.contributor.institutionT.C. SAĞLIK BAKANLIĞI
dc.contributor.institutionSAKARYA ÜNİVERSİTESİ
dc.contributor.institutionMARMARA ÜNİVERSİTESİ
dc.contributor.institutionTanımlanmamış Kurum
dc.contributor.institutionT.C. SAĞLIK BAKANLIĞI
dc.contributor.institutionBAHÇEŞEHİR ÜNİVERSİTESİ
dc.date.accessioned2025-09-20T19:57:26Z
dc.date.issued2021
dc.date.submitted17.05.2022
dc.description.abstractAmaç: Subaraknoid kanama (SAK) sonrası serebral vazospazm, önemli morbidite ve mortalite nedenidir. Enflamasyon ana moleküler vazospastik SAK'da gözlenen mekanizma. Ozon (O3 ) olarak kullanılmıştır. yıllardır çeşitli durum ve hastalıkların tedavisinde terapötik ajan. Bu çalışmanın amacı ozonun antiinflamatuar etkisini değerlendirmektir. değerlendirmek için bir sıçan SAH modelinde oksidatif ön koşullandırma (OOP) O3'ün terapötik potansiyeliSAH tedavisinde. Gereç ve Yöntem: sunulan çalışma, daralma sağlayan deneysel bir in vivo SAH sıçan modeli büyük serebral arterler kullanıldı. Serebral inflamatuar yanıt SAK sonrası vazospazm ve OOP'nin etkileri karşılaştırılarak değerlendirildi. inflamatuar moleküllerin mRNA seviyeleri (tümör nekroz faktörü‑α, interlökin‑1β, ve hücreler arası yapışma molekülü‑1) sıçanların serum örneklerinde. Sonuçlar: vazospazmda inflamatuar moleküllerin seviyesi 12 saat, 24 saat ve 48 saatte arttı tedavi sonrası gruplarda. Ancak intraperitoneal OOP, inflamatuar moleküller çarpıcı biçimde. Sonuç: Çalışmamız göstermiştir ki O3 tedavi, bir sıçan SAH'ında oluşturulan iltihaplanmanın yönetiminde potansiyele sahiptir. modeli. Bu bulgular, O3'ün olası kullanımlarını araştıran daha ileri çalışmaları bilgilendirebilir. vazospazm tedavisinde. Anahtar Kelimeler: Serebral anevrizma, inflamasyon, ozon oksidatif ön koşullandırma, subaraknoid kanama, vazospazm modeli
dc.identifier.doi10.4103/NSN.NSN_74_20
dc.identifier.endpage66
dc.identifier.issn2636-865X
dc.identifier.issue1
dc.identifier.startpage60
dc.identifier.urihttps://hdl.handle.net/20.500.14719/4847
dc.identifier.volume38
dc.language.isoen
dc.relation.journalNeurological sciences and neurophysiology (Online)
dc.subjectNörolojik Bilimler
dc.subjectAcil Tıp
dc.titleOzon Oksidatif Ön Koşullandırmanın Subaraknoid Üzerine Etkileri Sıçan Serebral Vazospazm Modeli Yoluyla Kanama
dc.typeResearch Article
dcterms.references1. Athar MK, Levine JM. Treatment options for cerebral vasospasm in aneurysmal subarachnoid hemorrhage. Neurotherapeutics 2012,9:37‑43.,2. Kassell NF, Sasaki T, Colohan AR, Nazar G. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 1985,16:562‑72.,3. Crowley RW, Medel R, Dumont AS, Ilodigwe D, Kassell NF, Mayer SA, et al. Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage. Stroke 2011,42:919‑23.,4. Kassell NF, Torner JC, Haley EC Jr., Jane JA, Adams HP, Kongable GL. The international cooperative study on the timing of aneurysm surgery. Part 1: Overall management results. J Neurosurg 1990,73:18‑36.,5. Lee JY, Huang DL, Keep R, Sagher O. Characterization of an improved double hemorrhage rat model for the study of delayed cerebral vasospasm. J Neurosci Methods 2008,168:358‑66.,6. Miller BA, Turan N, Chau M, Pradilla G. Inflammation, vasospasm, and brain injury after subarachnoid hemorrhage. Biomed Res Int 2014,2014:1‑16.,7. Schneider UC, Davids AM, Brandenburg S, Müller A, Elke A, Magrini S, et al. Microglia inflict delayed brain injury after subarachnoid hemorrhage. Acta Neuropathol 2015,130:215‑31.,8. Iigo Y, Suematsu M, Higashida T, Oheda J, Matsumoto K, Wakabayashi Y, et al. Constitutive expression of ICAM‑1 in rat microvascular systems analyzed by laser confocal microscopy. Am J Physiol 1997,273:H138‑47.,9. Klein CL, Bittinger F, Köhler H, Wagner M, Otto M, Hermanns I, et al. Comparative studies on vascular endothelium in vitro. 3. Effects of cytokines on the expression of E‑selectin, ICAM‑1 and VCAM‑1 by cultured human endothelial cells obtained from different passages. Pathobiology 1995,63:83‑92.,10. Bevilacqua M, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, et al. Selectins: A family of adhesion receptors. Cell 1991,67:233.,11. Ley K. The selectins and their ligands. In: Pearson JD, editor. Vascular Adhesion Molecules and Inflammation. Switzerland: Birkhauser Verlag, Basel, 1999. p. 11‑37.,12. Aihara Y, Kasuya H, Onda H, Hori T, Takeda J. Quantitative analysis of gene expressions related to inflammation in canine spastic artery after subarachnoid hemorrhage. Stroke 2001,32:212‑7.,13. Hirashima Y, Nakamura S, Endo S, Kuwayama N, Naruse Y, Takaku A. Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. Neurochem Res 1997,22:1249‑55.,14. Takizawa T, Tada T, Kitazawa K, Tanaka Y, Hongo K, Kameko M, et al. Inflammatory cytokine cascade released by leukocytes in cerebrospinal fluid after subarachnoid hemorrhage. Neurol Res 2001,23:724‑30.,15. Hernández F, Menéndez S, Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radic Biol Med 1995,19:115‑9.,16. Martínez‑Sánchez G, Al‑Dalain SM, Menéndez S, Re L, Giuliani A, Candelario‑Jalil E, et al. Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol 2005,523:151‑61.,17. Bocci V. Ozone as Janus: This controversial gas can be either toxic or medically useful. Mediators Inflamm 2004,13:3‑11.,18. Winkler G, Kiss S, Keszthelyi L, Sápi Z, Ory I, Salamon F, et al. Expression of tumor necrosis factor (TNF)‑alpha protein in the subcutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF‑alpha, soluble serum TNF‑receptor‑2 concentrations and C‑peptide level. Eur J Endocrinol 2003,149:129‑35.,19. Kelly KJ, Williams WW Jr., Colvin RB, Meehan SM, Springer TA, Gutierrez‑Ramos JC, et al. Intercellular adhesion molecule‑1‑deficient mice are protected against ischemic renal injury. J Clin Invest 1996,97:1056‑63.,20. Lin CL, Calisaneller T, Ukita N, Dumont AS, Kassell NF, Lee KS. A murine model of subarachnoid hemorrhage‑induced cerebral vasospasm. J Neurosci Methods 2003,123:89‑97.,21. Nakagomi T, Kassell NF, Hongo K, Sasaki T. Pharmacological reversibility of experimental cerebral vasospasm. Neurosurgery 1990,27:582‑6.,22. Gumus E, Adilay U, Gunaldi O, Bayindir C, Kazanci B, Guclu B. The effect of copper on vasospastic femoral artery in rats. Turk Neurosurg 2014,24:25‑9.,23. Dumont AS, Dumont RJ, Chow MM, Lin CL, Calisaneller T, Ley KF, et al. Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflammation. Neurosurgery 2003,53:123‑33.,24. Peterson JW, Kwun BD, Hackett JD, Zervas NT. The role of inflammation in experimental cerebral vasospasm. J Neurosurg 1990,72:767‑74.,25. Chyatte D, Bruno G, Desai S, Todor DR. Inflammation and intracranial aneurysms. Neurosurgery 1999,45:1137‑46.,26. Polin RS, Bavbek M, Shaffrey ME, Billups K, Bogaev CA, Kassell NF, et al. Detection of soluble E‑selectin, ICAM‑1, VCAM‑1, and L‑selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage. J Neurosurg 1998,89:559‑67.,27. Fassbender K, Hodapp B, Rossol S, Bertsch T, Schmeck J, Schütt S, et al. Inflammatory cytokines in subarachnoid haemorrhage: Association with abnormal blood flow velocities in basal cerebral arteries. J Neurol Neurosurg Psychiatry 2001,70:534‑7.,28. Kramer A, Fletcher J. Do endothelin‑receptor antagonists prevent delayed neurological deficits and poor outcomes after aneurysmal subarachnoid hemorrhage?: A meta‑analysis. Stroke 2009,40:3403‑6.,29. Yanamoto H, Kikuchi H, Okamoto S, Nozaki K. Preventive effect of synthetic serine protease inhibitor, FUT‑175, on cerebral vasospasm in rabbits. Neurosurgery 1992,30:351‑6.,30. Macdonald RL. Clazosentan: An endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage. Expert Opin Investig Drugs 2008,17:1761‑7.,31. Bakkal BH, Gultekin FA, Guven B, Turkcu UO, Bektas S, Can M. Effect of ozone oxidative preconditioning in preventing early radiation‑induced lung injury in rats. Braz J Med Biol Res 2013,46:789‑96.,32. Peralta C, Xaus C, Bartrons R, Leon OS, Gelpi E, Roselló‑Catafau J. Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia‑reperfusion. Free Radic Res 2000,33:595‑605.,33. Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, et al. Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury. Eur J Pharmacol 2008,581:306‑14.,34. Clavo B, Catalá L, Pérez JL, Rodríguez V, Robaina F. Ozone therapy on cerebral blood flow: A preliminary report. Evid Based Complement Alternat Med 2004,1:315‑9.,35. Borrelli E. Mechanism of action of oxygen ozone therapy in the treatment of disc herniation and low back pain. Acta Neurochir Suppl 2011,108:123‑5.,36. Sagai M, Bocci V. Mechanisms of action involved in ozone therapy: Is healing induced via a mild oxidative stress? Med Gas Res 2011,1:29.,37. Bocci V, Luzzi E, Corradeschi F, Paulesu L, Di Stefano A. Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines. Lymphokine Cytokine Res 1993,12:121‑6.,38. Hop JW, Rinkel GJ, Algra A, Berkelbach van der Sprenkel JW, van Gijn J. Randomized pilot trial of postoperative aspirin in subarachnoid hemorrhage. Neurology 2000,54:872‑8.,39. Vecchione C, Frati A, Di Pardo A, Cifelli G, Carnevale D, Gentile MT, et al. Tumor necrosis factor‑alpha mediates hemolysis‑induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage. Hypertension 2009,54:150‑6.,40. Handa Y, Kubota T, Kaneko M, Tsuchida A, Kobayashi H, Kawano H, et al. Expression of intercellular adhesion molecule 1 (ICAM‑1) on the cerebral artery following subarachnoid haemorrhage in rats. ActaNeurochir (Wien) 1995,132:92‑7.
dspace.entity.typePublication
local.indexed.atTRDizin

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The Effects of Ozone Oxidative Preconditioning on Subarachnoid Hemorrhage via Rat Cerebral Vasospasm Model.pdf
Size:
2.35 MB
Format:
Adobe Portable Document Format
Download

Collections

TR-Dizin İndeksli Yayınlar Koleksiyonu