Publication: İdiyopatik/Genetik Jeneralize ve Kendini Sınırlayan Fokal Epilepsilerde Febril Nöbetler
| dc.contributor.author | Rahşan İNAN | |
| dc.contributor.author | Mecbure Nalbantoglu | |
| dc.contributor.author | Figen Yavlal | |
| dc.contributor.author | Feray Tumay | |
| dc.contributor.author | Ahmet Veysi DEMIRBILEK | |
| dc.contributor.institution | SAĞLIK BİLİMLERİ ÜNİVERSİTESİ | |
| dc.contributor.institution | İSTANBUL DEMİROĞLU BİLİM ÜNİVERSİTESİ | |
| dc.contributor.institution | BAHÇEŞEHİR ÜNİVERSİTESİ | |
| dc.contributor.institution | T.C. SAĞLIK BAKANLIĞI | |
| dc.contributor.institution | İSTANBUL ÜNİVERSİTESİ - CERRAHPAŞA | |
| dc.date.accessioned | 2025-09-20T19:57:35Z | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 17.02.2022 | |
| dc.description.abstract | Amaç: Febril nöbet (FN) çocukluk çağı döneminin en sık görülen nöbet tipidir. İdiyopatik/jeneralize ve fokal/ kendini sınırlayan nöbetler de aynı yaş grubunda izlenmektedir. Genellikle iyi seyirlidirler. Bu çalışma idiyopatik/jeneralize ve fokal/ kendini sınırlayan epilepsileri olan hastalarda FN prevalansı ve demografik profili araştırmak amacıyla yapılmıştır.Gereç ve Yöntem: Bu geriye dönük çalışmaya polikliniğimize başvurmuş, gelişimsel değerlendirmeleri normal olan idiyopatik/jeneralize ve fokal/ kendini sınırlayan epilepsileri olan hastalar dahil edildi. Veriler hastaların tıbbi ve EEG kayıtlarından toplandı. Hastalar sendromlarına ve FN varlığına göre alt gruplara ayrıldı. Karşılaştırmalar FN özelliklerine göre yapıldı.Bulgular: Fokal ya da olası genetik nedenli jeneralize epilepsi tanılı 320 hasta arasında, FN’ler cinsiyet üstünlüğü olmaksızın %14.7 (n=47) hastada mevcuttu. Kendini sınırlayan fokal epilepsi 232 çocukta (%72.5) mevcuttu. Epilepsi başlangıç ortalama yaşı 7.97±3.38 yıldı (1–18 yıl). FN’lerin fokal ya da jeneralize epilepsi grupları (p=0.552) ya da bu grupların alt tipleri (p=0.701) içindeki dağılımı istatiksel anlamlılık göstermemekle birlikte, FN varlığı en yüksek oranla jüvenil miyoklonik epilepsi ve idiyopatik fotosensitif oksipital lob epilepsi gruplarında bulundu.Sonuç: Cinsiyet, FN ya da epilepsi aile öyküsü, epilepsi başlangıç yaşı, epilepsi tipi FN dışında normal olan çocuklarda ortaya çıkacak epilepsi için belirleyici bir faktör olarak görünmemektedir. | |
| dc.identifier.endpage | 118 | |
| dc.identifier.issn | 1300-7157 | |
| dc.identifier.issue | 2 | |
| dc.identifier.startpage | 113 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14719/4868 | |
| dc.identifier.volume | 27 | |
| dc.language.iso | en | |
| dc.relation.journal | Epilepsi | |
| dc.subject | Nörolojik Bilimler | |
| dc.title | İdiyopatik/Genetik Jeneralize ve Kendini Sınırlayan Fokal Epilepsilerde Febril Nöbetler | |
| dc.type | Research Article | |
| dcterms.references | 1. Commission on Epidemiology and Prognosis International League Against Epilepsy. Guidelines for epidemiologic studies on epilepsy. Epilepsia 1993,34(4):592–6.,2. Waruiru C, Appleton R. Febrile seizures: An update. Arch Dis Child 2004,89(8):751–6.,3. Shinnar S, Glauser TA. Febrile seizures. J Child Neurol 2002,17(1):S44–52.,4. Lux AL. Treatment of febrile seizures: Historical perspective, current opinions, and potential future directions. Brain Dev 2010,32(1):42–50.,5. Sadleir LG, Scheffer IE. Febrile seizures. BMJ 2007,334(7588):307– 11.,6. Kjeldsen MJ, Kyvik KO, Friis ML, Christensen K. Genetic and environmental factors in febrile seizures: A Danish population-based twin study. Epilepsy Res 2002,51(1-2):167–77.,7. Paul SP, Blaikley S, Chinthapalli R. Clinical update: Febrile convulsion in childhood. Community Pract 2012,85(7):36–8.,8. Panayiotopoulos CP. Idiopathic epileptic seizures and syndromes in infancy. In: Panayiotopoulos CP, editor. A Clinical Guide to Epileptic Syndromes and their Treatment. London: Springer-Verlag, 2010. p. 259–74.,9. Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, et al. ILAE classification of the epilepsies: Position paper of the ILAE commission for classification and terminology. Epilepsia 2017,58(4):512–21.,10. International League Against Epilepsy. Definitions and Guidelines on Epilepsy from ILAE, 2017. Available at: http://www.ilae. org/visitors/centre/definition_class.cfm. Accessed May 18, 2017.,11. Aaberg KM, Surén P, Søraas CL, Bakken IJ, Lossius MI, Stoltenberg C, et al. Seizures, syndromes, and etiologies in childhood epilepsy: The international league against epilepsy 1981, 1989, and 2017 classifications used in a population-based cohort. Epilepsia 2017,58(11):1880–91.,12. Nakayama J, Arinami T. Molecular genetics of febrile seizures. Epilepsy Res 2006,70(1):S190–8.,13. Kananura C, Haug K, Sander T, Runge U, Gu W, Hallmann K, et al. A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Arch Neurol 2002,59(7):1137–41.,14. Leung AK, Robson WL. Febrile seizures. J Pediatr Health Care 2007,21(4):250–5.,15. Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976,295(19):1029–33.,16. Baumann RJ, Duffner PK. Treatment of children with simple febrile seizures: The AAP practice parameter. American academy of pediatrics. Pediatr Neurol 2000,23(1):11–7.,17. Trinka E, Unterrainer J, Haberlandt E, Luef G, Unterberger I, Niedermüller U, et al. Childhood febrile convulsions-which factors determine the subsequent epilepsy syndrome? A retrospective study. Epilepsy Res 2002,50(3):283–92.,18. Verity CM, Golding J. Risk of epilepsy after febrile convulsions: A national cohort study. BMJ 1991,303(6841):1373–6.,19. Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987,316(9):493–8.,20. Yoshinaga H, Kobayashi K, Akiyama T, Shibata T, Endoh F, Ohtsuka Y. Clinical implications of preceding positive spikes in patients with benign partial epilepsy and febrile seizures. Brain Dev 2013,35(4):299–306.,21. Knudsen, FU, Paerregaard A, Andersen R, Andresen J. Long term outcome of prophylaxis for febrile convulsions. Arch Dis Child 1996,74(1):13–8.,22. Offringa M, Bossuyt PM, Lubsen J, Ellenberg JH, Nelson KB, Knudsen FU, et al. Risk factors for seizure recurrence in children with febrile seizures: A pooled analysis of individual patient data from five studies. J Pediatr 1994,124(4):574–84.,23. Camfield P, Camfield C, Gordon K, Dooley J. What types of epilepsy are preceded by febrile seizures? A population-based study of children. Dev Med Child Neurol 1994,36(10):887–92.,24. Canpolat M, Per H, Gumus H, Elmali F, Kumandas S. Investigating the prevalence of febrile convulsion in Kayseri, Turkey: An assessment of the risk factors for recurrence of febrile convulsion and for development of epilepsy. Seizure 2018,55:36–47.,25. Ateşoğlu M, İnce T, Lüleci D, Ergör A, Aydın A. Sociodemographic risk factors for febrile seizures: A school-based study from Izmir, Turkey. Seizure 2018,61:45–9.,26. Aydin A, Ergor A, Ozkan H. Effects of sociodemographic factors on febrile convulsion prevalence. Pediatr Int 2008,50(2):216–20.,27. Kajitani T, Kimura T, Sumita M, Kaneko M. Relationship between benign epilepsy of children with centro-temporal EEG foci and febrile convulsions. Brain Dev 1992,14(4):230–4.,28. Panayiotopoulos CP. Panayiotopoulos Syndrome: A Common and Benign Childhood Epileptic Syndrome. London: John Libbey & Company, 2002.,29. Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: Assessment of established and newly recognized syndromes. Brain 2008,131(9):2264–86.,30. Martínez-Ferrández C, Martínez-Salcedo E, Casas-Fernández C, Alarcón-Martínez H, Ibáñez-Micó S, Domingo-Jiménez R. Longterm prognosis of childhood absence epilepsy. Neurologia 2019,34(4):224–8.,31. Durón RM, Medina MT, Martínez-Juárez IE, Bailey JN, Perez-Gosiengfiao KT, Ramos-Ramírez R, et al. Seizures of idiopathic generalized epilepsies. Epilepsia 2005,46(9):34–47.,32. Marini C, Harkin LA, Wallace RH, Mulley JC, Scheffer IE, Berkovic SF. Childhood absence epilepsy and febrile seizures: A family with a GABA(A) receptor mutation. Brain 2003,126(1):230– 40.,33. Wallace RH, Marini C, Petrou S, Harkin LA, Bowser DN, Panchal RG, et al. Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet 2001,28(1):49–52.,34. Lu Y, Waltz S, Stenzel K, Muhle H, Stephani U. Photosensitivity in epileptic syndromes of childhood and adolescence. Epileptic Disord 2008,10(2):136–43.,35. Doose H, Ritter K, Völzke E. EEG longitudinal studies in febrile convulsions. Genetic aspects. Neuropediatrics 1983,14(2):81–7. | |
| dspace.entity.type | Publication | |
| local.indexed.at | TRDizin |